Abstract：
:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculus (which contains both receptor types with a majority of AT2). In adult rats, angiotensin II receptors are present in the suprachiasmatic nuclei and the superior colliculus but not in the lateral geniculate. Using quantitative autoradiography we found that, in adult rats, bilateral eye enucleation caused a significant decrease in AT2 receptor binding, but not in AT1 receptor binding, and only in the superior colliculus. Unilateral enucleation of 12-day-old pups led to a decrease in AT2 receptor binding from the contralateral superior colliculus, as early as day 2 post-enucleation. Conversely, there was a significant increase in binding to AT1 receptors in the ipsilateral superior colliculus after seven days. No changes were seen in the lateral geniculate or suprachiasmatic nuclei. Angiotensin II binding to subcellular fractions of tissue from the superior colliculus region of 19-day-old pups suggested that AT2 receptor sites were present on the plasma membrane of the postsynaptic cell body. Membrane binding studies also showed a significant decrease in AT2 receptor binding to the same subcellular fractions when 19-day-old pups, enucleated seven days earlier, were compared to sham-operated animals. Our results suggest that expression of AT1 and AT2 receptors in the superior colliculus may be regulated by retinal input.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Michels KM,Heemskerk FM,Saavedra JMdoi
10.1016/0306-4522(94)90460-xsubject
Has Abstractpub_date
1994-02-01 00:00:00pages
835-44issue
4eissn
0306-4522issn
1873-7544pii
0306-4522(94)90460-Xjournal_volume
58pub_type
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