当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus.

The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus.

Abstract：

:In synaptosomes prepared from dentate gyrus, activation of the metabotropic glutamate receptor by the specific agonist, trans-1-amino-cyclopentyl-1,3-dicarboxylate, increases release of glutamate in the presence of a low concentration of arachidonic acid. A similar interaction between trans-1-amino-cyclopentyl-1,3-dicarboxylate and arachidonic acid is observed on inositol phospholipid turnover and on protein kinase C activity. We report here that when long-term potentiation is induced in the dentate gyrus by high frequency tetanic stimulation to the perforant path, the synergism between arachidonic acid and trans-1-amino-cyclopentyl-1,3-dicarboxylate is occluded. The occlusion of the synergistic action between arachidonic acid and trans-1-amino-cyclopentyl-1,3-dicarboxylate on glutamate release extended to occlusion of the effect in inositol phospholipid turnover and protein kinase C activation in synaptosomes prepared from dentate gyrus in which long-term potentiation was induced in vivo. One interpretation of the results presented here is that tetanic stimulation is followed by stimulation of metabotropic glutamate receptors at a time when arachidonic acid concentration in the synaptic region is elevated, and that this interaction triggers the presynaptic changes required for expression of long-term potentiation.

journal_name

Neuroscience

journal_title

Neuroscience

authors

McGahon B,Lynch MA

doi

10.1016/0306-4522(95)00579-x

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

847-55

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(95)00579-X

journal_volume

72

pub_type

杂志文章

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