Abstract：
:The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant differences in neuronal migration, neocortical lamination, neuronal cilliogenesis or dendritic differentiation. Considering previous studies showing genetic interactions and potential functional redundancy among members of the DCX family, we tested whether decreasing Dcx expression by RNAi would differentially impair neurodevelopment in Dcdc2 knockouts and wild-type mice. Consistent with this hypothesis, we found that deficits in neuronal migration, and dendritic growth caused by RNAi of Dcx were more severe in Dcdc2 knockouts than in wild-type mice with the same transfection. These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with Dcx.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Wang Y,Yin X,Rosen G,Gabel L,Guadiana SM,Sarkisian MR,Galaburda AM,Loturco JJdoi
10.1016/j.neuroscience.2011.06.010subject
Has Abstractpub_date
2011-09-08 00:00:00pages
398-408eissn
0306-4522issn
1873-7544pii
S0306-4522(11)00676-2journal_volume
190pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:The distribution of the enzyme protein-O-carboxylmethyltransferase (EC 2.1.1.24) has been investigated in the rat brain using both immunohistochemical and biochemical techniques. The enzyme, which carboxylmethylates free aspartic and glutamic acid residues of protein substrates, was localized in neurons, but not other...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(85)90130-7
更新日期：1985-05-01 00:00:00
abstract：:This good laboratory practice (GLP) study of aluminum salts in Sprague-Dawley rats was conducted according to double-blind, vehicle-controlled randomized design by exposing offspring to aluminum citrate in-utero, through lactation, and then in drinking water post-weaning. Three dose levels were used: 30, 100, 300 mg A...
journal_title：Neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroscience.2011.05.008
更新日期：2011-10-13 00:00:00
abstract：:In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2011.08.051
更新日期：2011-12-15 00:00:00
abstract：:Stimulation of the cornea activates neurons in two distinct regions of the spinal trigeminal nucleus: at the transition between trigeminal subnucleus interpolaris and subnucleus caudalis and at the transition between trigeminal subnucleus caudalis and the upper cervical spinal cord as estimated by expression of the im...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00433-8
更新日期：1998-03-01 00:00:00
abstract：:We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(88)90262-x
更新日期：1988-05-01 00:00:00
abstract：:Administration of selective agonists of D1 dopamine receptors increases immediate early gene expression in striatal neurons, a response which is particularly robust in the dopamine-depleted striatum. Although interactions between dopamine and glutamate receptor-mediated responses in striatal neurons have been demonstr...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00327-3
更新日期：1999-03-01 00:00:00
abstract：:There are two different proposals regarding the role of the cerebellar flocculus in the adaptation of the vestibulo-ocular reflex: that the flocculus is the site for both the induction and retention of the adaptation, or that the flocculus plays an important role in the induction, but the vestibular nuclei to which th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00991-0
更新日期：2003-01-01 00:00:00
abstract：:Our previous studies on olfactory bulbar responses in salmonid fishes suggest that pheromone signals might be processed by a mechanism distinct from that of other odorants. Using in vivo single-unit and electroencephalographic recordings, we investigated response characteristics of olfactory neurons in lake whitefish,...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00717-0
更新日期：2003-01-01 00:00:00
abstract：:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to tr...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.10.005
更新日期：2015-01-22 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and affects the CNS. Dystrophin is absent in muscle and CNS of both DMD patients and mdx mouse, a model of DMD. While the involvement of vascular compartment in DMD was poorly investigated, some studies suggested a role for mast cells (MC). Tryp...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2003.11.006
更新日期：2004-01-01 00:00:00
abstract：:High resolution immunogold cytochemistry was used to investigate the subcellular distribution of protein kinase C gamma and delta in Purkinje cells of the rat cerebellum. Postembedding incubation with an antibody raised to a peptide sequence near the C-terminus of protein kinase C gamma resulted in strong labelling al...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00305-9
更新日期：1998-02-01 00:00:00
abstract：:L-arginine, a semi-essential amino acid, can be metabolized to form a number of bioactive molecules. Nitric oxide (NO), generated by NO synthase (NOS) from L-arginine, has been strongly implicated in the aging process. Agmatine, decarboxylated arginine, regulates the production of NO and other metabolites of L-arginin...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.05.015
更新日期：2012-08-30 00:00:00
abstract：:Motor, sensory, and autonomic abnormalities are reported for toll-like receptor 9 (TLR9) knock-out (KO) mice. However, a physiological role of TLR9 in the nervous system is largely unknown. Since altered synaptic transmission can contribute to sensory and motor abnormalities, we evaluated neuromuscular junction (NMJ) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.03.001
更新日期：2016-06-02 00:00:00
abstract：:Enkephalins are peptides which have pharmacological properties similar to those of morphine. Guinea pigs were immunized with a leucine-enkephalin/thyroglobulin conjugate. Immunofluorescence histochemistry with antiserum revealed a widely distributed system of axons and their terminals in the nervous system of the rat....
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(76)90063-4
更新日期：1976-08-01 00:00:00
abstract：:Maternal separation (MS) during the first postnatal weeks induces alcohol intake and a reduction in the expression of glucocorticoid receptors (GR). Adults' alcohol consumption may depend on changes in the endocannabinoid system (eCBs). Our goal was to evaluate the status of the eCBs before the exposition to alcohol t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.07.071
更新日期：2012-10-25 00:00:00
abstract：:Secretion of neurotrophins is critical for the delivery of neurotrophic support. Brain-derived neurotrophic factor is targeted to a regulated secretory pathway in neurons as well as the neurosecretory AtT-20 cells. Here, we show that pertussis toxin, which inactivates Gi and Go G proteins, inhibits up to 50% of the re...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00309-2
更新日期：2000-01-01 00:00:00
abstract：:The effect of systemic administration of domoic acid, a potent structural analogue of kainic acid, on the mouse hippocampus has been studied using light and electron microscopic techniques. Intraperitoneal injections of either domoic acid (4 mg/kg) or kainic acid (32 mg/kg) produced a series of behavioural changes inc...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90059-w
更新日期：1991-01-01 00:00:00
abstract：:Amyloid deposits in Alzheimer's disease, Down's syndrome and aged brain are composed largely of A beta protein, which is generated by proteolytic processing of beta-amyloid precursor protein. Proteases responsible for liberating the A beta protein from the precursor have not yet been identified. Here, we examined the ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90490-1
更新日期：1994-06-01 00:00:00
abstract：:Corticothalamic axons from layer 5 of primary and secondary auditory and visual areas have large terminals that make multiple synaptic contacts on proximal dendrites of relay cells in higher order thalamic nuclei and have been termed "driver" inputs. The corticothalamic cells express mRNA for the presynaptic growth-as...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.08.033
更新日期：2005-01-01 00:00:00
abstract：:While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level. Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprot...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(96)00334-x
更新日期：1997-01-01 00:00:00
abstract：:The expression of the messenger RNAs encoding N-methyl-D-aspartate receptor subunits in neurologically normal post-mortem human brain was studied by in situ hybridization. In the caudate, putamen and nucleus accumbens strong hybridization signals were observed for N-methyl-D-aspartate R1-1 messenger RNA but much weake...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(96)00089-9
更新日期：1996-07-01 00:00:00
abstract：:Nervous system formation integrates control of cellular proliferation and differentiation and is mediated by multipotent neural progenitor cells that become progressively restricted in their developmental potential before they give rise to differentiated neurons and glial cells. Evidence from different experimental sy...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.03.050
更新日期：2007-06-29 00:00:00
abstract：:It is well established that transforming growth factor alpha is involved prenatally in development of the nervous system, but its role in the postnatal brain is less well understood. Here, we document the occurrence of late-onset, morphological and behavioral deficits in the naturally occurring murine mutant, Waved-1 ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00558-8
更新日期：2000-01-01 00:00:00
abstract：:In stroke-prone spontaneously hypertensive rats (SHRSP/Izm), ischemia induces swelling of astrocytes, a process that subsequently leads to neuronal death. Following ischemic insult, arginine vasopressin (AVP) can induce edema and l-serine released by astrocytes supports the survival of neuronal cells. The purpose of t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.02.039
更新日期：2014-05-16 00:00:00
abstract：:Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López e...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90378-6
更新日期：1994-09-01 00:00:00
abstract：:Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of slowly adapting type I mechanoreceptors. Using an isolated rat sinus hair follicle preparation we tested a range of compounds. Surprisingly, only non-competitive mGlu1 receptor antagonists pr...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.07.015
更新日期：2009-10-20 00:00:00
abstract：:Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on post...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00093-7
更新日期：1999-01-01 00:00:00
abstract：:Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90282-7
更新日期：1992-06-01 00:00:00
abstract：:GABA(A) receptor/Cl- channels and voltage-gated Ca2+ channels are believed to be important sites of ethanol action in the CNS. Acute exposure of ethanol potentiates GABA(A) receptor/Cl- channel activity and inhibits voltage-gated Ca2+ channels in a number of preparations, mostly post-mitotic neurons. The effects of et...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00084-7
更新日期：2001-01-01 00:00:00
abstract：:Serotonergic systems are thought to play an important role in control of motor activity and emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a motor-eliciting stimulus in the presence or absence of induction of an acute fear state on serotonergic neurons in the dorsal raphe n...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.01.042
更新日期：2011-04-14 00:00:00
