Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene.

abstract：:The rapidly inactivating A-type K+ current (IA) is prominent in hippocampal neurons; and the speed of its inactivation may regulate electrical excitability. The auxiliary K+ channel subunit Kvbeta 1.1 confers fast inactivation to Shaker-related channels and is postulated to affect IA. Whole-cell patch clamp recordings...

journal_title：Neuroscience

authors： Falk T,Kilani RK,Strazdas LA,Borders RS,Steidl JV,Yool AJ,Sherman SJ

更新日期：2003-01-01 00:00:00

abstract：:Similarities in cellular morphology, afferentation, efferentation, and neurotransmitter content between the internal and external parts of the pallidum and the substantia nigra pars reticulata have long been noted. Here we present evidence that the globus pallidus, entopedunucular nucleus and substantia nigra pars ret...

journal_title：Neuroscience

authors： Sousa R,Hrinya Tannery N,Lafer EM

更新日期：1990-01-01 00:00:00

abstract：:In animal models of transients ischemia, selective vulnerability and delayed neuronal death in the hippocampus have been extensively described. However, little is known about selective damage in the neocortex and the thalamus, even though deficits in sensorimotor function are common in humans surviving hypoxic/ischemi...

journal_title：Neuroscience

authors： Lin CS,Polsky K,Nadler JV,Crain BJ

更新日期：1990-01-01 00:00:00

abstract：:Lipid peroxidation disrupts membrane integrity and causes structural and functional alterations in ischemic tissues. Taurine and ketamine are putative ischemic protectants that affect Ca2+ influx. Here we report the influence of these compounds on lipid peroxidation in subcellular fractions, isolated cells and intact ...

journal_title：Neuroscience

authors： Zhou M,Ma T,Tseng MT

更新日期：1991-01-01 00:00:00

abstract：:Subjective tinnitus is a chronic neurological disorder in which phantom sounds are perceived. Recent evidence supports the hypothesis that tinnitus is related to neuronal hyperactivity in auditory brain regions, and consequently drugs that increase GABAergic neurotransmission in the CNS, such as the GABA(B) receptor a...

journal_title：Neuroscience

authors： Zheng Y,McPherson K,Smith PF

更新日期：2014-01-31 00:00:00

abstract：:We examined the organization of spinal networks controlling locomotion in the isolated spinal cord of the neonatal rat, and in this study we provide the first demonstration of plateau and bursting mechanisms in mammalian interneurons that show locomotor-related activity. Using tight-seal whole-cell recordings, we char...

journal_title：Neuroscience

authors： Kiehn O,Johnson BR,Raastad M

更新日期：1996-11-01 00:00:00

abstract：:The distribution of neuropeptide Y immunoreactive cell bodies in relation to various types of catecholamine-containing cell bodies in the rat brain was analyzed immunohistochemically using antisera to tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. Coexistence of the peptide...

journal_title：Neuroscience

authors： Everitt BJ,Hökfelt T,Terenius L,Tatemoto K,Mutt V,Goldstein M

更新日期：1984-02-01 00:00:00

abstract：:Aged rats may be behaviorally classified as either cognitively impaired or unimpaired based upon their performance in the Morris water maze task. In aged Long-Evans rats, emergence of functional deficits has been related to the increase in the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor s...

journal_title：Neuroscience

authors： Andrés N,Rodríguez MJ,Andrade C,Rowe W,Quirion R,Mahy N

更新日期：2000-01-01 00:00:00

abstract：:Arginine vasopressin and corticotropin-releasing factor are two neuroactive peptides that regulate hypothalamic-pituitary-axis and associated stress response. While the potential antidepressant and anxiolytic profiles of corticotropin-releasing factor 1 antagonists have been well studied, the concept of blockade of va...

journal_title：Neuroscience

authors： Claustre Y,Rouquier L,Desvignes C,Leonetti M,Montégut J,Aubin N,Allouard N,Bougault I,Oury-Donat F,Steinberg R

更新日期：2006-09-01 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:This study evaluated Fos-like immunoreactivity in lumbar spinal cord neurons following intense cold stimulation and then the modifications induced by opioid administration. Under urethane anaesthesia, the rat's right foot was stimulated by holding it in a regulated temperature bath at 15, 10, 0, -10, -15, -17.5 or -20...

journal_title：Neuroscience

authors： Abbadie C,Honoré P,Besson JM

更新日期：1994-03-01 00:00:00

abstract：:The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...

journal_title：Neuroscience

authors： Wyneken U,Smalla KH,Marengo JJ,Soto D,de la Cerda A,Tischmeyer W,Grimm R,Boeckers TM,Wolf G,Orrego F,Gundelfinger ED

更新日期：2001-01-01 00:00:00

abstract：:The bladder and distal colon are innervated by lumbar splanchnic (LSN) and pelvic nerves (PN) whose axons arise from dorsal root ganglia (DRG) neurons at thoracolumbar (TL) and lumbosacral (LS) spinal levels, respectively. In an attempt to understand the molecular basis of differences between LSN and PN mechanosensiti...

journal_title：Neuroscience

authors： La JH,Schwartz ES,Gebhart GF

更新日期：2011-07-14 00:00:00

abstract：:Prolonged stress triggers neuroinflammation, which plays a significant role in the development of depression; however, stressed people do not always suffer from depression because of individual differences in stress vulnerability. Negative cognitive bias (NCB) toward pessimistic judgment often underlies depressive epi...

journal_title：Neuroscience

authors： Ito N,Sasaki K,Takemoto H,Kobayashi Y,Isoda H,Odaguchi H

更新日期：2020-09-01 00:00:00

abstract：:The identification and characterization of excitatory and inhibitory neurons are significant steps in understanding neural network functions. In this study, we investigated the intrinsic electrophysiological properties of neurons in the prepositus hypoglossi nucleus (PHN), a brainstem structure that is involved in gaz...

journal_title：Neuroscience

authors： Shino M,Kaneko R,Yanagawa Y,Kawaguchi Y,Saito Y

更新日期：2011-12-01 00:00:00

abstract：:Considerable evidence suggests that a dysfunction of the dopamine and serotonin (5-hydroxytryptamine or 5-HT) neurotransmitter systems contributes to a diverse range of pathological conditions including schizophrenia, depression and drug abuse. Recent electrophysiological and behavioral studies suggest that 5-HT modul...

journal_title：Neuroscience

authors： Nocjar C,Roth BL,Pehek EA

更新日期：2002-01-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis underlies both adaptive and maladaptive responses to stress and may be an important marker of childhood vulnerability to psychopathology, although little is known about genetic variants that influence cortisol reactivity. We therefore examined associations between corticot...

journal_title：Neuroscience

authors： Sheikh HI,Kryski KR,Smith HJ,Hayden EP,Singh SM

更新日期：2013-01-15 00:00:00

abstract：:Repeated nonreinforced preexposure to a stimulus interferes with the establishment of conditioned responding to this stimulus when it is subsequently paired with reinforcement. This stimulus-preexposure effect is known as latent inhibition (LI). Rather remarkably, LI appears to be resistant to the effects of numerous ...

journal_title：Neuroscience

authors： Schiller D,Weiner I

更新日期：2004-01-01 00:00:00

abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

journal_title：Neuroscience

authors： Clarke PG,Nussbaumer JC

更新日期：1987-12-01 00:00:00

abstract：:Sleep mechanisms and synaptic plasticity are thought to interact to regulate homeostasis and memory formation. However, the influences of molecules that mediate synaptic plasticity on sleep are not well understood. In this study we demonstrate that mice lacking Rab3 interacting molecule 1 alpha (RIM1 alpha) (Rim1 alph...

journal_title：Neuroscience

authors： Lonart G,Tang X,Simsek-Duran F,Machida M,Sanford LD

更新日期：2008-06-23 00:00:00

abstract：:Depression is a chronic disease that affects nearly twice as many women as men, and symptoms can differ by sex. Preclinical models disproportionately use male subjects and test a single behavioral endpoint immediately at the cessation of stress. We conducted variable stress in male and female mice for 6, 28, and 56 da...

journal_title：Neuroscience

authors： Johnson A,Rainville JR,Rivero-Ballon GN,Dhimitri K,Hodes GE

更新日期：2021-02-01 00:00:00

abstract：:Experiment 1 investigated the effects of catecholaminergic deafferentation or cell body lesions of the amygdala on fear conditioning to explicit and contextual cues. Bilateral infusions of quinolinic acid mainly damaged neurons within the basolateral region of the amygdala. 6-Hydroxydopamine infusions at the same coor...

journal_title：Neuroscience

authors： Selden NR,Everitt BJ,Jarrard LE,Robbins TW

更新日期：1991-01-01 00:00:00

abstract：:Strong converging evidence indicates that the intermediate and medial part of the hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. Clathrin proteins have been implicated in synaptic plasticity. In the present study we demonstrate for the first...

journal_title：Neuroscience

authors： Solomonia RO,McCabe BJ,Jackson AP,Horn G

更新日期：1997-09-01 00:00:00

abstract：:In a previous study, it was shown that populations of climbing fibers, derived from the inferior olivary complex (IOC) contain the peptide corticotropin releasing factor (CRF) and that the expression of this peptide in climbing fibers could be modulated by the level of activity in olivary afferents. The intent of this...

journal_title：Neuroscience

authors： Tian JB,King JS,Bishop GA

更新日期：2008-04-22 00:00:00

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:Activities of daily living require simultaneous and coordinated activation of trunk and upper-limb segments, which involves complex interlimb interaction within the central nervous system. Although many studies have reported associations between activity of trunk and limb muscles during functional tasks, evidence on c...

journal_title：Neuroscience

authors： Sasaki A,Milosevic M,Nakazawa K

更新日期：2020-12-15 00:00:00

abstract：:Neuroinflammatory processes associated with induction of cyclooxygenase (COX) have been implicated in the deleterious events resulting in neurodegeneration. The present study was designed to investigate the impact of acute methamphetamine (MA) administration on COX expression and prostaglandin E2 (PGE(2)) production, ...

journal_title：Neuroscience

authors： Zhang X,Dong F,Mayer GE,Bruch DC,Ren J,Culver B

更新日期：2007-12-19 00:00:00

abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

journal_title：Neuroscience

authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

更新日期：2011-06-02 00:00:00

abstract：:In the present study plastic neural responses to N-methyl-D-aspartate-induced excitotoxic lesions and the neuroprotective effects of the L-type voltage-dependent Ca(2+) channel antagonist nimodipine were investigated in the rat magnocellular nucleus basalis. Assessment of spontaneous behaviour in the elevated plus maz...

journal_title：Neuroscience

authors： Harkany T,Dijkstra IM,Oosterink BJ,Horvath KM,Abrahám I,Keijser J,Van der Zee EA,Luiten PG

更新日期：2000-01-01 00:00:00

abstract：:Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities...

journal_title：Neuroscience

authors： Buzsáki G

更新日期：1989-01-01 00:00:00