Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling.

abstract：:Depolarization-induced transmitter release in synaptosomes prepared from the hippocampus of aged rats is decreased compared with release from young animals. Although the underlying cause of this deficit is not known, some evidence suggests that increased membrane rigidity may contribute to these age-related synaptic c...

journal_title：Neuroscience

authors： McGahon BM,Martin DS,Horrobin DF,Lynch MA

更新日期：1999-01-01 00:00:00

abstract：:The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant ...

journal_title：Neuroscience

authors： Wang Y,Yin X,Rosen G,Gabel L,Guadiana SM,Sarkisian MR,Galaburda AM,Loturco JJ

更新日期：2011-09-08 00:00:00

abstract：:Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement ther...

journal_title：Neuroscience

authors： Smith ES,Hardy GA,Schallert T,Lee HJ

更新日期：2016-11-19 00:00:00

abstract：:The incidence of asthma is more common in boys than in girls during the childhood, and more common in premenopausal female than age-matched males. Our previous study demonstrated a gender difference in histamine-mediated neuroexcitability in nodose ganglia neurons (NGNs), highlighting a possibility of histamine-mediat...

journal_title：Neuroscience

authors： Li JN,Li XL,He J,Wang JX,Zhao M,Liang XB,Zhao SY,Ma MN,Liu Y,Wang YB,Chen H,Qiao GF,Li BY

更新日期：2015-09-10 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by selective vulnerability of specific neuronal populations within particular brain regions. For example, hippocampal glutamatergic cell populations within the CA1/subicular pyramidal cell fields have been found to be particularly vulnerable early in AD progression. In contras...

journal_title：Neuroscience

authors： Rissman RA,Mishizen-Eberz AJ,Carter TL,Wolfe BB,De Blas AL,Miralles CP,Ikonomovic MD,Armstrong DM

更新日期：2003-01-01 00:00:00

abstract：:The effect of cycloheximide (an inhibitor of protein synthesis) on the ionic currents through sodium and potassium channels was investigated in dialysed voltage-clamped N18 A-1 neuroblastoma cells. The cycloheximide concentration needed for half-inhibition of sodium peak conductance was about 0.5 micrograms/ml for 24 ...

journal_title：Neuroscience

authors： Zubov AN,Nisman BK,Panshina YT

更新日期：1983-07-01 00:00:00

abstract：:The ability to selectively control the differentiation of neural stem cells (NSCs) into cholinergic neurons in vivo would be an important step toward cell replacement therapy. First, green fluorescent protein (GFP)-NSCs were induced to differentiate into cholinergic neuron-like cells (CNLs) with retinoic acid (RA) pre...

journal_title：Neuroscience

authors： Gu G,Zhang W,Li M,Ni J,Wang P

更新日期：2015-04-16 00:00:00

abstract：:When human divers or experimental animals are exposed to high pressure, they develop the high-pressure neurological syndrome which is characterized by electroencephalographic changes, and behavioral disturbances. Recently, neurochemical disorders such as a pressure-induced increase in dopamine release have been demons...

journal_title：Neuroscience

authors： Abraini JH,Fechtali T,Rostain JC

更新日期：1992-09-01 00:00:00

abstract：:Gene therapy holds great potential for treating neurological disorders. However, delivering gene vectors to the brain has been either invasive or inefficacious in most studies to date. The aim of this study was to develop a safe and efficacious strategy for delivering gene vectors to the brain. A tetracycline-inducibl...

journal_title：Neuroscience

authors： Jiang Y,Wei N,Zhu J,Zhai D,Wu L,Chen M,Xu G,Liu X

更新日期：2012-01-10 00:00:00

abstract：:Western diets are high in fat and sucrose and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can influence the brain and behavior. This study was designed to determine whether diet-induced changes in the gut microbiota could contribute to alterations in anxiety, memor...

journal_title：Neuroscience

authors： Magnusson KR,Hauck L,Jeffrey BM,Elias V,Humphrey A,Nath R,Perrone A,Bermudez LE

更新日期：2015-08-06 00:00:00

abstract：:Prialt, a synthetic version of Ca(v)2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and considerable side effects associated with systemic dosing, Prialt is only ...

journal_title：Neuroscience

authors： Patel R,Rutten K,Valdor M,Schiene K,Wigge S,Schunk S,Damann N,Christoph T,Dickenson AH

更新日期：2015-06-25 00:00:00

abstract：:Post-traumatic syringomyelia (PTS) is a serious neurological disorder characterized by fluid filled cavities that develop in the spinal cord. PTS is thought to be caused by an imbalance between fluid inflow and outflow in the spinal cord, but the underlying mechanisms are unknown. The ion channel Kir4.1 plays an impor...

journal_title：Neuroscience

authors： Najafi E,Stoodley MA,Bilston LE,Hemley SJ

更新日期：2016-03-11 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN), a site for the integration of both the neuroendocrine and autonomic systems, has heterogeneous cell composition. These neurons are classified into type I and type II neurons based on their electrophysiological properties. In the present study, we investigated the molecul...

journal_title：Neuroscience

authors： Lee SK,Lee S,Shin SY,Ryu PD,Lee SY

更新日期：2012-03-15 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:Limb amputation in urodele amphibia is followed by formation of a blastema, which subsequently develops into a complete limb with normal pattern of innervation. In this study, we investigated the effects of axolotl limb blastemas on axonal growth in gels of collagen and extracellular matrix (matrigel). When peripheral...

journal_title：Neuroscience

authors： Tonge DA,Leclere PG

更新日期：2000-01-01 00:00:00

abstract：:Research in songbirds shows that singing behavior is regulated by both brain areas involved in vocal behavior as well as those involved in social behavior. Interestingly, the precise role of these regions in song can vary as a function of the social, environmental and breeding context. To date, little is known about t...

journal_title：Neuroscience

authors： Heimovics SA,Cornil CA,Ball GF,Riters LV

更新日期：2009-03-31 00:00:00

abstract：:Effects of glutamate agonists and their selective antagonists on the Ca(2+)-dependent release of [3H]GABA from rat hippocampal slices were studied in a superfusion system. The release was enhanced by glutamate, kainate, quisqualate, N-methyl-D-aspartate and glycine in a concentration-dependent manner. In general, (+)-...

journal_title：Neuroscience

authors： Janáky R,Saransaari P,Oja SS

更新日期：1993-04-01 00:00:00

abstract：:Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities...

journal_title：Neuroscience

authors： Buzsáki G

更新日期：1989-01-01 00:00:00

abstract：:Iron-overload can cause cognitive impairment due to blood-brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not been investigated. Moreover, s...

journal_title：Neuroscience

authors： Sripetchwandee J,Wongjaikam S,Krintratun W,Chattipakorn N,Chattipakorn SC

更新日期：2016-09-22 00:00:00

abstract：:Several types of brain injuries have been associated with alterations in the striatal expression of neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF). However, contradictory results on the striatal expression of GDNF have been reported in different animal models of Parkinson's disease....

journal_title：Neuroscience

authors： Mertens B,Massie A,Michotte Y,Sarre S

更新日期：2009-08-04 00:00:00

abstract：:The aim of the present study was to examine the fine structural changes in the superior cervical ganglion of adult rats following baclofen treatment. On the addition of this GABAB receptor agonist there was a transient increase in the number of coated vesicles and pits in the dendrites of principal sympathetic neurons...

journal_title：Neuroscience

authors： Parducz A,Joó F,Siklós L,Wolff JR

更新日期：1990-01-01 00:00:00

abstract：:Temporal and spatial characteristics of hippocampal neuronal network activation are modified during epileptiform afterdischarges. We developed a beta burst stimulation protocol to investigate subregional variations and substrates of rhythmic population spike discharges in vivo in urethane anesthetized Wistar rat hippo...

journal_title：Neuroscience

authors： Mikkonen JE,Penttonen M

更新日期：2005-01-01 00:00:00

abstract：:In this study, we investigated effects of intra-central amygdala (intra-CeA) administrations of a cannabinoid agonist, WIN55,212-2 by itself and its interaction with β1-adrenoceptor agents on memory consolidation. We used a step-through inhibitory avoidance (IA) task to assess memory in male Wistar rats. The results s...

journal_title：Neuroscience

authors： Zarrindast MR,Ghiasvand M,Rezayof A,Ahmadi S

更新日期：2012-06-14 00:00:00

abstract：:The increase in excitatory outflow from the medial prefrontal cortex is critical to the development of sensitization to amphetamine. There is evidence that psychostimulant-induced changes in dopamine-GABA interactions are key to understanding the behaviorally sensitized response. The objective of this study was to cha...

journal_title：Neuroscience

authors： Morshedi MM,Meredith GE

更新日期：2007-11-09 00:00:00

abstract：:The aim of this study was to test a possible role of A5 neurons in the expression of the pressor and tachycardic responses to conditioned fear and restraint, two forms of psychological stress. Previous Fos studies have shown that the C1 adrenergic neurons and spinally projecting neurons in the vasopressor region of th...

journal_title：Neuroscience

authors： Vianna DM,Carrive P

更新日期：2010-04-14 00:00:00

abstract：:Respiratory disturbances are a primary phenotype of the neurological disorder, Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Mouse models generated with null mutations in Mecp2 mimic respiratory abnormalities in RTT girls. Large deletions, however, are see...

journal_title：Neuroscience

authors： Bissonnette JM,Schaevitz LR,Knopp SJ,Zhou Z

更新日期：2014-05-16 00:00:00

abstract：:In the present normal anatomical light and electron microscopic study in the rat, histochemical (Nissl, Timm, Golgi) or immunocytochemical (microtubule-associated protein type 2, glutamate decarboxylase, glutamate receptor subunit 1, synaptophysin) stains were used to analyse neurons embedded within the stria terminal...

journal_title：Neuroscience

authors： Alheid GF,Beltramino CA,De Olmos JS,Forbes MS,Swanson DJ,Heimer L

更新日期：1998-06-01 00:00:00

abstract：:An electropharmacological analysis of the type(s) of calcium channel controlling neurotransmitter release in preganglionic sympathetic nerve terminals in the guinea-pig anterior pelvic ganglion has been carried out. Conventional intracellular recording techniques were used to record excitatory postsynaptic potentials ...

journal_title：Neuroscience

authors： Smith AB,Cunnane TC

更新日期：1999-01-01 00:00:00

abstract：:Animal studies have revealed that chronic stress shifts cognitive strategies from the flexible goal-directed action to the simple and rigid habit action. In addition, stress-induced atrophy in the prefrontal cortex and dorsomedial striatum which are involved in the goal-directed action and hypertrophy of the dorsolate...

journal_title：Neuroscience

authors： Ohira H,Matsunaga M,Kimura K,Murakami H,Osumi T,Isowa T,Fukuyama S,Shinoda J,Yamada J

更新日期：2011-10-13 00:00:00

abstract：:Neurodegeneration in Alzheimer's disease is characterized by a selective loss of particular cell populations. Several recent lines of evidence suggest that beta-amyloid protein directly contributes to the disease's progression and is likely responsible for the observed pattern of neuronal death. We have previously dem...

journal_title：Neuroscience

authors： Pike CJ,Cotman CW

更新日期：1993-09-01 00:00:00