Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats.

abstract：:Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of rat raised diabetic b...

journal_title：Neuroscience

authors： Giatti S,Pesaresi M,Cavaletti G,Bianchi R,Carozzi V,Lombardi R,Maschi O,Lauria G,Garcia-Segura LM,Caruso D,Melcangi RC

更新日期：2009-12-01 00:00:00

abstract：:Mammalian nociceptors have been classified into subclasses based on differential neurotrophin sensitivity and binding of the plant isolectin B4 (IB4). Most of the nerve growth factor-responsive IB4-negative (IB4 (-)) nociceptors contain neuropeptides such as substance P and calcitonin gene-related peptide, whereas the...

journal_title：Neuroscience

authors： Matsuka Y,Edmonds B,Mitrirattanakul S,Schweizer FE,Spigelman I

更新日期：2007-01-19 00:00:00

abstract：:The globus pallidus sends a significant GABAergic projection to the thalamic reticular nucleus. Because pallidal neurons express D4-dopamine receptors, we have explored their presence on pallidoreticular terminals by studying the effect of dopamine and D4-receptor agonists on the GABAergic transmission in the thalamic...

journal_title：Neuroscience

authors： Gasca-Martinez D,Hernandez A,Sierra A,Valdiosera R,Anaya-Martinez V,Floran B,Erlij D,Aceves J

更新日期：2010-09-15 00:00:00

abstract：:Cultures of 11 day old chick embryo pectoral muscle were used to study the effects of direct electrical stimulation and neurochemicals such as acetylcholine, acetyl-beta-methylcholine, tetrodotoxin, and d-tubocurarine on the acetylcholinesterase levels of muscle. The results suggest that excitation-contraction is an i...

journal_title：Neuroscience

authors： Walker CR,Wilson BW

更新日期：1976-06-01 00:00:00

abstract：:There is increasing evidence that a subset of midbrain dopamine (DA) neurons uses glutamate as a co-transmitter and expresses vesicular glutamate transporter (VGLUT) 2, one of the three vesicular glutamate transporters. In the present study, double in situ hybridization was used to examine tyrosine hydroxylase (TH) an...

journal_title：Neuroscience

authors： Dal Bo G,Bérubé-Carrière N,Mendez JA,Leo D,Riad M,Descarries L,Lévesque D,Trudeau LE

更新日期：2008-09-22 00:00:00

abstract：:Physiological evidence has indicated that serotonin (5-hydroxytryptamine) could be a regulator of cerebral blood flow in various regions of the brain. In the present study, tryptophan hydroxylase immunocytochemistry was used to characterize, both at the light and electron microscopic levels, serotonergic nerve termina...

journal_title：Neuroscience

authors： Cohen Z,Ehret M,Maitre M,Hamel E

更新日期：1995-06-01 00:00:00

abstract：:The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...

journal_title：Neuroscience

authors： Loughlin SE,Foote SL,Bloom FE

更新日期：1986-06-01 00:00:00

abstract：:To localize glycinergic cell bodies and fibers in the rat brain, we developed a sensitive immunohistochemical method combining the use of specific glycine antibodies (Campistron G. et al. (1986) Brain Res. 376, 400-405; Wenthold R. J. et al. (1987) Neuroscience 22, 897-912) with the streptavidin-horseradish peroxidase...

journal_title：Neuroscience

authors： Rampon C,Luppi PH,Fort P,Peyron C,Jouvet M

更新日期：1996-12-01 00:00:00

abstract：:Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...

journal_title：Neuroscience

authors： Rahimi Nedjat M,Wähmann M,Bächli H,Güresir E,Vatter H,Raabe A,Heimann A,Kempski O,Alessandri B

更新日期：2013-05-15 00:00:00

abstract：:In this study, we performed in situ hybridization analysis of the expression pattern of two growth-associated proteins, stathmin and SCG10, in the hippocampus after unilateral lesion of the perforant pathway, the main excitatory input from the entorhinal cortex to the hippocampus. Stathmin is one of the major neural-e...

journal_title：Neuroscience

authors： Bräuer AU,Savaskan NE,Plaschke M,Ninnemann O,Nitsch R

更新日期：2001-01-01 00:00:00

abstract：:There is little detailed information about retinal ganglion cells which project to specific central targets in the brain. The present study examined retinal ganglion cells projecting to the nucleus of the basal optic root, a major accessory retinal target in the turtle. These ganglion cells were first selectively labe...

journal_title：Neuroscience

authors： Zhang D,Eldred WD

更新日期：1994-08-01 00:00:00

abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

journal_title：Neuroscience

authors： Ding Q,Ying Z,Gómez-Pinilla F

更新日期：2011-09-29 00:00:00

abstract：:Intracellular recordings were made from neurons in a rat locus coeruleus slice preparation in vitro. A postsynaptic potential was evoked by electrical stimulation of afferents to the neurons. CI-977 ([5R-(5a,7a,8b)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec -8-yl[-4-benzofuranacetamide monohydrochloride) cause...

journal_title：Neuroscience

authors： Pinnock RD

更新日期：1992-01-01 00:00:00

abstract：:γ-Hydroxybutyrate (GHB) has a complex array of neural actions that include effects on its own high-affinity GHB receptor, the release of neuroactive steroids, and agonist actions at GABAA and GABAB receptors. We previously reported partial overlap in the c-Fos expression patterns produced by GHB and the GABAB agonist,...

journal_title：Neuroscience

authors： van Nieuwenhuijzen PS,McGregor IS,Chebib M,Hunt GE

更新日期：2014-09-26 00:00:00

abstract：:Synapsins are a family of synaptic vesicle (SV)-associated phosphoproteins that have been identified in several vertebrates and invertebrates. We report here the cloning and expression of synapsin family genes in the zebrafish Danio rerio. We identified the complete coding sequence of synapsin 3, which is not present ...

journal_title：Neuroscience

authors： Garbarino G,Costa S,Pestarino M,Candiani S

更新日期：2014-11-07 00:00:00

abstract：:The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised two controlled experiments including 16 and 15 healthy participants, respectively. Each study included six sessions during which painful or non-painful electrical stimu...

journal_title：Neuroscience

authors： Randoll C,Gagnon-Normandin V,Tessier J,Bois S,Rustamov N,O'Shaughnessy J,Descarreaux M,Piché M

更新日期：2017-05-04 00:00:00

abstract：:Astrocytes have been generally believed to perform mainly homeostatic and supportive functions for neurons in the central nervous system. Recently, a growing body of evidence suggests previously unrecognized and surprising functions for astrocytes, including regulation of synaptic formation, transmission and plasticit...

journal_title：Neuroscience

authors： Adamsky A,Goshen I

更新日期：2018-02-01 00:00:00

abstract：:Cholinergic and glutamatergic cells in the pedunculopontine tegmental nucleus are a principal source of excitatory input to midbrain dopamine neurons projecting to the striatum. Disruption of these brainstem inputs has been shown to respectively enhance and reduce psychostimulant and opiate self-administration in rats...

journal_title：Neuroscience

authors： Miller AD,Forster GL,Metcalf KM,Blaha CD

更新日期：2002-01-01 00:00:00

abstract：:Respiratory disturbances are a primary phenotype of the neurological disorder, Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Mouse models generated with null mutations in Mecp2 mimic respiratory abnormalities in RTT girls. Large deletions, however, are see...

journal_title：Neuroscience

authors： Bissonnette JM,Schaevitz LR,Knopp SJ,Zhou Z

更新日期：2014-05-16 00:00:00

abstract：:Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...

journal_title：Neuroscience

authors： Jeanjean AP,Moussaoui SM,Maloteaux JM,Laduron PM

更新日期：1995-09-01 00:00:00

abstract：:Synapsins (SynI, SynII, SynIII) are a multigene family of synaptic vesicle (SV) phosphoproteins implicated in the regulation of synaptic transmission and plasticity. Synapsin I, II, I/II and I/II/III knockout mice are epileptic and SYN1/2 genes have been identified as major epilepsy susceptibility genes in humans. We ...

journal_title：Neuroscience

authors： Boido D,Farisello P,Cesca F,Ferrea E,Valtorta F,Benfenati F,Baldelli P

更新日期：2010-11-24 00:00:00

abstract：:A long-term induction of Fos-related antigens has been shown in neurons after brain injury, suggesting that Fos-related antigens are involved in enhancing the transcription of genes related to the process of regeneration and repair. In the present study, we report that levels of Fos-related antigen-2 are elevated in s...

journal_title：Neuroscience

authors： Pennypacker KR,Yang X,Gordon MN,Benkovic S,Miller D,O'Callaghan JP

更新日期：2000-01-01 00:00:00

abstract：:To better understand the function of the Wnt pathway in the developing telencephalon, we analyzed neocortical development in low density lipoprotein receptor-related protein (LRP) 6 mutants. LRP6 mutant mice are hypomorphic for the canonical Wnt signaling pathway and have hypoplasia of the developing neocortex. While ...

journal_title：Neuroscience

authors： Zhou CJ,Borello U,Rubenstein JL,Pleasure SJ

更新日期：2006-11-03 00:00:00

abstract：:We addressed the issue of the possible degradation of the aiming precision of a whole-body pointing task, when movement coordination is deranged by selective fatigue of the postural task component. The protocol involved continuous repetition (0.1 Hz frequency) of rapid whole-body pointing trials toward a target locate...

journal_title：Neuroscience

authors： Schmid M,Schieppati M,Pozzo T

更新日期：2006-01-01 00:00:00

abstract：:The radioligands [3H]SCH 23390 and [3H]spiroperidol were used to label dopamine D1 and D2 receptors, respectively, in rat brain slices. Striatal sections were incubated in one of various concentrations of radioligand in the presence or absence of (+)-butaclamol and the resulting labeling was determined by liquid scint...

journal_title：Neuroscience

authors： Bardo MT,Hammer RP Jr

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

journal_title：Neuroscience

authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:The thoracolumbar and lumbosacral spinal cord contain respectively sympathetic and parasympathetic preganglionic neurons that supply the organs of the pelvis including the penis. These neurons are influenced by supraspinal information and receive aminergic projections from the brainstem. The presence of the alpha(1)- ...

journal_title：Neuroscience

authors： Yaïci ED,Rampin O,Calas A,Jestin A,McKenna KE,Leclerc P,Benoit G,Giuliano F

更新日期：2002-01-01 00:00:00

abstract：:The potential of a novel therapeutic approach for treating Parkinson's disease, which involves the transplantation of a transfected human astrocyte cell line SVG-TH, that stably expresses the rate-limiting enzyme for dopamine production, tyrosine hydroxylase, was examined. SVG-TH and untransfected parent cells were gr...

journal_title：Neuroscience

authors： Fitoussi N,Sotnik-Barkai I,Tornatore C,Herzberg U,Yadid G

更新日期：1998-07-01 00:00:00

abstract：:Anatomical and electrophysiological evidence has contributed to the hypothesis that microzones in the mammalian flocculus are organized to reflect control of eye movements in the planes of semicircular canals. Adult male Long-Evans rats received iontophoretic injections of FluoroGold and/or tetramethylrhodamine dextra...

journal_title：Neuroscience

authors： Balaban CD,Schuerger RJ,Porter JD

更新日期：2000-01-01 00:00:00

abstract：:Synaptic vesicle protein 2A (SV2A), which plays an important role in the pathophysiology of epilepsy, is a unique vesicular protein recognized as a pharmacological target of anticonvulsant drugs. Furthermore, SV2A is a potential synaptic density marker, as it is ubiquitously expressed throughout the brain in all nerve...

journal_title：Neuroscience

authors： Mendoza-Torreblanca JG,García-Cruz ME,Sánchez-Cruz I,Gomez-Gonzalez B,Juárez-Méndez S,Gómez-Lira G

更新日期：2019-11-01 00:00:00