Abstract：
:The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie voles through a central dopamine (DA)-dependent mechanism. The present study examined the effects of neonatal exposure to AMPH on behavior and central DA activity in adult male prairie voles. Our data show that neonatal exposure to AMPH makes voles less social in an affiliation test during adulthood, but does not affect animals' locomotor activity and anxiety-like behavior. Neonatal exposure to AMPH also increases the levels of tyrosine hydroxylase (TH) and DA transporter (DAT) mRNA expression in the ventral tegmental area (VTA) in the brain, indicating an increase in central DA activity. As DA has been implicated in AMPH effects on behavioral and cognitive functions, altered DA activity in the vole brain may contribute to the observed changes in social behavior.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Fukushiro DF,Olivera A,Liu Y,Wang Zdoi
10.1016/j.neuroscience.2015.08.051subject
Has Abstractpub_date
2015-10-29 00:00:00pages
109-16eissn
0306-4522issn
1873-7544pii
S0306-4522(15)00783-6journal_volume
307pub_type
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