Abstract：
:Subiculum receives output of hippocampal CA1 neurons and projects glutamatergic synapses onto nucleus accumbens (NAc), the subicular-NAc pathway linking memory and reward system. It is unknown whether morphine withdrawal influences synaptic plasticity in the subicular-NAc pathway. Here, we recorded the field excitatory postsynaptic potential (EPSP) within the shell of NAc by stimulating ventral subiculum in anesthetized adult rats. We found that high frequency stimulation (HFS, 200 Hz) induced long-term potentiation (LTP) but low frequency stimulation (LFS, 1 Hz) failed to induce long-term depression (LTD) in control animals. However, behavioral stress enabled LFS to induce a reliable LTD (sLTD) that was dependent on the glucocorticoid receptors. Both LTP and sLTD were prevented by the N-methyl-d-aspartate receptor antagonist AP-5. After repeated morphine treatment for 12 days, acute withdrawal (12 h) impaired LTP but had no effect on sLTD; prolonged withdrawal (4 days) restored the LTP but impaired the sLTD. Remarkably, basal synaptic efficacy reflected by baseline EPSP amplitude was potentiated in acute withdrawal but was depressed in prolonged withdrawal. Thus, acute and prolonged opiate withdrawal may cause endogenous LTP and LTD in the subicular-NAc pathway that occludes the subsequent induction of synaptic plasticity, demonstrating adaptive changes of the NAc functions during opiate withdrawal.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Dong Z,Cao J,Xu Ldoi
10.1016/j.neuroscience.2006.10.018subject
Has Abstractpub_date
2007-02-09 00:00:00pages
845-54issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(06)01376-5journal_volume
144pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:During the early developmental period, long-term potentiation (LTP) can be induced in both vertical and horizontal connections in the rat visual cortex. However, the temporal difference in LTP change between the two pathways during animal development remains unclear. In this study, LTP in vertical (from layer IV to la...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.03.017
更新日期：2017-05-14 00:00:00
abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90090-8
更新日期：1983-09-01 00:00:00
abstract：:Seipin is a widely expressed protein but with highest levels found in the brain and testes. Seipin function is not yet completely understood, therefore the aim of this study was to evaluate the expression of BSCL2 transcripts in the central nervous system (CNS) of humans and investigate the effect of their overexpress...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2018.11.004
更新日期：2019-01-01 00:00:00
abstract：:Investigation of rhythmic discharges may provide insights into integrative mechanisms underlying nervous system control of effectors. We have previously shown that, in CNS-intact, anesthetized rats, cutaneous sympathetic vasoconstrictor neurones innervating thermoregulatory circulations exhibit a robust rhythmicity in...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00969-7
更新日期：2003-01-01 00:00:00
abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.03.001
更新日期：2016-06-02 00:00:00
abstract：:Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still uncl...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.10.024
更新日期：2005-01-01 00:00:00
abstract：:Gene therapy holds great potential for treating neurological disorders. However, delivering gene vectors to the brain has been either invasive or inefficacious in most studies to date. The aim of this study was to develop a safe and efficacious strategy for delivering gene vectors to the brain. A tetracycline-inducibl...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.10.043
更新日期：2012-01-10 00:00:00
abstract：:Neurons in the superior paraolivary nucleus (SPON) of the rat respond to the offset of pure tones with a brief burst of spikes. Medial nucleus of the trapezoid body (MNTB) neurons, which inhibit the SPON, produce a sustained pure tone response followed by an offset response characterized by a period of suppressed spon...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.11.008
更新日期：2008-02-06 00:00:00
abstract：:How seizures arise and recur in epilepsy is unknown. Recent genetic, pharmacological and electrophysiological data indicate a significant but undisclosed role for voltage-dependent calcium channels. Since the contribution such channels make to nerve function reflects the targeting of discrete subtypes to distinct cell...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00371-1
更新日期：1999-01-01 00:00:00
abstract：:Saffron, the dried stigmata of Crocus sativus L., is used in traditional medicine for a wide range of indications including cramps, asthma, and depression. To investigate the influence of hydro-ethanolic saffron extract (CSE) and trans-crocetin on synaptic transmission, postsynaptic potentials (PSPs) were elicited by ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.02.037
更新日期：2011-04-28 00:00:00
abstract：:Mast cells are involved in allergic reactions, but may also participate in neurogenic inflammation. The morphology of mast cells in rat dura mater and tongue was evaluated by histochemistry, as well as by scanning and transmission electron microscopy following unilateral trigeminal ganglion stimulation (5 min, 5 Hz, 5...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90253-k
更新日期：1991-01-01 00:00:00
abstract：:The relation between quantal transmitter release and presynaptic Ca2+/Ba2+ entry at the mouse neuromuscular junction was studied, making use of the finding that in the presence of Ba2+ trains of nerve stimuli or brief nerve terminal depolarizations elicit "tails" of raised miniature end-plate potential frequency (fm) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90305-l
更新日期：1992-12-01 00:00:00
abstract：:The N-methyl-D-aspartate receptor antagonist 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid and the non-N-methyl-D-aspartate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione have been iontophoretically applied to cells in the cat dorsal lateral geniculate nucleus and their effects on the visual re...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(90)90137-s
更新日期：1990-01-01 00:00:00
abstract：:Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervat...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2017.09.014
更新日期：2018-01-01 00:00:00
abstract：:The possible role of acetylcholine as a modulator of neuronal differentiation has been tested using a neuroblastoma cell line (N18TG2), which does not synthesize any neurotransmitter. Acetylcholine synthesis has been activated in this line by transfection with a construct containing a choline acetyltransferase (ChAT) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00179-3
更新日期：2002-01-01 00:00:00
abstract：:High frequency stimulation (HFS) is applied to many brain regions to treat a variety of neurological disorders/diseases, yet the mechanism(s) underlying its effects remains unclear. While some studies showed that HFS inhibits the stimulated nucleus, others report excitation. In this in vitro study, we stimulated the r...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.06.055
更新日期：2007-10-12 00:00:00
abstract：:The distribution of seven different binding sites for the transmitters L-glutamate (L-glutamate binding sites and N-methyl-D-aspartate receptor), GABA (GABAA receptor), noradrenaline (alpha 1 receptor), acetylcholine (muscarinic M1 and M2 receptors) and serotonin (5-hydroxytryptamine1 receptor) are analysed in the pri...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90134-2
更新日期：1993-10-01 00:00:00
abstract：:Golgi, Nissl, Bielschowsky and cholinesterase techniques have been used to analyze the optic tectum of the weakly electric teleost fish Eigenmannia virescens and Apteronotus leptorhynchus. Six layers are readily distinguished: a fairly thick stratum marginale, a narrow stratum opticum and stratum fibrosum et griseum s...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(86)90190-9
更新日期：1986-05-01 00:00:00
abstract：:The motor output of hypoglossal motoneurons to tongue muscles takes place in concert with the respiratory rhythm and is determined by the balance between excitatory glutamatergic transmission and inhibitory transmission mediated by glycine or GABA. The relative contribution by these transmitters is a phasic phenomenon...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.09.046
更新日期：2005-01-01 00:00:00
abstract：:In several neurological disorders including hyperhomocysteinemia, homocysteine (Hcy) accumulates in the brain, and acts as a potent neurotoxin. However, the molecular mechanisms induced by increased levels of Hcy in brain are not well understood. Here we show an activation of the extracellular signal-regulated kinases...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.03.034
更新日期：2005-01-01 00:00:00
abstract：:Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically interpreted as a source of pain inhibition, may paradoxically result in facilitation after tibial and common peroneal nerve transection ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.02.023
更新日期：2009-04-21 00:00:00
abstract：:There is a consensus that active (REM) sleep (AS) is controlled by cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei (LDT/PPT) to neurons in the nucleus pontis oralis (NPO) that generate AS (i.e. AS-Generator neurons). The present study was designed to provide evidence that other proj...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.09.029
更新日期：2011-12-01 00:00:00
abstract：:The effect of muscarinic agonists on the spontaneous release of [3H]GABA was investigated in vitro on rat substantia nigra slices. Acetylcholine (5 x 10(-5) M) in the presence of eserine (5 x 10(-5) M) induced a 12.3% increase of the spontaneous release of [3H]GABA. Similarly, carbachol (5 x 10(-4) M) enhanced by 9% t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90567-3
更新日期：1994-12-01 00:00:00
abstract：:Efr3a has been found to be involved in the functional maintenance and structural degeneration of sensory and motor nervous tissues. Our previous data have suggested that Efr3a may be associated with the initiation of the degeneration of spiral ganglion neurons (SGNs). In this study, we used Efr3a knockdown (Efr3a KD) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.11.013
更新日期：2017-01-26 00:00:00
abstract：:The distribution of peptide histidine-isoleucine (PHI) and vasoactive intestinal polypeptide (VIP), two peptides derived from the same precursor molecule, was analysed with immunohistochemistry in the central nervous system of the rat, and to a limited extent in some other species including sheep, monkey and man. Spec...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90162-x
更新日期：1987-12-01 00:00:00
abstract：:The startle reflex is evoked by strong acoustic or tactile stimuli, or by electrical stimulation of acoustic or tactile pathways. To dissociate the contributions of acoustic and tactile pathways, stimulating electrodes were placed in adjacent cochlear and trigeminal nuclei. The currents needed to evoke startle-like re...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00708-8
更新日期：1999-01-01 00:00:00
abstract：:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2018.04.022
更新日期：2018-07-15 00:00:00
abstract：:Prenatal exposures to a variety of infections have been associated with an increased incidence of schizophrenia. We have reported that a single injection of the synthetic cytokine releaser PolyI:C to pregnant mice produced offspring that exhibited multiple schizophrenia-related behavioral deficits in adulthood. Here, ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.07.029
更新日期：2006-11-17 00:00:00
abstract：:Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo studies in humans. Because of the increasing importance of mitochondrial pathogenetic hypothesis of Depression, in this study the effects of sub-chronic treatment (21days) with desipramine (15mg/kg) and fluoxetine (10mg/kg) were e...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.05.051
更新日期：2016-08-25 00:00:00
abstract：:Longevity genes attenuate the aging process, but their expression in the brain during aging remains unknown. Loss of the majority of heteromeric brain nicotinic acetylcholine receptors (nAChRs) results in premature brain aging, and altered regulation of longevity genes could be involved. Using in situ hybridization, t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.09.007
更新日期：2011-11-24 00:00:00
