Abstract:
:In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed to contain many large neurons which made it possible to demarcate this nucleus from surrounding pontomesencephalic reticular formation. Two other neuronal populations, medium and small neurons, were also seen in the nucleus tegmenti pedunculopontinus pars compacta. Detailed measurements showed that 90% by volume of all neurons in the nucleus tegmenti pedunculopontinus pars compacta were large and medium-sized neurons. After injections of [3]leucine into the nucleus tegmenti pedunculopontinus pars compacta, transported label was observed in dorsally and ventrally coursing ascending fibers. The dorsally coursing fibers entered the centrolateral nucleus and centre median-parafascicular complex of the thalamus. The ventrally coursing fibers produced accumulation of silver grains in the ventral tegmental area, substantia nigra pars compacta, subthalamic nucleus, zona incerta and lateral hypothalamus. Crossed fibers of the nucleus tegmenti pedunculopontinus pars compacta were observed sparsely at the levels of the thalamus and posterior commissure, and to a greater degree through the supraoptic commissure of Meynert. Much less anterograde labeling was seen in the equivalent terminal sites on the contralateral side of the brain. By electron microscopic autoradiography major terminal sites of axons of the nucleus tegmenti pedunculopontinus pars compacta were examined in rats injected with [3H]leucine in the nucleus tegmenti pedunculopontinus pars compacta and later injected with horseradish peroxidase in the striatum and pallidum. Statistical data showed preferential radiolabeling of terminals forming asymmetrical synaptic contact with dendrites in the centrolateral nucleus, centre median-parafascicular complex and subthalamic nucleus. Apparent terminations in the substantia nigra pars compacta proposed in earlier studies and shown in the present light microscopic autoradiograms were not supported by this ultrastructural analysis. Several radiolabeled terminals of the asymmetrical type contacting horseradish peroxidase labeled dendrites in the thalamus confirmed direct input from the nucleus tegmenti pedunculopontinus pars compacta to the thalamostriate projection neurons. [3H]choline injections into the thalamus and subthalamic nucleus produced retrograde perikaryal labeling of large neurons in the nucleus tegmenti pedunculopontinus pars compacta.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Sugimoto T,Hattori Tdoi
10.1016/0306-4522(84)90204-5subject
Has Abstractpub_date
1984-04-01 00:00:00pages
931-46issue
4eissn
0306-4522issn
1873-7544pii
0306-4522(84)90204-5journal_volume
11pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::The dose-limiting side effect of the anti-neoplastic agent, paclitaxel, is a chronic distal symmetrical peripheral neuropathy that produces sensory dysfunction (hypoesthesia and neuropathic pain) but little or no distal motor dysfunction. Similar peripheral neuropathies are seen with chemotherapeutics in the vinca alk...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.10.010
更新日期:2011-12-29 00:00:00
abstract::There is increasing evidence indicating that estrogen replacement therapy produces neuroprotective actions but has undesirable side effects on the reproductive system. Raloxifene is a selective estrogen receptor modulator that exerts estrogen agonist action in the brain while acting as an estrogen antagonist in the re...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.04.037
更新日期:2007-06-29 00:00:00
abstract::Effects of glutamate agonists and their selective antagonists on the Ca(2+)-dependent release of [3H]GABA from rat hippocampal slices were studied in a superfusion system. The release was enhanced by glutamate, kainate, quisqualate, N-methyl-D-aspartate and glycine in a concentration-dependent manner. In general, (+)-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90623-n
更新日期:1993-04-01 00:00:00
abstract::Rearing rats in isolation has been shown to produce behavioral and neurochemical alterations similar to those observed in psychoses such as schizophrenia. Also, a dysregulation in both the endocannabinoid and dopaminergic systems has been implicated in schizophrenia. The aim of this study was to determine if there are...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.10.043
更新日期:2008-03-03 00:00:00
abstract::Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2005.06.015
更新日期:2006-01-01 00:00:00
abstract::In an earlier study we have shown that local application of capsaicin directly to one sciatic nerve induces a decrease of substance P and cholecystokinin octapeptide (CCK8)-like peptide from the dorsal spinal cord using immunocytochemical analysis. Here the effect of locally applied capsaicin on seven peptides known t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)90237-8
更新日期:1982-01-01 00:00:00
abstract::Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are functionally linked to estrogen receptors and play a key role in the plasticity of central neurons. Estrogen status strongly influences sensory input from the temporomandibular joint (TMJ) to neurons at the spinomedullary (Vc/C1-2) region. This study tes...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.04.051
更新日期:2015-07-23 00:00:00
abstract::Morphine (opiate agonist) produced a dose-dependent decrease in the spontaneous motility of 5- and 9-day chick embryos. Naloxone (opiate antagonist) appeared to reverse competitively the inhibition of motility caused by morphine. The effects of morphine on spontaneous motility in 5-day embryos were also reversed stere...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90012-0
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Peptide analog of thymulin (PAT) has been shown to have anti-hyperalgesic and anti-inflammatory properties in animal models of inflammation. Recent reports suggest that the peripheral cholinergic system has an anti-inflammatory role mediated by α7-nicotinic acetylcholine receptor (α7-nAChR). Our ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.07.031
更新日期:2013-10-10 00:00:00
abstract::A reappraisal of the relationship between length summation and receptive field length assessed by the minimum response field method, was made in complex cells recorded from the lightly anaesthetized feline striate cortex. This relationship has previously been proposed by Gilbert [(1977) J. Physiol., Lond. 268, 391-421...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90065-x
更新日期:1985-07-01 00:00:00
abstract::Excitotoxicity plays an important role in the pathogenesis of developing brain injury. The neuropeptide secretoneurin (SN) has neuroprotective potential. The aim of this study was to investigate SN plasma concentrations following excitotoxicity and to evaluate the effect of SN as therapeutic strategy in excitotoxic ne...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.05.023
更新日期:2019-07-01 00:00:00
abstract::Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement ther...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.09.022
更新日期:2016-11-19 00:00:00
abstract::In order to develop another selective marker for cholinergic cell bodies and fibres, we have raised a highly specific polyclonal antibody against a peptide derived from the C-terminus of a recently cloned putative vesicular acetylcholine transporter. This antibody recognizes the vesicular acetylcholine transporter pro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00291-1
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.10.053
更新日期:2012-01-10 00:00:00
abstract::High densities of mRNAs for three rhythm-related genes, rPeriod1 (rPer1), rPer2, and rClock, which share high homology in Drosophila and mice, were found in the hypothalamic suprachiasmatic nucleus (SCN). The SCN, however, is not the only brain region that expresses these genes. To understand the distributions and pos...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00004-6
更新日期:2003-01-01 00:00:00
abstract::Investigation of rhythmic discharges may provide insights into integrative mechanisms underlying nervous system control of effectors. We have previously shown that, in CNS-intact, anesthetized rats, cutaneous sympathetic vasoconstrictor neurones innervating thermoregulatory circulations exhibit a robust rhythmicity in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00969-7
更新日期:2003-01-01 00:00:00
abstract::alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90473-f
更新日期:1992-11-01 00:00:00
abstract::Neurosteroids such as dehydroepiandrosterone (DHEA), pregnenolone and 17beta-estradiol are synthesized by cytochrome P450s from endogenous cholesterol. We previously reported a new cytochrome P450 enzyme, CYP7B, highly expressed in rat and mouse brain that metabolizes DHEA and related steroids by hydroxylation at the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00438-x
更新日期:2003-01-01 00:00:00
abstract::Neural injury triggers changes in the expression of a large number of gene families. Particularly interesting are those encoding proteins involved in the generation, propagation or restoration of electric potentials. The expression of the Na+, K+-ATPase subunit isoforms (alpha, beta and gamma) was studied in dorsal ro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.08.041
更新日期:2004-01-01 00:00:00
abstract::Eleven healthy tobacco smoking adult male volunteers of mixed race were tobacco abstinent overnight for this study. In each subject, positron emission tomographic images of regional cerebral metabolism of glucose with [18F]fluorodeoxyglucose were obtained in two conditions in the morning on different days: about 3min ...
journal_title:Neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0306-4522(00)00357-2
更新日期:2000-01-01 00:00:00
abstract::Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00160-x
更新日期:2003-01-01 00:00:00
abstract::We have examined the effect of acrolein, an aldehyde product of lipid peroxidation, on axons in isolated guinea-pig spinal cord white matter. We found that 200 microM acrolein, but not 50 microM, induced a time-dependent loss of compound action potential conduction. Such conduction loss was irreversible within 1 h aft...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00457-8
更新日期:2002-01-01 00:00:00
abstract::Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic. To date, however, a quantitative description of the topographic distribution of GABAergic neurons in the rat's IC and their GABAergic or glyciner...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.12.030
更新日期:2005-01-01 00:00:00
abstract::Co-localization of neurotensin and cholecystokinin in tyrosine hydroxylase-containing neurons in the nucleus tractus solitarius of the rat was demonstrated by immunocytochemistry with fluorescent double-staining combined with the peroxidase-antiperoxidase method. Co-localization of neurotensin/tyrosine hydroxylase or ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90326-0
更新日期:1988-01-01 00:00:00
abstract::The available data on the innervation of the thoracolumbar fascia (TLF) are inconsistent and partly contradictory. Therefore, the role of the fascia as a potential source of pain in the low back is difficult to assess. In the present study, a quantitative evaluation of calcitonin gene-related peptide (CGRP) and substa...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.07.066
更新日期:2011-10-27 00:00:00
abstract::Conduction time is typically ignored in computational models of neural network function. Here we consider the effects of conduction delays on the synchrony of neuronal activity and neural oscillators, and evaluate the consequences of allowing conduction velocity (CV) to be regulated adaptively. We propose that CV vari...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.11.007
更新日期:2014-09-12 00:00:00
abstract::Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.05.039
更新日期:2011-08-25 00:00:00
abstract::Use of chemosensory event-related potentials (ERPs) is limited by relatively poor signal-to-noise ratios (SNRs). We hypothesized that by reducing the standard inter-stimulus interval (ISI), the increased number of trial repetitions possible may increase SNR. In order to further investigate this, we performed the large...
journal_title:Neuroscience
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroscience.2017.08.046
更新日期:2017-11-05 00:00:00
abstract::Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically sign...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00535-8
更新日期:1996-05-01 00:00:00
abstract::Distributions of somata and neurites of cholinergic neurons were studied after seeding dissociated cells onto organotypic slice cultures. Slice cultures were made from hippocampal formation and adjacent cortical regions from rats or mice. Dissociated cell suspensions of basal forebrain tissue from rat or mouse fetuses...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00460-8
更新日期:2002-01-01 00:00:00