当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Photolysis of caged inositol 1,4,5-trisphosphate induces action potentials in frog vomeronasal microvillar receptor neurones.

Photolysis of caged inositol 1,4,5-trisphosphate induces action potentials in frog vomeronasal microvillar receptor neurones.

Abstract：

:To study the effect of inositol 1,4,5-trisphosphate (IP(3)) in isolated frog vomeronasal microvillar receptor neurones, whole-cell recordings were performed with 0.5 microM caged IP(3) dissolved in the pipette solution. IP(3) was released by photolysis of caged IP(3) initiated by a 0.8-ms ultraviolet flash from a xenon flash lamp 70 s after the start of dialysis of caged IP(3) into the cell. Flash illuminating the whole receptor neurone with caged IP(3) triggered action potentials when the current was clamped at zero and a series of transient inward currents of 12-55 pA at a holding potential of -70 mV. The average number of spikes during the first 40 s after release of IP(3) was 7.2+/-2.5 (n=6, mean+/-S.E.M.). The average maximum current and the total inward transport of charge during the first 40 s after photolysis of caged IP(3) were -24+/-8.0 pA and -1.7+/-0.8 pC, respectively (n=5, mean+/-S.E.M.). Inward membrane currents of 12-55 pA after release of IP(3) were not observed with 50 microM La(3+) in the bath. Notably, flash focused on the terminal vesicle also triggered action potentials. No action potentials were observed following flash focused on the soma or outside the dendrite. The average number of spikes during the first 40 s after release of IP(3) initiated by flash spatially restricted to the terminal vesicle was 5.0+/-2.0 (n=4, mean+/-S.E.M.).The present study indicates that local release of IP(3) in the terminal vesicle of the vomeronasal neurones triggers transient depolarizations and induces action potentials. We suggest that IP(3) might be a second messenger in the vomeronasal microvillar receptor neurones.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Gjerstad J,Valen EC,Trotier D,Døving K

doi

10.1016/s0306-4522(03)00115-5

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

193-200

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306452203001155

journal_volume

119

pub_type

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