Selective sensorimotor modulation operates during cognitive representation of movement.

Abstract:

:Before movement onset, during the reaction time, excitability of M1 is selectively modulated by somatosensory inputs, only in the movement-related muscle. If a similar mechanism operates before the onset of mental movements, then somatosensory afferent inputs are exploited during cognitive representation of movement. We assessed sensorimotor modulation through short latency afferent inhibition (SAI) paradigm before the onset of executed and imagined movements. Participants performed or imagined an abduction of index or little finger, in response to an acoustic signal. SAI was evaluated between a Warning and a Go signal and 100 ms after the Go signal, before the real or expected EMG activity. Results showed a reduction of SAI after the Go signal, in the movement-related muscle, during motor imagery as well as movement execution. There was a positive correlation between the individual degree of sensorimotor modulation during executed and mental movements and between the sensorimotor modulation during mental movements and motor imagery ability. Sensorimotor modulation operates during the cognitive representation of movement with selective disinhibition of the cortical representation of the muscle involved in the task. Sensorimotor modulation mechanisms prior to mental and executed movements likely share overlapping circuits.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Bonassi G,Bisio A,Lagravinese G,Ruggeri P,Bove M,Avanzino L

doi

10.1016/j.neuroscience.2019.04.031

subject

Has Abstract

pub_date

2019-06-15 00:00:00

pages

16-25

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(19)30280-5

journal_volume

409

pub_type

杂志文章
  • Expression Levels of SMAD Specific E3 Ubiquitin Protein Ligase 2 (Smurf2) and its Interacting Partners Show Region-specific Alterations During Brain Aging.

    abstract::Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD specific E3 ubiquitin protein ligase 2 (smurf2). With age smurf2 expression increases and Smurf2...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.04.003

    authors: Sasik MUT,Eravsar ETK,Kinali M,Ergul AA,Adams MM

    更新日期:2020-06-01 00:00:00

  • Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants.

    abstract::Solid pieces of cerebellar primordia taken from 12-day-old C57BL embryos were implanted into the cerebellar parenchyma of 3- to 4-month-old "Purkinje cell degeneration" mutant mice and analysed 2-3 months later. Purkinje cell replacement was followed by means of immunocytochemistry with antisera against either cyclic ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90002-9

    authors: Sotelo C,Alvarado-Mallart RM

    更新日期:1987-01-01 00:00:00

  • Changes of inter-hemispheric functional connectivity between motor cortices after brachial plexuses injury: a resting-state fMRI study.

    abstract:OBJECT:The aim of this study is to explore the changes of inter-hemispheric functional connectivity in patients with unilateral brachial plexus injury. METHODS:Nine patients with five roots of unilateral brachial plexus avulsion injury and 11 healthy controls were recruited in this study. Resting-state functional conn...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.03.048

    authors: Liu B,Li T,Tang WJ,Zhang JH,Sun HP,Xu WD,Liu HQ,Feng XY

    更新日期:2013-07-23 00:00:00

  • Rapid turnover of spinules at synaptic terminals.

    abstract::Spinules found in brain consist of small invaginations of plasma membranes which enclose membrane evaginations from adjacent cells. Here, we focus on the dynamic properties of the most common type, synaptic spinules, which reside in synaptic terminals. In order to test whether depolarization triggers synaptic spinule ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.02.031

    authors: Tao-Cheng JH,Dosemeci A,Gallant PE,Miller S,Galbraith JA,Winters CA,Azzam R,Reese TS

    更新日期:2009-04-21 00:00:00

  • Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.

    abstract::How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.06.043

    authors: Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

    更新日期:2019-09-01 00:00:00

  • Significance of slow synaptic potentials for transmission of excitation in guinea-pig myenteric plexus.

    abstract::Intracellular recordings were made from neurones in myenteric ganglia of the guinea-pig ileum in vitro. Synaptic potentials were evoked by electrically stimulating presynaptic fibres as they entered the ganglion, using a small focal electrode. Slow synaptic depolarizations (excitatory postsynaptic potentials) were evo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90317-3

    authors: Morita K,North RA

    更新日期:1985-02-01 00:00:00

  • Dexamethasone pre-treatment protects brain against hypoxic-ischemic injury partially through up-regulation of vascular endothelial growth factor A in neonatal rats.

    abstract::Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood. It is known that vascular endothelial growth factor A (VEGF) has neuroprotective effects. The objective of this study was to evaluate the role of the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.01.050

    authors: Feng Y,Rhodes PG,Bhatt AJ

    更新日期:2011-04-14 00:00:00

  • Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.

    abstract::Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.12.041

    authors: Inoue M,Xie W,Matsushita Y,Chun J,Aoki J,Ueda H

    更新日期:2008-03-18 00:00:00

  • Hormonal enhancement of neurogenesis and its relationship to the duration of olfactory memory.

    abstract::On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90314-4

    authors: Kaba H,Rosser AE,Keverne EB

    更新日期:1988-01-01 00:00:00

  • Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes.

    abstract::Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.09.072

    authors: Moeller HB,Fenton RA,Zeuthen T,Macaulay N

    更新日期:2009-12-29 00:00:00

  • Neuronal vulnerability of stroke-prone spontaneously hypertensive rats to ischemia and its prevention with antioxidants such as vitamin E.

    abstract::Stroke-prone spontaneously hypertensive rats (SHRSP/Izm) develop severe hypertension, and more than 95% of them die of cerebral stroke. Hypoxic stimulation followed by oxygen reperfusion induces neuronal damage in both normotensive Wistar Kyoto/Izm (WKY/Izm) and SHRSP/Izm rats, and the percentage of neurons that under...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2010.07.013

    authors: Yamagata K,Tagami M,Yamori Y

    更新日期:2010-09-29 00:00:00

  • Some certainty for the "zone of uncertainty"? Exploring the function of the zona incerta.

    abstract::The zona incerta (ZI), first described over a century ago by Auguste Forel as a "region of which nothing certain can be said," forms a collection of cells that derives from the diencephalon. To this day, we are still not certain of the precise function of this "zone of uncertainty" although many have been proposed, fr...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2004.08.017

    authors: Mitrofanis J

    更新日期:2005-01-01 00:00:00

  • Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

    abstract::Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.04.046

    authors: Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

    更新日期:2016-07-22 00:00:00

  • Binocular matching in monkey visual cortex: single cell responses to correlated and uncorrelated dynamic random dot stereograms.

    abstract::This paper presents results obtained from experiments performed on two behaving monkeys (Macaca mulatta) viewing correlated and uncorrelated dynamic random dot stereograms. Extracellular single unit activity was recorded from areas V1 and V2. We found that cells sensitive to correlated stereograms (38%) were also sens...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90540-v

    authors: Gonzalez F,Krause F,Perez R,Alonso JM,Acuña C

    更新日期:1993-02-01 00:00:00

  • Effects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical minislices: influence of inhibitors of volume-sensitive amino acid transport.

    abstract::Rat cerebrocortical minislices were incubated with physiological saline in the absence or presence of 5 mM ammonium acetate ("ammonia") and/or inhibitors of osmosensitive amino acid transport: 50 microM niflumic acid and 100 microM N-ethyl-maleimide for 60 min, with medium changes after 20 min and 40 min. The efflux o...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00639-3

    authors: Zielińska M,Hilgier W,Law RO,Goryński P,Albrecht J

    更新日期:1999-01-01 00:00:00

  • When a line is a number: color yields magnitude information in a digit-color synesthete.

    abstract::The phenomenon of synesthesia has received a great deal of interest recently in the scientific literature. Many previous studies stressed the unidirectional nature of this phenomenon. For example, color-grapheme synesthetes automatically perceive achromatic numbers as colored (e.g. 7 is turquoise). Conversely, colors ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.08.057

    authors: Cohen Kadosh R,Henik A

    更新日期:2006-01-01 00:00:00

  • A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.

    abstract::Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00401-3

    authors: Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

    更新日期:2002-01-01 00:00:00

  • Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study.

    abstract::Ketamine is a dissociative anesthetic with complex actions on the CNS. We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique. Unanesthetized or ketamine-anesthetized male Sprague...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.01.039

    authors: Porro CA,Cavazzuti M,Giuliani D,Vellani V,Lui F,Baraldi P

    更新日期:2004-01-01 00:00:00

  • Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist.

    abstract::We investigated in this study the pharmacological properties of AC-3933 (5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one), a novel benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 potently inhibited [3H]-flumazenil binding to rat whole brain membrane with a Ki value of 5....

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.10.031

    authors: Hashimoto T,Kiyoshi T,Kohayakawa H,Iwamura Y,Yoshida N

    更新日期:2014-01-03 00:00:00

  • A physiological role for nitric oxide in the centrally mediated sympathetic and somatomotor ejaculatory response in anesthetized male Wistar rats.

    abstract::Neurones in the lumbosacral spinal cord are known to play a significant role in ejaculation. In these same areas neurones containing nitric oxide synthase (NOS) have been described. This raised the question as to whether there is a physiological role for nitrous oxide (NO) in the spinal cord in sexual behavior. We fir...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.09.010

    authors: Brack KE,Watkins N,Pyner S,Coote JH

    更新日期:2007-12-05 00:00:00

  • The development of lasting impairments: a mild pediatric brain injury alters gene expression, dendritic morphology, and synaptic connectivity in the prefrontal cortex of rats.

    abstract::Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.12.034

    authors: Mychasiuk R,Hehar H,Ma I,Kolb B,Esser MJ

    更新日期:2015-03-12 00:00:00

  • Reduction by naloxone of lipopolysaccharide-induced neurotoxicity in mouse cortical neuron-glia co-cultures.

    abstract::An inflammatory response in the CNS mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. Using mouse cortical mixed glia cultures, we have previously demonstrated that the bacterial endotoxin lipopolysaccharide induces the activation of microglia and ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00057-9

    authors: Liu B,Du L,Kong LY,Hudson PM,Wilson BC,Chang RC,Abel HH,Hong JS

    更新日期:2000-01-01 00:00:00

  • Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mdx mouse.

    abstract::Brain edema and severe alterations of the glial and endothelial cells have recently been demonstrated in the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy, and an increase in microvessel density in patients affected by Duchenne muscular dystrophy has also been shown. In order to ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.02.077

    authors: Nico B,Corsi P,Ria R,Crivellato E,Vacca A,Roccaro AM,Mangieri D,Ribatti D,Roncali L

    更新日期:2006-07-07 00:00:00

  • Whole transcriptome expression of trigeminal ganglia compared to dorsal root ganglia in Rattus Norvegicus.

    abstract::The trigeminal ganglia (TG) subserving the head and the dorsal root ganglia (DRG) subserving the rest of the body are homologous handling sensory neurons. Differences exist, as a number of signaling substances cause headache but no pain in the rest of the body. To date, very few genes involved in this difference have ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.03.027

    authors: Kogelman LJA,Christensen RE,Pedersen SH,Bertalan M,Hansen TF,Jansen-Olesen I,Olesen J

    更新日期:2017-05-14 00:00:00

  • Control of slow oscillations in the thalamocortical neuron: a computer model.

    abstract::We investigated computer models of a single thalamocortical neuron to assess the interaction of intrinsic voltage-sensitive channels and cortical synaptic input in producing the range of oscillation frequencies observed in these cells in vivo. A morphologically detailed model with Hodgkin-Huxley-like ion channels demo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)83006-5

    authors: Lytton WW,Destexhe A,Sejnowski TJ

    更新日期:1996-02-01 00:00:00

  • Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.

    abstract::Involvement of the local angiotensin receptor system in the central nervous system is well documented, yet its cellular localization and role in the glial cells have remained elusive. This study reports expression of angiotensin II and its receptors namely, angiotensin II receptor type 1 (AT(1)) and angiotensin II rec...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.11.046

    authors: Li JJ,Lu J,Kaur C,Sivakumar V,Wu CY,Ling EA

    更新日期:2009-02-18 00:00:00

  • Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs.

    abstract::Substance P-like immunoreactivity was localized by an indirect immunohistochemical technique in whole mounts and sections of blood vessels from the guinea-pig. There was a widespread association of nerve fibres that had substance P-like immunoreactivity with blood vessels, extending into all vascular beds. The relativ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90279-2

    authors: Furness JB,Papka RE,Della NG,Costa M,Eskay RL

    更新日期:1982-02-01 00:00:00

  • Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats.

    abstract::Inflammatory processes may play a critical role in the degeneration of basal forebrain cholinergic cells that underlies some of the cognitive impairments associated with Alzheimer's disease. In the present study, the proinflammagen lipopolysaccharide, from the cell wall of Gram-negative bacteria, was used to produce i...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00216-4

    authors: Willard LB,Hauss-Wegrzyniak B,Wenk GL

    更新日期:1999-01-01 00:00:00

  • Central terminals of nociceptors are targets for nicotine suppression of inflammation.

    abstract::Spinal intrathecal administration of nicotine inhibits bradykinin-induced plasma extravasation, a component of the inflammatory response, in the knee joint of the rat in a dose-related fashion. Nociceptors contain nicotinic receptors and activation of a nociceptor at its peripheral terminal, by capsaicin, also produce...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.10.027

    authors: Miao FJ,Green PG,Benowitz N,Levine JD

    更新日期:2004-01-01 00:00:00

  • Paternal deprivation affects social behaviors and neurochemical systems in the offspring of socially monogamous prairie voles.

    abstract::Early life experiences, particularly the experience with parents, are crucial to phenotypic outcomes in both humans and animals. Although the effects of maternal deprivation on offspring well-being have been studied, paternal deprivation (PD) has received little attention despite documented associations between father...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.12.011

    authors: Tabbaa M,Lei K,Liu Y,Wang Z

    更新日期:2017-02-20 00:00:00