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Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice.

Abstract：

:Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurological deficit scores, and spatial memory deficits after cerebral ischemia. Furthermore, UA significantly reduced neuron loss and promoted neurogenesis after ischemic stroke. We also found that UA attenuated apoptosis by regulating apoptotic-related proteins. Meanwhile, UA treatment inhibited glial activation via affecting inflammatory signaling pathways, specifically by enhancing cerebral AMPK and IκBa activation while decreasing the activation of Akt, P65NFκB, ERK, JNK, and P38MAPK. Our findings reveal a key role of UA against ischemic stroke through modulating apoptosis and neuroinflammation in mice.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Lin XH,Ye XJ,Li QF,Gong Z,Cao X,Li JH,Zhao ST,Sun XD,He XS,Xuan AG

doi

10.1016/j.neuroscience.2020.09.027

subject

Has Abstract

pub_date

2020-11-10 00:00:00

pages

94-106

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30600-X

journal_volume

448

pub_type

杂志文章

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