Abstract：
:Involvement of the local angiotensin receptor system in the central nervous system is well documented, yet its cellular localization and role in the glial cells have remained elusive. This study reports expression of angiotensin II and its receptors namely, angiotensin II receptor type 1 (AT(1)) and angiotensin II receptor type 2 (AT(2)) in the amoeboid microglial cells in the neonatal rat brain. In rats subjected to hypoxia, the amount of angiotensin II released in the corpus callosal tissue was reduced as revealed by enzyme immunoassay. Expression of AT(1) mRNA and protein was down-regulated after hypoxic exposure, but AT(2) was up-regulated. In BV-2 cells exposed to hypoxia for 4 h, expression of AT(1) mRNA was reduced but AT(2) was increased. These changes were further intensified respectively in LPS-stimulated microglia. Edaravone enhanced AT(1) expression but suppressed AT(2) expression significantly in lipopolysaccharide-stimulated cells. Neutralization of AT(2) with its antiserum significantly increased mRNA expression of tumor necrosis factor-alpha and interleukin-1beta but decreased that of transforming growth factor-beta1. In conclusion, the present results suggest that AT(1) may be linked to regulation of vasodilation for increase of blood flow in hypoxic conditions, while up-regulated expression of AT(2) may reduce inflammatory responses through suppression of proinflammatory cytokines and elimination of free radicals.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Li JJ,Lu J,Kaur C,Sivakumar V,Wu CY,Ling EAdoi
10.1016/j.neuroscience.2008.11.046subject
Has Abstractpub_date
2009-02-18 00:00:00pages
1488-99issue
4eissn
0306-4522issn
1873-7544pii
S0306-4522(08)01747-8journal_volume
158pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Previous studies have shown that amphetamine (AMPH) markedly activates dopaminergic projection areas, together with some important limbic nuclei. However, a global picture of the brain areas activated is lacking and the contribution of the dose of the drug and individual differences to this global brain activation is ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.04.020
更新日期：2010-07-14 00:00:00
abstract：:Progesterone (PROG) shows neuroprotective effects in numerous lesion models, including a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). However, the possible beneficial effects of PROG on the behavioral and neurochemical impairments incurred in the hemiparkinson...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.08.043
更新日期：2011-11-24 00:00:00
abstract：:Multiple system atrophy (MSA) is a sporadic neurodegenerative disease. The major pathological hallmark of MSA is the accumulation of α-synuclein in oligodendrocytes. In contrast to Parkinson's disease no definitive familial etiology for MSA has been determined. Yet, there is a growing body of evidence that perturbatio...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.02.042
更新日期：2016-05-13 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with no effective method for its treatment so far. The pathogenesis of AD has been reported, but the endogenous metabolic profile and disease-related biomarkers are still not clear. To better understand AD, an AD model induced by injecting β-amyloid...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:Transient outward rectifying conductances or A-like conductances in sympathetic preganglionic neurons (SPN) are prolonged, lasting for hundreds of milliseconds to seconds and are thought to play a key role in the regulation of SPN firing frequency. Here, a multidisciplinary electrophysiological, pharmacological and mo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.12.061
更新日期：2011-03-31 00:00:00
abstract：:It has previously been reported that the avian H5N1 type of influenza A virus can be detected in neurons and astrocytes of human brains in autopsy cases. However, the underlying neuropathogenicity remains unexplored. In this study, we used differentiated human astrocytic and neuronal cell lines as models to examine th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.04.013
更新日期：2010-07-14 00:00:00
abstract：:In order to investigate the basic cellular mechanisms involved in neuronal interactions within the striatum, we prepared a primary striatal cell culture from rat fetal brain in chemically defined medium. Using morphological and whole-cell recording methods, we observed that an intensive neuritic elongation with a prog...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)00453-c
更新日期：1995-02-01 00:00:00
abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.07.047
更新日期：2020-12-01 00:00:00
abstract：:Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system has been implicated in changes in the br...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.02.033
更新日期：2017-04-21 00:00:00
abstract：:Three closely-linked clusters of protocadherin (Pcdh) genes (alpha, beta, and gamma) encoding more than 50 distinct mRNAs have been identified in humans and mice, and proposed to play important roles in neuronal connectivity in the CNS. The human and mouse Pcdh alpha and gamma clusters each span a region of about 300 ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.10.011
更新日期：2007-01-19 00:00:00
abstract：:Nerve growth factor (NGF) synthesized in peripheral organs plays a critical role in the development and maintenance of the nervous system and also participates in processing nociceptive stimuli. Previous studies suggest that reproductive hormones may regulate the expression of NGF. Ovariectomies were performed on fema...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00568-1
更新日期：2002-01-01 00:00:00
abstract：:The sensitivity of Purkinje cells to short pulse applications of L-aspartate, L-glutamate and related derivatives in their dendritic fields was tested in normal and staggerer mutant mice using cerebellar slices maintained in vitro. In normal mice, the response of Purkinje cells to L-aspartate and L-glutamate consisted...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(84)90076-9
更新日期：1984-06-01 00:00:00
abstract：:We investigated the electrophysiology of morphologically identified human granule cells with conventional current-clamp recordings. Slices were prepared from 14 human epileptic sclerotic hippocampi. Granule cells appeared to have a diverse electrophysiology. Each cell was distinguished by the shape of the afterhyperpo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00574-0
更新日期：1999-01-01 00:00:00
abstract：:Since mild thermal stress seems to exert neuroprotection via induction of heat-shock protein 70 kDa (hsp70), we tested whether hsp70 would preserve striatal bioelectrical activity under conditions of mitochondrial impairment. Corticostriatal slices from rats that had undergone mild thermal stress were exposed to eithe...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.06.070
更新日期：2009-10-20 00:00:00
abstract：:The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(89)90120-6
更新日期：1989-01-01 00:00:00
abstract：:The globus pallidus, one of the basal ganglia nuclei, plays a major role in both basal ganglia physiology and pathophysiology. The globus pallidus is innervated mainly by striatal spiny neurons and globus pallidus collaterals. These GABAergic synapses constitute 90% of the input to globus pallidus cells. Despite the d...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.05.069
更新日期：2005-01-01 00:00:00
abstract：:Monoamine oxidase, monoamine oxidase-A, and monoamine oxidase-B activities were compared in free moving, rapid eye movement sleep-deprived, recovered, and control rat brains. The activities were estimated in the whole brain, cerebrum, cerebellum, whole brainstem, medulla, pons, and midbrain. The flowerpot method was u...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90433-g
更新日期：1993-08-01 00:00:00
abstract：:The tachykinin NK3 receptor (NK3R) is a G-protein coupled receptor that is activated, internalized, and trafficked to the nuclei of magnocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) in response to acute hyperosmolarity. The lack of information on the nuclear import pathway raises concerns ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.08.015
更新日期：2010-11-10 00:00:00
abstract：:We have studied the roles of nicotinic and muscarinic receptors in the acetylcholine-evoked secretion of catecholamine from guinea-pig chromaffin cells. Isolated guinea-pig chromaffin cells secrete catecholamine in response to acetylcholine, nicotine, and a variety of muscarinic agonists. Optimal concentrations of ace...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90236-1
更新日期：1983-11-01 00:00:00
abstract：:The distribution of putative melatonin receptors in the brains of two Old World primates of the superfamily Catarrhina, Cercopithecus aethiops and Papio ursinus, was characterized using 2-[125I]iodomelatonin autoradiography. The specific binding demonstrated a discrete distribution pattern. The median eminence was int...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90172-c
更新日期：1993-01-01 00:00:00
abstract：:Dephosphorylation by the Ca2+/calmodulin-dependent phosphatase calcineurin has been suggested as an important mechanism of Ca2+-dependent inactivation of voltage-gated Ca2+ channels. We have tested whether calcineurin plays a role in the inactivation process of two types of high-voltage-activated Ca2+ channels (L and ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00434-0
更新日期：2000-01-01 00:00:00
abstract：:Excessive expression of vascular endothelial growth factor (VEGF) is a common cause of blood-brain barrier (BBB) breakdown that triggers severe complications following traumatic brain injury (TBI). It has been shown that inhibition of VEGF activities may attenuate cerebral edema in pathological conditions. Vascular en...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.04.042
更新日期：2020-07-01 00:00:00
abstract：:Regular physical exercise has been described as a good strategy for prevention or reduction of musculoskeletal pain. The Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) has been investigated as a promising target for the control of inflammatory pain. Therefore, the aim of this study was to evaluate whether ac...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.12.017
更新日期：2020-02-10 00:00:00
abstract：:Having provided an anatomical description of the efferent projections of the dorsal midbrain anticonvulsant zone [Shehab S. et al. (1995) Neuroscience 65, 681-695], our purpose in the present study was to establish which outputs from this region are responsible for mediating the anticonvulsant and behavioural properti...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)00517-9
更新日期：1995-04-01 00:00:00
abstract：:Axonal growth requires insertion of newly synthesized membrane components into the plasmalemma. Imbalance between exocytotic membrane addition and endocytic retrieval at specific axonal sites may lead to the bulk plasma membrane flow along the axon and, thus, contribute to the renewal of plasma membrane components. By...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00022-1
更新日期：2000-01-01 00:00:00
abstract：:Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer's disease (AD). Non-invasive diagnostic methods are desirable to identify MCI for early therapeutic interventions. In this study, we proposed a support vector machine (SVM)-based method to discriminate between MCI patien...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2016.06.025
更新日期：2016-09-07 00:00:00
abstract：:The tectofugal pathway in birds consists of four stations, the retina, optic tectum, rotundal nucleus, and entopallium, and it conveys visual information via three ascending pathways. These pathways consist of retino-tectal, tecto-rotundal and rotundo-entopallial cells, all of which are glutamatergic. The present stud...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.12.032
更新日期：2016-03-01 00:00:00
abstract：:Serotonergic systems are thought to play an important role in control of motor activity and emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a motor-eliciting stimulus in the presence or absence of induction of an acute fear state on serotonergic neurons in the dorsal raphe n...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2011.01.042
更新日期：2011-04-14 00:00:00
abstract：:Immunohistochemical methods were used to characterize the distribution of staining for leucine enkephalin-like and methionine enkephalin-like immunoreactivities in the telencephalon of Caiman crocodilus. Very similar distributions of both leucine enkephalin-like and methionine enkephalin-like immunoreactivity were obs...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(84)90028-9
更新日期：1984-02-01 00:00:00
abstract：:Huntington's disease is a progressive, autosomal dominantly inherited, neurodegenerative disease that is characterized by involuntary movements (chorea), cognitive decline and psychiatric manifestations. This is one of a number of late-onset neurodegenerative disorders caused by expanded glutamine repeats, with a like...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00391-2
更新日期：2000-01-01 00:00:00
