Abstract:
:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less than a minute. Two competing hypotheses have been proposed for the first step in the process comprising endocytosis of vesicular membrane. The coated vesicle model proposes that vesicular membrane components merge with the plasma membrane and are subsequently recovered and possibly sorted in coated pits. These pinch off as coated vesicles that either fuse with a sorting endosome from which new vesicles emerge or uncoat to become synaptic vesicles directly. The alternative "kiss-and-run" model proposes that "empty" vesicles are retrieved intact from the plasma membrane after secretion occurs via a fusion pore; they are then immediately refilled with transmitter and re-enter the secretion-competent pool. This article summarizes the data for both models and focusses on new information that supports the kiss-and-run model. In particular, the phenomenon of rapid endocytosis, which may represent the key endocytotic step in recycling, is discussed. Rapid endocytosis has time-constants in the order of a few seconds, thus is temporally consistent with the rate of vesicle recycling. Moreover, rapid endocytosis appears to be clathrin-independent, thus does not involve the coated vesicle pathway. We present a model that accommodates both types of endocytosis, which appear to coexist in many secretory tissues including neurons. Rapid endocytosis may reflect the principal mechanism operative under normal physiological rates of stimulation while coated vesicles may come into play at higher rates of stimulation. These two processes may feed into different populations of vesicles corresponding to distinct pools defined by studies of the kinetics of transmitter release.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Palfrey HC,Artalejo CRdoi
10.1016/s0306-4522(97)00453-3subject
Has Abstractpub_date
1998-04-01 00:00:00pages
969-89issue
4eissn
0306-4522issn
1873-7544pii
S0306452297004533journal_volume
83pub_type
杂志文章,评审相关文献
NEUROSCIENCE文献大全abstract::Human Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32, also known as PPP1R1B) gene codes for different transcripts that are mainly translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The t-DARPP lacks the first 36 residues at the N-terminal,...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.07.022
更新日期:2016-10-01 00:00:00
abstract::Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90343-e
更新日期:1993-09-01 00:00:00
abstract::It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00201-9
更新日期:2001-01-01 00:00:00
abstract::The amygdaloid complex plays an essential role in auditory fear conditioning of the Pavlovian type. The available evidence suggests that the lateral nucleus is the input station of the amygdala for auditory conditioned stimuli, whereas the central medial nucleus is the output for conditioned fear responses. However, t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00272-k
更新日期:1995-11-01 00:00:00
abstract::Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion and migration, and neurite outgrowth. Since these processes have been found to be under thyroid control in the developing rat brain, we have investigated the effect of congenital hypothyroidism on tenascin-C expression. At birth, in situ hybr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00511-3
更新日期:1998-05-01 00:00:00
abstract::The schizophrenia-susceptibility gene, dystrobrevin-binding protein 1 (DTNBP1), encodes the dysbindin protein and mediates neurotransmission and neurodevelopment in normal subjects. Functional studies show that DTNBP1 loss may cause deficient presynaptic vesicle transmission, which is related to multiple psychiatric d...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.10.020
更新日期:2021-01-01 00:00:00
abstract::The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put genetically predisposed individuals at increased risk for psychiatric disorders...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.09.045
更新日期:2013-09-26 00:00:00
abstract::Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00010-g
更新日期:1995-08-01 00:00:00
abstract::The aim of the present study was to investigate the existence and distribution of neuropeptide Y receptor subtypes in various regions of the normal human brain using the peptide YY derivative receptor probes, [125I][Leu31,Pro34]polypeptide YY/Y1 and [125I]polypeptide YY(3-36)/Y2, in addition to the non-selective ligan...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00639-2
更新日期:1997-07-01 00:00:00
abstract::Considerable effort has been directed toward the development of methods to selectively activate specific subtypes of neurons. Focus has been placed on the heterologous expression of proteins that are capable of exciting neurons in which they are expressed. Here we describe the heterologous expression of the invertebra...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.05.052
更新日期:2008-08-13 00:00:00
abstract::Microelectrode recordings were made from 5-10 micron dia axons of adult rat spinal cord in vitro. Action potentials in response to electrical stimulation were recorded intracellularly and electrical characteristics of the axons were examined by injecting current pulses through a bridge circuit. All action potentials l...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90118-6
更新日期:1985-05-01 00:00:00
abstract::Chronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. The aim of this study was to determine the effect of chronic immobilization stress on the auditory and visual mesencephalic regions in the...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.07.032
更新日期:2005-01-01 00:00:00
abstract::Pairing vagus nerve stimulation (VNS) with movements or sounds can direct robust plasticity in motor or auditory cortex, respectively. The degree of map plasticity is influenced by the intensity and pulse width of VNS, number of VNS-event pairings, and the interval between each pairing. It is likely that these paramet...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.07.038
更新日期:2018-09-15 00:00:00
abstract::The effect of the availability of synaptic targets on neuronal survival was tested by explanting the cochleovestibular ganglion from embryonic day 3-1/2 chick embryos and maintaining it in the presence or absence of appropriate synaptic target tissues for 14 days in culture. The targets were the inner ear, peripherall...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90053-3
更新日期:1985-09-01 00:00:00
abstract::The purpose of this paper is to study the effect of smilagenin (SMI) (PYM50028), a sapogenin compound originally identified from Chinese medicinal herb, on dopamine neurons and locomotor ability in aged rats. Experiments were carried out on young and aged Sprague-Dawley rats, which were daily administered with either ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.04.028
更新日期:2013-08-15 00:00:00
abstract::The guanidine-like compound creatine exerts bioenergetic, antiexcitotoxic, antioxidant and neuroprotective properties; however, the intracellular mechanisms responsible for these effects are still not well established. The purpose of this study was to investigate the protective effect of creatine against 6-hydroxydopa...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.02.030
更新日期:2013-05-15 00:00:00
abstract::Dephosphin/dynamin is a 94,000/96,000 mol. wt protein kinase C substrate from rat brain that is phosphorylated in nerve terminals and dephosphorylated upon stimulation of exocytosis and synaptic vesicle recycling. Phosphorylation activates an intrinsic GTPase activity and dephosphin may play a role in endocytosis [Rob...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00337-5
更新日期:1995-02-01 00:00:00
abstract::The human brain is composed of complex networks of 100 billion neurons that underlie its higher functions. The set of neural connections in the brain has recently attracted growing interest from the scientific community. It is important to identify individual differences in these neural connections to study the backgr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.06.032
更新日期:2015-08-20 00:00:00
abstract::Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.06.029
更新日期:2017-09-01 00:00:00
abstract::The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.04.027
更新日期:2007-07-29 00:00:00
abstract::Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that can be released or activated in a neuronal activity dependent manner. Although pathologically elevated levels of MMPs may be synaptotoxic, physiologically appropriate levels of MMPs may instead enhance synaptic transmission. MMP inhibi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.12.061
更新日期:2010-03-17 00:00:00
abstract::We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific nucleotide probes and antisera. The distribution of VGLUT3 protein was compared ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2003.10.039
更新日期:2004-01-01 00:00:00
abstract::The sphenopalatine ganglion (SPG) is a gathering of the cell bodies of parasympathetic fibers that dominate the nasal gland, lacrimal gland and cerebral blood vessels. The SPG controls nasal secretions, tears, and the dilation of cerebral blood vessels. However, it is unclear how serotonin regulates SPG functions. In ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.05.028
更新日期:2019-07-15 00:00:00
abstract::Effects of glutamate agonists and their selective antagonists on the Ca(2+)-dependent release of [3H]GABA from rat hippocampal slices were studied in a superfusion system. The release was enhanced by glutamate, kainate, quisqualate, N-methyl-D-aspartate and glycine in a concentration-dependent manner. In general, (+)-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90623-n
更新日期:1993-04-01 00:00:00
abstract::Transplantation of embryonic dopaminergic neurons is an experimental therapy for Parkinson's disease, but limited tissue availability and suboptimal survival of grafted dopaminergic neurons impede more widespread clinical application. Glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-4/5 (NT-4/5) exe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00418-3
更新日期:2001-01-01 00:00:00
abstract::Hypoglycemia causes brain fuel deprivation, resulting in functional brain failure and brain death. It is a serious complication of insulin therapy in diabetic patients. A single intrafemoral dose of streptozotocin was administered to induce diabetes. Hypoglycemia was induced by appropriate doses of insulin s.c. in con...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.07.022
更新日期:2008-10-02 00:00:00
abstract::Humans perform object recognition effortlessly and accurately. However, it is unknown how the visual system copes with variations in objects' appearance and the environmental conditions. Previous studies have suggested that affine variations such as size and position are compensated for in the feed-forward sweep of vi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.02.050
更新日期:2017-05-04 00:00:00
abstract::Histamine, a putative neuromodulator and neurotransmitter, can depolarize supraoptic neurons and enhance depolarizing afterpotentials that play a key role in determining the excitability of these neurons. This study investigated intracellular signal transduction involved in histamine-induced enhancement of depolarizin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00168-2
更新日期:1999-01-01 00:00:00
abstract::Foetal mouse hippocampal primordia from mice homozygous for the Thy-1.1 allele were transplanted into the hippocampal region of adult histocompatible mice, homozygous for the Thy-1.2 allele. After survival periods of two months to one year the transplants consisted of a discrete tissue mass, well fused with the host, ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90096-x
更新日期:1985-12-01 00:00:00
abstract::Maternal diabetes during pregnancy may increase the risk of neurodevelopmental disorders in the offspring by increasing inflammation. A major source of inflammatory signaling observed in diabetes is activation of the receptor for advanced glycation end-products (RAGE), and increased RAGE expression has been reported i...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.06.063
更新日期:2015-09-10 00:00:00