The role of estrogens in seizures and epilepsy: the bad guys or the good guys?

abstract：:Cholinergic interneurons, which provide the main source of acetylcholine (ACh) in the striatum, control the striatal local circuits and deeply involve in the pathogenesis of neurodegenerative diseases. Glycogen synthase kinase-3 (GSK-3) is a crucial kinase with diverse fundamental functions and accepted that deregulat...

journal_title：Neuroscience

authors： Zhao L,Chu CB,Li JF,Yang YT,Niu SQ,Qin W,Hao YG,Dong Q,Guan R,Hu WL,Wang Y

更新日期：2013-01-01 00:00:00

abstract：:Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning ...

journal_title：Neuroscience

authors： Manning CE,Eagle AL,Kwiatkowski CC,Achargui R,Woodworth H,Potter E,Ohnishi Y,Leinninger GM,Robison AJ

更新日期：2019-05-15 00:00:00

abstract：:GABA has been shown to play an important role in the control of gonadotropin-releasing hormone (GnRH) and luteinizing hormone secretion in many mammals. In sheep, seasonal differences in the ability of GABA-B receptor antagonists to alter pulsatile luteinizing hormone secretion have led to the hypothesis that this rec...

journal_title：Neuroscience

authors： Sliwowska JH,Billings HJ,Goodman RL,Lehman MN

更新日期：2006-08-11 00:00:00

abstract：:The present study was designed to assess the possibility that sub-total ventral hippocampal lesions might leave intact a mechanism for only highly accurate navigation, whereas sub-total dorsal hippocampal lesions might leave intact a mechanism only for less precise navigation. Animals with selective dorsal, ventral or...

journal_title：Neuroscience

authors： Zhang WN,Pothuizen HH,Feldon J,Rawlins JN

更新日期：2004-01-01 00:00:00

abstract：:Prenatal exposures to a variety of infections have been associated with an increased incidence of schizophrenia. We have reported that a single injection of the synthetic cytokine releaser PolyI:C to pregnant mice produced offspring that exhibited multiple schizophrenia-related behavioral deficits in adulthood. Here, ...

journal_title：Neuroscience

authors： Nyffeler M,Meyer U,Yee BK,Feldon J,Knuesel I

更新日期：2006-11-17 00:00:00

abstract：:The cortical representation of the body surface is not fixed, but rather, is continuously modified by ongoing changes in sensory experience. Although the cellular and molecular mechanisms that subserve these changes are uncertain, increasing evidence suggests that synaptically-released zinc may play a role. Zinc is re...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2005-01-01 00:00:00

abstract：:Calmodulin (CaM) and neurogranin (Ng) are two abundant neuronal proteins in the forebrain whose interactions are implicated in the enhancement of synaptic plasticity. To gain further insight into the actions of these two proteins we investigated whether they co-localize in principle neurons and whether they respond to...

journal_title：Neuroscience

authors： Huang KP,Huang FL,Shetty PK

更新日期：2011-03-31 00:00:00

abstract：:It is well known that the electroencephalogram of the cat in the early stages of slow wave sleep is mainly characterized by rhythmic wave activity at 7-14 Hz, termed spindles, which recur periodically with a slow rhythm of 0.1-0.2 Hz. From early stimulation, decortication and transection studies (see Ref. 14), spindle...

journal_title：Neuroscience

authors： Marini G,Macchi G,Mancia M

更新日期：1992-12-01 00:00:00

abstract：:The distribution of N-methyl-D-aspartate- (NMDA) and kainic acid- (KA) sensitive ionotropic glutamate receptors (iGluR) in the zebrafish olfactory bulb was assessed using an activity-dependent labeling method. Olfactory bulbs were incubated with an ion channel permeant probe, agmatine (AGB), and iGluR agonists in vitr...

journal_title：Neuroscience

authors： Edwards JG,Michel WC

更新日期：2003-01-01 00:00:00

abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

journal_title：Neuroscience

authors： Parent A,Mackey A,De Bellefeuille L

更新日期：1983-12-01 00:00:00

abstract：:Most functional imaging studies of memory retrieval investigate memory for standardized laboratory stimuli. However, naturally acquired autobiographical memories differ from memories of standardized stimuli in important ways. Neuroimaging studies of natural memories may reveal distinctive patterns of brain activation ...

journal_title：Neuroscience

authors： Maddock RJ,Garrett AS,Buonocore MH

更新日期：2001-01-01 00:00:00

abstract：:Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of the channels containing the NR2B subunit and voltage-independent inhibition of those containing NR2A. Thus, it may represent a f...

journal_title：Neuroscience

authors： Gavazzo P,Tedesco M,Chiappalone M,Zanardi I,Marchetti C

更新日期：2011-03-17 00:00:00

abstract：:The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-da...

journal_title：Neuroscience

authors： Burnham NW,Thiele TE

更新日期：2017-12-26 00:00:00

abstract：:The ultrastructural features and synaptic contacts of two types of neurotensin-containing amacrine cells in turtle retina were examined by electron immunocytochemistry, and the retinal peptides were characterized using radioimmunoassay and high-pressure liquid chromatography. The two types of cell were distinguished o...

journal_title：Neuroscience

authors： Eldred WD,Carraway RE

更新日期：1987-05-01 00:00:00

abstract：:Enteric viscerofugal neurons are mechanosensory interneurons that form the afferent limb of intestino-intestinal reflexes involving prevertebral sympathetic neurons. Fast synaptic inputs to viscerofugal neurons arise from other enteric neurons, but their sources are unknown. We aimed to describe the origins of synapti...

journal_title：Neuroscience

authors： Hibberd TJ,Spencer NJ,Zagorodnyuk VP,Chen BN,Brookes SJ

更新日期：2014-09-05 00:00:00

abstract：:Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...

journal_title：Neuroscience

authors： Jonsson G,Hallman H

更新日期：1982-01-01 00:00:00

abstract：:Previous studies have raised the possibility that a decrease in voltage-gated K+ currents may contribute to hyperexcitability of injured dorsal root ganglion (DRG) neurons and the emergence of neuropathic pain. We examined the effects of axotomy on mRNA levels for various Kv1 family subunits and voltage-gated K+ curre...

journal_title：Neuroscience

authors： Yang EK,Takimoto K,Hayashi Y,de Groat WC,Yoshimura N

更新日期：2004-01-01 00:00:00

abstract：:Transcranial magnetic stimulation (TMS) has opened important perspectives on the pathophysiological bases and potential targets of treatment strategies for idiopathic Parkinson's disease (IPD). Studies have been mainly focusing on motor cortical inhibitory phenomena. However, differences in patients and methods caused...

journal_title：Neuroscience

authors： Cantello R,Tarletti R,Varrasi C,Cecchin M,Monaco F

更新日期：2007-11-30 00:00:00

abstract：:Synapsins (SynI, SynII, SynIII) are a multigene family of synaptic vesicle (SV) phosphoproteins implicated in the regulation of synaptic transmission and plasticity. Synapsin I, II, I/II and I/II/III knockout mice are epileptic and SYN1/2 genes have been identified as major epilepsy susceptibility genes in humans. We ...

journal_title：Neuroscience

authors： Boido D,Farisello P,Cesca F,Ferrea E,Valtorta F,Benfenati F,Baldelli P

更新日期：2010-11-24 00:00:00

abstract：:Hypocretin/orexin (Hcrt/Orx) and melanin concentrating hormone (MCH) are peptides contained in overlapping cell groups of the lateral hypothalamus and commonly involved in regulating sleep-wake states and energy balance, though likely in different ways. To see if these neurons are similarly or differentially modulated...

journal_title：Neuroscience

authors： Bayer L,Eggermann E,Serafin M,Grivel J,Machard D,Muhlethaler M,Jones BE

更新日期：2005-01-01 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00

abstract：:Up-regulation of proBDNF in ischemic brain and the detrimental role of proBDNF on cellular survival has already been established. We propose that the up-regulated proBDNF may trigger the harmful events and evoke a secondary ischemic damage after ischemia. This study aimed to establish the neuroprotective effects of an...

journal_title：Neuroscience

authors： Rahman M,Luo H,Bobrovskaya L,Zhou XF

更新日期：2020-10-15 00:00:00

abstract：:Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic. To date, however, a quantitative description of the topographic distribution of GABAergic neurons in the rat's IC and their GABAergic or glyciner...

journal_title：Neuroscience

authors： Merchán M,Aguilar LA,Lopez-Poveda EA,Malmierca MS

更新日期：2005-01-01 00:00:00

abstract：:Beta(2)-adrenergic receptors (beta(2)-AR) and CB1 cannabinoid receptors share the property of being constitutively active. The CB1 cannabinoid receptor can also sequester G(i/o) proteins; however, it is not known whether the beta(2)-AR can also sequester G proteins. Beta(2)-ARs were heterologously expressed in rat sup...

journal_title：Neuroscience

authors： Vásquez C,Lewis DL

更新日期：2003-01-01 00:00:00

abstract：:The effects of X-irradiation on proliferating cells in the dentate subgranular zone were assessed in young adult Fisher 344 rats exposed to a range of X-ray doses and followed for up to 120 days. Apoptosis was quantified using morphology and end-labeling immunohistochemistry, and cell proliferation was detected using ...

journal_title：Neuroscience

authors： Tada E,Parent JM,Lowenstein DH,Fike JR

更新日期：2000-01-01 00:00:00

abstract：:Sensorineural hearing loss (SNHL) comprises hearing disorders with diverse pathologies of the inner ear and the auditory nerve. To date, an unambiguous phenotypical characterization of the specific pathologies in an affected individual remains impossible. Here, we evaluated the use of scalp-recorded auditory steady-st...

journal_title：Neuroscience

authors： Pauli-Magnus D,Hoch G,Strenzke N,Anderson S,Jentsch TJ,Moser T

更新日期：2007-11-09 00:00:00

abstract：:The senses of hearing and balance in vertebrates are transduced by hair cells in the inner ear. Hair cells from a wide variety of organisms have been described electrophysiologically but this is the first report of the application of these techniques to the genetically tractable zebrafish model system. Auditory and ve...

journal_title：Neuroscience

authors： Haden M,Einarsson R,Yazejian B

更新日期：2013-09-17 00:00:00

abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

journal_title：Neuroscience

authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

更新日期：1999-03-01 00:00:00

abstract：:The effect of the availability of synaptic targets on neuronal survival was tested by explanting the cochleovestibular ganglion from embryonic day 3-1/2 chick embryos and maintaining it in the presence or absence of appropriate synaptic target tissues for 14 days in culture. The targets were the inner ear, peripherall...

journal_title：Neuroscience

authors： Ard MD,Morest DK,Hauger SH

更新日期：1985-09-01 00:00:00

abstract：:Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause glucocorticoid (GC) resistance. In the present study, we aimed to investi...

journal_title：Neuroscience

authors： Alhaddad H,Gordon DM,Bell RL,Jarvis EE,Kipp ZA,Hinds TD Jr,Sari Y

更新日期：2020-06-15 00:00:00