Activity-dependent regulation of interleukin-1 beta immunoreactivity in the developing rat olfactory bulb.

Abstract:

:Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on postnatal day 1 and then survived until postnatal day 30. Interleukin-1beta-immunoreactive fibers occupied distinct layers of the olfactory bulb. Dense immunostaining was found in the periglomerular and granule cell layers. Odor deprivation resulted in a noticeable reduction in interleukin-1beta immunoreactivity only in the periglomerular layer. The data demonstrate that interleukin-1beta is present abundantly in the bulbs, and that it can be regulated in an activity-dependent manner.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Lim JH,Brunjes PC

doi

10.1016/s0306-4522(99)00093-7

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

371-4

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(99)00093-7

journal_volume

93

pub_type

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