Calcium-dependent inactivation of neuronal calcium channel currents is independent of calcineurin.

abstract：:Dopamine stimulates the phosphorylation of the neuron-specific synaptic vesicle proteins Synapsin I, Protein IIIa and Protein IIIb in the posterior pituitary gland of the rat [Tsou and Greengard (1982) Proc. natn. Acad. Sci. U.S.A. 79, 6075-6079]. This effect has been characterized in the present investigation. The st...

journal_title：Neuroscience

authors： Treiman M,Greengard P

更新日期：1985-07-01 00:00:00

abstract：:Studies demonstrated that chronic high-dose homocysteine administration induced learning and memory impairment in animals. Atractylenolide III (Aen-III), a neuroprotective constituent of Atractylodis macrocephalae Koidz, was isolated in our previous study. In this study, we investigated potential benefits of Aen-III i...

journal_title：Neuroscience

authors： Zhao H,Ji ZH,Liu C,Yu XY

更新日期：2015-04-02 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00

abstract：:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...

journal_title：Neuroscience

authors： Palfrey HC,Artalejo CR

更新日期：1998-04-01 00:00:00

abstract：:The 5-HT6 receptor (5-HT6R) is almost exclusively expressed in the brain and has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In the present study, we have determined the cell types on which the 5-HT6R is expressed by colocalizing 5-HT6R mRNA with that of a range of neuronal an...

journal_title：Neuroscience

authors： Helboe L,Egebjerg J,de Jong IE

更新日期：2015-12-03 00:00:00

abstract：:Paired helical filaments isolated from brains of two different patients with Alzheimer's disease were extensively treated with the ionic detergent, sodium dodecyl sulphate. Filaments were solubilized at different extents, depending on the brain examined, thus suggesting the existence of two types of paired helical fil...

journal_title：Neuroscience

authors： González PJ,Correas I,Avila J

更新日期：1992-09-01 00:00:00

abstract：:Ciliary neurotrophic factor is known to exert both survival and differentiative actions on a number of neuronal populations of the peripheral and central nervous systems. In this study we have compared the trophic effects of ciliary neurotrophic factor and nerve growth factor on developing septal neurons of the rat in...

journal_title：Neuroscience

authors： Kew JN,Sofroniew MV

更新日期：1995-06-01 00:00:00

abstract：:We have examined the effect of acrolein, an aldehyde product of lipid peroxidation, on axons in isolated guinea-pig spinal cord white matter. We found that 200 microM acrolein, but not 50 microM, induced a time-dependent loss of compound action potential conduction. Such conduction loss was irreversible within 1 h aft...

journal_title：Neuroscience

authors： Shi R,Luo J,Peasley M

更新日期：2002-01-01 00:00:00

abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

journal_title：Neuroscience

authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

更新日期：2017-09-01 00:00:00

abstract：:Working memory has often been modeled and conceptualized as a kind of binary (bistable) memory switch, where stimuli turn on plateau-like persistent activity in subsets of cells, in line with many in vivo electrophysiological reports. A potentially related form of bistability, termed up- and down-states, has been stud...

journal_title：Neuroscience

authors： Durstewitz D,Seamans JK

更新日期：2006-04-28 00:00:00

abstract：:Organophosphates (OPs) pose a constant threat to human health due to their widespread use as pesticides and their potential employment in military and terrorist attacks. The acute toxicity of OPs has been extensively studied; however, the consequences of prolonged or repeated exposure to levels of OPs that produce no ...

journal_title：Neuroscience

authors： Terry AV Jr,Buccafusco JJ,Gearhart DA,Beck WD,Middlemore-Risher ML,Truan JN,Schwarz GM,Xu M,Bartlett MG,Kutiyanawala A,Pillai A

更新日期：2011-03-10 00:00:00

abstract：:Rat cerebellar granule cells, when subjected to a glucose-free environment for 4 h, developed extensive degeneration of neuronal cell bodies and their associated neurite network over the following 24 h. This neuronal damage was quantitated with a colorimetric assay using the metabolic dye 3-(4,5-dimethylthiazol-2-yl)-...

journal_title：Neuroscience

authors： Facci L,Leon A,Skaper SD

更新日期：1990-01-01 00:00:00

abstract：:Motor execution and imagery (ME and MI), as the basic abilities of human beings, have been considered to be effective strategies in motor skill learning and motor abilities rehabilitation. Neuroimaging studies have revealed several critical regions from functional activation for ME as well as MI. Recently, investigati...

journal_title：Neuroscience

authors： Xu L,Zhang H,Hui M,Long Z,Jin Z,Liu Y,Yao L

更新日期：2014-03-07 00:00:00

abstract：:Previous studies have shown that when peripheral nerves in axolotl limbs are cut and surgically misdirected, regenerating axons grow back to the original pathways and innervate their correct muscles. In the present study however, we demonstrate that when given a choice between their correct nerve stump and an incorrec...

journal_title：Neuroscience

authors： Aaronson OS,Golding JP,Tonge DA

更新日期：1995-05-01 00:00:00

abstract：:Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...

journal_title：Neuroscience

authors： Bakker J,Baum MJ,Slob AK

更新日期：1996-09-01 00:00:00

abstract：:Before movement onset, during the reaction time, excitability of M1 is selectively modulated by somatosensory inputs, only in the movement-related muscle. If a similar mechanism operates before the onset of mental movements, then somatosensory afferent inputs are exploited during cognitive representation of movement. ...

journal_title：Neuroscience

authors： Bonassi G,Bisio A,Lagravinese G,Ruggeri P,Bove M,Avanzino L

更新日期：2019-06-15 00:00:00

abstract：:We have investigated effects of letrozole, an aromatase inhibitor, on spatial learning and memory, expression of neural cell adhesion molecules (NCAM) and catecholaminergic neurotransmitters in the hippocampus and cortex of female rats. In the intact model, adult Sprague-Dawley rats were divided into four groups (n=8)...

journal_title：Neuroscience

authors： Aydin M,Yilmaz B,Alcin E,Nedzvetsky VS,Sahin Z,Tuzcu M

更新日期：2008-01-02 00:00:00

abstract：:The effect of the availability of synaptic targets on neuronal survival was tested by explanting the cochleovestibular ganglion from embryonic day 3-1/2 chick embryos and maintaining it in the presence or absence of appropriate synaptic target tissues for 14 days in culture. The targets were the inner ear, peripherall...

journal_title：Neuroscience

authors： Ard MD,Morest DK,Hauger SH

更新日期：1985-09-01 00:00:00

abstract：:[3H]Bremazocine, in the presence of saturating concentrations of mu and delta receptor blocking agents, was used to label putative kappa opiate binding sites in rat brain. The binding of [3H]bremazocine under these conditions was completely displaced with high affinity by U-50488H and dynorphin1-17, and the potency of...

journal_title：Neuroscience

authors： Morris BJ,Herz A

更新日期：1986-11-01 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:The enzyme choline-O-acetyltransferase catalyses the biosynthesis of acetylcholine from acetyl coenzyme A and choline and is considered as one of the best markers for cholinergic nerve endings. The distribution of this enzymatic activity was analysed during the purification of plasma membranes of purely cholinergic ne...

journal_title：Neuroscience

authors： Eder-Colli L,Amato S

更新日期：1985-06-01 00:00:00

abstract：:The distribution of N-methyl-D-aspartate- (NMDA) and kainic acid- (KA) sensitive ionotropic glutamate receptors (iGluR) in the zebrafish olfactory bulb was assessed using an activity-dependent labeling method. Olfactory bulbs were incubated with an ion channel permeant probe, agmatine (AGB), and iGluR agonists in vitr...

journal_title：Neuroscience

authors： Edwards JG,Michel WC

更新日期：2003-01-01 00:00:00

abstract：:In the neocortex, interaction and cooperation between different areas are important for information processing, which also applies to different areas within one sensory modality. In the temporal cortex of rodents and cats, both the primary auditory cortex (A1) and the anterior auditory field (AAF) have tonotopicity bu...

journal_title：Neuroscience

authors： Zhang G,Tao C,Zhou C,Yan S,Wang Z,Zhou Y,Xiong Y

更新日期：2017-10-11 00:00:00

abstract：:Although numerous studies have demonstrated the neurotrophic capacity of gp130 cytokines, it remains unclear whether endogenously expressed cytokines actually function in a direct neuromodulatory manner. Therefore, using the lithium-pilocarpine status epilepticus model, we performed a detailed in situ hybridization ti...

journal_title：Neuroscience

authors： Rosell DR,Nacher J,Akama KT,McEwen BS

更新日期：2003-01-01 00:00:00

abstract：:Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition...

journal_title：Neuroscience

authors： Shakya Shrestha S,Bannatyne BA,Jankowska E,Hammar I,Nilsson E,Maxwell DJ

更新日期：2012-12-13 00:00:00

abstract：:Recurring patterns of neural activity, a potential substrate of both information transfer and transformation in cortical networks, have been observed in the intact brain and in brain slices. Do these patterns require the inherent cortical microcircuitry of such preparations or are they a general property of self-organ...

journal_title：Neuroscience

authors： Rolston JD,Wagenaar DA,Potter SM

更新日期：2007-08-10 00:00:00

abstract：:Aging is associated with disturbances in autonomic cardiovascular control. The purpose of this study was to test the hypothesis that changes in nitric oxide occur with aging in brainstem nuclei involved in autonomic cardiovascular control. The principal and unexpected finding in this study was that NADPH-diaphorase re...

journal_title：Neuroscience

authors： Ma SX,Holley AT,Sandra A,Cassell MD,Abboud FM

更新日期：1997-02-01 00:00:00

abstract：:Production of tissue inhibitors of matrix metalloproteinases (TIMPs), a family of secreted proteins with inhibitory actions on matrix metalloproteinases (MMPs), is up-regulated following nerve injuries and is suggested to have protective effects against MMP-mediated tissue damages. To clarify the extracellular signals...

journal_title：Neuroscience

authors： Koyama Y,Baba A,Matsuda T

更新日期：2007-07-13 00:00:00

abstract：:When the neural tracer Fluoro-Gold is used to retrogradely label a population of axotomized neurons, cellular labeling can persist in the axotomized nucleus even when Nissl staining indicates that the injured neurons have degenerated. In order to determine the identity of the labeled cells that remain, this study comb...

journal_title：Neuroscience

authors： Rinaman L,Milligan CE,Levitt P

更新日期：1991-01-01 00:00:00

abstract：:In Parkinson's disease, subthalamic nucleus (STN) neurons burst fire with increased periodicity and synchrony. This may entail abnormal release of glutamate, the major source of which in STN is cortical afferents. Indeed, the cortico-subthalamic pathway is implicated in the emergence of excessive oscillations, which a...

journal_title：Neuroscience

authors： Yamawaki N,Magill PJ,Woodhall GL,Hall SD,Stanford IM

更新日期：2012-02-17 00:00:00