Compensatory effects of glutamatergic inputs to the substantia nigra pars compacta in experimental parkinsonism.

abstract：:The Ca(2+)-dependent release of the neurotransmitter glutamate from purified nerve terminals (synaptosomes) of the rat hippocampus was studied in a rapid perfusion apparatus. The response of the terminals was investigated with respect to the kinetics and duration of the release of endogenous glutamate upon brief and s...

journal_title：Neuroscience

authors： Verhage M,Lopes da Silva FH,Ghijsen WE

更新日期：1991-01-01 00:00:00

abstract：:S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuv...

journal_title：Neuroscience

authors： Tanga FY,Raghavendra V,Nutile-McMenemy N,Marks A,Deleo JA

更新日期：2006-07-07 00:00:00

abstract：:The role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit usin...

journal_title：Neuroscience

authors： Shirhan MD,Moochhala SM,Ng PY,Lu J,Ng KC,Teo AL,Yap E,Ng I,Hwang P,Lim T,Sitoh YY,Rumpel H,Jose R,Ling E

更新日期：2004-01-01 00:00:00

abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

journal_title：Neuroscience

authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

更新日期：2020-04-30 00:00:00

abstract：:Membrane potential or ionic conductance of neurones of the mammalian central or peripheral nervous system maintained in vitro can be measured over periods of several hours. Drugs or transmitters which change potential or conductance can be applied repeatedly under equilibrium conditions, and pharmacological null metho...

journal_title：Neuroscience

authors： North RA

更新日期：1986-04-01 00:00:00

abstract：:The distribution in the rat brain of high affinity nicotinic heteromeric acetylcholine receptors and of low affinity nicotinic, alpha7-containing, homomeric receptors was studied using in vitro light microscopic autoradiography. As ligands, we used [3H]epibatidine, or [125I]epibatidine, and [125I]alpha-bungarotoxin, r...

journal_title：Neuroscience

authors： Tribollet E,Bertrand D,Marguerat A,Raggenbass M

更新日期：2004-01-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) has been implicated in regulating synaptic plasticity mechanisms as well as memory consolidation processes. Attachment of polysialic acid to NCAM (PSA-NCAM) has been reported to down-regulate its adhesive forces, a process hypothesized to be implicated in synapse selection afte...

journal_title：Neuroscience

authors： Markram K,Gerardy-Schahn R,Sandi C

更新日期：2007-02-09 00:00:00

abstract：:Adenosine trisphosphate-sensitive potassium (K-ATP) channels in the substantia nigra pars reticulata were studied in rat brain slices using whole-cell patch clamp recording. Substantia nigra pars reticula neurons were identified as such by their spontaneous action potential firing at mean rate of 15.3 Hz1 virtual abse...

journal_title：Neuroscience

authors： Stanford IM,Lacey MG

更新日期：1996-09-01 00:00:00

abstract：:The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

journal_title：Neuroscience

authors： Spike RC,Watt C,Zafra F,Todd AJ

更新日期：1997-03-01 00:00:00

abstract：:The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...

journal_title：Neuroscience

authors： Berthold CH,Mellström A

更新日期：1986-12-01 00:00:00

abstract：:Calcium permeabilities were examined in large cerebellar neurons maintained in culture, and morphologically identified as Purkinje cells. When cells were supplied with a Dulbecco Minimum Eagle's Medium with 10% horse serum added (5-10 days), somatic recordings revealed complex spikes and these were shown to be generat...

journal_title：Neuroscience

authors： Bossu JL,Dupont JL,Feltz A

更新日期：1989-01-01 00:00:00

abstract：:Recent studies suggest that neurons containing adrenocorticotropin and catecholamines are localized to similar areas of the brain. In this immunocytochemical study, the distributions of neurons and terminals containing adrenocorticotropin and tyrosine hydroxylase, the first enzyme in the catecholamine biosynthetic pat...

journal_title：Neuroscience

authors： Baker H,Ruggiero DA,Alden S,Anwar M,Reis DJ

更新日期：1986-02-01 00:00:00

abstract：:An in vitro slice preparation of combined hippocampus and entorhinal cortex from adult rats was used to study the modalities of generation and propagation, as well as the pharmacological properties of the epileptiform activity induced by the muscarinic agonist pilocarpine (10 microM). Simultaneous field potentials rec...

journal_title：Neuroscience

authors： Nagao T,Alonso A,Avoli M

更新日期：1996-05-01 00:00:00

abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

journal_title：Neuroscience

authors： Turgeon SM,Albin RL

更新日期：1994-09-01 00:00:00

abstract：:Oxytocin (OT) levels in plasma increase during sexual response and are significantly lower in patients with depression. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. In this study, we showed that sildenafil had an antidepressant...

journal_title：Neuroscience

authors： Matsushita H,Matsuzaki M,Han XJ,Nishiki TI,Ohmori I,Michiue H,Matsui H,Tomizawa K

更新日期：2012-01-03 00:00:00

abstract：:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connec...

journal_title：Neuroscience

authors： Zahm DS,Brog JS

更新日期：1992-10-01 00:00:00

abstract：:Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...

journal_title：Neuroscience

authors： Weston J,Greenfield SA

更新日期：1986-04-01 00:00:00

abstract：:Recent reports show that striatal dopamine D1-type receptors from one side of the normal rat brain can control brain activity (as measured by c-fos induction) on both sides of the brain. However, this phenomenon has not yet been studied in the presence of sensitized dopamine D1-type receptors. Here we address this iss...

journal_title：Neuroscience

authors： Taymans JM,Kia HK,Groenewegen HJ,Leysen JE,Langlois X

更新日期：2005-01-01 00:00:00

abstract：:The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...

journal_title：Neuroscience

authors： Francis AB,Pace TW,Ginsberg AB,Rubin BA,Spencer RL

更新日期：2006-09-01 00:00:00

abstract：:Neuroscientists have often described the adult brain in similar terms to an electronic circuit board- dependent on fixed, precise connectivity. However, with the advent of technologies allowing chronic measurements of neural structure and function, the emerging picture is that neural networks undergo significant remod...

journal_title：Neuroscience

authors： Chambers AR,Rumpel S

更新日期：2017-08-15 00:00:00

abstract：:Methamphetamine (MA), neurotoxic drug of abuse, causes cell death in vitro and in vivo via several mechanisms such as mitochondrial dysfunction. In this study we evaluated the effect of MA on cell viability and mitochondrial biogenesis in primary midbrain culture. Primary mesencephalon cells prepared from E14.5 rat em...

journal_title：Neuroscience

authors： Valian N,Heravi M,Ahmadiani A,Dargahi L

更新日期：2019-05-15 00:00:00

abstract：:This article argues how dopamine controls working memory and how the dysregulation of the dopaminergic system is related to schizophrenia. In the dorsolateral prefrontal cortex, which is the principal part of the working memory system, recurrent excitation is subtly balanced with intracortical inhibition. A potent con...

journal_title：Neuroscience

authors： Tanaka S

更新日期：2006-04-28 00:00:00

abstract：:The pharmacological characteristics and anatomical distribution of benzodiazepine receptors in the human hippocampal formation were studied in seven cases aged 4-68 years. The pharmacology of the receptors was studied by computerized, non-linear least squares regression analysis of [3H]flunitrazepam displacement by fl...

journal_title：Neuroscience

authors： Faull RL,Villiger JW

更新日期：1988-09-01 00:00:00

abstract：:Brain responses to discrete short sounds have been studied intensively using the event-related potential (ERP) method, in which the electroencephalogram (EEG) signal is divided into epochs time-locked to stimuli of interest. Here we introduce and apply a novel technique which enables one to isolate ERPs in human elici...

journal_title：Neuroscience

authors： Poikonen H,Alluri V,Brattico E,Lartillot O,Tervaniemi M,Huotilainen M

更新日期：2016-01-15 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

journal_title：Neuroscience

authors： Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

更新日期：2010-10-13 00:00:00

abstract：:In vitro receptor autoradiography was used to localize, quantify and characterize [125I-Tyr8]bradykinin binding sites in all major spinal cord segments of normal rats and animals subjected to various chemical treatments and surgical lesions. [125I-Tyr8]bradykinin specific binding sites were predominantly located to su...

journal_title：Neuroscience

authors： Lopes P,Kar S,Chrétien L,Regoli D,Quirion R,Couture R

更新日期：1995-10-01 00:00:00

abstract：:Excitatory amino acid transporters (EAAT) uptake extracellular glutamate, the major excitatory neurotransmitter in the brain. EAAT type 3 (EAAT3), the main neuronal EAAT, is expressed widely in the CNS. We have shown that the volatile anesthetic isoflurane increases EAAT3 activity and trafficking to the plasma membran...

journal_title：Neuroscience

authors： Lee SN,Li L,Zuo Z

更新日期：2010-12-15 00:00:00

abstract：:Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNN expression around somas, proximal d...

journal_title：Neuroscience

authors： Chu P,Abraham R,Budhu K,Khan U,De Marco Garcia N,Brumberg JC

更新日期：2018-09-15 00:00:00

abstract：:1-Bromopropane is a newly introduced substitute for specific chlorofluorocarbons whose production was prohibited because of depletion of ozone layers. In this study, we analyzed disinhibitory effects induced by repetitive inhalation of 1-bromopropane for 12 weeks in the hippocampal CA1 and the dentate gyrus. In additi...

journal_title：Neuroscience

authors： Fueta Y,Fukuda T,Ishidao T,Hori H

更新日期：2004-01-01 00:00:00

abstract：:Estrogens influence neuronal activity and are important for normal brain functions. Effects of estrogens on seizures are contradictory. It is commonly accepted that estrogens may increase neuronal excitability and thus mediate proconvulsant effects. However, clinical and animal data show that estrogen may also have no...

journal_title：Neuroscience

authors： Velísková J

更新日期：2006-01-01 00:00:00