Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.

abstract：:The rat brain and spinal cord have been mapped for Type II glucocorticoid receptor-like immunoreactivity in neurons and glia, using a monoclonal antibody, BUGR2, which recognizes an epitope close to the DNA-binding domain of the rat Type II receptor. The study revealed a widespread distribution of Type II-like immunor...

journal_title：Neuroscience

authors： Ahima RS,Harlan RE

更新日期：1990-01-01 00:00:00

abstract：:The dose-limiting side effect of the anti-neoplastic agent, paclitaxel, is a chronic distal symmetrical peripheral neuropathy that produces sensory dysfunction (hypoesthesia and neuropathic pain) but little or no distal motor dysfunction. Similar peripheral neuropathies are seen with chemotherapeutics in the vinca alk...

journal_title：Neuroscience

authors： Xiao WH,Zheng H,Zheng FY,Nuydens R,Meert TF,Bennett GJ

更新日期：2011-12-29 00:00:00

abstract：:Noradrenergic neurons from the locus coeruleus innervate several brain regions, such as hippocampus and cortex. The hippocampus exhibits the highest concentration of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the brain. To study the role of the noradrenergic system i...

journal_title：Neuroscience

authors： Hutter P,Johansson M,Saria A,Humpel C

更新日期：1996-01-01 00:00:00

abstract：:Simvastatin is an HMG-CoA reductase inhibitor commonly used in the clinic to treat hypercholesterolemia. In addition, simvastatin has been shown to cross the blood-brain barrier and pleiotropic effects of simvastatin have been reported including anti-inflammatory properties, enhancement of neurite outgrowth, and memor...

journal_title：Neuroscience

authors： Métais C,Hughes B,Herron CE

更新日期：2015-04-16 00:00:00

abstract：:Obesity may result from dysfunction of the reward system, especially in the nucleus accumbens (Acb). Based on this hypothesis, many researchers have tested the effect of high-frequency stimulation (HFS) of the Acb shell (Acb-Sh) and/or core (Acb-Co) on ingestive behaviors, but few studies have explored the possible me...

journal_title：Neuroscience

authors： Wei N,Wang Y,Wang X,He Z,Zhang M,Zhang X,Pan Y,Zhang J,Qin Z,Zhang K

更新日期：2015-08-20 00:00:00

abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...

journal_title：Neuroscience

authors： Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

更新日期：1983-06-01 00:00:00

abstract：:Drug addiction behavior that is established and maintained by psychostimulants has been shown to be associated with the expression of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine (DA) system. Cocaine has been used for most prior studies testing this effect of psychostimulants and therefore relat...

journal_title：Neuroscience

authors： Shen YL,Chang TY,Chang YC,Tien HH,Yang FC,Wang PY,Liao RM

更新日期：2014-03-28 00:00:00

abstract：:It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely with...

journal_title：Neuroscience

authors： Kunze WA,Bornstein JC,Furness JB

更新日期：1995-05-01 00:00:00

abstract：:This paper presents results obtained from experiments performed on two behaving monkeys (Macaca mulatta) viewing correlated and uncorrelated dynamic random dot stereograms. Extracellular single unit activity was recorded from areas V1 and V2. We found that cells sensitive to correlated stereograms (38%) were also sens...

journal_title：Neuroscience

authors： Gonzalez F,Krause F,Perez R,Alonso JM,Acuña C

更新日期：1993-02-01 00:00:00

abstract：:In addition to triggering vasoconstriction of peripheral blood vessels, which led to its discovery as a circulating neurohormone 50 years ago, serotonin (5-hydroxytryptamine) acts as a neurotransmitter/ modulator in the central nervous system and regulates local cerebral blood flow and vascular permeability through di...

journal_title：Neuroscience

authors： Riad M,Tong XK,el Mestikawy S,Hamon M,Hamel E,Descarries L

更新日期：1998-10-01 00:00:00

abstract：:We previously reported that the novel antidepressant-like effect of tipepidine may be produced at least partly through the activation of mesolimbic dopamine (DA) neurons via inhibiting G protein-coupled inwardly rectifying potassium (GIRK) channels. In this study, we investigated the action of tipepidine on DA D2 rece...

journal_title：Neuroscience

authors： Hamasaki R,Shirasaki T,Soeda F,Takahama K

更新日期：2013-11-12 00:00:00

abstract：:Orientation tuning of 271 neurons of the cat visual cortex (area 17) was studied with a light bar flashing in the receptive field. Under different conditions, 27-57% of units were found to have double-orientation tuning: they demonstrated the main preferred orientation and an additional preferred orientation. The stat...

journal_title：Neuroscience

authors： Shevelev IA,Lazareva NA,Novikova BV,Tikhomirov AS,Sharaev GA

更新日期：1994-08-01 00:00:00

abstract：:The startle reflex is evoked by strong acoustic or tactile stimuli, or by electrical stimulation of acoustic or tactile pathways. To dissociate the contributions of acoustic and tactile pathways, stimulating electrodes were placed in adjacent cochlear and trigeminal nuclei. The currents needed to evoke startle-like re...

journal_title：Neuroscience

authors： Scott BW,Frankland PW,Li L,Yeomans JS

更新日期：1999-01-01 00:00:00

abstract：:In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells. Five different muscarinic receptor subtypes (M(1)-M(5)) have been identi...

journal_title：Neuroscience

authors： Iino S,Nojyo Y

更新日期：2006-01-01 00:00:00

abstract：:Field recordings of responses to activation of corticostriatal afferents were made in coronally sectioned rat brain slices. Each recording site was categorized according to its medial to lateral and rostral to caudal position to investigate anatomical differences in synaptic plasticity. Individual responses were highl...

journal_title：Neuroscience

authors： Smith R,Musleh W,Akopian G,Buckwalter G,Walsh JP

更新日期：2001-01-01 00:00:00

abstract：:The basal forebrain cholinergic system is a critical component of the neurobiological substrates underlying attentional function. Orexin neurons are important for arousal and maintenance of wakefulness and are found in the area of the hypothalamus previously shown to project to the basal forebrain. We used dual-probe ...

journal_title：Neuroscience

authors： Fadel J,Pasumarthi R,Reznikov LR

更新日期：2005-01-01 00:00:00

abstract：:Effects of L-arginine in the nervous system are often attributed to nitric oxide. Using whole-cell patch pipettes to record membrane currents in voltage-clamp from dopamine neurons in the rat midbrain slice, the present studies found that L-arginine potentiates GABA-dependent membrane currents via a nitric oxide-indep...

journal_title：Neuroscience

authors： Shen KZ,Cox BA,Johnson SW

更新日期：1997-08-01 00:00:00

abstract：:Organotypic cultures established from the third thoracic ganglion of locust embryo have been used to investigate dopamine receptors. In this in vitro system, neurites emerge directly from the explants and form a dense network around the explants, presenting cell surface freely exposed for experimental labelling. Polyc...

journal_title：Neuroscience

authors： Vanhems E,Delbos M,Geffard M,Viellemaringe J

更新日期：1994-02-01 00:00:00

abstract：:The 5-HT mixed agonist/antagonist 1-(2-methoxyphenyl)4-[4-(phthalimido)butyl]-piperazine hydrobromide (NAN-190) has been shown to greatly potentiate photic phase shifts in hamsters. The mechanism of this potentiation has yet to be determined. NAN-190 is believed to act primarily through the 5-HT(1A) receptor, but also...

journal_title：Neuroscience

authors： Smith VM,Hagel K,Antle MC

更新日期：2010-01-13 00:00:00

abstract：:The rat pineal gland is an attractive system for studies on the capacity of neural systems to recover following partial injury, allowing both for the creation of precise subtotal lesions and for the measurement of recovery of function at the cellular level. The pineal gland receives overlapping sympathetic innervation...

journal_title：Neuroscience

authors： Kuchel GA,Sherman RL,Zigmond RE

更新日期：1990-01-01 00:00:00

abstract：:Repeated exposure to cocaine during adolescence may affect both physical and psychological conditions in the brain, and increase the risk of psychiatric disorders and addiction behaviors in adulthood. Adolescence represents a critical development period for the hippocampus. Moreover, different regions of the hippocamp...

journal_title：Neuroscience

authors： Zhu W,Mao Z,Zhu C,Li M,Cao C,Guan Y,Yuan J,Xie G,Guan X

更新日期：2016-01-28 00:00:00

abstract：:Detailed analysis of a novel transgenic model of basal ganglia disease has been undertaken. In this model the expression of an attenuated form of the diphtheria toxin gene was tightly controlled by D1 dopamine receptor regulatory domains. The behavioral and both direct toxin-mediated and transneuronal effects observed...

journal_title：Neuroscience

authors： Wong JY,Padungchaichot P,Massalas JS,Drago J

更新日期：2000-01-01 00:00:00

abstract：:The effects of acute application of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) on levels of intracellular Ca(2+) ([Ca(2+)]i) and on whole-cell outward and inward K(+) currents were studied in cultured human microglia. TNFalpha elicited a linear increase in [Ca(2+)]i to a plateau level in micr...

journal_title：Neuroscience

authors： McLarnon JG,Franciosi S,Wang X,Bae JH,Choi HB,Kim SU

更新日期：2001-01-01 00:00:00

abstract：OBJECT:The aim of this study is to explore the changes of inter-hemispheric functional connectivity in patients with unilateral brachial plexus injury. METHODS:Nine patients with five roots of unilateral brachial plexus avulsion injury and 11 healthy controls were recruited in this study. Resting-state functional conn...

journal_title：Neuroscience

authors： Liu B,Li T,Tang WJ,Zhang JH,Sun HP,Xu WD,Liu HQ,Feng XY

更新日期：2013-07-23 00:00:00

abstract：:Mitochondrial defects including reduction of a key mitochondrial tricarboxylic acid cycle enzyme alpha-ketoglutarate-dehydrogenase complex (KGDHC) are characteristic of many neurodegenerative diseases. KGDHC consists of alpha-ketoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (E2k), and dihydrolipoamide de...

journal_title：Neuroscience

authors： Calingasan NY,Ho DJ,Wille EJ,Campagna MV,Ruan J,Dumont M,Yang L,Shi Q,Gibson GE,Beal MF

更新日期：2008-06-02 00:00:00

abstract：:Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain's resident immune cells, which likely participate in the clearanc...

journal_title：Neuroscience

authors： Gyoneva S,Swanger SA,Zhang J,Weinshenker D,Traynelis SF

更新日期：2016-08-25 00:00:00

abstract：:The expression of voltage-gated sodium channels is regulated at multiple levels, and in this study we addressed the potential for alternative splicing of the Na(v)1.2, Na(v)1.3, Na(v)1.6 and Na(v)1.7 mRNAs. We isolated novel mRNA isoforms of Na(v)1.2 and Na(v)1.3 from adult mouse and rat dorsal root ganglia (DRG), Na(...

journal_title：Neuroscience

authors： Kerr NC,Holmes FE,Wynick D

更新日期：2008-08-26 00:00:00

abstract：:The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...

journal_title：Neuroscience

authors： Moreno-Flores MT,Wandosell F

更新日期：1999-01-01 00:00:00

abstract：:Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...

journal_title：Neuroscience

authors： Dwivedi Y,Rizavi HS,Pandey GN

更新日期：2006-01-01 00:00:00

abstract：:Over the years it has become crystal clear that a variety of processes encode time-of-day information, ranging from gene expression, protein stability, or subcellular localization of key proteins, to the fine tuning of network properties and modulation of input signals, ultimately ensuring that physiology and behavior...

journal_title：Neuroscience

authors： Muraro NI,Pírez N,Ceriani MF

更新日期：2013-09-05 00:00:00