当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors.

The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors.

Abstract：

:The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put genetically predisposed individuals at increased risk for psychiatric disorders. Neuregulin 1 (NRG1) is a frequently identified schizophrenia susceptibility gene that has also been associated with the psychotic features of bipolar disorder. Previously, we established that Type II NRG1 is expressed in the hypothalamic-pituitary-adrenal (HPA) axis neurocircuitry. We also found, using a line of Nrg1 hypomorphic rats (Nrg1(Tn)), that genetic disruption of Type II NRG1 results in altered HPA axis function and environmental reactivity. The present studies used the Nrg1(Tn) rats to test whether Type II NRG1 gene disruption and chronic stress exposure during adolescence interact to alter adult anxiety- and fear-related behaviors. Male and female Nrg1(Tn) and wild-type rats were exposed to chronic variable stress (CVS) during mid-adolescence and then tested for anxiety-like behavior, cued fear conditioning and basal corticosterone secretion in adulthood. The disruption of Type II NRG1 alone significantly impacts rat anxiety-related behavior by reversing normal sex-related differences and impairs the ability to acquire cued fear conditioning. Sex-specific interactions between genotype and adolescent stress also were identified such that CVS-treated wild-type females exhibited a slight reduction in anxiety-like behavior and basal corticosterone, while CVS-treated Nrg1(Tn) females exhibited a significant increase in cued fear extinction. These studies confirm the importance of Type II NRG1 in anxiety and fear behaviors and point to adolescence as a time when stressful experiences can shape adult behavior and HPA axis function.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Taylor SB,Taylor AR,Koenig JI

doi

10.1016/j.neuroscience.2012.09.045

subject

Has Abstract

pub_date

2013-09-26 00:00:00

pages

31-42

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(12)00965-7

journal_volume

249

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.

    abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90265-9

    authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

    更新日期：1985-08-01 00:00:00

  • Vesicle recycling revisited: rapid endocytosis may be the first step.

    abstract：:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(97)00453-3

    authors： Palfrey HC,Artalejo CR

    更新日期：1998-04-01 00:00:00

  • Fiber tracts that contain more opioid binding sites than gray matter does: a quantitative autoradiographic study in the guinea-pig.

    abstract：:Opioid binding sites were localized in cryostat sections of guinea-pig brain by in vitro autoradiography using (-)-[3H]bremazocine. Quantification of binding sites in gray matter was accomplished using standard samples of tritium mixed in brain gray matter. The binding sites in fiber tracts were quantified using stand...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90007-8

    authors： Foote RW

    更新日期：1987-01-01 00:00:00

  • Steroid hormones protect spinal cord neurons from glutamate toxicity.

    abstract：:The effects of steroid hormones on glutamate neurotoxicity were examined in cultured spinal cord neurons. The extent of neuronal damage, produced by glutamate exposure for 15 min, was estimated based on the activity of lactate dehydrogenase released from degenerated neurons to the media during 24 h of post-exposure in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90513-f

    authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K

    更新日期：1993-07-01 00:00:00

  • The action of oxytocin originating in the hypothalamic paraventricular nucleus on mitral and granule cells in the rat main olfactory bulb.

    abstract：:The effects of electrical stimulation of the hypothalamus paraventricular nucleus on the spontaneous firing of mitral and granule cells in the main olfactory bulb were examined in ovariectomized female rats under urethane anaesthesia. High-frequency stimulation (0.5-1.0 mA, 10-20 pulses at 100 Hz) of the paraventricul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00599-4

    authors： Yu GZ,Kaba H,Okutani F,Takahashi S,Higuchi T,Seto K

    更新日期：1996-06-01 00:00:00

  • Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.

    abstract：:Chronic Mountain Sickness (CMS) occurs in high-altitude residents with major neurological symptoms such as migraine headaches, dizziness and cognitive deficits. Recent work demonstrated that highlanders have increased intracellular pH (pHi) in their brain cells, perhaps for the sake of adaptation to hypoxemia and help...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.02.008

    authors： Yao H,Zhao H,Wang J,Haddad GG

    更新日期：2018-04-01 00:00:00

  • The role of Efr3a in age-related hearing loss.

    abstract：:Efr3a has been found to be involved in the functional maintenance and structural degeneration of sensory and motor nervous tissues. Our previous data have suggested that Efr3a may be associated with the initiation of the degeneration of spiral ganglion neurons (SGNs). In this study, we used Efr3a knockdown (Efr3a KD) ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.11.013

    authors： Hu H,Ma Y,Ye B,Wang Q,Yang T,Lv J,Shi J,Wu H,Xiang M

    更新日期：2017-01-26 00:00:00

  • On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat.

    abstract：:The effects of intrathecal administration of neurokinin A, substance P and [Tyr5, D-Trp6,8,9 Arg10]neurokinin A-(4-10) (Men 10207), a specific NK-2 receptor antagonist, on the spinal nociceptive flexor reflex were studied in decerebrate, spinalized, unanesthetized rats. Intrathecal neurokinin A and substance P facilit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90071-u

    authors： Xu XJ,Maggi CA,Wiesenfeld-Hallin Z

    更新日期：1991-01-01 00:00:00

  • Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo.

    abstract：:Subiculum receives output of hippocampal CA1 neurons and projects glutamatergic synapses onto nucleus accumbens (NAc), the subicular-NAc pathway linking memory and reward system. It is unknown whether morphine withdrawal influences synaptic plasticity in the subicular-NAc pathway. Here, we recorded the field excitator...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.10.018

    authors： Dong Z,Cao J,Xu L

    更新日期：2007-02-09 00:00:00

  • The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry.

    abstract：:The sympathetic and sensory innervation of guinea-pig trachea and lung were studied by means of retrograde neuronal tracing using fluorescent dyes, and double-labelling immunofluorescence. Sympathetic neurons supplying the lung were located in stellate ganglia and in thoracic sympathetic chain ganglia T2-T4; those sup...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90239-x

    authors： Kummer W,Fischer A,Kurkowski R,Heym C

    更新日期：1992-08-01 00:00:00

  • Effects of acoustic trauma on the auditory system of the rat: The role of microglia.

    abstract：:Exposure to loud, prolonged sounds (acoustic trauma, AT) leads to the death of both inner and outer hair cells (IHCs and OHCs), death of neurons of the spiral ganglion and degeneration of the auditory nerve. The auditory nerve (8cn) projects to the three subdivisions of the cochlear nuclei (CN), the dorsal cochlear nu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.07.004

    authors： Baizer JS,Wong KM,Manohar S,Hayes SH,Ding D,Dingman R,Salvi RJ

    更新日期：2015-09-10 00:00:00

  • Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.

    abstract：:Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.058

    authors： Dwivedi Y,Rizavi HS,Pandey GN

    更新日期：2006-01-01 00:00:00

  • Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.

    abstract：:We investigated the electrophysiology of morphologically identified human granule cells with conventional current-clamp recordings. Slices were prepared from 14 human epileptic sclerotic hippocampi. Granule cells appeared to have a diverse electrophysiology. Each cell was distinguished by the shape of the afterhyperpo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00574-0

    authors： Dietrich D,Clusmann H,Kral T,Steinhäuser C,Blümcke I,Heinemann U,Schramm J

    更新日期：1999-01-01 00:00:00

  • Direct pathways to the supraoptic nucleus from the brainstem and the main olfactory bulb are activated at parturition in the rat.

    abstract：:Sensory input from female reproductive structures is paramount for the co-ordination of neuroendocrine changes at parturition. Using a retrograde tracer (fluorescent latex microspheres) in combination with Fos (as an indicator of neuronal activation) and tyrosine hydroxylase (to identify catecholaminergic neurons) imm...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00300-6

    authors： Meddle SL,Leng G,Selvarajah JR,Bicknell RJ,Russell JA

    更新日期：2000-01-01 00:00:00

  • The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein.

    abstract：:The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00361-3

    authors： McFarlane I,Georgopoulou N,Coughlan CM,Gillian AM,Breen KC

    更新日期：1999-04-01 00:00:00

  • alpha 2-Adrenoreceptor-mediated inhibition of acetylcholine-induced noradrenaline release from rat sympathetic neurons: an action at voltage-gated Ca2+ channels.

    abstract：:[3H]Noradrenaline release was studied in cultured sympathetic neurons derived from superior cervical ganglia of neonatal rats. Acetylcholine elicited a concentration- and time-dependent increase in 3H outflow which was half-maximal at about 300 microM and within 5 s. The overflow induced by 10 s exposure to 300 micro ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00235-b

    authors： Boehm S,Huck S

    更新日期：1995-11-01 00:00:00

  • Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.

    abstract：:The mechanism of action of conventional antidepressants (e.g. imipramine) has been linked to modulation of central monoamine systems. Substance P (NK1) receptor antagonists may have antidepressant and anxiolytic effects in patients with major depressive disorder and high anxiety but, unlike conventional antidepressant...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00467-5

    authors： Maubach KA,Martin K,Chicchi G,Harrison T,Wheeldon A,Swain CJ,Cumberbatch MJ,Rupniak NM,Seabrook GR

    更新日期：2002-01-01 00:00:00

  • Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy.

    abstract：:Peripheral and central diabetic neuropathies were studied in streptozotocin-diabetic rats, using behavioral, biochemical and electrophysiological techniques. Diabetic rats showed thermal hypoalgesia and decreasing motor nerve conduction velocity at 4 and 8 weeks of diabetes. In addition, amplitude of the evoked potent...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.047

    authors： Piriz J,Torres-Aleman I,Nuñez A

    更新日期：2009-05-05 00:00:00

  • Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain.

    abstract：:DNA repair is one of the most essential systems for maintaining the inherited nucleotide sequence of genomic DNA over time. Repair of DNA damage would be particularly important in neurons, because these cells are among the longest-living cells in the body. MSH2 is one of the proteins which are involved in the recognit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00380-2

    authors： Belloni M,Uberti D,Rizzini C,Ferrari-Toninelli G,Rizzonelli P,Jiricny J,Spano P,Memo M

    更新日期：1999-01-01 00:00:00

  • Hyperbaric oxygen treatment attenuated the decrease in regional glucose metabolism of rats subjected to focal cerebral ischemia: a high resolution positron emission tomography study.

    abstract：:Cerebral hypoxia may be the main component of cell damage caused by ischemia. Previous studies demonstrated a neuroprotective effect of early hyperbaric oxygen (HBO) treatment in various animal models of focal cerebral ischemia. Neuropathologic study showed that exposure of HBO may prevent cell death in ischemic corte...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.046

    authors： Lou M,Zhang H,Wang J,Wen SQ,Tang ZQ,Chen YZ,Yan WQ,Ding MP

    更新日期：2007-05-11 00:00:00

  • Microglia and astrocyte activation in the frontal cortex of rats with experimental autoimmune encephalomyelitis.

    abstract：:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory pro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.11.060

    authors： Chanaday NL,Roth GA

    更新日期：2016-02-09 00:00:00

  • Biological demonstration of nerve growth factor in the rat pituitary gland.

    abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90362-x

    authors： Lahtinen T,Soinila S,Lakshmanan J

    更新日期：1989-01-01 00:00:00

  • Gonadal hormone regulation of the emotion circuitry in humans.

    abstract：:Gonadal hormones are known to influence the regulation of emotional responses and affective states. Whereas fluctuations in progesterone and estradiol are associated with increased vulnerability for mood disorders, testosterone is mainly associated with social dominance, aggressive, and antisocial behavior. Here, we r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.042

    authors： van Wingen GA,Ossewaarde L,Bäckström T,Hermans EJ,Fernández G

    更新日期：2011-09-15 00:00:00

  • The visual encoding of tool-object affordances.

    abstract：:The perception of tool-object pairs involves understanding their action-relationships (affordances). Here, we sought to evaluate how an observer visually encodes tool-object affordances. Eye-movements were recorded as right-handed participants freely viewed static, right-handed, egocentric tool-object images across th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.09.060

    authors： Natraj N,Pella YM,Borghi AM,Wheaton LA

    更新日期：2015-12-03 00:00:00

  • Endogenous opioids regulate glucocorticoid-dependent stress-coping strategies in mice.

    abstract：:Coping skills are essential in determining the outcomes of aversive life events. Our research was aimed to elucidate the molecular underpinnings of different coping styles in two inbred mouse strains, C57BL/6J and SWR/J. We compared the influence of a preceding stressor (0.5h of restraint) on behavioral and gene expre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.05.034

    authors： Szklarczyk K,Korostynski M,Golda S,Piechota M,Ficek J,Przewlocki R

    更新日期：2016-08-25 00:00:00

  • Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma.

    abstract：:Prostaglandin E(1) is frequently used for the clinical treatment of acute sensorineural hearing loss. However, the mechanisms underlying the effects of prostaglandin E(1) on the inner ear have not yet been elucidated. The physiological effects of prostaglandin E(1) are mediated by the prostanoid receptors prostaglandi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.03.014

    authors： Hori R,Nakagawa T,Sugimoto Y,Sakamoto T,Yamamoto N,Hamaguchi K,Ito J

    更新日期：2009-06-02 00:00:00

  • Action of Hydrogen Peroxide on Synaptic Transmission at the Mouse Neuromuscular Junction.

    abstract：:Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission by targeting the most redox-sensitive presynaptic compartment (Ginia...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.12.027

    authors： Giniatullin A,Petrov A,Giniatullin R

    更新日期：2019-02-10 00:00:00

  • Calcium-induced long-term potentiation in the hippocampus.

    abstract：:The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippocampal slice preparation. Brief exposure of slices (5-10 min) to...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90254-8

    authors： Turner RW,Baimbridge KG,Miller JJ

    更新日期：1982-06-01 00:00:00

  • Central corticotropin-releasing hormone receptors modulate hypothalamic-pituitary-adrenocortical and sympathoadrenal activity during stress.

    abstract：:The role of brain corticotropin-releasing hormone receptors in modulating hypothalamic-pituitary-adrenal and sympathoadrenal responses to acute immobilization stress was studied in conscious rats under central corticotropin-releasing hormone receptor blockade by intracerebroventricular injection of a peptide corticotr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00333-4

    authors： Jezova D,Ochedalski T,Glickman M,Kiss A,Aguilera G

    更新日期：1999-01-01 00:00:00

  • The subcortical afferents to caudate nucleus and putamen in primate: a fluorescence retrograde double labeling study.

    abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90104-5

    authors： Parent A,Mackey A,De Bellefeuille L

    更新日期：1983-12-01 00:00:00