Abstract：
:Enkephalins are peptides which have pharmacological properties similar to those of morphine. Guinea pigs were immunized with a leucine-enkephalin/thyroglobulin conjugate. Immunofluorescence histochemistry with antiserum revealed a widely distributed system of axons and their terminals in the nervous system of the rat. Prominent networks of enkephalin-like immunoreactivity were found in some brainstem nuclei and in portions of the limbic forebrain. The myenteric plexus in the gastrointestinal tract also contained fluorescent fibers. The distribution of the positive immunofluorescence parallels the occurrence of enkephalin as revealed by biochemical techniques. Some areas known to have a high opiate receptor density were also shown to contain striking networks of enkephalin-like immunoreactivity. Such findings provide morphological support for the hypothesis that enkephalins are contained in nerve terminals close to opiate receptors.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Elde R,Hökfelt T,Johansson O,Terenius Ldoi
10.1016/0306-4522(76)90063-4keywords:
subject
Has Abstractpub_date
1976-08-01 00:00:00pages
349-51issue
4eissn
0306-4522issn
1873-7544pii
0306-4522(76)90063-4journal_volume
1pub_type
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