Abstract：
:Correlated pre- and postsynaptic activity is thought to promote maturation of excitatory synapses in the developing brain by directing AMPA receptors to pure NMDA synapses. However, this hypothesis has not been tested in vivo. Here, we have performed such test by inhibiting correlated neural activity in vivo using a single injection of tetanus toxin into the rat hippocampal CA1 area at postnatal day 1. When examined in the acute slice preparation (1-7 days post-injection), there was a strong reduction, down to 20% of control level, in the frequency of glutamatergic and GABAergic spontaneous postsynaptic currents (sPSCs). This activity deprivation led to a growth retardation of CA1 pyramidal neurons and to markedly faster decay kinetics of NMDA sPCSs. However, it did not alter the relationship between AMPA and NMDA sPSCs with respect to either their frequency or amplitude. Thus, although critical for certain aspects of neuronal development, correlated neural activity in the neonatal hippocampus does not seem to promote incorporation of AMPA receptors at pure NMDA synapses.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Groc L,Gustafsson B,Hanse Edoi
10.1016/s0306-4522(03)00366-xkeywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
65-72issue
1eissn
0306-4522issn
1873-7544pii
S030645220300366Xjournal_volume
121pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic stimulation overcomes these limitations by offering adva...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.02.018
更新日期：2020-04-15 00:00:00
abstract：:Perineuronal nets of extracellular matrix are associated with distinct types of neurons in the cerebral cortex and many subcortical regions. Large complexes of aggregating proteoglycans form a chemically specified microenvironment around the somata, proximal dendrites and the axon initial segment, including the presyn...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.11.068
更新日期：2006-01-01 00:00:00
abstract：:The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90137-d
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Recent studies suggest that normobaric hyperoxia (HO) reduces hypoxia-reoxygenation injury in the rat brain. We have attempted to determine the effect of HO on Na(+)-Ca(2+) exchangers (NCX) in the rat stroke model. METHODS:Rats were divided into two experimental groups. The first group was exposed to 95% in...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2013.01.064
更新日期：2013-05-01 00:00:00
abstract：:The activity of 62 antidromically identified prepositus hypoglossi neurons was recorded in 10 alert cats during spontaneous, vestibular or visually induced eye movements. Neurons were antidromically activated from stimulating electrodes implanted in the ipsilateral medial longitudinal fasciculus (n = 24), the ipsilate...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(89)90058-4
更新日期：1989-01-01 00:00:00
abstract：:Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.12.058
更新日期：2006-01-01 00:00:00
abstract：:To determine the role of the frontal cortex in the generalization of limbic seizures, we first produced unilateral cortical spreading depression to reversibly suppress neuronal activity in the motor cortex and then triggered an amygdala-kindled seizure. Three minutes following induction of unilateral spreading depress...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00656-3
更新日期：1999-01-01 00:00:00
abstract：:An electropharmacological analysis of the type(s) of calcium channel controlling neurotransmitter release in preganglionic sympathetic nerve terminals in the guinea-pig anterior pelvic ganglion has been carried out. Conventional intracellular recording techniques were used to record excitatory postsynaptic potentials ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00286-9
更新日期：1999-01-01 00:00:00
abstract：:Melatonin, an indoleamine hormone secreted into circulation at night primarily by the brain's pineal gland, has been shown to have a wide variety of actions on the development and physiology of neurons in the CNS. Acting via two G-protein-coupled membrane receptors (MT1 and MT2), melatonin modulates neurogenesis, syna...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.07.018
更新日期：2014-09-26 00:00:00
abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.03.001
更新日期：2016-06-02 00:00:00
abstract：:Brain injury-derived neurotrophic peptide is a 13-amino acid peptide derived from a 15,000 mol. wt neurotrophic factor released from sites of mechanical injury in neonatal rat brain. This peptide promotes survival of septal cholinergic neurons and mesencephalic dopaminergic neurons, and protects hippocampal neurons fr...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00136-6
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To examine the efficiency of hydrogen-rich saline in the treatment of intensive noise-induced cochlear injury. MATERIALS AND METHODS:Forty guinea pigs were assigned to one of four groups: HS+NOISE (i.p. injection hydrogen-rich saline), NS+NOISE (i.p. injection normal saline), NOISE ALONE (noise control), and...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.02.028
更新日期：2012-05-03 00:00:00
abstract：:In anaesthetized albino rabbits, the cerebellar flocculus was systematically mapped with a glass microelectrode to identify the location of Purkinje cells that inhibit specific vestibulo-ocular reflex pathways. The effects of microstimulation of the flocculus Purkinje cell layer on vestibular nerve-evoked reflexes to ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(82)90024-0
更新日期：1982-07-01 00:00:00
abstract：:Characterization of the expression pattern of connexins in neural tissue is a necessary prerequisite for understanding the functional relevance of the corresponding gap junction channels in brain. Here we describe the cell type-specific expression of connexin45 in the CNS and the spatiotemporal expression pattern from...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00077-0
更新日期：2003-01-01 00:00:00
abstract：:Reg-2 is a secreted protein that is expressed de novo in motoneurons, sympathetic neurons, and dorsal root ganglion (DRG) neurons after nerve injury and which can act as a Schwann cell mitogen. We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat mo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2008.06.049
更新日期：2008-09-09 00:00:00
abstract：:The present study compared the peripheral and systemic antinociceptive effect of morphine on formalin-induced facial pain behavior in the rat. Formalin (5%, 50 microliters) was injected subcutaneously into the vibrissal pad of adult rats (250-300 g). Morphine sulfate at doses of 100-1000 micrograms was subcutaneously ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00565-x
更新日期：1996-05-01 00:00:00
abstract：:Neurosteroids such as dehydroepiandrosterone (DHEA), pregnenolone and 17beta-estradiol are synthesized by cytochrome P450s from endogenous cholesterol. We previously reported a new cytochrome P450 enzyme, CYP7B, highly expressed in rat and mouse brain that metabolizes DHEA and related steroids by hydroxylation at the ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00438-x
更新日期：2003-01-01 00:00:00
abstract：:Retrograde transport of horseradish peroxidase has been used to single out a distinct functional cortical cell type for ultrastructural study. Following injection of horseradish peroxidase into the superior colliculus, labelled pyramidal cells were found in layer V of the visual cortex. Examination of the labelled cor...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(82)90127-0
更新日期：1982-01-01 00:00:00
abstract：:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90044-3
更新日期：1987-06-01 00:00:00
abstract：:Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically interpreted as a source of pain inhibition, may paradoxically result in facilitation after tibial and common peroneal nerve transection ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.02.023
更新日期：2009-04-21 00:00:00
abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00140-7
更新日期：1998-11-01 00:00:00
abstract：:The tight junctions found between cerebral vascular endothelial cells form the basis of the blood-brain barrier. Breakdown of the blood-brain barrier is a feature of a variety of CNS pathologies that are characterized by extensive leucocyte recruitment, such as multiple sclerosis and stroke. The molecular mechanisms a...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00058-x
更新日期：1998-10-01 00:00:00
abstract：:Accumulating evidences indicate that ceramide is closely involved in apoptotic cell death in neurodegenerative disorders and aging. We examined ceramide levels in the cerebrospinal fluid (CSF) or brain tissues from patients with neurodegenerative disorders and the mechanism of how intra- and extracellular ceramide was...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.08.056
更新日期：2005-01-01 00:00:00
abstract：:Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). To determine if oxidative stress is a significant contributor to this non-inflammatory pathology, cortex tissues from mice with clinical sign...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.04.041
更新日期：2011-06-30 00:00:00
abstract：:Intracellular recordings were made from neurones in the thalamic reticular nucleus (TRN) and ventro-basal (VB) thalamus in slices of rat midbrain in vitro. Electrical stimulation of the medial lemniscus or TRN resulted in the generation of complex synaptic potentials containing disynaptic inhibitory post-synaptic pote...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2003.08.014
更新日期：2003-01-01 00:00:00
abstract：:Hippocampal anatomy and network organization are capable to generate drug-resistant temporal lobe epilepsy (TLE) in humans and particularly vulnerable to segmental neuronal cell loss. Surgical hippocampectomy has been proven successful in treatment and available human tissue specimens allow systematic clinico-patholog...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.08.003
更新日期：2015-11-19 00:00:00
abstract：:The effects of the mu-receptor agonist fentanyl on extracellular levels of dopamine in rat nucleus accumbens were studied in awake animals by in vivo brain microdialysis. Fentanyl dose-dependently increased the levels of dopamine when given intravenously (microg/kg) or via a microdialysis probe placed into the ventral...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00046-9
更新日期：1999-01-01 00:00:00
abstract：:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/s0306-4522(97)00453-3
更新日期：1998-04-01 00:00:00
abstract：:Electrical stimulation of the distal stump of cut peripheral nerves is a commonly accepted way to evoke neurogenic inflammation. Nevertheless, the modulatory effect of biogenic amines and vasoactive peptides released from efferent fibres can be excluded only if the dorsal roots are stimulated. The present study was fo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00104-q
更新日期：1995-09-01 00:00:00
abstract：:Despite extensive investigations into the mechanisms of aerobic respiration in mitochondria, the spontaneous metabolic activity of individual cells within a whole animal has not been observed in real time. Consequently, little is known about whether and how the level of mitochondrial energy metabolism is regulated in ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.12.020
更新日期：2008-03-03 00:00:00
