Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia.

abstract：:Neuropeptide Y and somatostatin immunoreactive neurons and processes were examined in human striatum using both immunofluorescence and avidin biotin immunoperoxidase methods. Reduced nicotinamide adenine dinucleotide phosphate diaphorase activity was histochemically determined by the reduction of nitro blue tetrazoliu...

journal_title：Neuroscience

authors： Kowall NW,Ferrante RJ,Beal MF,Richardson EP Jr,Sofroniew MV,Cuello AC,Martin JB

更新日期：1987-03-01 00:00:00

abstract：:GABAA-receptors in the brain display a striking structural heterogeneity, which is based on a multiplicity of diverse subunits. The allocation of GABAA-receptor subtypes to identified neurons is essential for an analysis of the functional significance of receptor heterogeneity. Among GABA-receptive neurons, well-chara...

journal_title：Neuroscience

authors： Gao B,Fritschy JM,Benke D,Mohler H

更新日期：1993-06-01 00:00:00

abstract：:Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms. Tinnitus was induced in rats using unilateral, 1 h, 17 kHz-centered octave-band noise (116 dB SPL) and assessed using a gap-startle method....

journal_title：Neuroscience

authors： Wang H,Brozoski TJ,Turner JG,Ling L,Parrish JL,Hughes LF,Caspary DM

更新日期：2009-12-01 00:00:00

abstract：:How seizures arise and recur in epilepsy is unknown. Recent genetic, pharmacological and electrophysiological data indicate a significant but undisclosed role for voltage-dependent calcium channels. Since the contribution such channels make to nerve function reflects the targeting of discrete subtypes to distinct cell...

journal_title：Neuroscience

authors： Bernstein GM,Mendonça A,Wadia J,Burnham WM,Jones OT

更新日期：1999-01-01 00:00:00

abstract：:A role has been suggested for hypothalamic alpha1 adrenoceptors in the acute stress-induced activation of the hypothalamic-pituitary-adrenal axis. Using a polyclonal antiserum against the rat alpha1B adrenergic receptor protein, we have demonstrated alpha1B receptor immunoreactivity in neurons and especially in puncta...

journal_title：Neuroscience

authors： Williams AM,Morilak DA

更新日期：1997-02-01 00:00:00

abstract：:The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functioning, and the oxidant and antioxidant capacity of plasma. We recruited 52 healthy s...

journal_title：Neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Patruno A,Ballerini P,De Lutiis MA,Felaco M,Grilli A

更新日期：2018-02-01 00:00:00

abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

journal_title：Neuroscience

authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

更新日期：1999-01-01 00:00:00

abstract：:Peripheral nerve injury in a limb usually causes functional reorganization of the contralateral motor cortex. However, a dynamic process of the novel transhemispheric functional reorganization in the motor cortex was found in adult rats after transferring the seventh cervical nerve root from the contralateral healthy ...

journal_title：Neuroscience

authors： Lou L,Shou T,Li Z,Li W,Gu Y

更新日期：2006-01-01 00:00:00

abstract：:Spontaneous activity in medial vestibular nucleus (MVN) neurons is modulated by synaptic inputs. These inputs are crucial for maintaining gaze and posture and contribute to vestibular compensation after lesions of peripheral vestibular organs. We investigated how chronically attenuated glycinergic input affects excita...

journal_title：Neuroscience

authors： Camp AJ,Lim R,Anderson WB,Schofield PR,Callister RJ,Brichta AM

更新日期：2010-09-29 00:00:00

abstract：:Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes i...

journal_title：Neuroscience

authors： Stamatakis A,Toutountzi E,Fragioudaki K,Kouvelas ED,Stylianopoulou F,Mitsacos A

更新日期：2009-12-29 00:00:00

abstract：:Thymosin beta4 is a major actin-sequestering peptide widely distributed in mammalian tissues, including the nervous system. In the present study, we analyse the expression of thymosin beta4 in normal and kainate-treated rat forebrain. In untreated animals, thymosin beta4 messenger RNA is mainly expressed in neurons of...

journal_title：Neuroscience

authors： Carpintero P,Anadón R,Díaz-Regueira S,Gómez-Márquez J

更新日期：1999-01-01 00:00:00

abstract：:In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium a...

journal_title：Neuroscience

authors： Wang HT,Zeng L,Chen Q,Zhang X,Liu JW,Lu TJ,Xiong ZQ,Zheng J,Hu ZL

更新日期：2015-01-22 00:00:00

abstract：:It has been reported that N-methyl-D-aspartate receptor (NMDAR)-triggered neurotoxicity is related to excessive Ca(2+) loading and an increase in nitric oxide (NO) concentration. However, the molecular mechanisms that underlie these events are not completely understood. NMDARs and neuronal NO synthase each binds to th...

journal_title：Neuroscience

authors： Zhang M,Xu JT,Zhu X,Wang Z,Zhao X,Hua Z,Tao YX,Xu Y

更新日期：2010-04-14 00:00:00

abstract：:Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...

journal_title：Neuroscience

authors： Estes S,Zhong LR,Artinian L,Rehder V

更新日期：2015-12-17 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and the increased risk of developing Parkinson's disease. Previously we have reported that Dichlorvos exposure can induce oxidative stress, resulting in over-expression of pro-apoptotic genes and finally caspase-dependent nigrostriat...

journal_title：Neuroscience

authors： Wani WY,Sunkaria A,Sharma DR,Kandimalla RJ,Kaushal A,Gerace E,Chiarugi A,Gill KD

更新日期：2014-01-31 00:00:00

abstract：:3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, induced ATP depletion and both necrosis and apoptosis in human NT2-N neurons. Necrosis occurred predominantly within the first two days, and increased in a dose-dependent fashion with the concentration of 3-NP, whereas apoptosis was ob...

journal_title：Neuroscience

authors： Lee WT,Itoh T,Pleasure D

更新日期：2002-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+tf/J (BTBR) is an inbred mouse strain that displays robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of...

journal_title：Neuroscience

authors： Silverman JL,Yang M,Turner SM,Katz AM,Bell DB,Koenig JI,Crawley JN

更新日期：2010-12-29 00:00:00

abstract：:This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal lev...

journal_title：Neuroscience

authors： Sawada K,Hosoi E,Bando M,Sakata-Haga H,Lee NS,Jeong YG,Fukui Y

更新日期：2008-03-27 00:00:00

abstract：:N-Methyl-D-aspartate receptors are fundamental for neuronal plasticity and development in the CNS. Most studies have examined postsynaptic roles of this receptor, but there are also indications for a presynaptic location and function. Here, we provide electrophysiological evidence for the existence of presynaptic N-me...

journal_title：Neuroscience

authors： Berretta N,Jones RS

更新日期：1996-11-01 00:00:00

abstract：:Psychostimulants and antipsychotic drugs increase mRNA expression of the neuropeptide neurotensin (NT) in the striatum and nucleus accumbens. In the present study, we used mice lacking the dopamine transporter (DAT) to investigate the consequences of a chronic hyperdopaminergic state on NT gene expression. NT mRNA exp...

journal_title：Neuroscience

authors： Roubert C,Spielewoy C,Soubrié P,Hamon M,Giros B,Betancur C

更新日期：2004-01-01 00:00:00

abstract：:Status epilepticus is a major medical emergency that results in significant alteration of neuronal function. Status epilepticus involves seizure activity recurring frequently enough to induce a sustained alteration in brain function. This study was initiated to investigate how status epilepticus affects the activity o...

journal_title：Neuroscience

authors： Kochan LD,Churn SB,Omojokun O,Rice A,DeLorenzo RJ

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:High-mobility group box 1 (HMGB1), an active receptor for advanced glycation endproducts (RAGE), functions as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of vasculature. Diabetes mellitus (DM) is associated with accelerated development of both microvascular and macrovasc...

journal_title：Neuroscience

authors： Ye X,Chopp M,Liu X,Zacharek A,Cui X,Yan T,Roberts C,Chen J

更新日期：2011-09-08 00:00:00

abstract：:GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed a novel requirement for GABA(B) receptor signalling. Studies have demonstrated that the two receptor subunits associate as a...

journal_title：Neuroscience

authors： Charles KJ,Evans ML,Robbins MJ,Calver AR,Leslie RA,Pangalos MN

更新日期：2001-01-01 00:00:00

abstract：:Professional Pingju actors have been shown to exhibit practice-induced plastic changes in spontaneous regional brain activity; however, whether these changes are present in resting-state regional cerebral blood flow (CBF) remains largely unclear. Here, twenty professional Pingju opera actors and 20 age-, sex-, and han...

journal_title：Neuroscience

authors： Zhao F,Zhang W,Zhu D,Wang X,Qin W,Liu F

更新日期：2020-06-01 00:00:00

abstract：:Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number an...

journal_title：Neuroscience

authors： Jankowska E,Krutki P,Läckberg ZS,Hammar I

更新日期：1995-07-01 00:00:00

abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

journal_title：Neuroscience

authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

更新日期：2013-02-12 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether an objective measure of freezing of gait (FOG) using a validated alternating stepping in place (SIP) task, is related to executive and/or visuospatial cognitive impairment in Parkinson's disease (PD). METHODS:We studied prospectively 30 PD subjects with the U...

journal_title：Neuroscience

authors： Nantel J,McDonald JC,Tan S,Bronte-Stewart H

更新日期：2012-09-27 00:00:00

abstract：:The enteric nervous system plays an integral role in the gastrointestinal tract. Within this intricate network, enteric glia are crucial in the maintenance of normal bowel function, yet their signaling mechanisms are poorly understood. Enteric glia, and not enteric neurons, selectively responded to lysophosphatidic ac...

journal_title：Neuroscience

authors： Segura BJ,Zhang W,Cowles RA,Xiao L,Lin TR,Logsdon C,Mulholland MW

更新日期：2004-01-01 00:00:00

abstract：:It has been hypothesized [Colpaert, F.C., 1994. In: Briley, M., Marien, M. (Eds.), Noradrenergic Mechanisms in Parkinson's Disease. CRC Press, Boca Raton, FL, pp. 225-254] that a deficiency in the noradrenergic system originating from the locus coeruleus is a decisive factor in the progression of central neurodegenera...

journal_title：Neuroscience

authors： Debeir T,Marien M,Chopin P,Martel JC,Colpaert F,Raisman-Vozari R

更新日期：2002-01-01 00:00:00

abstract：:Physiological studies suggest visceral spinal afferents are generally small diameter, unmyelinated C-fibers or myelinated Adelta-fibers, but little is known about the size and chemical phenotypes of visceral sensory neurons supplying the small intestine. This study examines the size and expression patterns of transien...

journal_title：Neuroscience

authors： Tan LL,Bornstein JC,Anderson CR

更新日期：2008-10-02 00:00:00