Abstract:
:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during the parametric progression of thirst. We measured subjective thirst ratings, serum parameters and cerebral blood flow in 20 healthy subjects across four different thirst stages: intense thirst, moderate thirst, subjective satiation and physiological satiation. Imaging data revealed dehydration-related perfusion differences in previously identified brain areas, such as the anterior cingulate cortex, the middle temporal gyrus and the insular cortex. However, significant differences across all four thirst stages (including the moderate thirst level), were exclusively found in the posterior insular cortex. The subjective thirst ratings over the different thirst stages, however, were associated with perfusion differences in the right anterior insula. These findings add to our understanding of the insular cortex as a key player in human thirst - both on the level of physiological dehydration and the level of the subjective thirst experience.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Meier L,Federspiel A,Jann K,Wiest R,Strik W,Dierks Tdoi
10.1016/j.neuroscience.2018.04.022subject
Has Abstractpub_date
2018-07-15 00:00:00pages
170-177eissn
0306-4522issn
1873-7544pii
S0306-4522(18)30273-2journal_volume
383pub_type
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