当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors.

Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors.

Abstract：

:Longevity genes attenuate the aging process, but their expression in the brain during aging remains unknown. Loss of the majority of heteromeric brain nicotinic acetylcholine receptors (nAChRs) results in premature brain aging, and altered regulation of longevity genes could be involved. Using in situ hybridization, the expression of SIRT1, Ku70, Nampt, p53, forkhead Box O3 (FoxO3), and mitochondria uncoupling protein 5 (UCP5) was determined in neocortex and hippocampus of young adult 3-month and middle-aged 18-month-old wild-type (WT), and age-matched mice lacking β2* heteromeric nAChRs (β2-/-). Age-related structural changes were detected in WT mice. In particular, cortical thickness was decreased but neuronal density increased, and hippocampal volume increased with age. In contrast, young β2-/- mice exhibited increased cortical neuronal density, and with age, cortical thickness decreased more dramatically, and hippocampal volume did not increase. Thus, young β2-/- mice exhibited cortical signs of aging, and aging was accelerated at 18 months. The longevity genes probed exhibited similar expression patterns in frontal brain structures, with strong expression in hippocampus, medial habenula (MHb), and cortex. In WT mice, age significantly decreased expression of all genes except SIRT1 in cortical structures, and a similar pattern was detected in the MHb. Genotype had no effect on expression in young adults in either cortex or MHb, but increased mRNA expression of SIRT1, Nampt, and Ku70 was detected in cortex, hippocampus, and MHb of aged β2-/- mice compared with WT mice. This is the first study to determine age-related expression of survival genes in forebrain areas. Although, structural changes indicative of accelerated aging are evident in young β2-/- mice, the data suggest that nAChRs do not directly regulate expression of survival genes. However, loss of β2* nAChRs could result in augmented cellular stress, which indirectly increases expression of SIRT1, Nampt, and Ku70 as an adaptive response to provide protection against neurodegeneration.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Huang PS,Son JH,Abbott LC,Winzer-Serhan UH

doi

10.1016/j.neuroscience.2011.09.007

subject

Has Abstract

pub_date

2011-11-24 00:00:00

pages

189-202

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(11)01052-9

journal_volume

196

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Activation of the primary motor cortex by somatosensory stimulation in adult rats is mediated mainly by associational connections from the somatosensory cortex.

    abstract：:In anaesthetized adult rats, facial nerve injury causes a disinhibition of the interhemispheric connections between homotopic representation fields in the primary motor cortex with a latency of 4 min (Toldi et al., 1996, Neurosci Lett. 203, 179-182). One possible explanation for the induction of such rapid changes is ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00451-5

    authors： Farkas T,Kis Z,Toldi J,Wolff JR

    更新日期：1999-05-01 00:00:00

  • Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.

    abstract：:Ethanol modulates the actions of multiple neurotransmitter systems, including GABA. However, its enhancing effects on GABA signaling typically are seen only at high concentrations. In contrast, although GABA is a prominent neurotransmitter in the circadian clock of the suprachiasmatic nucleus (SCN), we see ethanol mod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.08.020

    authors： McElroy B,Zakaria A,Glass JD,Prosser RA

    更新日期：2009-12-01 00:00:00

  • Evoked field potential analysis of dopaminergic mechanisms in the isolated turtle olfactory bulb.

    abstract：:Dopaminergic mechanisms were analyzed in an isolated preparation of the turtle olfactory bulb. Field potentials were evoked by antidromic or orthodromic stimulation, and the effects determined of pharmacological manipulations of the bathing medium. In the presence of dopamine or a dopamine agonist, apomorphine, there ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90005-2

    authors： Nowycky MC,Halász N,Shepherd GM

    更新日期：1983-04-01 00:00:00

  • Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.

    abstract：:The pathological significance of intracellular Abeta accumulation in vivo is not yet fully understood. To address this, we have studied transgenic rats expressing Alzheimer's-related transgenes that accumulate Abeta intraneuronally in the cerebral and hippocampal cortices but do not develop extracellular amyloid plaqu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.07.036

    authors： Echeverria V,Ducatenzeiler A,Dowd E,Jänne J,Grant SM,Szyf M,Wandosell F,Avila J,Grimm H,Dunnett SB,Hartmann T,Alhonen L,Cuello AC

    更新日期：2004-01-01 00:00:00

  • Co-localization of tyrosine hydroxylase and zebrin II immunoreactivities in Purkinje cells of the mutant mice, tottering and tottering/leaner.

    abstract：:The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00444-0

    authors： Abbott LC,Isaacs KR,Heckroth JA

    更新日期：1996-03-01 00:00:00

  • The role of the protein glycosylation state in the control of cellular transport of the amyloid beta precursor protein.

    abstract：:The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00361-3

    authors： McFarlane I,Georgopoulou N,Coughlan CM,Gillian AM,Breen KC

    更新日期：1999-04-01 00:00:00

  • Burst firing in identified rat geniculate interneurons.

    abstract：:We used whole-cell patch recording to study 102 local interneurons in the rat dorsal lateral geniculate nucleus in vitro. Input impedance with this technique (607.0+/-222.4 MOhm) was far larger than that measured with sharp electrode techniques, suggesting that interneurons may be more electrotonically compact than pr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00665-4

    authors： Zhu JJ,Uhlrich DJ,Lytton WW

    更新日期：1999-01-01 00:00:00

  • Latent inhibition of conditioned taste aversion is not disrupted, but can be enhanced, by selective nucleus accumbens shell lesions in rats.

    abstract：:Latent inhibition is a form of negative priming in which repeated non-reinforced pre-exposures to a stimulus retard subsequent learning about the predictive significance of that stimulus. The nucleus accumbens shell and the anatomical projection it receives from the hippocampal formation have been attributed a pivotal...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.10.032

    authors： Pothuizen HH,Jongen-Rêlo AL,Feldon J,Yee BK

    更新日期：2006-01-01 00:00:00

  • Environmental enrichment differentially modifies specific components of sensory-evoked activity in rat barrel cortex as revealed by simultaneous electrophysiological recordings and optical imaging in vivo.

    abstract：:Environmental enrichment of laboratory animals leads to multi-faceted changes to physiology, health and disease prognosis. An important and under-appreciated factor in enhancing cognition through environmental manipulation may be improved basic sensory function. Previous studies have highlighted changes in cortical se...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.07.029

    authors： Devonshire IM,Dommett EJ,Grandy TH,Halliday AC,Greenfield SA

    更新日期：2010-10-13 00:00:00

  • High frequency stimulation or elevated K+ depresses neuronal activity in the rat entopeduncular nucleus.

    abstract：:High frequency stimulation (HFS) is applied to many brain regions to treat a variety of neurological disorders/diseases, yet the mechanism(s) underlying its effects remains unclear. While some studies showed that HFS inhibits the stimulated nucleus, others report excitation. In this in vitro study, we stimulated the r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.06.055

    authors： Shin DS,Samoilova M,Cotic M,Zhang L,Brotchie JM,Carlen PL

    更新日期：2007-10-12 00:00:00

  • On the significance of subterritories in the "accumbens" part of the rat ventral striatum.

    abstract：:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connec...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4522(92)90202-d

    authors： Zahm DS,Brog JS

    更新日期：1992-10-01 00:00:00

  • Some certainty for the "zone of uncertainty"? Exploring the function of the zona incerta.

    abstract：:The zona incerta (ZI), first described over a century ago by Auguste Forel as a "region of which nothing certain can be said," forms a collection of cells that derives from the diencephalon. To this day, we are still not certain of the precise function of this "zone of uncertainty" although many have been proposed, fr...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2004.08.017

    authors： Mitrofanis J

    更新日期：2005-01-01 00:00:00

  • Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons.

    abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00430-3

    authors： van den Pol AN,Spencer DD

    更新日期：2000-01-01 00:00:00

  • Systemic capsaicin in the adult rat differentially affects gene expression for neuropeptides and neurotrophin receptors in primary sensory neurons.

    abstract：:While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level. Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprot...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00334-x

    authors： Kashiba H,Ueda Y,Senba E

    更新日期：1997-01-01 00:00:00

  • The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord.

    abstract：:In anaesthetized rats, the intraspinal release of immunoreactive prostaglandin E2 was measured using antibody microprobes. We addressed the question of whether the release of immunoreactive prostaglandin E2 is altered during development of acute inflammation in the knee evoked by intra-articular injections of kaolin a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00164-5

    authors： Ebersberger A,Grubb BD,Willingale HL,Gardiner NJ,Nebe J,Schaible HG

    更新日期：1999-01-01 00:00:00

  • Neurons lying in the white matter of the upper cervical spinal cord project to the intermediolateral cell column.

    abstract：:Neurons lying in the white matter of the upper cervical spinal cord become transneuronally labelled following pseudorabies virus injections into the kidney or stellate ganglion, suggesting that they project directly to sympathetic preganglionic neurons. In the present study, we extend these findings and report here th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)86660-2

    authors： Jansen AS,Loewy AD

    更新日期：1997-04-01 00:00:00

  • Calpastatin overexpression attenuates amyloid-beta-peptide toxicity in differentiated PC12 cells.

    abstract：:Amyloid beta peptide (Abeta) plays a major role in the pathogenesis of Alzheimer's disease (AD). Abeta is toxic to neurons, possibly through causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca(2+). Calpain (Ca(2+)-dependent protease) and caspase have been implicated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.072

    authors： Vaisid T,Barnoy S,Kosower NS

    更新日期：2008-10-28 00:00:00

  • Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge.

    abstract：:Major illnesses, including heart attack and sepsis, can cause cognitive impairments, depression, and progressive memory decline that persist long after recovery from the original illness. In rodent models of sepsis or subchronic immune challenge, memory deficits also persist for weeks or months, even in the absence of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.12.019

    authors： Tchessalova D,Tronson NC

    更新日期：2020-01-21 00:00:00

  • Gö6976 inhibits LPS-induced microglial TNFalpha release by suppressing p38 MAP kinase activation.

    abstract：:Microglial responses to endotoxin, including the synthesis of inflammatory factors, contribute to gliosis and neuron degeneration in cultured brain tissue. We have previously shown that Gö6976, a protein kinase C (PKC) inhibitor, suppressed the lipopolysaccharide (LPS)-induced production of inflammatory factors in mic...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00356-1

    authors： Jeohn GH,Cooper CL,Jang KJ,Liu B,Lee DS,Kim HC,Hong JS

    更新日期：2002-01-01 00:00:00

  • Training-induced cortical plasticity compared between three tongue-training paradigms.

    abstract：:The primary aim of this study was to investigate the effect of different training types and secondary to test gender differences on the training-related cortical plasticity induced by three different tongue-training paradigms: (1) therapeutic tongue exercises (TTE), (2) playing computer games with the tongue using the...

    journal_title：Neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroscience.2013.04.040

    authors： Kothari M,Svensson P,Jensen J,Kjærsgaard A,Jeonghee K,Nielsen JF,Ghovanloo M,Baad-Hansen L

    更新日期：2013-08-29 00:00:00

  • Local infusion of the (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione does not block D1 dopamine receptor-mediated increases in immediate early gene expression in the dopamine-dep

    abstract：:Administration of selective agonists of D1 dopamine receptors increases immediate early gene expression in striatal neurons, a response which is particularly robust in the dopamine-depleted striatum. Although interactions between dopamine and glutamate receptor-mediated responses in striatal neurons have been demonstr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00327-3

    authors： Keefe KA,Gerfen CR

    更新日期：1999-03-01 00:00:00

  • The role of dihydropyridine-sensitive Ca2+ channels in stimulus-evoked catecholamine release from chemoreceptor cells of the carotid body.

    abstract：:The present study utilized an in vitro preparation of the rabbit carotid body, with tissue catecholamine stores labeled by incubation with 3H-tyrosine. The goal was to characterize pharmacologically the voltage-dependent Ca2+ channels present in the type I (glomus) cells of this arterial chemoreceptor organ, and to el...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90260-9

    authors： Obeso A,Rocher A,Fidone S,Gonzalez C

    更新日期：1992-01-01 00:00:00

  • Endothelins are extracellular signals modulating cytoskeletal actin organization in rat cultured astrocytes.

    abstract：:Effects of endothelin-3 on rapid morphological changes and cytoskeletal actin organization of rat cortical cultured astrocytes were examined. In serum-free medium, treatments with 1 mM dibutyryl cAMP and 5 microM cytochalasin B, an inhibitor of actin polymerization, caused astrocytic morphological changes with cytopla...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90420-0

    authors： Koyama Y,Baba A

    更新日期：1994-08-01 00:00:00

  • Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury.

    abstract：:Granulocyte colony-stimulating factor (G-CSF) was investigated in the present study to examine whether it could affect the activation status of microglia under microenvironment of spinal cord injury and provide a potential therapeutic treatment for spinal cord injury. We established mouse spinal cord hemisection model...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.01.047

    authors： Guo Y,Zhang H,Yang J,Liu S,Bing L,Gao J,Hao A

    更新日期：2013-05-15 00:00:00

  • Sweat gland innervation is pioneered by sympathetic neurons expressing a cholinergic/noradrenergic co-phenotype in the mouse.

    abstract：:Classic neurotransmitter phenotypes are generally predetermined and develop as a consequence of target-independent lineage decisions. A unique mode of target-dependent phenotype instruction is the acquisition of the cholinergic phenotype in the peripheral sympathetic nervous system. A body of work suggests that the sw...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.06.074

    authors： Schütz B,von Engelhardt J,Gördes M,Schäfer MK,Eiden LE,Monyer H,Weihe E

    更新日期：2008-10-02 00:00:00

  • Tonic and stimulus-evoked nitric oxide production in the mouse olfactory bulb.

    abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.003

    authors： Lowe G,Buerk DG,Ma J,Gelperin A

    更新日期：2008-05-15 00:00:00

  • Specific and rapid effects of acoustic stimulation on the tonotopic distribution of Kv3.1b potassium channels in the adult rat.

    abstract：:Recent studies have demonstrated that total cellular levels of voltage-gated potassium channel subunits can change on a time scale of minutes in acute slices and cultured neurons, raising the possibility that rapid changes in the abundance of channel proteins contribute to experience-dependent plasticity in vivo. In o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.02.046

    authors： Strumbos JG,Polley DB,Kaczmarek LK

    更新日期：2010-05-19 00:00:00

  • Ultrastructural cytochemical localization of carbonic anhydrase activity in rat peripheral sensory and motor nerves, dorsal root ganglia and dorsal column nuclei.

    abstract：:Some of the myelinated axons in rat peripheral nerves possess marked axoplasmic carbonic anhydrase activity [Riley, Ellis and Bain (1982) J. Histochem. Cytochem. 30, 1275-1288; Riley and Lang (1984) J. Hand Surg. 9A, 112-120]. A mixture of reactive and nonreactive neurons was a general observation in cervical, thoraci...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90269-0

    authors： Riley DA,Ellis S,Bain JL

    更新日期：1984-09-01 00:00:00

  • Expression of NR2B in different brain regions and effect of NR2B antagonism on learning deficits after experimental subarachnoid hemorrhage.

    abstract：:Approximately 50% of patients who survived after aneurysmal subarachnoid hemorrhage (SAH) have cognitive or neurobehavioral dysfunction. The mechanisms are not known. NR2B, one of the subunits of N-methyl-d-aspartate (NMDA) receptors, has been proved to be an important factor for synapse function and behavior cognitio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.024

    authors： Chen G,Li Q,Feng D,Hu T,Fang Q,Wang Z

    更新日期：2013-02-12 00:00:00

  • Gray Matter Volume Differences Between More Versus Less Resilient Adults with Chronic Musculoskeletal Pain: A Voxel-based Morphology Study.

    abstract：:Resilience, a personality construct that reflects capacities to persevere, maintain a positive outlook and/or thrive despite ongoing stressors, has emerged as an important focus of research on chronic pain (CP). Although behavior studies have found more resilient persons with CP experience less pain-related dysfunctio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2021.01.019

    authors： You B,Jackson T

    更新日期：2021-01-21 00:00:00