Abstract：
:Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number and/or increased the latency of spike potentials evoked by these afferents. In contrast, synaptic actions of low-threshold cutaneous afferents (mono- or oligosynaptic) were facilitated in the majority of the neurons, as judged by decrease in the latency of spike potentials evoked by stimulation of a cutaneous nerve and/or an increase in the number of these potentials. It is proposed that facilitatory actions assist in maintaining tonic discharges of dorsal spinocerebellar tract neurons in some movements and that the selective control of group II input is used to correlate activity of spinal and supraspinal neurons. Both actions may be subserved by tight contacts between serotoninergic nerve fibres and dorsal spinocerebellar tract neurons, which have been revealed in a parallel study.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Jankowska E,Krutki P,Läckberg ZS,Hammar Idoi
10.1016/0306-4522(95)00060-vsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
489-95issue
2eissn
0306-4522issn
1873-7544pii
030645229500060Vjournal_volume
67pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Toll-like receptor 2 (TLR2) and TLR4 belong to a family of highly conserved pattern recognition receptors and are well-known upstream sensors of signaling pathways of innate immunity. TLR2 and TLR4 upregulation is thought to be associated with poor outcome in stroke patients. We currently show that transient focal isc...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2018.01.014
更新日期：2018-03-01 00:00:00
abstract：:Pain is processed in a large neural network that partially overlaps structures involved in emotion processing. Despite the fact that pain and emotion are known to share neural regions and interact in numerous clinical conditions, relatively little is known about the interaction of pain and emotion at the neural level....
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.02.047
更新日期：2017-05-04 00:00:00
abstract：:The aim of this study was to examine the participation of nitrergic neurotransmission in the initiation of micturition hyperreflexia associated to cyclophosphamide (CP)-induced cystitis in rats. Micturition threshold volume was significantly reduced 4 h after CP administration (100 mg/kg, i.p.); this reduction was att...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2003.10.048
更新日期：2004-01-01 00:00:00
abstract：:There is increasing evidence that alterations in the focus of attention result in changes in neural responding at the most peripheral levels of the auditory system. To date, however, those studies have not ruled out differences in task demands or overall arousal in explaining differences in responding across intermoda...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.07.062
更新日期：2012-10-25 00:00:00
abstract：:We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90422-c
更新日期：1993-02-01 00:00:00
abstract：:Alzheimer's disease (AD) increases the risk for late-onset seizures and neuronal network abnormalities. An elevated co-occurrence of AD and seizures has been established in the more prevalent sporadic form of AD. Recent evidence suggests that nonconvulsive network abnormalities, including seizures and other electroenc...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2014.11.051
更新日期：2015-02-12 00:00:00
abstract：:Training of a musical skill is known to produce a distributed neural representation of the ability to perceive music and perform musical tasks. In the present study we tested the hypothesis that the audiovisual perception of music involves a wider activation of multimodal sensory and sensorimotor structures in the bra...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.08.013
更新日期：2020-10-15 00:00:00
abstract：:The steroid hormone vitamin D has important biological roles in calcium transport, cell growth, and cell differentiation. Its cellular activities are mediated by high affinity interaction with the vitamin D receptor. In brain, autoradiographic, immunohistologic, and messenger RNA expression studies implicate a number ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00049-5
更新日期：2001-01-01 00:00:00
abstract：:We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(96)00613-6
更新日期：1997-05-01 00:00:00
abstract：:The study of the neural basis of predatory behavior has been largely neglected over the recent years. Using an ethologically based approach, we presently delineate the prosencephalic systems mobilized during predation by examining Fos immunoreactivity in rats performing insect hunting. These results were further compa...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.10.020
更新日期：2005-01-01 00:00:00
abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90344-n
更新日期：1991-01-01 00:00:00
abstract：:This study examines the effect of chronic alcohol consumption on the human cerebellum using operational criteria for case selection [Caine D. et al. (1997) J. Neurol. Neurosurg. Psychiat. 62, 51-60] and unbiased stereological techniques. We describe, for the first time, structural changes in different functional zones...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)90664-9
更新日期：1999-01-01 00:00:00
abstract：:Dopamine receptors (DARs) in the nucleus accumbens (NAc) are critical for cocaine's actions but the nature of adaptations in DAR function after repeated cocaine exposure remains controversial. This may be due in part to the fact that different methods used in previous studies measured different DAR pools. In the prese...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.04.056
更新日期：2010-08-11 00:00:00
abstract：:Interactions between dopamine and glutamate receptors are essential for the prefrontal cortical (PFC) and hippocampal cognitive functions. In order to understand the molecular basis of dopamine/glutamate interactions in rat PFC and hippocampus, we investigated (a) the effect of in vitro dopamine D1 receptor stimulatio...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.07.056
更新日期：2009-11-10 00:00:00
abstract：:Activation of the adenosine A(2A) receptor (A(2A)R) at the time of reperfusion has been shown to reduce ischemia-reperfusion injury in peripheral tissues and spinal cord. In this study we show that treating mice with the A(2A)R agonist, 4-{3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-pu...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.05.014
更新日期：2006-09-15 00:00:00
abstract：:Astrocytes in the somatosensory ventrobasal (VB) thalamus of rats respond to glutamatergic synaptic input with metabotropic glutamate receptor (mGluR) mediated intracellular calcium ([Ca²⁺](i)) elevations. Astrocytes in the VB thalamus also release the gliotransmitter (GT) glutamate in a Ca²⁺-dependent manner. The tri...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.12.049
更新日期：2012-03-15 00:00:00
abstract：:It has been observed that motor neuron death is induced in adult rats by ventral root avulsion which involves pulling out the spinal cord root. Since motor neurons are reported to be selectively vulnerable to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated injury in vitro, we investigated chang...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00816-3
更新日期：2003-01-01 00:00:00
abstract：:Endotoxin-induced uveitis (EIU) is a common animal model for anterior uveitis in humans that causes long-term changes in trigeminal brain stem neurons. This study used c-fos immunohistochemistry to assess the effects of different routes of administration of endotoxin on activation of trigeminal brain stem neurons prod...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2008.12.015
更新日期：2009-03-17 00:00:00
abstract：:Isolated neurointermediate lobes or neural lobes of the rat pituitary gland attached to the pituitary stalk were incubated in vitro and the spontaneous or electrically (pituitary stalk stimulation, 5 Hz, 1,500 pulses) evoked release of 5-hydroxytryptamine was determined. The evoked release of 5-hydroxytryptamine from ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90085-6
更新日期：1987-11-01 00:00:00
abstract：:The behavioral and motivational changes that result from use of abused substances depend upon activation of neuronal populations in the reward centers of the brain, located primarily in the corpus striatum in primates. To gain insight into the cellular mechanisms through which abused drugs reinforce behavior in the pr...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.06.002
更新日期：2009-09-29 00:00:00
abstract：:The peripheral reorganization of pulpal nerves after tooth injury was studied, in the rat, with anterograde horseradish peroxidase tracing techniques, and combined retrograde Fluorogold tracing and immunohistochemistry was employed to examine the effects of inferior alveolar nerve lesions or tooth injury on some cytoc...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90434-p
更新日期：1991-01-01 00:00:00
abstract：:Sensory input from female reproductive structures is paramount for the co-ordination of neuroendocrine changes at parturition. Using a retrograde tracer (fluorescent latex microspheres) in combination with Fos (as an indicator of neuronal activation) and tyrosine hydroxylase (to identify catecholaminergic neurons) imm...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00300-6
更新日期：2000-01-01 00:00:00
abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2019.07.036
更新日期：2020-07-15 00:00:00
abstract：:The purpose of the present study was to examine whether the rostroventral portion of the medulla oblongata (RVM) exerts descending modulation on the cardiosomatic motor reflex (CMR) in rats. Capsaicin (1 μg/ml, 0.2 ml) was injected into the pericardial sac as an algesic substance to induce the CMR, which was monitored...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.04.016
更新日期：2011-06-30 00:00:00
abstract：:5-HT and agonists of the 5-HT receptor can modify the response of the mammalian pacemaker, which is located in the hypothalamic suprachiasmatic nuclei (SCN), to photic and nonphotic stimulation. Previous studies suggest that the 5-HT7 receptor is involved in the regulation of photic input, and the modulation of nonpho...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.10.028
更新日期：2008-03-03 00:00:00
abstract：:Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tis...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90509-z
更新日期：1992-01-01 00:00:00
abstract：:The effects of steroid hormones on glutamate neurotoxicity were examined in cultured spinal cord neurons. The extent of neuronal damage, produced by glutamate exposure for 15 min, was estimated based on the activity of lactate dehydrogenase released from degenerated neurons to the media during 24 h of post-exposure in...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90513-f
更新日期：1993-07-01 00:00:00
abstract：:Interleukin-1 plays an important role as mediator of endotoxin-induced responses in the brain such as fever, sleep, anorexia, behavioural and neuroendocrine changes. In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and sub...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)00549-k
更新日期：1995-04-01 00:00:00
abstract：:In stroke-prone spontaneously hypertensive rats (SHRSP/Izm), ischemia induces swelling of astrocytes, a process that subsequently leads to neuronal death. Following ischemic insult, arginine vasopressin (AVP) can induce edema and l-serine released by astrocytes supports the survival of neuronal cells. The purpose of t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.02.039
更新日期：2014-05-16 00:00:00
abstract：:The work of Aguayo and colleagues [Aguayo, David and Bray (1981) J. Exp. Biol. 95, 231-240] demonstrates that grafts of peripheral neural tissue are able to induce regenerative elongation of cut axons in the adult central nervous system. Elucidation of the mechanism of this response requires an understanding of the ce...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90261-2
更新日期：1987-03-01 00:00:00
