Acrolein inflicts axonal membrane disruption and conduction loss in isolated guinea-pig spinal cord.

abstract：:Long-term treatment with diazepam, a full allosteric modulator of the GABA(A) receptor, results in tolerance to its anticonvulsant effects, whereas an equipotent treatment with the partial allosteric modulator imidazenil does not produce tolerance. Use of subunit-specific antibodies linked to gold particles allowed an...

journal_title：Neuroscience

authors： Pesold C,Caruncho HJ,Impagnatiello F,Berg MJ,Fritschy JM,Guidotti A,Costa E

更新日期：1997-07-01 00:00:00

abstract：:Insulin peptide, acting through tyrosine kinase receptor pathways, contributes to nerve development or repair. In this work, we examined the direction, impact and repertoire of insulin signaling in vivo during peripheral nerve regeneration in rats. First, we demonstrated that insulin receptor is expressed on lumbar do...

journal_title：Neuroscience

authors： Toth C,Brussee V,Martinez JA,McDonald D,Cunningham FA,Zochodne DW

更新日期：2006-05-12 00:00:00

abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

journal_title：Neuroscience

authors： Blight AR

更新日期：1983-10-01 00:00:00

abstract：:Increasing evidence indicates that both the ATP P2X receptors and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the interactions between these two systems in the dorsal root ganglia (DRG). In the present study, we examined the effects o...

journal_title：Neuroscience

authors： Tan Y,Sun L,Zhang Q

更新日期：2011-03-10 00:00:00

abstract：:Theta frequency oscillation of the septo-hippocampal system has been considered as a prominent activity associated with cognitive function and affective processes. It is well documented that anxiolytic drugs diminish septo-hippocampal oscillatory Theta activity contributing to their either therapeutic or unwanted side...

journal_title：Neuroscience

authors： Hajós M,Hoffmann WE,Orbán G,Kiss T,Erdi P

更新日期：2004-01-01 00:00:00

abstract：:The extent to which glutamate receptors in the nucleus accumbens and ventral tegmental area regulate feeding-evoked increases in dopamine release in the nucleus accumbens was determined using in vivo brain microdialysis in the rat. In some animals a second dialysis probe was implanted in the ventral tegmental area ips...

journal_title：Neuroscience

authors： Taber MT,Fibiger HC

更新日期：1997-02-01 00:00:00

abstract：:The tectofugal pathway in birds consists of four stations, the retina, optic tectum, rotundal nucleus, and entopallium, and it conveys visual information via three ascending pathways. These pathways consist of retino-tectal, tecto-rotundal and rotundo-entopallial cells, all of which are glutamatergic. The present stud...

journal_title：Neuroscience

authors： Atoji Y

更新日期：2016-03-01 00:00:00

abstract：:Although the major mode of transmission for serotonin in the brain is volume transmission, previous anatomical studies have demonstrated that serotonergic axons do form synaptic contacts. The olfactory glomeruli of the olfactory bulb of mammals receive a strong serotonergic innervation from the dorsal and medial raphe...

journal_title：Neuroscience

authors： Gracia-Llanes FJ,Blasco-Ibáñez JM,Nácher J,Varea E,Liberia T,Martínez P,Martínez-Guijarro FJ,Crespo C

更新日期：2010-08-25 00:00:00

abstract：:We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins. We show that animals that learn a spatial memory tas...

journal_title：Neuroscience

authors： Molteni R,Barnard RJ,Ying Z,Roberts CK,Gómez-Pinilla F

更新日期：2002-01-01 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

journal_title：Neuroscience

authors： Zurgil N,Yarom M,Zisapel N

更新日期：1986-12-01 00:00:00

abstract：:The distribution of the urea cycle enzyme, argininosuccinate synthetase, in the rat brain was determined using immunohistochemistry. This enzyme participates in the only known metabolic pathway for citrulline, its condensation with aspartate to form argininosuccinate, which can then be cleaved to fumarate and arginine...

journal_title：Neuroscience

authors： Arnt-Ramos LR,O'Brien WE,Vincent SR

更新日期：1992-12-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:The presence of subgroups in vomeronasal sensory neurons has been known in various animals. To elucidate possible functional subdivisions in the guinea-pig accessory olfactory bulb, the combined studies with GTP-binding protein immunohistochemistry, electrophysiological and optical recordings were carried out. Gi2 alp...

journal_title：Neuroscience

authors： Sugai T,Sugitani M,Onoda N

更新日期：1997-08-01 00:00:00

abstract：:Neuromedin U is a newly described regulatory peptide, found by radioimmunoassay in significant concentrations in both the brain and gut of the rat. The aim of the present study was to localize this peptide immunoreactivity to discrete structures of the gut and brain and to map its distribution using immunocytochemistr...

journal_title：Neuroscience

authors： Ballesta J,Carlei F,Bishop AE,Steel JH,Gibson SJ,Fahey M,Hennessey R,Domin J,Bloom SR,Polak JM

更新日期：1988-06-01 00:00:00

abstract：:Tumor necrosis factor is a potent activator of myeloid cells, which acts via two cell-surface receptors, the p55 and p75 tumor necrosis factor receptors. The present study describes the cellular distribution of both receptor messenger RNAs across the rat brain under basal conditions and in response to systemic injecti...

journal_title：Neuroscience

authors： Nadeau S,Rivest S

更新日期：1999-01-01 00:00:00

abstract：:Subcutaneous or intracerebroventricular injection of either arginine8-vasopressin or desglycinamide9-arginine8-vasopressin has been shown to facilitate memory, reduce or reverse the effects of amnesic drugs, and maintain tolerance to some effects of ethanol. These actions of vasopressin (and, by inference, of desglyci...

journal_title：Neuroscience

authors： Lança AJ,Wu PH,Jung B,Liu JF,Ng V,Kalant H

更新日期：1999-01-01 00:00:00

abstract：:Endotoxin-induced uveitis (EIU) is a common animal model for anterior uveitis in humans that causes long-term changes in trigeminal brain stem neurons. This study used c-fos immunohistochemistry to assess the effects of different routes of administration of endotoxin on activation of trigeminal brain stem neurons prod...

journal_title：Neuroscience

authors： Okamoto K,Bereiter DF,Tashiro A,Bereiter DA

更新日期：2009-03-17 00:00:00

abstract：:This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5Hz) rTMS was pe...

journal_title：Neuroscience

authors： Zhang N,Xing M,Wang Y,Tao H,Cheng Y

更新日期：2015-12-17 00:00:00

abstract：:Altered gene expression mediated by calcium/calmodulin-dependent protein kinase II (CaMKII) and other intracellular signaling molecules plays an important role in activity-dependent neuroplasticity. We discovered that sustained depolarization induced by KCl, a commonly used paradigm for studying activity-dependent gen...

journal_title：Neuroscience

authors： Padmanabhan S,Prasad BM

更新日期：2009-09-29 00:00:00

abstract：:To investigate whether the ageing process might affect neuron-target interactions which influence the phenotype of septal cholinergic neurons, we compared the response of these neurons to partial loss of target tissue in young adult and aged animals. Groups of young adult (four to six months) or aged (24-33 months) ma...

journal_title：Neuroscience

authors： Cooper JD,Sofroniew MV

更新日期：1996-11-01 00:00:00

abstract：:Victims of minimal traumatic brain injury (mTBI) do not show clear morphological brain defects, but frequently suffer lasting cognitive deficits, emotional difficulties and behavioral disturbances. In the present study we adopted a non-invasive closed-head weight-drop mouse model to produce mTBI. We examined the effec...

journal_title：Neuroscience

authors： Zohar O,Schreiber S,Getslev V,Schwartz JP,Mullins PG,Pick CG

更新日期：2003-01-01 00:00:00

abstract：:Microdialysis probes were used to measure dopamine in, and to administer glutamate receptor antagonists and agonists to, the striatum of unanesthetized rats. Antagonists used were: kynurenate, 2-amino-5-phosphonovalerate and 6-cyano-7-nitroquinoxaline-2,3-dione. Agonists used were: N-methyl-D-aspartate and kainate. In...

journal_title：Neuroscience

authors： Keefe KA,Zigmond MJ,Abercrombie ED

更新日期：1992-01-01 00:00:00

abstract：:Huntington's disease (HD) is a severe genetically inherited neurodegenerative disorder. Patients present with three principal phenotypes of motor symptoms: choreatic, hypokinetic-rigid and mixed. The Q175 mouse model of disease offers an opportunity to investigate the cellular basis of the hypokinetic-rigid form of HD...

journal_title：Neuroscience

authors： Rothe T,Deliano M,Wójtowicz AM,Dvorzhak A,Harnack D,Paul S,Vagner T,Melnick I,Stark H,Grantyn R

更新日期：2015-12-17 00:00:00

abstract：:The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant ...

journal_title：Neuroscience

authors： Wang Y,Yin X,Rosen G,Gabel L,Guadiana SM,Sarkisian MR,Galaburda AM,Loturco JJ

更新日期：2011-09-08 00:00:00

abstract：:An antisense oligonucleotide probe was used to examine the expression of gene encoding the obligatory NMDAR1 subunit of the N-methyl-D-aspartate receptor in the hippocampus and adjacent cortical areas (entorhinal and perirhinal cortices) of seven Alzheimer patients and in the same brain regions of seven control indivi...

journal_title：Neuroscience

authors： Ulas J,Cotman CW

更新日期：1997-08-01 00:00:00

abstract：:S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuv...

journal_title：Neuroscience

authors： Tanga FY,Raghavendra V,Nutile-McMenemy N,Marks A,Deleo JA

更新日期：2006-07-07 00:00:00

abstract：:An original pathway of centrifugal acetylcholinesterase-positive fibres is described in the olfactory bulb of the rat. A dense network of positive fibres spreads out superficially at the boundaries of the lateral olfactory tract and the glomerular layer. These labelled fibres converge towards atypical glomerular struc...

journal_title：Neuroscience

authors： Zheng LM,Ravel N,Jourdan F

更新日期：1987-12-01 00:00:00

abstract：:We studied whether interactions between the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic neurons of the mouse brain cortex occur. Cerebral cortex slices from the mouse (and, in few experiments, from the rat) were preincubated with [3H]noradrenaline and then superfused with a physiologi...

journal_title：Neuroscience

authors： Schlicker E,Marr I

更新日期：1997-07-01 00:00:00

abstract：:Transparent larval zebrafish offer the opportunity to unravel genetic and neuronal networks underlying behavior in a developing system. In this study, we developed a choice chamber paradigm to measure reward-associated behavior in larval zebrafish. In the chamber where larval zebrafish have a choice of spending their ...

journal_title：Neuroscience

authors： Bretaud S,Li Q,Lockwood BL,Kobayashi K,Lin E,Guo S

更新日期：2007-05-25 00:00:00