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The contribution of the non-N-methyl-D-aspartate group of excitatory amino acid receptors to retinogeniculate transmission in the cat.

Abstract：

:The N-methyl-D-aspartate receptor antagonist 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid and the non-N-methyl-D-aspartate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione have been iontophoretically applied to cells in the cat dorsal lateral geniculate nucleus and their effects on the visual response compared. The objective was to examine the possibility of both N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors being involved in the transfer of the retinal input to X and Y cells in the dorsal lateral geniculate nucleus. The results show that selective blockade of either N-methyl-D-aspartate receptors or non-N-methyl-D-aspartate receptors can block the visual response of both X and Y cells. Overall, the most potent reductions of visual responses across the population of cells studied were obtained with the N-methyl-D-aspartate receptor antagonist with X cells showing a slightly greater reduction on average (80%) than Y cells (66%). The relatively smaller overall reductions in visual responses obtained with the non-N-methyl-D-aspartate receptor blockade reflected the lower levels of blockade that were compatible with selectivity using iontophoretic applications of 6-cyano-7-nitroquinoxaline-2,3-dione. It is concluded that N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors are critically involved in the visual response of both "on" and "off" centre X and Y cells.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Sillito AM,Murphy PC,Salt TE

doi

10.1016/0306-4522(90)90137-s

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

273-80

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(90)90137-S

journal_volume

34

pub_type

杂志文章

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