Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus.

abstract：:Neuroinflammatory processes associated with induction of cyclooxygenase (COX) have been implicated in the deleterious events resulting in neurodegeneration. The present study was designed to investigate the impact of acute methamphetamine (MA) administration on COX expression and prostaglandin E2 (PGE(2)) production, ...

journal_title：Neuroscience

authors： Zhang X,Dong F,Mayer GE,Bruch DC,Ren J,Culver B

更新日期：2007-12-19 00:00:00

abstract：:The mechanical response of human m. flexor pollicis longus to slow (3.2 degrees/s) linear stretch by 5.5 degrees was measured during sustained (45-60 s, 9-13.5 p.p.s.) unfused tetanus evoked by electrical stimulation. The stiffness increased during unfused tetanus. At the late phase of unfused tetanus it was 1.8 +/- 0...

journal_title：Neuroscience

authors： Gurfinkel VS,Ivanenko YP,Levik YS

更新日期：1997-09-01 00:00:00

abstract：:Vagal afferents ascending from the gastrointestinal tract synapse on neurons in the nucleus of the solitary tract. Although these neurons constitute a significant proportion of solitary tract cells their firing behaviour and synaptic properties are not documented. Since gastrointestinal tract afferent termination site...

journal_title：Neuroscience

authors： Paton JF,Li YW,Deuchars J,Kasparov S

更新日期：2000-01-01 00:00:00

abstract：:Aging is associated with disturbances in autonomic cardiovascular control. The purpose of this study was to test the hypothesis that changes in nitric oxide occur with aging in brainstem nuclei involved in autonomic cardiovascular control. The principal and unexpected finding in this study was that NADPH-diaphorase re...

journal_title：Neuroscience

authors： Ma SX,Holley AT,Sandra A,Cassell MD,Abboud FM

更新日期：1997-02-01 00:00:00

abstract：:The cortical representation of the body surface is not fixed, but rather, is continuously modified by ongoing changes in sensory experience. Although the cellular and molecular mechanisms that subserve these changes are uncertain, increasing evidence suggests that synaptically-released zinc may play a role. Zinc is re...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2005-01-01 00:00:00

abstract：:The Fmr1 gene knockout mouse is a model for the human Fragile X mental retardation syndrome. Fmr1 knockout mice with a C57BL/6-129/OlaHsd hybrid background have been reported to have only a very mild deficiency in learning the Morris water maze task. We compared the effect of this knockout mutation on learning in mice...

journal_title：Neuroscience

authors： Dobkin C,Rabe A,Dumas R,El Idrissi A,Haubenstock H,Brown WT

更新日期：2000-01-01 00:00:00

abstract：:Mutations in γ-aminobutyric acid A receptor (GABAA) subunits and sodium channel genes, especially GABRG2 and SCN1A, have been reported to be associated with febrile seizures (FS) and genetic epilepsy with febrile seizures plus (GEFS+). GEFS+ is a well-known family of epileptic syndrome with autosomal dominant inherita...

journal_title：Neuroscience

authors： Li X,Guo S,Liu K,Zhang C,Chang H,Yang W,Rong S,Hu Q,Cui J,Wang F,Sun T

更新日期：2020-07-01 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00

abstract：:The effects of hypothermia on ischemia-reperfusion injury of the cochlea were studied in gerbils. Hearing was assessed by sequentially recording compound action potentials before, during and after the ischemia. The degree of hair cell loss in the organ of Corti was evaluated in specimens stained with rhodamine-phalloi...

journal_title：Neuroscience

authors： Watanabe F,Koga K,Hakuba N,Gyo K

更新日期：2001-01-01 00:00:00

abstract：:Following injection of horseradish peroxidase-labeled wheat germ agglutinin or of rhodamine-labeled microspheres as non-selective tracers into the rat red nucleus, the origins of the corticorubral and cerebellorubral pathways, as well as a considerable number of other brain structures including dorsal raphé nucleus, z...

journal_title：Neuroscience

authors： Bernays RL,Heeb L,Cuenod M,Streit P

更新日期：1988-08-01 00:00:00

abstract：:Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

journal_title：Neuroscience

authors： Tairyan K,Illes J

更新日期：2009-11-24 00:00:00

abstract：:Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to...

journal_title：Neuroscience

authors： Wang HW,Huang BS,White RA,Chen A,Ahmad M,Leenen FH

更新日期：2016-08-04 00:00:00

abstract：:Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...

journal_title：Neuroscience

authors： Luo F,Tang H,Cheng ZY

更新日期：2015-08-06 00:00:00

abstract：:The effects of centrifugal afferents on membrane potentials of identified granule cell layer using evoked field potential profiles, and trans-synaptic activation via antidromic stimulation of output cell axon collaterals. Intracellular recordings maintained for 4-30 min showed complex spontaneous spike discharges and ...

journal_title：Neuroscience

authors： Kunze WA,Shafton AD,Kem RE,McKenzie JS

更新日期：1992-01-01 00:00:00

abstract：:The bed nucleus of stria terminalis is a basal forebrain region involved in regulation of hormonal and behavioral responses to stress. In this report we demonstrate that bed nucleus of stria terminalis has a high and localized expression of tissue plasminogen activator, a serine protease with neuromodulatory propertie...

journal_title：Neuroscience

authors： Matys T,Pawlak R,Strickland S

更新日期：2005-01-01 00:00:00

abstract：:In contrast to other rhythmic tasks such as running, the preferred movement rate in cycling does not minimize energy consumption. It is possible that neurophysiological mechanisms contribute to the choice of cadence, however this phenomenon is not well understood. Eleven participants cycled at a fixed workload of 125 ...

journal_title：Neuroscience

authors： Sidhu SK,Lauber B

更新日期：2020-08-10 00:00:00

abstract：:Deficits in forepaw adjusting steps in rats have been proposed as a non-drug-induced model of the akinesia associated with Parkinson's disease. The present study examined the relationship between contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with 6-hydroxydopamine. ...

journal_title：Neuroscience

authors： Chang JW,Wachtel SR,Young D,Kang UJ

更新日期：1999-01-01 00:00:00

abstract：:The substantia nigra and ventral tegmental area of the rat were examined by retrograde transport methods to determine the topography and collateralization patterns of projections to cortex and certain subcortical sites. The topographical relationships between cells and their terminal fields were confirmed and clarifie...

journal_title：Neuroscience

authors： Loughlin SE,Fallon JH

更新日期：1984-02-01 00:00:00

abstract：:Stereotaxic injections of a dopamine D1 receptor agonist (SKF 38393) into different regions of the supersensitive striatum of rats with a unilateral 6-hydroxydopamine-induced lesion duplicated the systemic effects of the drug in a topographical manner. Although there was considerable overlap, it was possible to recogn...

journal_title：Neuroscience

authors： Fletcher GH,Starr MS

更新日期：1987-02-01 00:00:00

abstract：:Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically interpreted as a source of pain inhibition, may paradoxically result in facilitation after tibial and common peroneal nerve transection ...

journal_title：Neuroscience

authors： Brightwell JJ,Taylor BK

更新日期：2009-04-21 00:00:00

abstract：:An animal's choice behavior is shaped by the outcome feedback from selected actions in a trial-and-error approach. Tonically active neurons (TANs), presumed cholinergic interneurons in the striatum, are thought to be involved in the learning and performance of reward-directed behaviors, but it remains unclear how TANs...

journal_title：Neuroscience

authors： Inokawa H,Matsumoto N,Kimura M,Yamada H

更新日期：2020-10-15 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:In the diurnal unstriped Nile grass rat (Arvicanthis niloticus) access to a running wheel can trigger a shift in active phase preference, with some individuals becoming night-active (NA), while others continue to be day-active (DA). To investigate the contributions of different neural systems to the support of this sh...

journal_title：Neuroscience

authors： Castillo-Ruiz A,Nixon JP,Smale L,Nunez AA

更新日期：2010-01-20 00:00:00

abstract：:Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

journal_title：Neuroscience

authors： Dipietrantonio HJ,Dymecki SM

更新日期：2009-09-01 00:00:00

abstract：:The midbrain is essential for prepulse inhibition (PPI) of the startle reflex, but the exact neural circuits for PPI are not yet determined. Electrical stimulation of the superior colliculus (SC) or pedunculopontine tegmentum was used to characterize the neurons and pathways that mediate PPI and the activation of star...

journal_title：Neuroscience

authors： Yeomans JS,Lee J,Yeomans MH,Steidl S,Li L

更新日期：2006-11-03 00:00:00

abstract：:Electrophysiological and anatomical studies were carried out in parallel to investigate the ability of lateral geniculate body neurons to regenerate axons damaged by the removal of the primary visual cortex and to innervate graft neurons functionally after transplantation of fetal neocortical tissue to a lesion cavity...

journal_title：Neuroscience

authors： Girman SV

更新日期：1994-06-01 00:00:00

abstract：:The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate...

journal_title：Neuroscience

authors： Espeseth T,Endestad T,Rootwelt H,Reinvang I

更新日期：2007-07-29 00:00:00

abstract：:The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide has been reported to be an important mediator in neuronal degeneration in different models of cell death involving NMDA-receptor activation, increasing evidence for protective mechanisms has b...

journal_title：Neuroscience

authors： Lautenschlager M,Onufriev MV,Gulyaeva NV,Harms C,Freyer D,Sehmsdorf U,Ruscher K,Moiseeva YV,Arnswald A,Victorov I,Dirnagl U,Weber JR,Hörtnagl H

更新日期：2000-01-01 00:00:00

abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

journal_title：Neuroscience

authors： Huntsman MM,Jones EG

更新日期：1998-11-01 00:00:00

abstract：:Apart from its role in regulating calcium there is growing evidence that vitamin D is a neuroactive steroid capable of regulating multiple pathways important for both brain development and mature brain function. Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR). Although t...

journal_title：Neuroscience

authors： Eyles DW,Liu PY,Josh P,Cui X

更新日期：2014-05-30 00:00:00