Thirst-Dependent Activity of the Insular Cortex Reflects its Emotion-Related Subdivision: A Cerebral Blood Flow Study.

Abstract:

:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during the parametric progression of thirst. We measured subjective thirst ratings, serum parameters and cerebral blood flow in 20 healthy subjects across four different thirst stages: intense thirst, moderate thirst, subjective satiation and physiological satiation. Imaging data revealed dehydration-related perfusion differences in previously identified brain areas, such as the anterior cingulate cortex, the middle temporal gyrus and the insular cortex. However, significant differences across all four thirst stages (including the moderate thirst level), were exclusively found in the posterior insular cortex. The subjective thirst ratings over the different thirst stages, however, were associated with perfusion differences in the right anterior insula. These findings add to our understanding of the insular cortex as a key player in human thirst - both on the level of physiological dehydration and the level of the subjective thirst experience.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Meier L,Federspiel A,Jann K,Wiest R,Strik W,Dierks T

doi

10.1016/j.neuroscience.2018.04.022

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

170-177

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(18)30273-2

journal_volume

383

pub_type

杂志文章
  • Ventrolateral periaqueductal gray mediates rapid eye movement sleep regulation by melanin-concentrating hormone neurons.

    abstract::Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.03.020

    authors: Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

    更新日期:2019-05-15 00:00:00

  • Regenerative Failure Following Rat Neonatal Chorda Tympani Transection is Associated with Geniculate Ganglion Cell Loss and Terminal Field Plasticity in the Nucleus of the Solitary Tract.

    abstract::Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤P10) development. It is unclear how chorda tympani soma and terminal fields are affecte...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.01.011

    authors: Martin LJ,Lane AH,Samson KK,Sollars SI

    更新日期:2019-03-15 00:00:00

  • Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons.

    abstract::In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00430-3

    authors: van den Pol AN,Spencer DD

    更新日期:2000-01-01 00:00:00

  • Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination.

    abstract::Mast cells are known for their participation in immediate and, more recently, delayed hypersensitivity reactions. They have been found in the meninges and certain brain areas where they are strictly perivascular, in close apposition to neurons, and they are activated by direct nerve stimulation or by neuropeptides. In...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90030-j

    authors: Theoharides TC,Dimitriadou V,Letourneau R,Rozniecki JJ,Vliagoftis H,Boucher W

    更新日期:1993-12-01 00:00:00

  • A possible role of tryptase in angiogenesis in the brain of mdx mouse, a model of Duchenne muscular dystrophy.

    abstract::Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and affects the CNS. Dystrophin is absent in muscle and CNS of both DMD patients and mdx mouse, a model of DMD. While the involvement of vascular compartment in DMD was poorly investigated, some studies suggested a role for mast cells (MC). Tryp...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.11.006

    authors: Nico B,Marzullo A,Corsi P,Vacca A,Roncali L,Ribatti D

    更新日期:2004-01-01 00:00:00

  • Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis.

    abstract:BACKGROUND:Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase are transiently phosphorylated (activated) in the spinal cord and trigeminal nucleus by acute noxious stimuli. Acute stimulation of dental pulp induces short-lived ERK activation in trigeminal subnucleus caudalis (Vc), and p...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.03.056

    authors: Worsley MA,Allen CE,Billinton A,King AE,Boissonade FM

    更新日期:2014-06-06 00:00:00

  • Expression of myelin-associated glycoprotein transcripts in murine oligodendrocytes.

    abstract::The recognition molecule myelin-associated glycoprotein is expressed by oligodendrocytes, the myelinating cells of the central nervous system. The myelin-associated glycoprotein gene gives rise to two alternatively spliced transcript variants ("early" and "late" message) which are developmentally regulated. In this st...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00586-6

    authors: Kirchhoff F,Ohlemeyer C,Kettenmann H

    更新日期:1997-05-01 00:00:00

  • The mechanism of back pain relief by spinal manipulation relies on decreased temporal summation of pain.

    abstract::The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised two controlled experiments including 16 and 15 healthy participants, respectively. Each study included six sessions during which painful or non-painful electrical stimu...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.03.006

    authors: Randoll C,Gagnon-Normandin V,Tessier J,Bois S,Rustamov N,O'Shaughnessy J,Descarreaux M,Piché M

    更新日期:2017-05-04 00:00:00

  • The brain mapping of the retrieval of conditioned taste aversion memory using manganese-enhanced magnetic resonance imaging in rats.

    abstract::Manganese-enhanced MRI (MEMRI) is a newly developed noninvasive imaging technique of brain activities. The signal intensity of MEMRI reflects cumulative activities of the neurons. To validate the use of MEMRI technique to investigate the neural mechanisms of learning and memory, we tried to map brain areas involved in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.02.027

    authors: Inui-Yamamoto C,Yoshioka Y,Inui T,Sasaki KS,Ooi Y,Ueda K,Seiyama A,Ohzawa I

    更新日期:2010-05-05 00:00:00

  • Topographical organization of the tecto-olivo-cerebellar projection in the cat.

    abstract::The superior colliculus sends a climbing fiber output to cerebellar vermal lobules VI-VII through the inferior olive. The present study in cats morphologically clarified the existence of a topographical organization in the tecto-olivo-cerebellar projection. A horseradish peroxidase study on the tecto-olivary projectio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90212-7

    authors: Kyuhou S,Matsuzaki R

    更新日期:1991-01-01 00:00:00

  • C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1).

    abstract::The transport of excitatory amino acids (EAA) in CNS is performed by a family of high affinity, sodium dependent carriers. One of these transporters, excitatory amino acid carrier 1 (EAAC1), is known to be regulated by several mechanisms that modify carrier abundance on the plasma membrane. Much less is known on EAAC1...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.11.055

    authors: Bianchi MG,Gazzola GC,Tognazzi L,Bussolati O

    更新日期:2008-02-19 00:00:00

  • Cloning and serotonergic regulation of RING finger protein38 (rnf38) in the brain of medaka (Oryzias latipes).

    abstract::Serotonin (5-HT) is a key regulator of mood and sexual behaviors. 5-HT reuptake inhibitors have been used as antidepressants. Really interesting new gene (RING) finger proteins have been associated with 5-HT regulation but their role remains largely unknown. Some RING finger proteins are involved in the serotonergic s...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.03.012

    authors: Moriya S,Khel NB,Parhar IS

    更新日期:2015-05-21 00:00:00

  • Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy.

    abstract::This study examines the effect of chronic alcohol consumption on the human cerebellum using operational criteria for case selection [Caine D. et al. (1997) J. Neurol. Neurosurg. Psychiat. 62, 51-60] and unbiased stereological techniques. We describe, for the first time, structural changes in different functional zones...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)90664-9

    authors: Baker KG,Harding AJ,Halliday GM,Kril JJ,Harper CG

    更新日期:1999-01-01 00:00:00

  • KATP-channels play a minor role in the protective hypoxic shut-down of cerebellar activity in eider ducks (Somateria mollissima).

    abstract::Eider duck (Somateria mollissima) cerebellar neurons are highly tolerant toward hypoxia in vitro, which in part is due to a hypoxia-induced depression of their spontaneous activity. We have studied whether this response involves ATP-sensitive potassium (KATP) channels, which are known to be involved in the hypoxic/isc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.10.046

    authors: Geiseler SJ,Ludvigsen S,Folkow LP

    更新日期:2015-01-22 00:00:00

  • Mechanisms of Neurological Dysfunction in GOSR2 Progressive Myoclonus Epilepsy, a Golgi SNAREopathy.

    abstract::Successive fusion events between transport vesicles and their target membranes mediate trafficking of secreted, membrane- and organelle-localised proteins. During the initial steps of this process, termed the secretory pathway, COPII vesicles bud from the endoplasmic reticulum (ER) and fuse with the cis-Golgi membrane...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2019.03.057

    authors: Jepson JEC,Praschberger R,Krishnakumar SS

    更新日期:2019-11-10 00:00:00

  • Anatomical and gene expression mapping of the ventral pallium in a three-dimensional model of developing human brain.

    abstract::Combining gene expression data with morphological information has revolutionized developmental neuroanatomy in the last decade. Visualization and interpretation of complex images have been crucial to these advances in our understanding of mechanisms underlying early brain development, as most developmental processes a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.06.093

    authors: Lindsay S,Sarma S,Martínez-de-la-Torre M,Kerwin J,Scott M,Luis Ferran J,Baldock R,Puelles L

    更新日期:2005-01-01 00:00:00

  • Muscarinic inhibition of quantal transmitter release from the magnesium-paralysed frog sartorius muscle.

    abstract::The existence of presynaptic muscarinic acetylcholine receptors on motor nerve terminals of the isolated frog sartorius muscle was investigated. The modulatory role of these receptors was studied by observing the effects of muscarinic ligands on the frequency of miniature endplate potentials and on the quantal content...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90174-7

    authors: Arenson MS

    更新日期:1989-01-01 00:00:00

  • Imaging genetics and the power of combined technologies: a perspective from neuroethics.

    abstract::Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2009.01.052

    authors: Tairyan K,Illes J

    更新日期:2009-11-24 00:00:00

  • Functional, biochemical and anatomical changes in the rat urinary bladder induced by perigangliar injection of colchicine.

    abstract::The aim of this study was to assess the effect of blocking the axonal transport of sensory neuropeptides, by local injection of colchicine at pelvic ganglia level, on the sensory and efferent functions mediated by capsaicin-sensitive primary afferent neurons innervating the rat urinary bladder. Bilateral injection of ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00422-x

    authors: Lecci A,Patacchini R,De Giorgio R,Corinaldesi R,Theodorsson E,Giuliani S,Santicioli P,Maggi CA

    更新日期:1996-03-01 00:00:00

  • Opposite modulation of cortical N-methyl-D-aspartate receptor-mediated responses by low and high concentrations of dopamine.

    abstract::To examine whether dopamine modulates cortical N-methyl-D-aspartate receptor-mediated glutamate transmission, whole-cell recordings were made from identified pyramidal cells located in layers V and VI of the medial prefrontal cortex of the rat using a slice preparation. In the presence of tetrodotoxin and the absence ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00604-6

    authors: Zheng P,Zhang XX,Bunney BS,Shi WX

    更新日期:1999-01-01 00:00:00

  • Noise trauma induced plastic changes in brain regions outside the classical auditory pathway.

    abstract::The effects of intense noise exposure on the classical auditory pathway have been extensively investigated; however, little is known about the effects of noise-induced hearing loss on non-classical auditory areas in the brain such as the lateral amygdala (LA) and striatum (Str). To address this issue, we compared the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.12.005

    authors: Chen GD,Sheppard A,Salvi R

    更新日期:2016-02-19 00:00:00

  • Early deprivation, atypical brain development, and internalizing symptoms in late childhood.

    abstract::Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. ...

    journal_title:Neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuroscience.2015.09.026

    authors: Bick J,Fox N,Zeanah C,Nelson CA

    更新日期:2017-02-07 00:00:00

  • Immunohistochemical localization of choline acetyltransferase using a monoclonal antibody: a radioautographic method.

    abstract::Monoclonal antibodies to rat striatal choline acetyltransferase were produced by fusion of sensitized mouse lymphocytes with murine plasmacytoma (NS1) cells. Two stable anti-choline acetyltransferase lines were established by limiting dilution cloning. Specificity of antibody was established by the following criteria:...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90229-4

    authors: Ross ME,Park DH,Teitelman G,Pickel VM,Reis DJ,Joh TH

    更新日期:1983-11-01 00:00:00

  • Ultrastructure of electrophysiologically-characterized synapses formed by serotonergic raphe neurons in culture.

    abstract::Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00010-g

    authors: Johnson MD,Yee AG

    更新日期:1995-08-01 00:00:00

  • Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.

    abstract::Dopamine-mediated behaviors and certain biochemical and molecular events associated with these behaviors were examined following continuous infusion of the D1 dopamine agonist SKF38393 or the D2 dopamine agonist quinpirole into mice for six days. SKF38393 produced a transient grooming behavior while quinpirole initial...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90238-b

    authors: Chen JF,Aloyo VJ,Weiss B

    更新日期:1993-06-01 00:00:00

  • Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice.

    abstract::Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.05.058

    authors: Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

    更新日期:2004-01-01 00:00:00

  • Understanding stress-effects in the brain via transcriptional signal transduction pathways.

    abstract::Glucocorticoid hormones exert crucial effects on the brain in relation to physiology, endocrine regulation, mood and cognition. Their two receptor types, glucocorticoid and mineralocorticoid receptors (GR and MR), are members of the nuclear receptor superfamily and act in large measure as transcription factors. The ou...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2013.03.038

    authors: Zalachoras I,Houtman R,Meijer OC

    更新日期:2013-07-09 00:00:00

  • Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats.

    abstract::Clozapine, an atypical antipsychotic agent important for the treatment of schizophrenia, has marked inhibitory effects on sympathetic outflow to the thermoregulatory cutaneous circulation. In rabbits clozapine reverses ear pinna vasoconstriction induced either by administration of MDMA (3,4-methylenedioxymethamphetami...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.05.050

    authors: Blessing WW,Zilm A,Ootsuka Y

    更新日期:2006-09-15 00:00:00

  • Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control.

    abstract::The degree of behavioral control that an organism has over a stressor determines the behavioral and neurochemical sequelae of the stressor, with the presence of control preventing the typical outcomes that occur when the stressor is uncontrollable (e.g. failure to learn, exaggerated fear, dorsal raphe nucleus (DRN) 5-...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.04.005

    authors: Amat J,Paul E,Watkins LR,Maier SF

    更新日期:2008-07-17 00:00:00

  • Training-induced cortical plasticity compared between three tongue-training paradigms.

    abstract::The primary aim of this study was to investigate the effect of different training types and secondary to test gender differences on the training-related cortical plasticity induced by three different tongue-training paradigms: (1) therapeutic tongue exercises (TTE), (2) playing computer games with the tongue using the...

    journal_title:Neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuroscience.2013.04.040

    authors: Kothari M,Svensson P,Jensen J,Kjærsgaard A,Jeonghee K,Nielsen JF,Ghovanloo M,Baad-Hansen L

    更新日期:2013-08-29 00:00:00