Abstract：
:Cytochrome oxidase is the terminal enzyme in the mitochondrial respiratory chain engaged in oxidative metabolism and energy production. In mammals, the holoenzyme is composed of 13 subunits encoded by both nuclear and mitochondrial genomes. The goal of the present study was to compare the effect of afferent impulse blockade on the expression of these two genomes at the subunit protein level. It also aimed to determine the correlation between the level of cytochrome oxidase activity and the relative amount of subunit proteins. Relative enzyme activity was analysed histochemically, and relative amounts of subunits IV (nuclear-encoded) and II/III (mitochondrial-derived) proteins were obtained immunohistochemically by anti-subunit IV and anti-subunit II/III antibodies in the lateral geniculate nucleus and the primary visual cortex of adult monkeys. In the normal visual centers, similar staining patterns were found for all three markers. After three and seven days of tetrodotoxin treatment, levels of enzyme activity and subunit proteins declined disproportionately in the deprived laminae of the visual center. Densitometric analysis indicates that changes in enzyme activity and subunit IV proteins were significantly greater than those of subunit II/III proteins (P < 0.01). The finding that nuclear and mitochondrial genomes are disproportionately regulated at subunit protein levels by neuronal activity implies that the two genomes operate under different regulatory mechanisms. Changes in subunit IV paralleled most closely those of cytochrome oxidase activity (coefficient of determination r2 = 0.95). This suggests that nuclear-derived subunit IV protein may play a pivotal role in controlling cytochrome oxidase holoenzyme activity.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Liu S,Wong-Riley Mdoi
10.1016/0306-4522(95)00043-isubject
Has Abstractpub_date
1995-07-01 00:00:00pages
197-210issue
1eissn
0306-4522issn
1873-7544pii
030645229500043Ijournal_volume
67pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:The forced swim test (FST) has been considered as a pharmacologically valid test of the depressive syndrome in rodents. However, few studies have focused on neurochemical and behavioral responses during FST in both male and female rats. Thus, we investigated certain behavioral and neuroendocrine responses as well as t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.04.044
更新日期：2004-01-01 00:00:00
abstract：:In vitro receptor autoradiography was used to localize, quantify and characterize [125I-Tyr8]bradykinin binding sites in all major spinal cord segments of normal rats and animals subjected to various chemical treatments and surgical lesions. [125I-Tyr8]bradykinin specific binding sites were predominantly located to su...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00161-b
更新日期：1995-10-01 00:00:00
abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.06.032
更新日期：2011-09-29 00:00:00
abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(85)90265-9
更新日期：1985-08-01 00:00:00
abstract：:The present study tests the hypothesis that propentofylline, an adenosine re-uptake inhibitor, will reduce free radical generation during cerebral hypoxia. Ten newborn piglets were pretreated with propentofylline (10 mg/kg), five of which were subjected to hypoxia, while the other five were maintained at normoxia. Fiv...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00542-3
更新日期：1998-06-01 00:00:00
abstract：:Chronic stress affects brain areas involved in learning and emotional responses. These alterations have been related with the development of cognitive deficits in major depression. The aim of this study was to determine the effect of chronic immobilization stress on the auditory and visual mesencephalic regions in the...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.07.032
更新日期：2005-01-01 00:00:00
abstract：:Several lines of evidence indicate that L-glutamate may be a neurotransmitter of fine myelinated and unmyelinated primary afferent fibres in the spinal cord. The aim of the present study was to determine if L-glutamate was enriched in the terminals of these fibres. We performed the post-embedding immunogold technique ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(90)90353-6
更新日期：1990-01-01 00:00:00
abstract：:Monoclonal antibodies SMI-31 and 150 recognize phosphorylation epitopes on microtubule-associated protein 1B that have been shown to be developmentally down-regulated in the nervous system. We have used these antibodies to establish changes in the pattern of expression of their epitopes on microtubule-associated prote...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(96)00078-4
更新日期：1996-07-01 00:00:00
abstract：:Erythropoietin (EPO) and its receptor (EPO-R), mediate neuroprotection from axonopathy and apoptosis in the peripheral nervous system (PNS). We examined the impact and potential mechanisms of local EPO signaling on regenerating PNS axons in vivo and in vitro. As a consequence of injury, peripheral nerve axons and DRG ...
journal_title：Neuroscience
pub_type： 杂志文章,收录出版
doi：10.1016/j.neuroscience.2008.03.052
更新日期：2008-06-23 00:00:00
abstract：:Latent inhibition, the process whereby pre-exposure to a conditioned stimulus without consequence impairs subsequent learning of an association between the conditioned stimulus and an unconditioned stimulus, is reportedly disrupted in both amphetamine-treated rats and in acute schizophrenics. This has led to the sugge...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00043-9
更新日期：2000-01-01 00:00:00
abstract：:Myristoylated alanine-rich C-kinase substrate (MARCKS) is a major in vivo substrate for protein kinase C in the brain and has been implicated in cellular processes associated with cytoskeletal restructuring such as synaptic trafficking and neurotransmitter release. A phosphorylation-site specific antibody against Ser1...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.10.022
更新日期：2005-01-01 00:00:00
abstract：:To study the effect of inositol 1,4,5-trisphosphate (IP(3)) in isolated frog vomeronasal microvillar receptor neurones, whole-cell recordings were performed with 0.5 microM caged IP(3) dissolved in the pipette solution. IP(3) was released by photolysis of caged IP(3) initiated by a 0.8-ms ultraviolet flash from a xeno...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00115-5
更新日期：2003-01-01 00:00:00
abstract：:Synaptic plasticity is considered a physiological substrate for learning and memory [Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87-136] that contributes to maladaptive learning in drug addiction [Schoenbaum G, Roesch MR, Stalnaker TA (2006) Orbitofrontal cortex, decision-making and drug addictio...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.03.061
更新日期：2009-06-30 00:00:00
abstract：:The effects of electrical stimulation of the hypothalamus paraventricular nucleus on the spontaneous firing of mitral and granule cells in the main olfactory bulb were examined in ovariectomized female rats under urethane anaesthesia. High-frequency stimulation (0.5-1.0 mA, 10-20 pulses at 100 Hz) of the paraventricul...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00599-4
更新日期：1996-06-01 00:00:00
abstract：:Serotonin (5-HT) is a key regulator of mood and sexual behaviors. 5-HT reuptake inhibitors have been used as antidepressants. Really interesting new gene (RING) finger proteins have been associated with 5-HT regulation but their role remains largely unknown. Some RING finger proteins are involved in the serotonergic s...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.03.012
更新日期：2015-05-21 00:00:00
abstract：:Nucleotide-activated P2X channels and P2Y metabotropic receptors participate in nociceptive signaling. Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y agonist) and AMP. They provide...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.07.044
更新日期：2011-10-13 00:00:00
abstract：:The paraventricular nucleus of the hypothalamus is increasingly being viewed as an important site for cardiovascular integration because of its connections to regions in the brain and spinal cord which are known to be important in cardiovascular control. Like the vasomotor neurons of the rostral ventrolateral medulla,...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00255-3
更新日期：1999-01-01 00:00:00
abstract：:The topographical organization of the subnuclear projections towards the thalamus was studied with autographic methods in adult Wistar rats. The four cerebellar deep nuclei give rise to projections to the ventral region of the rostral thalamus. Most of the fibers end contralaterally, according to a topographical patte...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(85)90221-0
更新日期：1985-06-01 00:00:00
abstract：:In the present study plastic neural responses to N-methyl-D-aspartate-induced excitotoxic lesions and the neuroprotective effects of the L-type voltage-dependent Ca(2+) channel antagonist nimodipine were investigated in the rat magnocellular nucleus basalis. Assessment of spontaneous behaviour in the elevated plus maz...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00296-7
更新日期：2000-01-01 00:00:00
abstract：:Non-synaptic transmission is pervasive throughout the nervous system. It appears especially prevalent in peripheral ganglia, where non-synaptic interactions between neighboring cell bodies have been described in both physiological and pathological conditions, a phenomenon referred to as cross-depolarization (CD) and t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.09.038
更新日期：2019-12-15 00:00:00
abstract：:The ontogeny of the cholecystokinin-8 neuron system in the lower brain stem of the rat was investigated by means of indirect immunofluorescence. Cholecystokinin-8-like immunoreactive structures first appeared in the primordium of the ventral tegmental area, ventral tegmental nucleus of Gudden and the area lateral to t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90116-1
更新日期：1983-12-01 00:00:00
abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90163-5
更新日期：1994-01-01 00:00:00
abstract：:Recently, we reported that erythropoietin attenuates neonatal brain injury caused by focal cerebral ischemia. The long-term effects of erythropoietin on focal cerebral ischemia-induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The cu...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.02.057
更新日期：2006-01-01 00:00:00
abstract：:The afferent inputs to the rostral pole of the anterior pretectal nucleus have been examined by utilizing the retrograde axonal transport of a fluorescent dye, Fast Blue. After unilateral injection of the dye into the rostral anterior prectectal nucleus, large numbers of labelled neuronal somata were found in the soma...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(89)90141-3
更新日期：1989-01-01 00:00:00
abstract：:M1 muscarinic receptors have long been identified as a potential therapeutic target for the treatment of cognitive impairment in Alzheimer's disease (AD). Our previous study has shown that M1 receptors promote membrane insertion and synaptic delivery of AMPA receptor GluA1 subunit. In this study, we sought to determin...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.04.007
更新日期：2019-06-01 00:00:00
abstract：:Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.10.056
更新日期：2015-12-17 00:00:00
abstract：:Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic. To date, however, a quantitative description of the topographic distribution of GABAergic neurons in the rat's IC and their GABAergic or glyciner...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.12.030
更新日期：2005-01-01 00:00:00
abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00430-3
更新日期：2000-01-01 00:00:00
abstract：:Arousal enhances the readiness to process sensory information and respond to it. Rapid increment of arousal, referred to as arousal reaction or startle, increases the level of attention and the chance of survival. Arousal reaction is known to originate from the brainstem ascending reticular activating system and to mo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.05.060
更新日期：2014-08-22 00:00:00
abstract：:The pedunculopontine nucleus (PPN) shows altered electrophysiological and anatomic characteristics in Parkinson's disease (PD), but little is known about the effect of 6-hydroxydopamine (6-OHDA) lesion and levodopa (L-DOPA) therapy on the relationship between spike and local field potential (LFP) activities in the PPN...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.01.044
更新日期：2019-04-15 00:00:00
