当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > The supramammillo-hippocampal and supramammillo-septal glutamatergic/aspartatergic projections in the rat: a combined [3H]D-aspartate autoradiographic and immunohistochemical study.

The supramammillo-hippocampal and supramammillo-septal glutamatergic/aspartatergic projections in the rat: a combined [3H]D-aspartate autoradiographic and immunohistochemical study.

Abstract：

:It is well established that the supramammillary nucleus plays a critical role in hippocampal theta rhythm generation/regulation by its direct and indirect (via the septal complex) connections to the hippocampus. Previous morphological and electrophysiological studies indicate that both the supramammillo-hippocampal and supramammillo-septal efferents contain excitatory transmitter. To test the validity of this assumption, transmitter specific retrograde tracer experiments were performed. [3H]D-aspartate was injected into different locations of the hippocampus (granular and supragranular layers of the dentate gyrus and CA2 and CA3a areas of the Ammon's horn) and septal complex (medial septum and the area between the medial and lateral septum) that are known targets of the supramammillary projection. Consecutive vibratome sections prepared from the entire length of the posterior hypothalamus, including the supramammillary area, were immunostained for calretinin, tyrosine hydroxylase, or calbindin, and further processed for autoradiography. Radiolabeled, radiolabeled plus calretinin-containing, and calretinin-immunoreactive neurons were plotted at six different oro-caudal levels of the supramammillary area. The results demonstrated that following both hippocampal and septal injection of the tracer, the majority of the retrogradely radiolabeled (glutamatergic/aspartatergic) cells are immunoreactive for calretinin. However, non-radiolabeled calretinin-containing neurons and radiolabeled calretinin-immunonegative cells were also seen, albeit at a much lower density. These observations clearly indicate the presence of glutamatergic/aspartatergic projections to both the hippocampus and septal complex. It may be assumed that this transmitter could play a role in hippocampal theta rhythm generation/regulation.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Kiss J,Csáki A,Bokor H,Shanabrough M,Leranth C

doi

10.1016/s0306-4522(00)00127-5

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

657-69

issue

4

eissn

0306-4522

issn

1873-7544

pii

S0306452200001275

journal_volume

97

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5'-fluorouridine into nascent RNA.

    abstract：:In this study we have used the transcription assay with 5'-fluorouridine incorporation into nascent RNA to analyze the nuclear organization and dynamics of transcription sites in rat trigeminal ganglia neurons. The 5'-FU administrated by i.p. injection was successfully incorporated into nuclear domains containing acti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.030

    authors： Casafont I,Navascués J,Pena E,Lafarga M,Berciano MT

    更新日期：2006-06-30 00:00:00

  • BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression.

    abstract：:We have previously shown that the spinal cord is capable of learning a sensorimotor task in the absence of supraspinal input. Given the action of brain-derived neurotrophic factor (BDNF) on hippocampal learning, the current studies examined the role of BDNF in spinal learning. BDNF is a strong synaptic facilitator and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.05.051

    authors： Gómez-Pinilla F,Huie JR,Ying Z,Ferguson AR,Crown ED,Baumbauer KM,Edgerton VR,Grau JW

    更新日期：2007-09-21 00:00:00

  • Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development.

    abstract：:Rapid eye movement sleep decreases between 10 and 30 days postnatally in the rat. The pedunculopontine nucleus is known to modulate waking and rapid eye movement sleep, and pedunculopontine nucleus neurons are thought to be hyperpolarized by noradrenergic input from the locus coeruleus. The goal of the study was to in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.045

    authors： Bay KD,Mamiya K,Good CH,Skinner RD,Garcia-Rill E

    更新日期：2006-08-25 00:00:00

  • Organotypic brain slice cultures: A review.

    abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2015.07.086

    authors： Humpel C

    更新日期：2015-10-01 00:00:00

  • Long-term Pingju Opera Training Induces Plasticity Changes in Cerebral Blood Flow: An Arterial Spin Labelling MRI Study.

    abstract：:Professional Pingju actors have been shown to exhibit practice-induced plastic changes in spontaneous regional brain activity; however, whether these changes are present in resting-state regional cerebral blood flow (CBF) remains largely unclear. Here, twenty professional Pingju opera actors and 20 age-, sex-, and han...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.04.007

    authors： Zhao F,Zhang W,Zhu D,Wang X,Qin W,Liu F

    更新日期：2020-06-01 00:00:00

  • Noradrenaline enhances ATP P2X3 receptor expression in dorsal root ganglion neurons of rats.

    abstract：:Increasing evidence indicates that both the ATP P2X receptors and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the interactions between these two systems in the dorsal root ganglia (DRG). In the present study, we examined the effects o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.12.048

    authors： Tan Y,Sun L,Zhang Q

    更新日期：2011-03-10 00:00:00

  • A Single Bout of High-intensity Interval Exercise Increases Corticospinal Excitability, Brain-derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males.

    abstract：:Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced ne...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.03.042

    authors： Nicolini C,Michalski B,Toepp SL,Turco CV,D'Hoine T,Harasym D,Gibala MJ,Fahnestock M,Nelson AJ

    更新日期：2020-06-15 00:00:00

  • Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects.

    abstract：:In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90204-5

    authors： Sugimoto T,Hattori T

    更新日期：1984-04-01 00:00:00

  • Immunohistochemical characterization of parvalbumin-containing interneurons in the monkey basolateral amygdala.

    abstract：:Interneurons expressing the calcium-binding protein parvalbumin (PV) are a critical component of the inhibitory circuitry of the basolateral nuclear complex (BLC) of the mammalian amygdala. These neurons form interneuronal networks interconnected by chemical and electrical synapses, and provide a strong perisomatic in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.11.017

    authors： Mascagni F,Muly EC,Rainnie DG,McDonald AJ

    更新日期：2009-02-18 00:00:00

  • KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.

    abstract：:Spatial memory retrieval and hippocampal long-term potentiation (LTP) are impaired by stress. KCNQ/Kv7 channels are closely associated with memory and the KCNQ/Kv7 channel activator flupirtine represents neuroprotective effects. This study aims to test whether KCNQ/Kv7 channel activation prevents acute stress-induced ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.09.009

    authors： Li C,Huang P,Lu Q,Zhou M,Guo L,Xu X

    更新日期：2014-11-07 00:00:00

  • Synaptic connectivity of serotonergic axons in the olfactory glomeruli of the rat olfactory bulb.

    abstract：:Although the major mode of transmission for serotonin in the brain is volume transmission, previous anatomical studies have demonstrated that serotonergic axons do form synaptic contacts. The olfactory glomeruli of the olfactory bulb of mammals receive a strong serotonergic innervation from the dorsal and medial raphe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.05.034

    authors： Gracia-Llanes FJ,Blasco-Ibáñez JM,Nácher J,Varea E,Liberia T,Martínez P,Martínez-Guijarro FJ,Crespo C

    更新日期：2010-08-25 00:00:00

  • The localization of nitric oxide synthase in the rat eye and related cranial ganglia.

    abstract：:Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90393-t

    authors： Yamamoto R,Bredt DS,Snyder SH,Stone RA

    更新日期：1993-05-01 00:00:00

  • Differential regulation of alpha-calcitonin gene-related peptide and preprocholecystokinin messenger RNA expression in alpha-motoneurons: effects of testosterone and inactivity induced factors.

    abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90473-f

    authors： Popper P,Abelson L,Micevych PE

    更新日期：1992-11-01 00:00:00

  • Functional innervation of cultured human skeletal muscle proceeds by two modes with regard to agrin effects.

    abstract：:Nerve-derived agrin is a specific isoform of agrin that promotes clustering of nicotinic acetylcholine receptors (AChR) and other components of the neuromuscular junction (NMJ). We investigated the effects of agrin on functional maturation of NMJs at the early stages of synaptogenesis in human muscle. Specifically, we...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00765-0

    authors： Mars T,King MP,Miranda AF,Walker WF,Mis K,Grubic Z

    更新日期：2003-01-01 00:00:00

  • Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.

    abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90265-9

    authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

    更新日期：1985-08-01 00:00:00

  • Modulation of theta rhythmicity in the medial septal neurons and the hippocampal electroencephalogram in the awake rabbit via actions at noradrenergic alpha2-receptors.

    abstract：:The modulation of the firing discharge of medial septal neurons and of the hippocampal electroencephalogram (EEG) mediated by actions on alpha2-adrenoreceptors (ARs) was investigated in awake rabbits. Bilateral i.c.v. infusion of a relatively low dose (0.5 microg) of the alpha2-AR agonist clonidine produced a reductio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00331-2

    authors： Kitchigina VF,Kutyreva EV,Brazhnik ES

    更新日期：2003-01-01 00:00:00

  • Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain.

    abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00494-1

    authors： Carpintero P,Anadón R,Díaz-Regueira S,Gómez-Márquez J

    更新日期：1999-01-01 00:00:00

  • Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.

    abstract：:Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels contribute to rhythmic spontaneous activity in the heart and CNS. Ectopic spontaneous neuronal activity has been implicated in the development and maintenance of acute and chronic hyperalgesia, allodynia and spontaneous pain. Previously, we docume...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.10.048

    authors： Luo L,Chang L,Brown SM,Ao H,Lee DH,Higuera ES,Dubin AE,Chaplan SR

    更新日期：2007-02-23 00:00:00

  • Calcium permeable AMPA receptors and autoreceptors in external tufted cells of rat olfactory bulb.

    abstract：:Glomeruli are functional units of the olfactory bulb responsible for early processing of odor information encoded by single olfactory receptor genes. Glomerular neural circuitry includes numerous external tufted (ET) cells whose rhythmic burst firing may mediate synchronization of bulbar activity with the inhalation c...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.10.041

    authors： Ma J,Lowe G

    更新日期：2007-02-09 00:00:00

  • Substance P-, calcitonin gene-related peptide- and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis.

    abstract：:By means of antisera to cytoplasmic components of nerve fibres and neuropeptides which are known to be present in sensory or sympathetic nerves we have examined the distribution of both total and different types of nerve fibres in normal and inflamed human synovial tissue. Samples of synovia were obtained at surgery f...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90199-e

    authors： Mapp PI,Kidd BL,Gibson SJ,Terry JM,Revell PA,Ibrahim NB,Blake DR,Polak JM

    更新日期：1990-01-01 00:00:00

  • Alteration in the levels of thyrotropin releasing hormone, substance P and enkephalins in the spinal cord, brainstem, hypothalamus and midbrain of the Wobbler mouse at different stages of the motoneuron disease.

    abstract：:The present study was undertaken to quantify selected neuropeptides (thyrotropin releasing hormone, substance P, methionine and leucine enkephalin) in the cervical spinal cord and other regions of the central nervous system of Wobbler mice by radioimmunoassays during several stages of the motoneuron disease compared w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90393-g

    authors： Yung KK,Tang F,Fielding R,Du YH,Vacca-Galloway LL

    更新日期：1992-09-01 00:00:00

  • 8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells.

    abstract：:8-oxoguanine DNA glycosylase and Kin17 are proteins widely distributed and phylogenetically conserved in the CNS. 8-oxoguanine DNA glycosylase is a DNA repair enzyme that excises 7,8-dihydro-8-oxoguanine present in DNA damaged by oxidative stress. Kin17 protein is involved in DNA repair and illegitimate recombination ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.06.080

    authors： Araneda S,Pelloux S,Radicella JP,Angulo J,Kitahama K,Gysling K,Forray MI

    更新日期：2005-01-01 00:00:00

  • Growth factor regulation of neurogenesis in adult olfactory epithelium.

    abstract：:Neurogenesis continues throughout adult life in the mammalian olfactory epithelium. This process is a dynamic state of proliferation, differentiation and cell death, probably regulated by autocrine and paracrine signals such as peptide growth factors. Previous investigations have demonstrated roles for some growth fac...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00194-9

    authors： Newman MP,Féron F,Mackay-Sim A

    更新日期：2000-01-01 00:00:00

  • Masking of forskolin-induced long-term potentiation by adenosine accumulation in area CA1 of the rat hippocampus.

    abstract：:At hippocampal Schaffer collateral-CA1 synapses, activation of beta-adrenergic receptors and adenylyl cyclase increases transmitter release. However, this effect is transient, which is in contrast to that seen at mossy fiber-CA3 synapses, where activation of cyclic-AMP-dependent protein kinase results in long-lasting ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00200-0

    authors： Lu KT,Gean PW

    更新日期：1999-01-01 00:00:00

  • Lactate and glutamate dynamics during prolonged stimulation of the rat barrel cortex suggest adaptation of cerebral glucose and oxygen metabolism.

    abstract：:A better understanding of BOLD responses stems from a better characterization of the brain's ability to metabolize glucose and oxygen. Non-invasive techniques such as functional magnetic resonance spectroscopy (fMRS) have thus been developed allowing for the reproducible assessment of metabolic changes during barrel c...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.01.034

    authors： Sonnay S,Duarte JMN,Just N

    更新日期：2017-03-27 00:00:00

  • Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin.

    abstract：:Insulin peptide, acting through tyrosine kinase receptor pathways, contributes to nerve development or repair. In this work, we examined the direction, impact and repertoire of insulin signaling in vivo during peripheral nerve regeneration in rats. First, we demonstrated that insulin receptor is expressed on lumbar do...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.065

    authors： Toth C,Brussee V,Martinez JA,McDonald D,Cunningham FA,Zochodne DW

    更新日期：2006-05-12 00:00:00

  • Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat.

    abstract：:It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.05.029

    authors： Machado ML,Lelong-Boulouard V,Smith PF,Freret T,Philoxene B,Denise P,Besnard S

    更新日期：2012-08-30 00:00:00

  • Concerted enhancement of calcium influx, neurotransmitter release and protein phosphorylation by a phorbol ester in cultured brain neurons.

    abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90140-5

    authors： Zurgil N,Yarom M,Zisapel N

    更新日期：1986-12-01 00:00:00

  • Neuronal plasticity in the hedgehog supraoptic nucleus during hibernation.

    abstract：:The purpose of the present study was to identify processes of plasticity in the receptive field of neurosecretory neurons of the supraoptic nucleus during hibernation in the hedgehog, in order to correlate them with the increased neurosecretory activity observed in this nucleus during this annual period. Using the Rap...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90396-5

    authors： Sanchez-Toscano F,Caminero AA,Machin C,Abella G

    更新日期：1989-01-01 00:00:00

  • Biological demonstration of nerve growth factor in the rat pituitary gland.

    abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90362-x

    authors： Lahtinen T,Soinila S,Lakshmanan J

    更新日期：1989-01-01 00:00:00