Abstract:
:Previous research indicates that distinct subregions of the cerebellum are involved in the processing of different primary emotions. How this is achieved in terms of connectional specificity with other brain areas still needs to be elucidated. We employed functional magnetic resonance imaging in order to investigate cerebellar activation and connectivity relevant for the processing of two basic emotions. Thirty-four healthy women were presented with pictures that specifically elicited happiness and disgust with the instruction to rate the intensity of the experienced feelings. The contrasting of both affective conditions showed that disgust evoked activation of the vermis and the cerebellar hemispheres, whereas happiness-associated activation was restricted to the posterior cerebellum. Both emotions provoked increased connectivity of the cerebellum with limbic regions. The observed extended connectivity patterns can explain why cerebellar lesions are able to produce pronounced changes of affective experience in the afflicted patients.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Schienle A,Scharmüller Wdoi
10.1016/j.neuroscience.2013.04.048subject
Has Abstractpub_date
2013-08-29 00:00:00pages
375-81eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00380-1journal_volume
246pub_type
杂志文章,随机对照试验相关文献
NEUROSCIENCE文献大全abstract::Brain-derived neurotrophic factor (BDNF) promotes synaptic plasticity via an enhancement in expression of specific synaptic proteins. Recent results suggest that the neuronal monocarboxylate transporter MCT2 is a postsynaptic protein critically involved in synaptic plasticity and long-term memory. To investigate in vi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.06.059
更新日期:2011-09-29 00:00:00
abstract::We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00325-4
更新日期:1998-02-01 00:00:00
abstract::The consequences of epileptiform discharge on the expression of glutamate and GABA receptors were examined by in situ hybridization histochemistry after treatment of rat hippocampal slice cultures with convulsants. Application of 500 microM picrotoxin for two days led to decreases in the messenger RNA levels for the N...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00130-b
更新日期:1995-08-01 00:00:00
abstract::This review covers the intrinsic organization and afferent and efferent connections of the midbrain dopaminergic complex, comprising the substantia nigra, ventral tegmental area and retrorubral field, which house, respectively, the A9, A10 and A8 groups of nigrostriatal, mesolimbic and mesocortical dopaminergic neuron...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2014.04.010
更新日期:2014-12-12 00:00:00
abstract::The thoracolumbar and lumbosacral spinal cord contain respectively sympathetic and parasympathetic preganglionic neurons that supply the organs of the pelvis including the penis. These neurons are influenced by supraspinal information and receive aminergic projections from the brainstem. The presence of the alpha(1)- ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00367-6
更新日期:2002-01-01 00:00:00
abstract::Considerable sex differences occur in the incidence and prevalence of anxiety disorders where women are more anxious than men, particularly in situations where social interaction is required. In preclinical studies, the social interaction test represents a valid animal model to study sex differences in social anxiety....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.03.041
更新日期:2012-06-14 00:00:00
abstract::The borders of the ventral striatum and ventral pallidum of the rat brain have been studied with immunocytochemistry for two protein markers that are present in these regions. One of these, DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, Mr 32,000), is specifically enriched in medium-sized spiny neurons of...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90013-4
更新日期:1989-01-01 00:00:00
abstract::Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.12.058
更新日期:2006-01-01 00:00:00
abstract::Calpain-mediated tau cleavage into the neurotoxic tau45-230 fragment plays an important role in Alzheimer's disease (AD). This tau fragment accumulates mainly in the cytoplasm of degenerating neurons. However, subcellular localization studies indicated that a pool of tau45-230 associates with the cytoskeleton in hippo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.05.046
更新日期:2019-08-01 00:00:00
abstract::Interleukin-1 plays an important role as mediator of endotoxin-induced responses in the brain such as fever, sleep, anorexia, behavioural and neuroendocrine changes. In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and sub...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00549-k
更新日期:1995-04-01 00:00:00
abstract::Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it difficult to develop strategies for preventing epilepsy. Here we have studied the role of the CRE binding transcription factors, cyclic-AMP responsive element modulator (CREM) a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.10.064
更新日期:2008-03-27 00:00:00
abstract::When human divers or experimental animals are exposed to high pressure, they develop the high-pressure neurological syndrome which is characterized by electroencephalographic changes, and behavioral disturbances. Recently, neurochemical disorders such as a pressure-induced increase in dopamine release have been demons...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90432-2
更新日期:1992-09-01 00:00:00
abstract::Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the aim ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.07.014
更新日期:2018-09-15 00:00:00
abstract::Limb amputation in urodele amphibia is followed by formation of a blastema, which subsequently develops into a complete limb with normal pattern of innervation. In this study, we investigated the effects of axolotl limb blastemas on axonal growth in gels of collagen and extracellular matrix (matrigel). When peripheral...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00255-4
更新日期:2000-01-01 00:00:00
abstract::Mast cells are known for their participation in immediate and, more recently, delayed hypersensitivity reactions. They have been found in the meninges and certain brain areas where they are strictly perivascular, in close apposition to neurons, and they are activated by direct nerve stimulation or by neuropeptides. In...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90030-j
更新日期:1993-12-01 00:00:00
abstract::Correlated pre- and postsynaptic activity is thought to promote maturation of excitatory synapses in the developing brain by directing AMPA receptors to pure NMDA synapses. However, this hypothesis has not been tested in vivo. Here, we have performed such test by inhibiting correlated neural activity in vivo using a s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00366-x
更新日期:2003-01-01 00:00:00
abstract::Recently, we reported that erythropoietin attenuates neonatal brain injury caused by focal cerebral ischemia. The long-term effects of erythropoietin on focal cerebral ischemia-induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The cu...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.02.057
更新日期:2006-01-01 00:00:00
abstract::An antisense oligonucleotide probe was used to examine the expression of gene encoding the obligatory NMDAR1 subunit of the N-methyl-D-aspartate receptor in the hippocampus and adjacent cortical areas (entorhinal and perirhinal cortices) of seven Alzheimer patients and in the same brain regions of seven control indivi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00023-7
更新日期:1997-08-01 00:00:00
abstract::Humans perform object recognition effortlessly and accurately. However, it is unknown how the visual system copes with variations in objects' appearance and the environmental conditions. Previous studies have suggested that affine variations such as size and position are compensated for in the feed-forward sweep of vi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.02.050
更新日期:2017-05-04 00:00:00
abstract::According to the simulation theory, the internal simulation of a movement (imagined movement, IM) and its execution (actual movement, AM) are based on the same motor representations. The brain uses these representations for controlling action. The specific objective of this study was to investigate the updating proces...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.07.002
更新日期:2012-10-11 00:00:00
abstract::Ca(v)2.1 channels mediate neurotransmitter release at the neuromuscular junction (NMJ) and at many central synapses. Mutations in the encoding gene, CACNA1A, are thus likely to affect neurotransmitter release. Previously, we generated mice carrying the R192Q mutation, associated with human familial hemiplegic migraine...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.04.069
更新日期:2005-01-01 00:00:00
abstract::The visual word form area (VWFA) has been consistently identified as a crucial structure in visual word processing. Nevertheless, it is controversial whether the VWFA represents external visual information (e.g., case information) of visual words. To address that question, we functionally localized VWFA at the group l...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.10.040
更新日期:2021-01-01 00:00:00
abstract::Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms. Tinnitus was induced in rats using unilateral, 1 h, 17 kHz-centered octave-band noise (116 dB SPL) and assessed using a gap-startle method....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.08.026
更新日期:2009-12-01 00:00:00
abstract::Rat cerebellar granule cells, when subjected to a glucose-free environment for 4 h, developed extensive degeneration of neuronal cell bodies and their associated neurite network over the following 24 h. This neuronal damage was quantitated with a colorimetric assay using the metabolic dye 3-(4,5-dimethylthiazol-2-yl)-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90101-9
更新日期:1990-01-01 00:00:00
abstract::In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2011.08.051
更新日期:2011-12-15 00:00:00
abstract::There are distinct distributions and associations with vesicular glutamate transporters (VGLUTs) for auditory nerve and specific somatosensory projections in the cochlear nucleus (CN). Auditory nerve fibers project primarily to the magnocellular areas of the ventral cochlear nucleus and deepest layer of the dorsal coc...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.12.010
更新日期:2011-03-10 00:00:00
abstract::Rats were systemically pre-treated with capsaicin either on the first day of life or at an age of 1 month. Both treatments were found to deplete substance P levels in the trigeminal nucleus caudalis (55.6% and 57.9% depletions, respectively). Extracellular single neurone recordings in the trigeminal nucleus caudalis r...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)91121-6
更新日期:1982-05-01 00:00:00
abstract::We have examined the effects of low pH and the selectivity of the capsaicin antagonist capsazepine on single sensory fibres innervating the guinea-pig trachea in vitro, and on the whole isolated vagus nerve. Application of a pH 5 solution for 1 min to the exposed receptive fields of single fibres caused excitation of ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00115-y
更新日期:1995-08-01 00:00:00
abstract::The lateral habenular complex (LHb) is a key signal integrator between limbic forebrain regions and monoaminergic hindbrain nuclei. Major projections of LHb neurons target the dopaminergic ventral tegmental area (VTA) and the serotonergic dorsal (DR) and median raphe nuclei (MnR). Both monoaminergic neurotransmitter s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.07.013
更新日期:2011-10-13 00:00:00
abstract::The midbrain is essential for prepulse inhibition (PPI) of the startle reflex, but the exact neural circuits for PPI are not yet determined. Electrical stimulation of the superior colliculus (SC) or pedunculopontine tegmentum was used to characterize the neurons and pathways that mediate PPI and the activation of star...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.06.025
更新日期:2006-11-03 00:00:00