Dopaminergic modulation of striatal neurons, circuits, and assemblies.

abstract：:Extremely mild hypothermia to 36.0 °C is not thought to appreciably differ clinically from 37.0 °C. However, it is possible that 36.0 °C stimulates highly sensitive hypothermic signaling mechanism(s) and alters biochemistry. To the best of our knowledge, no such ultra-sensitive pathway/mechanisms have been described. ...

journal_title：Neuroscience

authors： Jackson TC,Manole MD,Kotermanski SE,Jackson EK,Clark RS,Kochanek PM

更新日期：2015-10-01 00:00:00

abstract：:Increasing evidence indicates that endothelin-1 has a role for peripheral nociceptive signaling in animals and humans. However, the mechanisms of the nociceptive effects of endothelin-1 have not been fully understood. The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+...

journal_title：Neuroscience

authors： Yamamoto H,Kawamata T,Ninomiya T,Omote K,Namiki A

更新日期：2006-02-01 00:00:00

abstract：:Specific acetylcholinesterase and non-specific cholinesterases are present in all three lobes of the rat pituitary gland. This paper describes two new observations on hypophyseal acetylcholinesterase. Firstly, a prolonged increase of neurohormone secretion evoked by dehydration and sodium loading was accompanied by a ...

journal_title：Neuroscience

authors： Alexandrova M,Holzbauer M,Racke K,Sharman DF

更新日期：1987-05-01 00:00:00

abstract：:Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes ope...

journal_title：Neuroscience

authors： Qin P,Duncan NW,Chen DY,Chen CJ,Huang LK,Huang Z,Lin CE,Wiebking C,Yang CM,Northoff G,Lane TJ

更新日期：2018-05-21 00:00:00

abstract：:L-arginine, a semi-essential amino acid, can be metabolized to form a number of bioactive molecules. Nitric oxide (NO), generated by NO synthase (NOS) from L-arginine, has been strongly implicated in the aging process. Agmatine, decarboxylated arginine, regulates the production of NO and other metabolites of L-arginin...

journal_title：Neuroscience

authors： Rushaidhi M,Collie ND,Zhang H,Liu P

更新日期：2012-08-30 00:00:00

abstract：:We have studied allogeneic transplants of adult rat enteric ganglia in order to evaluate their use as donor tissue for eventual autografts in rodent spinal cord injury models. Female Sprague-Dawley rats of similar weights served either as transplant donors or as recipients. A glass micropipette of 0.8 mm diameter was ...

journal_title：Neuroscience

authors： Jaeger CB,Toombs JP,Borgens RB

更新日期：1993-01-01 00:00:00

abstract：:The participation of excitatory neurotransmitter systems in the basal ganglia in the initiation and propagation of limbic seizures induced by pilocarpine has been investigated in the rat. Limbic seizures (electrographic and motor) occur in rats receiving bilateral microinjections into the entopeduncular nucleus of 12....

journal_title：Neuroscience

authors： Patel S,De Sarro GB,Meldrum BS

更新日期：1988-12-01 00:00:00

abstract：:Microglial responses to endotoxin, including the synthesis of inflammatory factors, contribute to gliosis and neuron degeneration in cultured brain tissue. We have previously shown that Gö6976, a protein kinase C (PKC) inhibitor, suppressed the lipopolysaccharide (LPS)-induced production of inflammatory factors in mic...

journal_title：Neuroscience

authors： Jeohn GH,Cooper CL,Jang KJ,Liu B,Lee DS,Kim HC,Hong JS

更新日期：2002-01-01 00:00:00

abstract：:Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (Ach). Exogenous supplementation with ChAT can functionally compensate for decreased Ach levels and ameliorate memory and cognitive deficits. In this paper, the treatment efficacy of recombinant ChAT (peptide transduction domain (PTD)-ChAT...

journal_title：Neuroscience

authors： Zhu Z,Zhang L,Cui Y,Li M,Ren R,Li G,Sun X,Li Q

更新日期：2020-08-21 00:00:00

abstract：:We had previously shown that in rat spinal cord motoneurons urotensin II (UII) precursor mRNA was down-regulated by androgens. Very recently, a gene encoding the precursor of a UII analog, termed UII-related peptide (URP), has been identified. Using in situ hybridization, we studied the localization of UII and URP pre...

journal_title：Neuroscience

authors： Pelletier G,Lihrmann I,Dubessy C,Luu-The V,Vaudry H,Labrie F

更新日期：2005-01-01 00:00:00

abstract：:Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression and drug abuse. Both serotonin-2A (5-HT2A) and -2C (5-HT2C) receptors are known t...

journal_title：Neuroscience

authors： Nocjar C,Alex KD,Sonneborn A,Abbas AI,Roth BL,Pehek EA

更新日期：2015-06-25 00:00:00

abstract：:Organotypic cultures established from the third thoracic ganglion of locust embryo have been used to investigate dopamine receptors. In this in vitro system, neurites emerge directly from the explants and form a dense network around the explants, presenting cell surface freely exposed for experimental labelling. Polyc...

journal_title：Neuroscience

authors： Vanhems E,Delbos M,Geffard M,Viellemaringe J

更新日期：1994-02-01 00:00:00

abstract：:There is increasing evidence that a subset of midbrain dopamine (DA) neurons uses glutamate as a co-transmitter and expresses vesicular glutamate transporter (VGLUT) 2, one of the three vesicular glutamate transporters. In the present study, double in situ hybridization was used to examine tyrosine hydroxylase (TH) an...

journal_title：Neuroscience

authors： Dal Bo G,Bérubé-Carrière N,Mendez JA,Leo D,Riad M,Descarries L,Lévesque D,Trudeau LE

更新日期：2008-09-22 00:00:00

abstract：:Several lines of clinical evidence support the idea that fragile X syndrome (FXS) may involve a dysregulation of hypothalamic-pituitary-adrenal axis function [Wisbeck et al. (2000) J Dev Behav Pediatr 21:278-282; Hessl et al. (2002) Psychoneuroendocrinology 27:855-872]. We had tested this idea in a mouse model of FXS ...

journal_title：Neuroscience

authors： Qin M,Xia Z,Huang T,Smith CB

更新日期：2011-10-27 00:00:00

abstract：:The location of sympathetic preganglionic neurons (SPN) in the spinal cord of the reeler mouse mutant is abnormal. Instead of their normal location in the intermediolateral column, the majority of SPN in the reeler cluster around the central canal. To determine whether ectopically located SPN in the reeler form approp...

journal_title：Neuroscience

authors： Yip YP,Rinaman L,Capriotti C,Yip JW

更新日期：2003-01-01 00:00:00

abstract：:The uncrossed retinotectal projection of rats undergoes extensive axonal elimination and subsequent growth of axonal arbors in topographically appropriate territories within the first two/three postnatal weeks. Nitric oxide has been implicated in development and stabilization of synapses in the retinotectal pathway si...

journal_title：Neuroscience

authors： Campello-Costa P,Fosse-Júnior AM,Oliveira-Silva P,Serfaty CA

更新日期：2006-01-01 00:00:00

abstract：:Interactions between the hippocampus and the prefrontal cortex (PFC) are of major interest in the neurobiology of psychiatric and neurodegenerative disorders and are central to many experimental rodent models. Non-invasive imaging techniques offer a translatable approach to probing this system if homologous features c...

journal_title：Neuroscience

authors： Schwarz AJ,Gass N,Sartorius A,Zheng L,Spedding M,Schenker E,Risterucci C,Meyer-Lindenberg A,Weber-Fahr W

更新日期：2013-01-03 00:00:00

abstract：:Recent advances in multiple areas of research have contributed to the identification of several pathophysiological factors underlying obsessive-compulsive disorder (OCD). In particular, the glutamate transporter gene SLC1A1 has been associated with the diagnosis of OCD. Immunological and infectious studies have report...

journal_title：Neuroscience

authors： Rotge JY,Aouizerate B,Tignol J,Bioulac B,Burbaud P,Guehl D

更新日期：2010-01-20 00:00:00

abstract：:Depolarization-induced transmitter release in synaptosomes prepared from the hippocampus of aged rats is decreased compared with release from young animals. Although the underlying cause of this deficit is not known, some evidence suggests that increased membrane rigidity may contribute to these age-related synaptic c...

journal_title：Neuroscience

authors： McGahon BM,Martin DS,Horrobin DF,Lynch MA

更新日期：1999-01-01 00:00:00

abstract：:We report that a small population of neurons expresses both choline acetyltransferase and classical estrogen receptor immunoreactivity and they are found primarily in the bed nucleus of the stria terminalis. In short-term ovariectomized ageing mice (24 months, n = 5) there were 41.0 +/- 4.1% fewer of these double-labe...

journal_title：Neuroscience

authors： Miller MM,Hyder SM,Assayag R,Panarella SR,Tousignant P,Franklin KB

更新日期：1999-01-01 00:00:00

abstract：:Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique. The two peptides have been found to coexist in one and the same neuron. After sectioning of ...

journal_title：Neuroscience

authors： Suzuki N,Hardebo JE,Owman C

更新日期：1989-01-01 00:00:00

abstract：:Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...

journal_title：Neuroscience

authors： Ambrosini S,Sarchielli E,Comeglio P,Porfirio B,Gallina P,Morelli A,Vannelli GB

更新日期：2015-03-19 00:00:00

abstract：:Although GABA is the major inhibitory neurotransmitter in adult brain, it exerts depolarizing actions in developing neurons that include activation of voltage-gated calcium channels. The depolarizing actions of GABA serve an obvious trophic function, but the specific physiological significance of excitatory versus inh...

journal_title：Neuroscience

authors： Perrot-Sinal TS,Auger AP,McCarthy MM

更新日期：2003-01-01 00:00:00

abstract：:The lurcher mutation induces Purkinje cell degeneration in heterozygous mice, and neonatal death in homozygous animals. Using the D6Mit16 Simple Sequence Length Polymorphic marker in F2 hybrids between AKR +/+ mice and B6+/Lc mice, homozygous lurcher fetuses and newborns as well as heterozygous and normal littermates ...

journal_title：Neuroscience

authors： Resibois A,Cuvelier L,Goffinet AM

更新日期：1997-09-01 00:00:00

abstract：:Allowing a resident hamster a single "priming" attack on a conspecific induces a transient aggressive arousal as indicated by a reduction in the latency and increase in the probability of attack on a second intruder presented within the next 30 min. We present two lines of evidence identifying the corticomedial amygda...

journal_title：Neuroscience

authors： Potegal M,Ferris CF,Hebert M,Meyerhoff J,Skaredoff L

更新日期：1996-12-01 00:00:00

abstract：:Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission by targeting the most redox-sensitive presynaptic compartment (Ginia...

journal_title：Neuroscience

authors： Giniatullin A,Petrov A,Giniatullin R

更新日期：2019-02-10 00:00:00

abstract：:The present research explored the cortical correlates of emotional memories in response to words and pictures. Subjects' performance (Accuracy Index, AI; response times, RTs; RTs/AI) was considered when a repetitive Transcranial Magnetic Stimulation (rTMS) was applied on the left dorsolateral prefrontal cortex (LDLPFC...

journal_title：Neuroscience

authors： Balconi M,Cobelli C

更新日期：2015-02-26 00:00:00

abstract：:We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...

journal_title：Neuroscience

authors： Yan Q,Rosenfeld RD,Matheson CR,Hawkins N,Lopez OT,Bennett L,Welcher AA

更新日期：1997-05-01 00:00:00

abstract：:The neurotensin/neuromedin N precursor molecule possesses four lysine-arginine dibasic residues which represent potential sites of cleavage by proteolytic maturation enzymes. As shown in the preceding paper, all of these dibasic residues are cleaved to a variable extent in rat brain. The aim of the present study was t...

journal_title：Neuroscience

authors： Woulfe J,Lafortune L,de Nadai F,Kitabgi P,Beaudet A

更新日期：1994-05-01 00:00:00

abstract：:Dorsal vagal complex (DVC) AMPK regulation of food intake in the estradiol-treated ovariectomized (OVX) female rat is energy state-dependent. Here, RT-PCR array technology was used to identify estradiol-sensitive AMPK-regulated DVC signal transduction pathways that exhibit differential reactivity to sensor activation ...

journal_title：Neuroscience

authors： Ibrahim BA,Alenazi FSH,Briski KP

更新日期：2015-01-22 00:00:00