Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.

abstract：:Thalamocortical neurons display a wide spectrum of activity patterns that are the expressions of the non-linear interactions between the various voltage-gated ion channels. Here, we show how bistable behaviour can emerge in these neurons, and how it is brought about by the steady-state residual ("window") component of...

journal_title：Neuroscience

authors： Tóth TI,Hughes SW,Crunelli V

更新日期：1998-11-01 00:00:00

abstract：:Neurons restore their function in response to external or internal perturbations and maintain neuronal or network stability through a homeostatic scaling mechanism. Homeostatic responses at synapses along the auditory system would be important for adaptation to normal and abnormal fluctuations in the sensory environme...

journal_title：Neuroscience

authors： Whiting B,Moiseff A,Rubio ME

更新日期：2009-11-10 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:It has previously been found that, in the presence of naloxone, the ganglionic blocking drug hexamethonium fails to completely block peristaltic motility in the isolated ileum of the guinea-pig. This hexamethonium-resistant peristaltic activity is coordinated by enteric nerves since it is abolished by tetrodotoxin. In...

journal_title：Neuroscience

authors： Barthó L,Holzer P,Leander S,Lembeck F

更新日期：1989-01-01 00:00:00

abstract：:Layer V pyramidal cells in the intermediate part of the cerebral cortex enter the lumbar spinal gray, but not the cervical spinal gray matter, during the first postnatal week. To study if the ingrowth of intermediate corticospinal axons into the lumbar spinal gray is guided by a diffusible tropic factor, we co-culture...

journal_title：Neuroscience

authors： Joosten EA,Gispen WH,Bär PR

更新日期：1994-03-01 00:00:00

abstract：:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...

journal_title：Neuroscience

authors： Legendre A,Courville J

更新日期：1987-06-01 00:00:00

abstract：:It is well established that physical exercise can exert neuroprotection both in clinical settings and animal experiments. A series of studies have demonstrated that physical exercise may be a promising preconditioning method to induce brain ischemic tolerance through the promotion of angiogenesis, mediation of the inf...

journal_title：Neuroscience

authors： Zhang F,Wu Y,Jia J

更新日期：2011-03-17 00:00:00

abstract：:The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

journal_title：Neuroscience

authors： Fukami K,Kiyama H,Shiotani Y,Tohyama M

更新日期：1988-09-01 00:00:00

abstract：:Adenosine has been proposed as a homeostatic "sleep factor" that promotes the transition from waking to sleep by affecting several sleep-wake regulatory systems. In the basal forebrain, adenosine accumulates during wakefulness and, when locally applied, suppresses neuronal activity and promotes sleep. However, the neu...

journal_title：Neuroscience

authors： Arrigoni E,Chamberlin NL,Saper CB,McCarley RW

更新日期：2006-06-30 00:00:00

abstract：:The borders of the ventral striatum and ventral pallidum of the rat brain have been studied with immunocytochemistry for two protein markers that are present in these regions. One of these, DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, Mr 32,000), is specifically enriched in medium-sized spiny neurons of...

journal_title：Neuroscience

authors： Walaas SI,Ouimet CC

更新日期：1989-01-01 00:00:00

abstract：:We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins. We show that animals that learn a spatial memory tas...

journal_title：Neuroscience

authors： Molteni R,Barnard RJ,Ying Z,Roberts CK,Gómez-Pinilla F

更新日期：2002-01-01 00:00:00

abstract：:Stress has long been associated with the development of neuropsychiatric and neurological disorders. The effects of stress vary depending upon the age during which the stress is incurred, the duration and severity of the stressor, and can further be influenced by levels of circulating gonadal hormones. To date, the ma...

journal_title：Neuroscience

authors： Bath KG,Schilit A,Lee FS

更新日期：2013-06-03 00:00:00

abstract：:S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuv...

journal_title：Neuroscience

authors： Tanga FY,Raghavendra V,Nutile-McMenemy N,Marks A,Deleo JA

更新日期：2006-07-07 00:00:00

abstract：:Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...

journal_title：Neuroscience

authors： Leslie RA,Reynolds DJ,Andrews PL,Grahame-Smith DG,Davis CJ,Harvey JM

更新日期：1990-01-01 00:00:00

abstract：:The pedunculopontine nucleus (PPN) shows altered electrophysiological and anatomic characteristics in Parkinson's disease (PD), but little is known about the effect of 6-hydroxydopamine (6-OHDA) lesion and levodopa (L-DOPA) therapy on the relationship between spike and local field potential (LFP) activities in the PPN...

journal_title：Neuroscience

authors： Geng X,Wang X,He F,Zhang X,Xie J,Gao G,Han H,Yao X,Zhang H,Gao Y,Wang Y,Wang M

更新日期：2019-04-15 00:00:00

abstract：:Kinetic properties of synaptic depression were analysed for excitatory postsynaptic potentials in neuron number 3 in the right pallial ganglion of Helix pomatia. It was observed that long-term depression did not only suppress the amplitudes of excitatory postsynaptic potentials but also changed the kinetics of short-t...

journal_title：Neuroscience

authors： Christoffersen GR,Schilhab TS

更新日期：1996-08-01 00:00:00

abstract：:Chronic stress, the administration of glucocorticoids and the prolonged activation of glucocorticoid receptors (GRs) are reported to induce affective changes in humans and rodents that resemble a depressive state. However, data concerning the behavioral and molecular effects of the selective activation of specific GRs...

journal_title：Neuroscience

authors： Skupio U,Tertil M,Sikora M,Golda S,Wawrzczak-Bargiela A,Przewlocki R

更新日期：2015-02-12 00:00:00

abstract：:Locomotion involves complex combinations of translational and rotational head movements. For gaze stability, this necessitates the interplay of angular and linear vestibulo-ocular reflexes (VOR) as well as the integration of visual feedback about the desired viewing distance. Furthermore, gaze stabilizing systems must...

journal_title：Neuroscience

authors： Dietrich H,Wuehr M

更新日期：2019-06-01 00:00:00

abstract：:For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...

journal_title：Neuroscience

authors： Jones OD

更新日期：2015-11-19 00:00:00

abstract：:Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole...

journal_title：Neuroscience

authors： Oosthuizen MK,Amrein I

更新日期：2016-06-02 00:00:00

abstract：:Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes i...

journal_title：Neuroscience

authors： Stamatakis A,Toutountzi E,Fragioudaki K,Kouvelas ED,Stylianopoulou F,Mitsacos A

更新日期：2009-12-29 00:00:00

abstract：:Up-regulation of proBDNF in ischemic brain and the detrimental role of proBDNF on cellular survival has already been established. We propose that the up-regulated proBDNF may trigger the harmful events and evoke a secondary ischemic damage after ischemia. This study aimed to establish the neuroprotective effects of an...

journal_title：Neuroscience

authors： Rahman M,Luo H,Bobrovskaya L,Zhou XF

更新日期：2020-10-15 00:00:00

abstract：:FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR. Its association with mental disorders has been identified, but its function in disease development is largely unknown. Long-term potentiation (LTP) is a functiona...

journal_title：Neuroscience

authors： Qiu B,Xu Y,Wang J,Liu M,Dou L,Deng R,Wang C,Williams KE,Stewart RB,Xie Z,Ren W,Zhao Z,Shou W,Liang T,Yong W

更新日期：2019-03-15 00:00:00

abstract：:To elucidate the role and the mechanism of action of nerve growth factor in the adult central nervous system, we investigated the localization of nerve growth factor-like immunoreactivity in adult rat brain, both quantitatively and immunohistochemically, using polyclonal anti-nerve growth factor immunoglobulin G. We r...

journal_title：Neuroscience

authors： Nishio T,Furukawa S,Akiguchi I,Oka N,Ohnishi K,Tomimoto H,Nakamura S,Kimura J

更新日期：1994-05-01 00:00:00

abstract：:In situ hybridization was used to measure the levels of proenkephalin mRNA and prodynorphin mRNA in regions of rat striatum and nucleus accumbens. Chronic administration of haloperidol (2.4 mg/kg/day for 7 days) increased the levels of proenkephalin mRNA in both striatum and nucleus accumbens. In contrast, the levels ...

journal_title：Neuroscience

authors： Morris BJ,Höllt V,Herz A

更新日期：1988-05-01 00:00:00

abstract：:Conductive hearing loss is a prevalent condition globally. It remains unclear whether conductive hearing loss that occurs during early development disrupts auditory peripheral systems. In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal ...

journal_title：Neuroscience

authors： Qi Y,Yu S,Du Z,Qu T,He L,Xiong W,Wei W,Liu K,Gong S

更新日期：2019-05-15 00:00:00

abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

journal_title：Neuroscience

authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

更新日期：2018-10-15 00:00:00

abstract：:Repeated induction of a temporary threshold shift (TTS) may result in a permanent threshold shift (PTS) and is thought to be associated with early onset of age-related hearing loss (ARHL). The possibility that a PTS might be induced by administration of repeated TTS-inducing noise exposures (NEs) over a short period d...

journal_title：Neuroscience

authors： Luo Y,Qu T,Song Q,Qi Y,Yu S,Gong S,Liu K,Jiang X

更新日期：2020-03-01 00:00:00

abstract：:The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria m...

journal_title：Neuroscience

authors： Davidsen T,Koomey M,Tønjum T

更新日期：2007-04-14 00:00:00

abstract：:It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution and influence aspects of speech and language. Recently it was shown that when these substitutions are introduced into the endogenous Foxp2 gene of mice, they increase dendrite l...

journal_title：Neuroscience

authors： Reimers-Kipping S,Hevers W,Pääbo S,Enard W

更新日期：2011-02-23 00:00:00