Muscarinic acetylcholine receptors induce neurite outgrowth and activate the synapsin I gene promoter in neuroblastoma clones.

abstract：:The neuropeptides somatostatin, neurotensin and substance P were investigated in rats during and after limbic seizures induced by systemic injection of kainic acid (10 mg/kg, i.p.). Three hours after injection of the toxin, pronounced decreases (40-50%) in somatostatin-like immunoreactivity in frontal cortex, striatum...

journal_title：Neuroscience

authors： Sperk G,Wieser R,Widmann R,Singer EA

更新日期：1986-04-01 00:00:00

abstract：:This paper presents results obtained from experiments performed on two behaving monkeys (Macaca mulatta) viewing correlated and uncorrelated dynamic random dot stereograms. Extracellular single unit activity was recorded from areas V1 and V2. We found that cells sensitive to correlated stereograms (38%) were also sens...

journal_title：Neuroscience

authors： Gonzalez F,Krause F,Perez R,Alonso JM,Acuña C

更新日期：1993-02-01 00:00:00

abstract：:beta-Endorphin is a non-selective opioid peptide which binds mu-, delta- and putative epsilon (beta-endorphin-sensitive non-mu-, non-delta- and non-kappa(1)-)-opioid receptors. We have previously reported that beta-endorphin-produced G-protein activation is mediated by the stimulation of both mu- and putative epsilon-...

journal_title：Neuroscience

authors： Mizoguchi H,Wu HE,Narita M,Hall FS,Sora I,Uhl GR,Nagase H,Tseng LF

更新日期：2002-01-01 00:00:00

abstract：:Excitatory amino acid transporters (EAAT) uptake extracellular glutamate, the major excitatory neurotransmitter in the brain. EAAT type 3 (EAAT3), the main neuronal EAAT, is expressed widely in the CNS. We have shown that the volatile anesthetic isoflurane increases EAAT3 activity and trafficking to the plasma membran...

journal_title：Neuroscience

authors： Lee SN,Li L,Zuo Z

更新日期：2010-12-15 00:00:00

abstract：:Spumiform basement membrane degeneration (sbmd) is a specific kind of aberration present in the capillaries of the midbrain periaqueductal gray (PAG) region of the senescent hamster. These capillaries, separated by the ependymal cell layer, are bordering the Sylvian cerebral aqueduct. The aqueduct, connecting the 3rd ...

journal_title：Neuroscience

authors： Gerrits PO,Kortekaas R,de Weerd H,Luiten PG,van der Want JJ,Veening JG

更新日期：2013-01-03 00:00:00

abstract：:A reappraisal of the relationship between length summation and receptive field length assessed by the minimum response field method, was made in complex cells recorded from the lightly anaesthetized feline striate cortex. This relationship has previously been proposed by Gilbert [(1977) J. Physiol., Lond. 268, 391-421...

journal_title：Neuroscience

authors： Hammond P,Ahmed B

更新日期：1985-07-01 00:00:00

abstract：:Activation of cardiac sympathetic afferents elicits pain and excitatory cardiovascular reflexes including acute hypertension and tachyarrhythmias. Our previous studies have shown that specific regions in the medulla, such as the nucleus of solitary tract and ventrolateral medulla, are involved in central regulation of...

journal_title：Neuroscience

authors： Guo Z-,Li P,Longhurst JC

更新日期：2002-01-01 00:00:00

abstract：:Recent studies demonstrate that P2X7 receptor subunits (P2X7RS) are present at central and peripheral synapses and suggest that P2X7RS can regulate transmitter release. In brainstem slices from 15 to 26 day old pentobarbitone-anesthetized mice, we examined the effect of P2X7RS activation on excitatory postsynaptic cur...

journal_title：Neuroscience

authors： Ireland MF,Noakes PG,Bellingham MC

更新日期：2004-01-01 00:00:00

abstract：:Identification of novel molecules that can induce neuronal differentiation of embryonic stem (ES) cells is essential for deciphering the molecular mechanisms of early development and for exploring cell therapy approaches. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide ...

journal_title：Neuroscience

authors： Chafai M,Basille M,Galas L,Rostene W,Gressens P,Vaudry H,Gonzalez BJ,Louiset E

更新日期：2011-12-29 00:00:00

abstract：:The sensitivity of Purkinje cells to short pulse applications of L-aspartate, L-glutamate and related derivatives in their dendritic fields was tested in normal and staggerer mutant mice using cerebellar slices maintained in vitro. In normal mice, the response of Purkinje cells to L-aspartate and L-glutamate consisted...

journal_title：Neuroscience

authors： Dupont JL,Fournier E,Gardette R,Crepel F

更新日期：1984-06-01 00:00:00

abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

journal_title：Neuroscience

authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

更新日期：2002-01-01 00:00:00

abstract：:The study of the neural basis of predatory behavior has been largely neglected over the recent years. Using an ethologically based approach, we presently delineate the prosencephalic systems mobilized during predation by examining Fos immunoreactivity in rats performing insect hunting. These results were further compa...

journal_title：Neuroscience

authors： Comoli E,Ribeiro-Barbosa ER,Negrão N,Goto M,Canteras NS

更新日期：2005-01-01 00:00:00

abstract：:Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-...

journal_title：Neuroscience

authors： Jijón-Lorenzo R,Caballero-Florán IH,Recillas-Morales S,Cortés H,Avalos-Fuentes JA,Paz-Bermúdez FJ,Erlij D,Florán B

更新日期：2018-02-21 00:00:00

abstract：:The polarization of neuronal trees by external point stimulation is modelled. In one form of model, an almost spheroidal field encloses the dendritic tree. Radially projecting, electrically linear dendrites, along with extracellular medium, are considered to occupy the entire field. The spheroid is modified by a penet...

journal_title：Neuroscience

authors： Hentall ID

更新日期：1989-01-01 00:00:00

abstract：:Zinc plays an important role in synaptic signaling in the mammalian cerebral cortex. Zinc is sequestered into presynaptic vesicles of subpopulations of glutamatergic neurons and is released by depolarization, in a calcium-dependent manner. As the majority of mechanisms that have been suggested to participate in experi...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2003-01-01 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is often characterized pathologically by severe neuronal loss in the hippocampus. In this study we investigated concomitant appearance of the pro-apoptotic and anti-apoptotic mechanisms in injured neurons in epileptic human hippocampi. Postsurgical hippocampal specimens of randomly...

journal_title：Neuroscience

authors： Dericioglu N,Soylemezoglu F,Gursoy-Ozdemir Y,Akalan N,Saygi S,Dalkara T

更新日期：2013-05-01 00:00:00

abstract：:Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production. The present study examined the effects of endothelins on production of neurotrophin-3, a member of the neurotrophin family of neurotrophic factors, in cultured astrocytes and r...

journal_title：Neuroscience

authors： Koyama Y,Baba A,Matsuda T

更新日期：2005-01-01 00:00:00

abstract：:Effects of endothelin-3 on rapid morphological changes and cytoskeletal actin organization of rat cortical cultured astrocytes were examined. In serum-free medium, treatments with 1 mM dibutyryl cAMP and 5 microM cytochalasin B, an inhibitor of actin polymerization, caused astrocytic morphological changes with cytopla...

journal_title：Neuroscience

authors： Koyama Y,Baba A

更新日期：1994-08-01 00:00:00

abstract：:In the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the Na+-dependent glutamate transporter, which was activated by extracellular K+. Glutamate transport current was measured by a conventional whole-cell patch recording mode under voltage-clamp co...

journal_title：Neuroscience

authors： Noda M,Nakanishi H,Akaike N

更新日期：1999-01-01 00:00:00

abstract：:Up-regulation of proBDNF in ischemic brain and the detrimental role of proBDNF on cellular survival has already been established. We propose that the up-regulated proBDNF may trigger the harmful events and evoke a secondary ischemic damage after ischemia. This study aimed to establish the neuroprotective effects of an...

journal_title：Neuroscience

authors： Rahman M,Luo H,Bobrovskaya L,Zhou XF

更新日期：2020-10-15 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

journal_title：Neuroscience

authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

更新日期：2016-07-22 00:00:00

abstract：:The expression pattern of pannexin1, a gene coding for a protein that forms gap junction channels, was studied as both mRNA and protein in the CNS of adult mouse. Pannexin1 was widely expressed in the CNS by neuronal cell types but not glial cells, except for Bergmann glial cells of the cerebellar cortex. Cells positi...

journal_title：Neuroscience

authors： Zappalà A,Cicero D,Serapide MF,Paz C,Catania MV,Falchi M,Parenti R,Pantò MR,La Delia F,Cicirata F

更新日期：2006-08-11 00:00:00

abstract：:The hippocampus is a multifaceted, complex brain structure considered to be the learning center. The use of primary hippocampal cell cultures has uncovered important cellular mechanisms involved in overall physiological function. Yet, the use of primary culture is inherently difficult, and the lack of immortalized cel...

journal_title：Neuroscience

authors： Gingerich S,Kim GL,Chalmers JA,Koletar MM,Wang X,Wang Y,Belsham DD

更新日期：2010-09-29 00:00:00

abstract：:Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurologica...

journal_title：Neuroscience

authors： Lin XH,Ye XJ,Li QF,Gong Z,Cao X,Li JH,Zhao ST,Sun XD,He XS,Xuan AG

更新日期：2020-11-10 00:00:00

abstract：:Gephyrin is a postsynaptic clustering molecule that forms a protein scaffold to anchor inhibitory neurotransmitter receptors at the postsynaptic membrane of neurons. Gephyrin was first identified as a protein component of the glycine receptor complex and is also colocalized with several GABAA receptor subunits in rode...

journal_title：Neuroscience

authors： Baer K,Waldvogel HJ,During MJ,Snell RG,Faull RL,Rees MI

更新日期：2003-01-01 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00

abstract：:In vertebrates, locomotion is associated with changes in respiratory activity, but the neural mechanisms by which this occurs remain unknown. We began examining this in lampreys using a semi-intact preparation of young adult Petromyzon marinus, in which respiratory and locomotor behaviors can be recorded simultaneousl...

journal_title：Neuroscience

authors： Gravel J,Brocard F,Gariépy JF,Lund JP,Dubuc R

更新日期：2007-02-09 00:00:00

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

journal_title：Neuroscience

authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

更新日期：1999-03-01 00:00:00

abstract：:The nicotinic antagonists d-tubocurarine and trimethaphan camsylate competitively inhibit GABA-induced currents. Hexamethonium, mecamylamine and dihydro-beta-erythroidine, other nicotinic antagonists, do not affect GABA-elicited currents. The trimethaphan effect is completely reversed by a putative convulsant receptor...

journal_title：Neuroscience

authors： Wotring VE,Yoon KW

更新日期：1995-07-01 00:00:00