The Role of the Subplate in Schizophrenia and Autism: A Systematic Review.

abstract：BACKGROUND:Psychiatric illness and anxiety disorders have strong neurodevelopmental components. Environmental insults such as prenatal exposure to stress and genetic differences in stress responses may affect brain development. METHODS:A rat model of random variable prenatal stress was used to study the expression and...

journal_title：Neuroscience

authors： Neeley EW,Berger R,Koenig JI,Leonard S

更新日期：2011-07-28 00:00:00

abstract：:This study aimed to investigate the effects of regular treadmill exercise on nerve growth factor (NGF) expression, the improvement of cognitive function in the hippocampus of diabetic rats, and to understand the molecular mechanisms through which the relevant signaling factors act. We investigated the effects of regul...

journal_title：Neuroscience

authors： Chae CH,Jung SL,An SH,Park BY,Wang SW,Cho IH,Cho JY,Kim HT

更新日期：2009-12-29 00:00:00

abstract：:Using an indirect immunofluorescence method the distribution of vasoactive intestinal peptide (VIP) immunoreactivity was studied in human foetus and newborn infant spinal cord and dorsal root ganglia. Further, for comparison some newborn infant brains were also investigated. Vasoactive intestinal peptide-like immunore...

journal_title：Neuroscience

authors： Charnay Y,Chayvialle JA,Said SI,Dubois PM

更新日期：1985-01-01 00:00:00

abstract：:Tetramethylpyrazine (TMP) is an active compound extracted from the traditional Chinese medicinal herb Chuanxiong. Recently, it has been reported that TMP enhances neurogenesis, and promotes neural stem cell differentiation toward neurons. However, its molecular basis remains unknown. Topoisomerase IIβ (TopoIIβ) is a n...

journal_title：Neuroscience

authors： Yan Y,Zhao J,Cao C,Jia Z,Zhou N,Han S,Wang Y,Xu Y,Zhao J,Yan Y,Cui H

更新日期：2014-10-10 00:00:00

abstract：:The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human Parkinson's disease...

journal_title：Neuroscience

authors： Bezard E,Boraud T,Bioulac B,Gross CE

更新日期：1997-11-01 00:00:00

abstract：:Compelling lines of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS brain. In the present study, we used a novel, phospho-dependent antibody r...

journal_title：Neuroscience

authors： Kida E,Walus M,Jarząbek K,Palminiello S,Albertini G,Rabe A,Hwang YW,Golabek AA

更新日期：2011-11-10 00:00:00

abstract：:Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...

journal_title：Neuroscience

authors： Smyk MK,van Luijtelaar G,Huysmans H,Drinkenburg WH

更新日期：2019-06-01 00:00:00

abstract：:Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and neuronal functions. Calcineurin-dependent pathways are important for complex brain functions such as learning and memory. More recently, they have be...

journal_title：Neuroscience

authors： Crozatier C,Farley S,Mansuy IM,Dumas S,Giros B,Tzavara ET

更新日期：2007-02-23 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:Current neurobiological theory of drug use is based on the observation that all addictive drugs induce changes in activity of dopaminergic circuitry, interfering with reward processing, and thus enhancing drug seeking and consumption behaviors. Current theory of drug origins, in contrast, views almost all major drugs ...

journal_title：Neuroscience

authors： Hagen EH,Sullivan RJ,Schmidt R,Morris G,Kempter R,Hammerstein P

更新日期：2009-04-21 00:00:00

abstract：:Acetylcholine can stimulate the release of vasopressin. In organ-cultured hypothalamo-neurohypophyseal systems, acetylcholine enhanced vasopressin release by acting in or near the supraoptic nucleus Extracellular recordings suggested that acetylcholine can increase supraoptic neuron excitability. These effects could b...

journal_title：Neuroscience

authors： Zaninetti M,Blanchet C,Tribollet E,Bertrand D,Raggenbass M

更新日期：2000-01-01 00:00:00

abstract：:Lack of dystrophin in mdx mice leads to muscle fibre degeneration followed by the formation of new myofibres. This degeneration-regeneration event occurs in clusters. It is accompanied by inflammation and remodelling of the intramuscular terminal nerve fibres. Since the growth-associated protein B-50/GAP-43 has been s...

journal_title：Neuroscience

authors： Verzè L,Buffo A,Rossi F,Oestreicher AB,Gispen WH,Strata P

更新日期：1996-02-01 00:00:00

abstract：:Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...

journal_title：Neuroscience

authors： Dwivedi Y,Rizavi HS,Pandey GN

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of dopamine on the function of synapses formed by cholinergic neurons derived from the rat retina. We used an experimental culture system in which rat striated muscle cells served as postsynaptic targets for cholinergic neurons of the retina. This culture system ...

journal_title：Neuroscience

authors： Yeh HH,Battelle BA,Puro DG

更新日期：1984-11-01 00:00:00

abstract：:In the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the Na+-dependent glutamate transporter, which was activated by extracellular K+. Glutamate transport current was measured by a conventional whole-cell patch recording mode under voltage-clamp co...

journal_title：Neuroscience

authors： Noda M,Nakanishi H,Akaike N

更新日期：1999-01-01 00:00:00

abstract：:Interactions between the hippocampus and the prefrontal cortex (PFC) are of major interest in the neurobiology of psychiatric and neurodegenerative disorders and are central to many experimental rodent models. Non-invasive imaging techniques offer a translatable approach to probing this system if homologous features c...

journal_title：Neuroscience

authors： Schwarz AJ,Gass N,Sartorius A,Zheng L,Spedding M,Schenker E,Risterucci C,Meyer-Lindenberg A,Weber-Fahr W

更新日期：2013-01-03 00:00:00

abstract：:The central nervous system responds to diverse neurologic injuries with a vigorous activation of astrocytes. While this phenomenon is found in many different species, its function is obscure. Understanding the molecular profile characteristic of reactive astrocytes should help define their function. The purpose of thi...

journal_title：Neuroscience

authors： Eddleston M,Mucke L

更新日期：1993-05-01 00:00:00

abstract：:There is a consensus that active (REM) sleep (AS) is controlled by cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei (LDT/PPT) to neurons in the nucleus pontis oralis (NPO) that generate AS (i.e. AS-Generator neurons). The present study was designed to provide evidence that other proj...

journal_title：Neuroscience

authors： Xi M,Fung SJ,Sampogna S,Chase MH

更新日期：2011-12-01 00:00:00

abstract：:The zona incerta (ZI), first described over a century ago by Auguste Forel as a "region of which nothing certain can be said," forms a collection of cells that derives from the diencephalon. To this day, we are still not certain of the precise function of this "zone of uncertainty" although many have been proposed, fr...

journal_title：Neuroscience

authors： Mitrofanis J

更新日期：2005-01-01 00:00:00

abstract：:The dorsal hippocampus (DH) is a structure of the limbic system that is involved in emotional, learning and memory processes. There is evidence indicating that the DH modulates cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint stress (RS) is an unavoidable stress situation that ev...

journal_title：Neuroscience

authors： Moraes-Neto TB,Scopinho AA,Biojone C,Corrêa FM,Resstel LB

更新日期：2014-01-31 00:00:00

abstract：:We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...

journal_title：Neuroscience

authors： Green PG,Luo J,Heller PH,Levine JD

更新日期：1993-02-01 00:00:00

abstract：:The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...

journal_title：Neuroscience

authors： Berthold CH,Mellström A

更新日期：1986-12-01 00:00:00

abstract：:Dementia, especially Alzheimer's disease, is a rapidly increasing medical condition that presents with enormous challenge for treatment. It is characterized by impairment in memory and cognitive function often accompanied by changes in synaptic transmission and plasticity in relevant brain regions such as the hippocam...

journal_title：Neuroscience

authors： Nashawi H,Bartl T,Bartl P,Novotny L,Oriowo MA,Kombian SB

更新日期：2012-09-18 00:00:00

abstract：:Although much prior work has focused on the known cortical pathology that defines Alzheimer's disease (AD) histologically, recent work has additionally demonstrated substantial damage to the cerebral white matter in this condition. While there is large evidence of diffuse damage to the white matter in AD, it is unclea...

journal_title：Neuroscience

authors： Lee SH,Coutu JP,Wilkens P,Yendiki A,Rosas HD,Salat DH,Alzheimer’s disease Neuroimaging Initiative (ADNI).

更新日期：2015-08-20 00:00:00

abstract：:Brainstem networks generating the respiratory rhythm in lampreys are still not fully characterized. In this study, we described the patterns of respiratory activities and we identified the general location of underlying neural networks. In a semi-intact preparation including the brain and gills, rhythmic discharges we...

journal_title：Neuroscience

authors： Martel B,Guimond JC,Gariépy JF,Gravel J,Auclair F,Kolta A,Lund JP,Dubuc R

更新日期：2007-08-10 00:00:00

abstract：:Efferent projections of the zona incerta were examined in the rat using the autoradiographic and horseradish peroxidase methods, with special reference to the cytoarchitectonic structure of the zona incerta. Autoradiographic experiments showed that the incertofugal fiber systems reach ipsilaterally to the thalamus (la...

journal_title：Neuroscience

authors： Watanabe K,Kawana E

更新日期：1982-10-01 00:00:00

abstract：:Organophosphates (OPs) pose a constant threat to human health due to their widespread use as pesticides and their potential employment in military and terrorist attacks. The acute toxicity of OPs has been extensively studied; however, the consequences of prolonged or repeated exposure to levels of OPs that produce no ...

journal_title：Neuroscience

authors： Terry AV Jr,Buccafusco JJ,Gearhart DA,Beck WD,Middlemore-Risher ML,Truan JN,Schwarz GM,Xu M,Bartlett MG,Kutiyanawala A,Pillai A

更新日期：2011-03-10 00:00:00

abstract：:Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...

journal_title：Neuroscience

authors： Moeller HB,Fenton RA,Zeuthen T,Macaulay N

更新日期：2009-12-29 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) signals through multisubunit receptor complex consisting of RET tyrosine kinase and a glycosylphosphatidylinositol-anchored coreceptor called GDNF family receptor alpha1 (GFRalpha1). In the current study, we cloned a human SEP1 gene as a GDNF-inducible gene using huma...

journal_title：Neuroscience

authors： Shimoyama Y,Morikawa Y,Ichihara M,Kodama Y,Fukuda N,Hayashi H,Morinaga T,Iwashita T,Murakumo Y,Takahashi M

更新日期：2003-01-01 00:00:00

abstract：:Cholinergic neurons of the striatum play a crucial role in controlling output from this region. Their firing is under the control of a relatively limited glutamatergic input, deriving principally from the thalamus. Glutamate transmission is effected via three major subtypes of receptors, including those with affinity ...

journal_title：Neuroscience

authors： Bloomfield C,O'Donnell P,French SJ,Totterdell S

更新日期：2007-12-12 00:00:00