Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.

abstract：:Tissue injury results in several changes in spinal cord neurons that contribute to hyperalgesia arising from the injured tissue. In models of unilateral hindpaw inflammation, changes in the neurochemistry and electrophysiology of dorsal horn neurons ipsilateral, and to a much lesser extent contralateral, to the inflam...

journal_title：Neuroscience

authors： Solodkin A,Traub RJ,Gebhart GF

更新日期：1992-12-01 00:00:00

abstract：:The spinal cord is innervated by brainstem serotonergic neurons, some of which contain substance P and/or thyrotropin-releasing hormone in addition to serotonin. These neurons project at least three types of axons to the spinal cord: those containing both substance P and thyrotropin-releasing hormone, those containing...

journal_title：Neuroscience

authors： Wu W,Elde R,Wessendorf MW

更新日期：1993-07-01 00:00:00

abstract：:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...

journal_title：Neuroscience

authors： Hatton GI,Yang QZ,Cobbett P

更新日期：1987-06-01 00:00:00

abstract：:The response to iontophoretic application of acetylcholine in the mouse neuroblastoma cell line N1E-115 was composed of three phases. The initial fast depolarizing phase was blocked by 10 microM d-tubocurarine, but not by 0.1 microM atropine. This phase was followed by a transient hyperpolarization which in turn was f...

journal_title：Neuroscience

authors： Kato E,Anwyl R,Quandt FN,Narahashi T

更新日期：1983-03-01 00:00:00

abstract：:It is well established that chronic food restriction enhances sensitivity to the rewarding and motor-activating effects of abused drugs. However, neuroadaptations underlying these behavioral effects have not been characterized. The purpose of the present study was to explore the possibility that food restriction produ...

journal_title：Neuroscience

authors： Carr KD,Tsimberg Y,Berman Y,Yamamoto N

更新日期：2003-01-01 00:00:00

abstract：:This study investigated the effect of ionotropic glutamate receptor agonist or antagonist administration into the nucleus accumbens on the maintenance of cocaine self-administration and the reinstatement of cocaine-seeking behavior. The stimulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or N-meth...

journal_title：Neuroscience

authors： Cornish JL,Duffy P,Kalivas PW

更新日期：1999-01-01 00:00:00

abstract：:The temporal pattern of distribution of somatostatin receptor was investigated using the somatostatin analogue [125I]Tyr0-DTrp8-somatostatin14 as a ligand and compared with that of somatostatin immunoreactivity during early developmental stages in the spinal cord and the sensory derivatives in rat fetuses. Qualitative...

journal_title：Neuroscience

authors： Maubert E,Slama A,Ciofi P,Viollet C,Tramu G,Dupouy JP,Epelbaum J

更新日期：1994-09-01 00:00:00

abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

journal_title：Neuroscience

authors： Michels KM,Heemskerk FM,Saavedra JM

更新日期：1994-02-01 00:00:00

abstract：:Excessive inflammatory response produced after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is one of major causes of cerebral injury. High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine and its role in brain injury after CA/CPR is unclear. Herein we investigated whether blocking HMGB1 signal...

journal_title：Neuroscience

authors： Shi X,Li M,Huang K,Zhou S,Hu Y,Pan S,Gu Y

更新日期：2017-09-30 00:00:00

abstract：:The midbrain periaqueductal gray (PAG) is the area promoting emotional motor responses, reproductive behaviors and analgesia. Recent studies suggest that neurons in the PAG may be crucial for regulating the micturition reflex in both experimental animals and humans. We examined single neuronal activities in the PAG an...

journal_title：Neuroscience

authors： Liu Z,Sakakibara R,Nakazawa K,Uchiyama T,Yamamoto T,Ito T,Hattori T

更新日期：2004-01-01 00:00:00

abstract：:Migration of neurons is a key step in the formation of the central nervous system, and an increase in internal Ca(2+) concentration has been shown to increase the rate of migration of granule cells along radial glial processes in slices of postnatal cerebellum. In embryonic spinal cord, the non-radial migration of aut...

journal_title：Neuroscience

authors： Wetts R,Vaughn JE

更新日期：2000-01-01 00:00:00

abstract：:The sympathetic and sensory innervation of guinea-pig trachea and lung were studied by means of retrograde neuronal tracing using fluorescent dyes, and double-labelling immunofluorescence. Sympathetic neurons supplying the lung were located in stellate ganglia and in thoracic sympathetic chain ganglia T2-T4; those sup...

journal_title：Neuroscience

authors： Kummer W,Fischer A,Kurkowski R,Heym C

更新日期：1992-08-01 00:00:00

abstract：:The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-da...

journal_title：Neuroscience

authors： Burnham NW,Thiele TE

更新日期：2017-12-26 00:00:00

abstract：:The extracellular matrix is a complex network of macromolecules including glycoproteins, polysaccharides and proteoglycans. Tenascin-R and chondroitin sulfate proteoglycans are essential components of hippocampal extracellular matrix co-localised in perineuronal nets on interneurons. Mutant mice deficient in expressio...

journal_title：Neuroscience

authors： Bukalo O,Schachner M,Dityatev A

更新日期：2001-01-01 00:00:00

abstract：:The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). However, these compounds also inhibit many other enzymes, any of which may play a role in their toxicity. We tested the neurotoxic mechanism of two organophosphorous insecticides, chlorpyrifos a...

journal_title：Neuroscience

authors： Rush T,Liu XQ,Hjelmhaug J,Lobner D

更新日期：2010-03-31 00:00:00

abstract：:Diabetes type 1 is a common autoimmune disease manifesting by insulin deficiency and hyperglycemia, which can lead to dementia-like brain dysfunctions. The factors triggering the pathological processes in hyperglycemic brain remain unknown. We reported in this study that brain areas with different susceptibility to di...

journal_title：Neuroscience

authors： Fiedorowicz A,Prokopiuk S,Zendzian-Piotrowska M,Chabowski A,Car H

更新日期：2014-01-03 00:00:00

abstract：:Dopamine receptors (DARs) in the nucleus accumbens (NAc) are critical for cocaine's actions but the nature of adaptations in DAR function after repeated cocaine exposure remains controversial. This may be due in part to the fact that different methods used in previous studies measured different DAR pools. In the prese...

journal_title：Neuroscience

authors： Conrad KL,Ford K,Marinelli M,Wolf ME

更新日期：2010-08-11 00:00:00

abstract：:The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with...

journal_title：Neuroscience

authors： David J,O'Toole E,O'Reilly K,Thuery G,Assmann N,Finlay D,Harkin A

更新日期：2018-11-10 00:00:00

abstract：:Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement ther...

journal_title：Neuroscience

authors： Smith ES,Hardy GA,Schallert T,Lee HJ

更新日期：2016-11-19 00:00:00

abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

journal_title：Neuroscience

authors： Lahtinen T,Soinila S,Lakshmanan J

更新日期：1989-01-01 00:00:00

abstract：:Neurones within the rostral ventromedial medulla project to the intermediolateral cell column of the spinal cord where they may influence sympathetic preganglionic neuronal activity controlling cutaneous vascular beds. Here we assess whether such neurones contribute to cutaneous sympathetic vasoconstrictor activity in...

journal_title：Neuroscience

authors： Korsak A,Gilbey MP

更新日期：2004-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron loss and gliosis in the spinal cord, brain stem and cortex. The Notch signaling pathway has been reported to be dysfunctional in neurodegenerative diseases, including ALS. However, the exact mechanism is still uncle...

journal_title：Neuroscience

authors： Liu C,Li D,Lv C,Gao Z,Qi Y,Wu H,Tian Y,Guo Y

更新日期：2020-04-15 00:00:00

abstract：:Iron-overload can cause cognitive impairment due to blood-brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not been investigated. Moreover, s...

journal_title：Neuroscience

authors： Sripetchwandee J,Wongjaikam S,Krintratun W,Chattipakorn N,Chattipakorn SC

更新日期：2016-09-22 00:00:00

abstract：:The ontogeny of substance P-containing neuron system in the forebrain and upper brain stem of the rat was investigated by means of the indirect immunofluorescence technique. Substance P-positive structures first appeared in the primordium of the epithalamus and the area which surrounded the commissura posterior of the...

journal_title：Neuroscience

authors： Inagaki S,Sakanaka M,Shiosaka S,Senba E,Takatsuki K,Takagi H,Kawai Y,Minagawa H,Tohyama M

更新日期：1982-01-01 00:00:00

abstract：:Evidence suggests that nicotinic receptors play a role in nigrostriatal function, a finding that may be relevant to Parkinson's disease. Knowledge of the conditions that regulate nicotinic receptor expression is therefore important. Previous studies showed that several different nicotinic receptors, including alpha-co...

journal_title：Neuroscience

authors： Lai A,Sum J,Fan H,McIntosh JM,Quik M

更新日期：2004-01-01 00:00:00

abstract：:Individuals continuously confronted with various stresses in modern life generate high levels of cortisol (corticosterone in rodents), the major glucocorticoid secreted by adrenal gland when hypothalamic-pituitary-adrenal axis is activated. Chronic stress can induce constant release of glucocorticoid and cause many se...

journal_title：Neuroscience

authors： Jiang Y,Botchway BOA,Hu Z,Fang M

更新日期：2019-07-15 00:00:00

abstract：:Latent inhibition, the process whereby pre-exposure to a conditioned stimulus without consequence impairs subsequent learning of an association between the conditioned stimulus and an unconditioned stimulus, is reportedly disrupted in both amphetamine-treated rats and in acute schizophrenics. This has led to the sugge...

journal_title：Neuroscience

authors： Murphy CA,Pezze M,Feldon J,Heidbreder C

更新日期：2000-01-01 00:00:00

abstract：:We had previously shown that in rat spinal cord motoneurons urotensin II (UII) precursor mRNA was down-regulated by androgens. Very recently, a gene encoding the precursor of a UII analog, termed UII-related peptide (URP), has been identified. Using in situ hybridization, we studied the localization of UII and URP pre...

journal_title：Neuroscience

authors： Pelletier G,Lihrmann I,Dubessy C,Luu-The V,Vaudry H,Labrie F

更新日期：2005-01-01 00:00:00

abstract：:The monoclonal antibody PAC 1 (postsynaptic density and cytoskeleton enriched) recognizes an epitope present on two postsynaptic density-enriched glycoproteins of 130,000 (postsynaptic density-enriched glycoprotein 130) and 117,000 mol. wt (postsynaptic density-enriched glycoprotein 117), and a cytoskeleton-enriched p...

journal_title：Neuroscience

authors： Willmott T,Williamson TL,Mummery R,Hawkes RB,Can A,Gurd JW,Gordon-Weeks PR,Beesley PW

更新日期：1994-01-01 00:00:00

abstract：:This study aimed to investigate the effects of regular treadmill exercise on nerve growth factor (NGF) expression, the improvement of cognitive function in the hippocampus of diabetic rats, and to understand the molecular mechanisms through which the relevant signaling factors act. We investigated the effects of regul...

journal_title：Neuroscience

authors： Chae CH,Jung SL,An SH,Park BY,Wang SW,Cho IH,Cho JY,Kim HT

更新日期：2009-12-29 00:00:00