Abstract:
:Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on postnatal day 1 and then survived until postnatal day 30. Interleukin-1beta-immunoreactive fibers occupied distinct layers of the olfactory bulb. Dense immunostaining was found in the periglomerular and granule cell layers. Odor deprivation resulted in a noticeable reduction in interleukin-1beta immunoreactivity only in the periglomerular layer. The data demonstrate that interleukin-1beta is present abundantly in the bulbs, and that it can be regulated in an activity-dependent manner.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Lim JH,Brunjes PCdoi
10.1016/s0306-4522(99)00093-7keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
371-4issue
1eissn
0306-4522issn
1873-7544pii
S0306-4522(99)00093-7journal_volume
93pub_type
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