当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Behavioral analysis of opiate-mediated inhibition in the early chick embryo.

Behavioral analysis of opiate-mediated inhibition in the early chick embryo.

Abstract：

:Morphine (opiate agonist) produced a dose-dependent decrease in the spontaneous motility of 5- and 9-day chick embryos. Naloxone (opiate antagonist) appeared to reverse competitively the inhibition of motility caused by morphine. The effects of morphine on spontaneous motility in 5-day embryos were also reversed stereospecifically by the opiate antagonist pairs WIN 44441-3/WIN 44441-2 and levallorphan/dextrallorphan. Levorphanol (opiate agonist) also produced a dose-dependent decrease in the motility of 5-day embryos while its inactive (+)-isomer, dextrophan, was not effective. Etorphine (opiate agonist) was more than 1000-fold more effective than morphine in inhibiting the motility of 5-day embryos. The effectiveness of several opiate agonists and antagonists on the spontaneous motility of 5-day embryos was similar to their effectiveness in radioligand-binding studies on isolated membrane receptors from either adult mammalian brain or ileum. Levorphanol was more effective than dextrophan and etorphine was substantially more effective than morphine in decreasing the spontaneous motility of 4-day embryos. WIN 44441-3 was more effective than WIN 44441-2 in reversing the inhibition of motility in 4-day embryos caused by morphine. Morphine inhibited spontaneous hind-limb motility in both thoracic spinal and sham-operated 7-day embryos; the inhibition of motility caused by morphine was reversed by WIN 44441-3 in both thoracic spinal and sham-operated 7-day embryos. [Leu5]enkephalin-like immunoreactivity in the lumbar spinal cord was concentrated in the superficial laminae of the dorsal horn and along the midline rostral to the central canal. A lesser concentration of immunoreactive processes occurred in the medial and lateral motor columns where labelled varicosities appeared to contact motoneurons. Opiate receptors appear to be present at least as early as day 5 (and perhaps as early as day 4) in the chick embryo. Opiate receptors appear to be present in the lumbar spinal cord of the chick embryo at least as early as day 7. The structural requirements for ligand binding to opiate receptors in the 5-day chick embryo are similar to the requirements for ligand binding to opiate receptors in the adult.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Maderdrut JL,Reitzel JL,Okado N,Oppenheim RW

doi

10.1016/0306-4522(85)90012-0

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

405-16

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(85)90012-0

journal_volume

16

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Simultaneous estimation of global background synaptic inhibition and excitation from membrane potential fluctuations in layer III neurons of the rat entorhinal cortex in vitro.

    abstract：:It is becoming clear that the detection and integration of synaptic input and its conversion into an output signal in cortical neurons are strongly influenced by background synaptic activity or "noise." The majority of this noise results from the spontaneous release of synaptic transmitters, interacting with ligand-ga...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.05.016

    authors： Greenhill SD,Jones RS

    更新日期：2007-07-29 00:00:00

  • Synaptic excitation in the dorsal nucleus of the lateral lemniscus: whole-cell patch-clamp recordings from rat brain slice.

    abstract：:The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00580-5

    authors： Fu XW,Brezden BL,Kelly JB,Wu SH

    更新日期：1997-06-01 00:00:00

  • Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.

    abstract：:Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. Recent studies have shown that IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OS...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.07.009

    authors： Bando T,Morikawa Y,Komori T,Senba E

    更新日期：2006-11-03 00:00:00

  • Anatomically distinct output channels of the caudate nucleus and orofacial dyskinesia: critical role of the subcommissural part of the globus pallidus in oral dyskinesia.

    abstract：:The findings in this feline study indicate that the enkephalin-positive subcommissural part of the globus pallidus, which is known to contain GABA and cholinergic cells projecting to the cortex, is innervated by the anterodorsal region of the caudate nucleus, but not by the core. Like stimulation of a particular subcl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90405-3

    authors： Cools AR,Spooren W,Bezemer R,Cuypers E,Jaspers R,Groenewegen H

    更新日期：1989-01-01 00:00:00

  • A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.

    abstract：:This study investigated the effect of ionotropic glutamate receptor agonist or antagonist administration into the nucleus accumbens on the maintenance of cocaine self-administration and the reinstatement of cocaine-seeking behavior. The stimulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or N-meth...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00214-6

    authors： Cornish JL,Duffy P,Kalivas PW

    更新日期：1999-01-01 00:00:00

  • Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.

    abstract：:The sensitivity of Purkinje cells to short pulse applications of L-aspartate, L-glutamate and related derivatives in their dendritic fields was tested in normal and staggerer mutant mice using cerebellar slices maintained in vitro. In normal mice, the response of Purkinje cells to L-aspartate and L-glutamate consisted...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90076-9

    authors： Dupont JL,Fournier E,Gardette R,Crepel F

    更新日期：1984-06-01 00:00:00

  • Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.

    abstract：:We have previously shown that voluntary exercise produces enhanced neurogenesis and long-term potentiation (LTP) in the dentate gyrus (DG) of mice in vitro. In the present experiments we show that rats given access to a running wheel (Runners) exhibit significantly more short-term potentiation and LTP with theta-patte...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2003.09.029

    authors： Farmer J,Zhao X,van Praag H,Wodtke K,Gage FH,Christie BR

    更新日期：2004-01-01 00:00:00

  • The effects of globus pallidus lesions on dopamine-dependent motor behaviour in rats.

    abstract：:Motor effects of bilateral lesions of the globus pallidus induced by quinolinic acid (30 and 60 nmol in 0.5 microl) were investigated in rats. Globus pallidus lesions with 60 nmol quinolinic acid produced a significant reduction of spontaneous motor activity measured by a reduced locomotor activity in an open field an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00009-8

    authors： Hauber W,Lutz S,Münkle M

    更新日期：1998-09-01 00:00:00

  • Endothelins are extracellular signals modulating cytoskeletal actin organization in rat cultured astrocytes.

    abstract：:Effects of endothelin-3 on rapid morphological changes and cytoskeletal actin organization of rat cortical cultured astrocytes were examined. In serum-free medium, treatments with 1 mM dibutyryl cAMP and 5 microM cytochalasin B, an inhibitor of actin polymerization, caused astrocytic morphological changes with cytopla...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90420-0

    authors： Koyama Y,Baba A

    更新日期：1994-08-01 00:00:00

  • Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb--II. Prominent differences in the intraglomerular dendritic arborization and their relationship to olfactory nerve terminals.

    abstract：:In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00308-9

    authors： Kosaka K,Toida K,Margolis FL,Kosaka T

    更新日期：1997-02-01 00:00:00

  • Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.

    abstract：:Calcium is an important mediator of programmed cell death induced by transient cerebral ischemia, and calcium-binding proteins have been implicated in calcium-regulated signal transduction. Apoptosis-linked gene 2 is a calcium-binding protein required for cell death induced by different apoptotic stimuli. By Western b...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00531-x

    authors： Li W,Jin K,Nagayama T,He X,Chang J,Minami M,Graham SH,Simon RP,Greenberg DA

    更新日期：2000-01-01 00:00:00

  • The effect of surgical and psychological stress on learning and memory function in aged C57BL/6 mice.

    abstract：:Postoperative cognitive dysfunction (POCD) is an important complication following major surgery and general anesthesia in older patients. However, the etiology of POCD remains largely to be determined. It is unknown how surgical stress and psychological stress affect the postoperative learning and memory function in g...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.02.015

    authors： Zhang C,Li C,Xu Z,Zhao S,Li P,Cao J,Mi W

    更新日期：2016-04-21 00:00:00

  • Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol.

    abstract：:Activation of muscarinic receptors leads to proliferation of astroglial cells and this effect is inhibited by ethanol. Among the intracellular pathways involved in the mitogenic action of muscarinic agonists, activation of the atypical protein kinase C zeta (PKC zeta) appears to be of most importance, and is also affe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00401-9

    authors： Guizzetti M,Bordi F,Dieguez-Acuña FJ,Vitalone A,Madia F,Woods JS,Costa LG

    更新日期：2003-01-01 00:00:00

  • Visual pathways to the cerebellum: segregation in the pontine nuclei of terminal fields from different visual cortical areas in the cat.

    abstract：:The cerebellum receives input from visual cortical areas via a relay in the pontine nuclei. We have compared the location in the pontine nuclei of terminal fields of fibres from visual areas 18 and 20, and the posteromedial lateral suprasylvian visual area. Due to individual variations in the precise location of termi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90335-7

    authors： Bjaalie JG,Brodal P

    更新日期：1989-01-01 00:00:00

  • 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors.

    abstract：:Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2005.06.015

    authors： Frye CA,Rhodes ME,Petralia SM,Walf AA,Sumida K,Edinger KL

    更新日期：2006-01-01 00:00:00

  • Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.

    abstract：:The mechanism underlying phencyclidine (PCP)-induced apoptosis in perinatal rats and the development of schizophrenia-like behaviors is incompletely understood. We used antagonists for N-methyl-D-aspartate (NMDA) receptor subunit NR2A- and NR2B-containing NMDA receptor to test the hypothesis that the behavioral and ap...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.07.058

    authors： Anastasio NC,Xia Y,O'Connor ZR,Johnson KM

    更新日期：2009-11-10 00:00:00

  • Hypo-excitation across all cortical laminae defines intermediate stages of cortical neuronal dysfunction in diffuse traumatic brain injury.

    abstract：:Traumatic brain injury (TBI) is a major cause of morbidity and mortality world-wide and can result in persistent cognitive, sensory and behavioral dysfunction. Understanding the time course of TBI-induced pathology is essential to effective treatment outcomes. We induced TBI in rats using an impact acceleration method...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.08.018

    authors： Allitt BJ,Iva P,Yan EB,Rajan R

    更新日期：2016-10-15 00:00:00

  • Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice.

    abstract：:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.058

    authors： Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

    更新日期：2004-01-01 00:00:00

  • Thyroid hormone distribution in the mouse brain: the role of transthyretin.

    abstract：:Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans. The choroid plexus synthesizes transthyretin and secretes it to the cerebrospinal fluid. Although it was suggested that transthyretin might play a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00228-2

    authors： Palha JA,Nissanov J,Fernandes R,Sousa JC,Bertrand L,Dratman MB,Morreale de Escobar G,Gottesman M,Saraiva MJ

    更新日期：2002-01-01 00:00:00

  • Distribution of [3H]diadenosine tetraphosphate binding sites in rat brain.

    abstract：:The distribution of the diadenosine tetraphosphate high-affinity binding sites has been studied in rat brain by an autoradiographic method using [3H]diadenosine tetraphosphate as the ligand. The binding characteristics are comparable to those described in studies performed on rat brain synaptosomes. White matter is de...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00424-1

    authors： Rodríguez-Pascual F,Cortes R,Torres M,Palacios JM,Miras-Portugal MT

    更新日期：1997-03-01 00:00:00

  • Congruence of zebrin II expression and functional zones defined by climbing fiber topography in the flocculus.

    abstract：:The cerebellum is organized into parasagittal zones with respect to the topography of climbing fiber (CF) afferents and the expression of molecular markers such as zebrin II. Zebrin is expressed by a subset of Purkinje cells that are distributed as a parasagittal array of immunopositive and immunonegative stripes. Sev...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.08.062

    authors： Pakan JM,Wylie DR

    更新日期：2008-11-11 00:00:00

  • Neural Correlations Underlying Self-Generated Decision in the Frontal Pole Cortex during a Cued Strategy Task.

    abstract：:We have previously shown how the Frontal Pole cortex (FPC) neurons play a unique role in both the monitoring and evaluating of self-generated decisions during feedback in a visually cued strategy task. For each trial of this task, a cue instructed one of two strategies: to either stay with the previous goal or shift t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.02.023

    authors： Mione V,Tsujimoto S,Genovesio A

    更新日期：2019-04-15 00:00:00

  • Patterns of colocalization of neuronal nitric oxide synthase and somatostatin-like immunoreactivity in the mouse hippocampus: quantitative analysis with optical disector.

    abstract：:In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons. Here we estimated the immunocytochemical colocalization of nNOS and SOM in the mouse ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.01.027

    authors： Jinno S,Kosaka T

    更新日期：2004-01-01 00:00:00

  • Stress effects on BDNF expression: effects of age, sex, and form of stress.

    abstract：:Stress has long been associated with the development of neuropsychiatric and neurological disorders. The effects of stress vary depending upon the age during which the stress is incurred, the duration and severity of the stressor, and can further be influenced by levels of circulating gonadal hormones. To date, the ma...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2013.01.074

    authors： Bath KG,Schilit A,Lee FS

    更新日期：2013-06-03 00:00:00

  • Functional development of the vagal and glossopharyngeal nerve-related nuclei in the embryonic rat brainstem: optical mapping with a voltage-sensitive dye.

    abstract：:We investigated functional organization of the vagus nerve (N. X)- and glossopharyngeal nerve (N. IX)-related nuclei in the embryonic rat brainstem and compared their development and spatial distribution patterns, using multiple-site optical recording with a fast voltage-sensitive dye, NK2761. Intact brainstem prepara...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.019

    authors： Momose-Sato Y,Nakamori T,Sato K

    更新日期：2011-09-29 00:00:00

  • Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease.

    abstract：:Huntington's disease is a progressive, inherited neurodegenerative disorder characterized by the loss of subsets of neurons primarily in the striatum. In this study, we assessed the neuroprotective effect of lithium against striatal lesion formation in a rat model of Huntington's disease in which quinolinic acid was u...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00311-6

    authors： Wei H,Qin ZH,Senatorov VV,Wei W,Wang Y,Qian Y,Chuang DM

    更新日期：2001-01-01 00:00:00

  • The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.

    abstract：:The disturbance of the insulin-signaling pathway plays an important role in Alzheimer's disease. Resistance to insulin signaling renders neurons energy-deficient and vulnerable to oxidization or other metabolic insults and impairs synaptic plasticity. In search of neuroprotective drugs, we synthesized a peptide analog...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.10.069

    authors： Wang P,Jiang S,Cui Y,Yue Z,Su C,Sun J,Sheng S,Tian J

    更新日期：2011-01-26 00:00:00

  • Expression of agrin in the developing and adult rat brain.

    abstract：:Agrin, a synaptic basal lamina protein, is essential for the formation of the vertebrate neuromuscular junction. Agrin's role in synaptogenesis in the central nervous system has, however, not been elucidated. Therefore, we performed immunohistochemical analysis of agrin localization in adult rat brain using agrin-spec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00345-4

    authors： Cohen NA,Kaufmann WE,Worley PF,Rupp F

    更新日期：1997-01-01 00:00:00

  • Transneuronal labeling in hamster brainstem following lingual injections with herpes simplex virus-1.

    abstract：:Brainstem projections to hypoglossal motoneurons innervating the intrinsic and extrinsic muscles of the tongue were determined using the transneuronal transfer of Herpes simplex virus-1. Injections of Herpes simplex virus-1 into the intrinsic muscles of the anterior tongue, the geniohyoid and styloglossus muscles each...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00203-u

    authors： Travers JB,Montgomery N,Sheridan J

    更新日期：1995-10-01 00:00:00

  • Correlations between immediate early gene induction and the persistence of long-term potentiation.

    abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90369-q

    authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

    更新日期：1993-10-01 00:00:00