Repeated Moderate Sound Exposure Causes Accumulated Trauma to Cochlear Ribbon Synapses in Mice.

abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

journal_title：Neuroscience

authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

更新日期：2016-03-01 00:00:00

abstract：:In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

journal_title：Neuroscience

authors： Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

更新日期：2016-06-14 00:00:00

abstract：:Microglial responses to endotoxin, including the synthesis of inflammatory factors, contribute to gliosis and neuron degeneration in cultured brain tissue. We have previously shown that Gö6976, a protein kinase C (PKC) inhibitor, suppressed the lipopolysaccharide (LPS)-induced production of inflammatory factors in mic...

journal_title：Neuroscience

authors： Jeohn GH,Cooper CL,Jang KJ,Liu B,Lee DS,Kim HC,Hong JS

更新日期：2002-01-01 00:00:00

abstract：:A previous study investigating potential adult hippocampal neurogenesis in microchiropteran bats failed to reveal a strong presence of this neural trait. As microchiropterans have a high field metabolic rate and a small body mass, it is possible that capture/handling stress may lead to a decrease in the detectable pre...

journal_title：Neuroscience

authors： Chawana R,Alagaili A,Patzke N,Spocter MA,Mohammed OB,Kaswera C,Gilissen E,Bennett NC,Ihunwo AO,Manger PR

更新日期：2014-09-26 00:00:00

abstract：:Angiogenesis after intracerebral hemorrhage (ICH) injury can effectively alleviate brain damage and improve neurological function. Hypoxia-inducible factor 2α (HIF-2α) is an important angiogenic regulator and exhibits protective effects in several neurological diseases; however, its role in ICH has not yet been report...

journal_title：Neuroscience

authors： Chen H,Xiao H,Gan H,Zhang L,Wang L,Li S,Wang D,Li T,Zhai X,Zhao J

更新日期：2020-11-10 00:00:00

abstract：:In the nervous system, the aminoacylhistidine dipeptide carnosine (beta-alanyl-L-histidine) has been shown to be expressed in the olfactory receptor neurons and in brain astrocytes. Using immunocytochemical techniques, we report here a dense carnosine-like immunoreactivity in the subependymal layer of the rodent foreb...

journal_title：Neuroscience

authors： Peretto P,Bonfanti L,Merighi A,Fasolo A

更新日期：1998-07-01 00:00:00

abstract：:The glucocorticoid-induced receptor (GIR) is an orphan G-protein-coupled receptor awaiting pharmacological characterization. GIR was originally identified in murine thymoma cells, and shows a widespread, yet not completely complementary distribution in mouse and human brain. Expression of the mouse GIR gene is modulat...

journal_title：Neuroscience

authors： Sah R,Pritchard LM,Richtand NM,Ahlbrand R,Eaton K,Sallee FR,Herman JP

更新日期：2005-01-01 00:00:00

abstract：:The dorsal hippocampus (DH) is a structure of the limbic system that is involved in emotional, learning and memory processes. There is evidence indicating that the DH modulates cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint stress (RS) is an unavoidable stress situation that ev...

journal_title：Neuroscience

authors： Moraes-Neto TB,Scopinho AA,Biojone C,Corrêa FM,Resstel LB

更新日期：2014-01-31 00:00:00

abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

journal_title：Neuroscience

authors： Parent A,Mackey A,De Bellefeuille L

更新日期：1983-12-01 00:00:00

abstract：:In three rhesus monkeys (Macaca mulatta), the inferior motor cortex was explored by electrical stimulation for sites yielding vocal fold adduction. The retrograde tracer wheat germ-agglutinin-conjugated horseradish peroxidase was injected into the effective sites. Within the forebrain, retrogradely labeled cells were ...

journal_title：Neuroscience

authors： Simonyan K,Jürgens U

更新日期：2005-01-01 00:00:00

abstract：:Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

journal_title：Neuroscience

authors： Eiland L,Romeo RD

更新日期：2013-09-26 00:00:00

abstract：:Major limitations to the pharmacotherapy of Parkinson's disease (PD) are the motor complications resulting from L-DOPA treatment. Abnormal involuntary movements (dyskinesia) affect a majority of the patients after a few years of L-DOPA treatment and can become troublesome and debilitating. Once dyskinesia has debuted,...

journal_title：Neuroscience

authors： Iderberg H,Francardo V,Pioli EY

更新日期：2012-06-01 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:Previous research indicates that distinct subregions of the cerebellum are involved in the processing of different primary emotions. How this is achieved in terms of connectional specificity with other brain areas still needs to be elucidated. We employed functional magnetic resonance imaging in order to investigate c...

journal_title：Neuroscience

authors： Schienle A,Scharmüller W

更新日期：2013-08-29 00:00:00

abstract：:Tianeptine (Tian) has been widely used in treating mood and anxiety disorders, and recently as a nootropic to improve cognitive performance. However, its mechanisms of action are insufficiently clear. We used a comparative proteomic approach to identify sub-proteome changes in hippocampal cytosol and non-synaptic mito...

journal_title：Neuroscience

authors： Perić I,Costina V,Findeisen P,Gass P,Filipović D

更新日期：2020-12-15 00:00:00

abstract：:The paraventricular nucleus of the hypothalamus is increasingly being viewed as an important site for cardiovascular integration because of its connections to regions in the brain and spinal cord which are known to be important in cardiovascular control. Like the vasomotor neurons of the rostral ventrolateral medulla,...

journal_title：Neuroscience

authors： Pyner S,Coote JH

更新日期：1999-01-01 00:00:00

abstract：:The recognition molecule myelin-associated glycoprotein is expressed by oligodendrocytes, the myelinating cells of the central nervous system. The myelin-associated glycoprotein gene gives rise to two alternatively spliced transcript variants ("early" and "late" message) which are developmentally regulated. In this st...

journal_title：Neuroscience

authors： Kirchhoff F,Ohlemeyer C,Kettenmann H

更新日期：1997-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor has been shown to be neuroprotective in models of excitotoxicity, axotomy and cerebral ischemia. The present study evaluated the therapeutic potential of brain-derived neurotrophic factor following traumatic brain injury in the rat. Male Sprague-Dawley rats (N=99) were anesthetized an...

journal_title：Neuroscience

authors： Blaha GR,Raghupathi R,Saatman KE,McIntosh TK

更新日期：2000-01-01 00:00:00

abstract：:Carbachol, a long-acting cholinergic agonist, was microinjected (4 micrograms/250 nl per 90 s) into 90 sites within the anterodorsal pontine tegmentum of four cats and the time to onset and percentage of time spent in a desynchronized sleep-like state during 40 min postinjection were calculated. Compared with more pos...

journal_title：Neuroscience

authors： Yamamoto K,Mamelak AN,Quattrochi JJ,Hobson JA

更新日期：1990-01-01 00:00:00

abstract：:Hippocampal anatomy and network organization are capable to generate drug-resistant temporal lobe epilepsy (TLE) in humans and particularly vulnerable to segmental neuronal cell loss. Surgical hippocampectomy has been proven successful in treatment and available human tissue specimens allow systematic clinico-patholog...

journal_title：Neuroscience

authors： Coras R,Blümcke I

更新日期：2015-11-19 00:00:00

abstract：:This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

journal_title：Neuroscience

authors： Fletcher GH,Starr MS

更新日期：1987-12-01 00:00:00

abstract：:The peripheral reorganization of pulpal nerves after tooth injury was studied, in the rat, with anterograde horseradish peroxidase tracing techniques, and combined retrograde Fluorogold tracing and immunohistochemistry was employed to examine the effects of inferior alveolar nerve lesions or tooth injury on some cytoc...

journal_title：Neuroscience

authors： Fried K,Arvidsson J,Robertson B,Pfaller K

更新日期：1991-01-01 00:00:00

abstract：:The blocking action of recently synthesized benzothiazolamine derivative R56865 was compared with that of dihydropyridine (nimodipine) and diphenylalkylamine (flunarizine) on low-voltage-activated and non-inactivating high-voltage-activated Ca2+ currents. The experiments were carried out on freshly isolated Purkinje n...

journal_title：Neuroscience

authors： Panchenko VA,Krishtal OA,Tegtmeier F,Tsyndrenko AYa

更新日期：1993-06-01 00:00:00

abstract：:Beta(2)-adrenergic receptors (beta(2)-AR) and CB1 cannabinoid receptors share the property of being constitutively active. The CB1 cannabinoid receptor can also sequester G(i/o) proteins; however, it is not known whether the beta(2)-AR can also sequester G proteins. Beta(2)-ARs were heterologously expressed in rat sup...

journal_title：Neuroscience

authors： Vásquez C,Lewis DL

更新日期：2003-01-01 00:00:00

abstract：:The viral transneuronal labeling method was used to examine whether the suprachiasmatic nucleus (SCN) is linked by multisynaptic connections to the medial prefrontal cortex of the rat. In separate experiments, pseudorabies virus (PRV) was injected into one of the three different cytoarchitectonic regions that comprise...

journal_title：Neuroscience

authors： Sylvester CM,Krout KE,Loewy AD

更新日期：2002-01-01 00:00:00

abstract：:Alzheimer's disease is characterized by amyloid peptide formation and deposition, neurofibrillary tangles, central cholinergic dysfunction, and dementia; however, the relationship between these parameters is not well understood. We studied the effect of amyloid peptide formation and deposition on central cholinergic f...

journal_title：Neuroscience

authors： Hartmann J,Erb C,Ebert U,Baumann KH,Popp A,König G,Klein J

更新日期：2004-01-01 00:00:00

abstract：:The sleep spindle rhythm of thalamic origin (7-14 Hz) displays widespread synchronization among thalamic nuclei and over most of the neocortex. The mechanisms which mediate such global synchrony are not yet well understood. Here, we theoretically address the hypothesis of Steriade and colleagues that the reticularis t...

journal_title：Neuroscience

authors： Wang XJ,Rinzel J

更新日期：1993-04-01 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) plays a central role in brain development, regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in 5-HT signaling early in life have critical implications for behavior and mental health across the life span. Drawing on preclinical and emerg...

journal_title：Neuroscience

authors： Brummelte S,Mc Glanaghy E,Bonnin A,Oberlander TF

更新日期：2017-02-07 00:00:00

abstract：:Secretion of neurotrophins is critical for the delivery of neurotrophic support. Brain-derived neurotrophic factor is targeted to a regulated secretory pathway in neurons as well as the neurosecretory AtT-20 cells. Here, we show that pertussis toxin, which inactivates Gi and Go G proteins, inhibits up to 50% of the re...

journal_title：Neuroscience

authors： Gunther EC,von Bartheld CS,Goodman LJ,Johnson JE,Bothwell M

更新日期：2000-01-01 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00