Abstract:
:Aging is associated with disturbances in autonomic cardiovascular control. The purpose of this study was to test the hypothesis that changes in nitric oxide occur with aging in brainstem nuclei involved in autonomic cardiovascular control. The principal and unexpected finding in this study was that NADPH-diaphorase reactivity, which is considered a marker of neuronal nitric oxide synthase activity, was decidedly increased in the neuronal bodies of the gracile nucleus but decreased in the axons and axon terminals in old compared with young rats. In situ hybridization also revealed that nitric oxide synthase gene expression was enhanced predominantly in the gracile nucleus neurons of aged rats. The differences between the young and old rats were most dramatically evident in the gracile nucleus, but not evident in other brainstem nuclei. The significance of this finding as it might relate to autonomic or other specific neural dysfunction with aging is not evident at this time.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Ma SX,Holley AT,Sandra A,Cassell MD,Abboud FMsubject
Has Abstractpub_date
1997-02-01 00:00:00pages
659-63issue
3eissn
0306-4522issn
1873-7544pii
S0306452296004794journal_volume
76pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90173-5
更新日期:1989-01-01 00:00:00
abstract::Accumulation of mutant ubiquitin-B (UBB(+1)) in neurons is considered the hallmark of proteasomal dysfunction in neurodegenerative disorders, however no such evidence in ischemic brain has been reported. We investigated the contribution of UBB(+1) in delayed neuronal death after transient global ischemia. Transient gl...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.03.048
更新日期:2007-06-15 00:00:00
abstract::The pedunculopontine nucleus (PPN) shows altered electrophysiological and anatomic characteristics in Parkinson's disease (PD), but little is known about the effect of 6-hydroxydopamine (6-OHDA) lesion and levodopa (L-DOPA) therapy on the relationship between spike and local field potential (LFP) activities in the PPN...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.01.044
更新日期:2019-04-15 00:00:00
abstract::Cranial parasympathetic outflow is mediated through the sphenopalatine ganglion (SPG). The present study was performed to examine the expression of the parasympathetic signaling transmitters and their receptors in human and rat SPG. Indirect immunofluorescence technique was used for the demonstration of vasoactive int...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.10.055
更新日期:2012-01-27 00:00:00
abstract::The mechanisms underlying antiepileptic or antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS) are poorly understood. In this study, we investigated the effect of rTMS applied during rapid amygdala kindling on some electrophysiological properties of hippocampal CA1 pyramidal neurons. Male Wi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.09.022
更新日期:2014-11-07 00:00:00
abstract::The angular vestibulo-ocular reflex maintains gaze during head movements. It is thought to be mediated by two components: direct and velocity storage pathways. The direct angular vestibulo-ocular reflex is conveyed by a three neuron chain from the labyrinth to the ocular motoneurons. The indirect pathway involves a mo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00142-6
更新日期:1999-01-01 00:00:00
abstract::Compulsive drug abuse has been conceptualized as a behavioral state where behavioral stimuli override normal decision making. Clinical studies of methamphetamine users have detailed decision making changes and imaging studies have found altered metabolism and activation in the parietal cortex. To examine the molecular...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.08.076
更新日期:2007-01-05 00:00:00
abstract::The effect of the availability of synaptic targets on neuronal survival was tested by explanting the cochleovestibular ganglion from embryonic day 3-1/2 chick embryos and maintaining it in the presence or absence of appropriate synaptic target tissues for 14 days in culture. The targets were the inner ear, peripherall...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90053-3
更新日期:1985-09-01 00:00:00
abstract::Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in sch...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.08.047
更新日期:2014-11-07 00:00:00
abstract::Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.06.010
更新日期:2018-08-21 00:00:00
abstract::The hippocampus plays an important role in the formation of new memories and spatial navigation. Recently, growing evidence supports the view that it is also involved in addiction to opiates and other drugs. Theoretical and experimental studies suggest that hippocampal neural-network oscillations at specific frequenci...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.09.052
更新日期:2010-12-15 00:00:00
abstract::Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in childr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.07.013
更新日期:2016-10-15 00:00:00
abstract::The acute behavioural and metabolic consequences of functional changes following unilateral intracaudate kainic acid at the level of the feline caudate nucleus, the substantia nigra pars reticulata and the deeper layers of the colliculus superior were investigated. The present study became possible since it was previo...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90240-6
更新日期:1989-01-01 00:00:00
abstract::The influence of transient increases in adrenal steroid hormones on the number of Fos-positive neurons after nociceptor activation was assessed in adrenalectomized rats. Fos protein, the product of the immediate early gene, c-fos, was detected immunocytochemically within the spinal trigeminal nucleus 2 h after noxious...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00624-e
更新日期:1995-06-01 00:00:00
abstract::When human divers or experimental animals are exposed to high pressure, they develop the high-pressure neurological syndrome which is characterized by electroencephalographic changes, and behavioral disturbances. Recently, neurochemical disorders such as a pressure-induced increase in dopamine release have been demons...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90432-2
更新日期:1992-09-01 00:00:00
abstract::It is well established that the supramammillary nucleus plays a critical role in hippocampal theta rhythm generation/regulation by its direct and indirect (via the septal complex) connections to the hippocampus. Previous morphological and electrophysiological studies indicate that both the supramammillo-hippocampal an...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00127-5
更新日期:2000-01-01 00:00:00
abstract::In this study, the nonlinear prediction method combined with Gaussian-scaled surrogate data was used to quantify, as a first goal, the chaotic behavior of the interspike interval of ventral tegmental area dopaminergic neurons, extracellularly recorded in vivo, in anesthetized rats. The second goal was to determine the...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00702-7
更新日期:1999-01-01 00:00:00
abstract::Age-related functional alterations in a variety of neurotransmitter systems result in modulation of interneuronal communications which has some relevance in neurological deficits observed in the aging process. The synergistic interactions between protein kinase and inositol 1,4,5-trisphosphate (insP3)/Ca2+ pathways un...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00298-w
更新日期:1995-12-01 00:00:00
abstract::We studied whether interactions between the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic neurons of the mouse brain cortex occur. Cerebral cortex slices from the mouse (and, in few experiments, from the rat) were preincubated with [3H]noradrenaline and then superfused with a physiologi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00685-9
更新日期:1997-07-01 00:00:00
abstract::Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00010-g
更新日期:1995-08-01 00:00:00
abstract::Excessive expression of vascular endothelial growth factor (VEGF) is a common cause of blood-brain barrier (BBB) breakdown that triggers severe complications following traumatic brain injury (TBI). It has been shown that inhibition of VEGF activities may attenuate cerebral edema in pathological conditions. Vascular en...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.04.042
更新日期:2020-07-01 00:00:00
abstract::The effects of muscarinic agonists on GABAergic synaptic transmission were examined using whole-cell patch-clamp recording in chick brain slices containing the lateral spiriform nucleus. Bath application of muscarine (10 microM) both increased the frequency of spontaneous GABAergic postsynaptic currents and reduced th...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00152-x
更新日期:2001-01-01 00:00:00
abstract::The distribution of wheatgerm agglutinin-horseradish peroxidase-labelled mossy fibre terminals of internal and external cuneate projections to the cerebellar anterior and posterior lobes were quantitatively analysed in adult rats. Computer-based image analysis mapped the spatial distribution of labelled cuneocerebella...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00081-x
更新日期:1997-09-01 00:00:00
abstract::Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90342-4
更新日期:1989-01-01 00:00:00
abstract::Immunoreactive nerve cell bodies and fibres in the intestine have been examined using three antibody preparations raised against 5-hydroxytryptamine. Cross reactivity studies indicate that the substance localized was an hydroxylated indoleamine. In the guinea-pig small intestine, nerve cell bodies were located in the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)90272-x
更新日期:1982-02-01 00:00:00
abstract::Interleukin-1 plays an important role as mediator of endotoxin-induced responses in the brain such as fever, sleep, anorexia, behavioural and neuroendocrine changes. In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and sub...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)00549-k
更新日期:1995-04-01 00:00:00
abstract::Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.02.017
更新日期:2017-04-21 00:00:00
abstract::Extremely mild hypothermia to 36.0 °C is not thought to appreciably differ clinically from 37.0 °C. However, it is possible that 36.0 °C stimulates highly sensitive hypothermic signaling mechanism(s) and alters biochemistry. To the best of our knowledge, no such ultra-sensitive pathway/mechanisms have been described. ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.08.012
更新日期:2015-10-01 00:00:00
abstract::In partially denervated skeletal muscle, spared motor fibres sprout, enlarging motor unit size. Neuritogenesis and sprouting are known to depend on the synaptic input to the neurons. This suggests that spared motoneuron reaction to partial muscle denervation might be controlled by primary sensory neurons which directl...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00506-x
更新日期:1998-05-01 00:00:00
abstract::Glomeruli are functional units of the olfactory bulb responsible for early processing of odor information encoded by single olfactory receptor genes. Glomerular neural circuitry includes numerous external tufted (ET) cells whose rhythmic burst firing may mediate synchronization of bulbar activity with the inhalation c...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.10.041
更新日期:2007-02-09 00:00:00