Abstract：
:Previous research has demonstrated antidepressant-like effects in rodents upon intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala. However, the effect of HDAC inhibition within the medial prefrontal cortex, which is integral to depression-related symptoms and their treatment, remains unknown. Here we show that local infusion of the highly selective HDAC inhibitor, MS-275, into the medial prefrontal cortex exerts robust antidepressant-like effects in the chronic social defeat stress paradigm in mice. These findings provide further impetus for the assessment of HDAC inhibitors for the treatment of depression.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Covington HE 3rd,Maze I,Vialou V,Nestler EJdoi
10.1016/j.neuroscience.2015.04.030subject
Has Abstractpub_date
2015-07-09 00:00:00pages
329-35eissn
0306-4522issn
1873-7544pii
S0306-4522(15)00371-1journal_volume
298pub_type
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