Abstract：
:Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Hassani OK,Mouroux M,Féger Jdoi
10.1016/0306-4522(95)00535-8subject
Has Abstractpub_date
1996-05-01 00:00:00pages
105-15issue
1eissn
0306-4522issn
1873-7544pii
0306452295005358journal_volume
72pub_type
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