Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.

abstract：:Calmodulin (CaM) and neurogranin (Ng) are two abundant neuronal proteins in the forebrain whose interactions are implicated in the enhancement of synaptic plasticity. To gain further insight into the actions of these two proteins we investigated whether they co-localize in principle neurons and whether they respond to...

journal_title：Neuroscience

authors： Huang KP,Huang FL,Shetty PK

更新日期：2011-03-31 00:00:00

abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

journal_title：Neuroscience

authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

更新日期：2020-04-30 00:00:00

abstract：:The fenestrated microvasculature of the area postrema shows a less restrictive blood-brain barrier than is found in other areas of the CNS. We have studied the expression and relationship of vascular endothelial tight junctional proteins, astrocytes, macrophages, and the extracellular matrix with the extravasation of ...

journal_title：Neuroscience

authors： Willis CL,Garwood CJ,Ray DE

更新日期：2007-12-05 00:00:00

abstract：:Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurologica...

journal_title：Neuroscience

authors： Lin XH,Ye XJ,Li QF,Gong Z,Cao X,Li JH,Zhao ST,Sun XD,He XS,Xuan AG

更新日期：2020-11-10 00:00:00

abstract：:Throughout rat embryogenesis we analysed the expression patterns of the three mature transcripts generated from the two calcitonin gene-related peptide genes: calcitonin, alpha-calcitonin gene-related peptide, and beta-calcitonin gene-related peptide messenger RNAs. In addition, we examined in parallel the distributio...

journal_title：Neuroscience

authors： Terrado J,Gerrikagoitia I,Domínguez L,Raldúa D,Martínez-Millán L,Sarasa M

更新日期：1999-01-01 00:00:00

abstract：:Brain injury can often result in the subsequent appearance of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibitio...

journal_title：Neuroscience

authors： Ding MC,Lo EH,Stanley GB

更新日期：2008-06-23 00:00:00

abstract：:The effect of re-exposure of rats to an aversive environment on the induction of long-term potentiation was investigated in the CA3 region 3 and 12 h after contextual conditioning. Electro-physiological recordings showed that re-exposure of rats to the conditioning chamber produced a significant and long-lasting decre...

journal_title：Neuroscience

authors： Garcia R,Tocco G,Baudry M,Thompson RF

更新日期：1998-01-01 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

journal_title：Neuroscience

authors： Sershen H,Balla A,Lajtha A,Vizi ES

更新日期：1997-03-01 00:00:00

abstract：:5-HT and agonists of the 5-HT receptor can modify the response of the mammalian pacemaker, which is located in the hypothalamic suprachiasmatic nuclei (SCN), to photic and nonphotic stimulation. Previous studies suggest that the 5-HT7 receptor is involved in the regulation of photic input, and the modulation of nonpho...

journal_title：Neuroscience

authors： Gardani M,Biello SM

更新日期：2008-03-03 00:00:00

abstract：:Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. The histological composition of GG, with the presence of dysplastic neurons, corroborates their maldevelopmental origin. However, their histogenesis, the pathogenetic relationship with other dev...

journal_title：Neuroscience

authors： Aronica E,Boer K,Becker A,Redeker S,Spliet WG,van Rijen PC,Wittink F,Breit T,Wadman WJ,Lopes da Silva FH,Troost D,Gorter JA

更新日期：2008-01-02 00:00:00

abstract：:The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...

journal_title：Neuroscience

authors： Francis AB,Pace TW,Ginsberg AB,Rubin BA,Spencer RL

更新日期：2006-09-01 00:00:00

abstract：:The presynaptic changes caused by 4-aminopyridine were studied in the electric organ of Torpedo marmorata, in the resting state and during the period following transmission of a single giant discharge. Incubation with 4-aminopyridine provoked a 30-40% decrease in the density of synaptic vesicles in nerve terminals, an...

journal_title：Neuroscience

authors： Parducz A,Dunant Y,Loctin F,Muller D,Garcia-Segura LM

更新日期：1987-08-01 00:00:00

abstract：:S100A1 and S100B are members of a multigenic family of Ca(2+)-binding proteins of the EF-hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca(2+)-dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type III ...

journal_title：Neuroscience

authors： Sorci G,Agneletti AL,Donato R

更新日期：2000-01-01 00:00:00

abstract：:Synaptic plasticity is associated with morphological changes in dendritic spines. The actin-based cytoskeleton plays a key role in regulating spine structure, and actin reorganization in spines is critical for the maintenance of long term potentiation. To test the hypothesis that a stable pool of F-actin rests in the ...

journal_title：Neuroscience

authors： Racz B,Weinberg RJ

更新日期：2006-01-01 00:00:00

abstract：:The regulation of D₃ receptor has not been well documented in diffuse Lewy body disease (DLBD). In this study, a novel D₃-preferring radioligand [(3)H]WC-10 and a D₂-preferring radioligand [(3)H]raclopride were used and the absolute densities of the dopamine D₃ and D₂ receptors were determined in the striatal regions ...

journal_title：Neuroscience

authors： Sun J,Cairns NJ,Perlmutter JS,Mach RH,Xu J

更新日期：2013-09-17 00:00:00

abstract：:Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...

journal_title：Neuroscience

authors： Duchemin A,Seelke AM,Simmons TC,Freeman SM,Bales KL

更新日期：2017-04-21 00:00:00

abstract：:Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...

journal_title：Neuroscience

authors： Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

更新日期：2002-01-01 00:00:00

abstract：:Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in sch...

journal_title：Neuroscience

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-11-07 00:00:00

abstract：:The schizophrenia-susceptibility gene, dystrobrevin-binding protein 1 (DTNBP1), encodes the dysbindin protein and mediates neurotransmission and neurodevelopment in normal subjects. Functional studies show that DTNBP1 loss may cause deficient presynaptic vesicle transmission, which is related to multiple psychiatric d...

journal_title：Neuroscience

authors： Hu H,Wang X,Li C,Li Y,Hao J,Zhou Y,Yang X,Chen P,Shen X,Zhang S

更新日期：2021-01-01 00:00:00

abstract：:A variety of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, and the antiepileptic drug lamotrigine, were examined for their ability to restore locomotion and other behaviours when injected stereotaxically via indwelling cannulae into the striatum or substantia n...

journal_title：Neuroscience

authors： Kaur S,Starr MS

更新日期：1997-01-01 00:00:00

abstract：:Extracellular nucleotides exert their actions via two subfamilies of purinoceptors: P2X and P2Y. Eight mammalian P2Y receptor subtypes (P2Y(1,2,4,6,11,12,13,14)) have been identified. In this work, the localization of P2Y(6) was studied in rat retina using double immunofluorescence labeling and confocal scanning micro...

journal_title：Neuroscience

authors： Zhang PP,Yang XL,Zhong YM

更新日期：2012-09-18 00:00:00

abstract：:The effect of exogenously applied cholinergic agents upon mitral-granule cell complex activity of the olfactory bulb was studied in anesthetized rats. Output neurons were activated by electrical paired-pulse stimulation (40-80 ms time interval) applied either to the olfactory nerve (orthodromic stimulation) or to the ...

journal_title：Neuroscience

authors： Elaagouby A,Ravel N,Gervais R

更新日期：1991-01-01 00:00:00

abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

journal_title：Neuroscience

authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

更新日期：2013-02-12 00:00:00

abstract：:Intracellular stimulation of single propriospinal axons evoked excitatory postsynaptic potentials (EPSPs) in lumbar motoneurons. Mean EPSP amplitudes differed by two orders of magnitude when measured in different connections. After analyzing the distribution of mean amplitudes of 47 single-fiber EPSPs, two populations...

journal_title：Neuroscience

authors： Dityatev A,Birinyi A,Puskár Z,Antal M,Clamann HP

更新日期：2001-01-01 00:00:00

abstract：:Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. ...

journal_title：Neuroscience

authors： Bick J,Fox N,Zeanah C,Nelson CA

更新日期：2017-02-07 00:00:00

abstract：:Regular physical exercise has been described as a good strategy for prevention or reduction of musculoskeletal pain. The Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) has been investigated as a promising target for the control of inflammatory pain. Therefore, the aim of this study was to evaluate whether ac...

journal_title：Neuroscience

authors： de Azambuja G,Botasso Gomes B,Messias LHD,Aquino BM,Jorge CO,Manchado-Gobatto FB,Oliveira-Fusaro MCG

更新日期：2020-02-10 00:00:00

abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

journal_title：Neuroscience

authors： Huntsman MM,Jones EG

更新日期：1998-11-01 00:00:00

abstract：:Inhibitory serotonergic and cholecystokinergic mechanisms in the lateral parabrachial nucleus and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. In the present study we investigated if the GABA(A) receptors in the lateral parabrachial nucleus are involved in the control of water,...

journal_title：Neuroscience

authors： Callera JC,Oliveira LB,Barbosa SP,Colombari DS,De Luca LA Jr,Menani JV

更新日期：2005-01-01 00:00:00

abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

journal_title：Neuroscience

authors： Humpel C

更新日期：2015-10-01 00:00:00