Repeated transcranial magnetic stimulation prevents kindling-induced changes in electrophysiological properties of rat hippocampal CA1 pyramidal neurons.

abstract：:Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...

journal_title：Neuroscience

authors： Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

更新日期：2016-07-22 00:00:00

abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

journal_title：Neuroscience

authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

更新日期：2015-08-06 00:00:00

abstract：:In this study we have used the transcription assay with 5'-fluorouridine incorporation into nascent RNA to analyze the nuclear organization and dynamics of transcription sites in rat trigeminal ganglia neurons. The 5'-FU administrated by i.p. injection was successfully incorporated into nuclear domains containing acti...

journal_title：Neuroscience

authors： Casafont I,Navascués J,Pena E,Lafarga M,Berciano MT

更新日期：2006-06-30 00:00:00

abstract：:The borders of the ventral striatum and ventral pallidum of the rat brain have been studied with immunocytochemistry for two protein markers that are present in these regions. One of these, DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, Mr 32,000), is specifically enriched in medium-sized spiny neurons of...

journal_title：Neuroscience

authors： Walaas SI,Ouimet CC

更新日期：1989-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is triggered by exposure to traumatic events, but not everyone who experiences trauma develops this disorder. Like humans, PTSD-like symptoms develop in some laboratory rodents (susceptible individuals), while others express less or no symptoms (resilient individuals). Here, consi...

journal_title：Neuroscience

authors： Lguensat A,Bentefour Y,Bennis M,Ba-M'hamed S,Garcia R

更新日期：2019-10-15 00:00:00

abstract：:Remyelination is common under physiological conditions and usually occurs as a response to a pathological demyelinating event. Its potentiation is an important goal for the development of therapies against pathologies such as multiple sclerosis and white matter injury. Visualization and quantification in vivo of demye...

journal_title：Neuroscience

authors： Cisneros-Mejorado AJ,Garay E,Ortiz-Retana J,Concha L,Moctezuma JP,Romero S,Arellano RO

更新日期：2020-07-15 00:00:00

abstract：:The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their targ...

journal_title：Neuroscience

authors： Uusisaari M,Knöpfel T

更新日期：2008-10-15 00:00:00

abstract：:The generation of long-term potentiation of synaptic transmission in area CA1 of hippocampal slices of the guinea-pig has been examined in solutions containing low concentrations of magnesium ions. It was found that the induction of long-term potentiation is greatly facilitated in slices perfused with 0.1 mM magnesium...

journal_title：Neuroscience

authors： Huang YY,Wigström H,Gustafsson B

更新日期：1987-07-01 00:00:00

abstract：:Secretion of neurotrophins is critical for the delivery of neurotrophic support. Brain-derived neurotrophic factor is targeted to a regulated secretory pathway in neurons as well as the neurosecretory AtT-20 cells. Here, we show that pertussis toxin, which inactivates Gi and Go G proteins, inhibits up to 50% of the re...

journal_title：Neuroscience

authors： Gunther EC,von Bartheld CS,Goodman LJ,Johnson JE,Bothwell M

更新日期：2000-01-01 00:00:00

abstract：:X-linked forms of non-specific mental retardation are complex disorders, for which mutations in several genes have recently been identified. These include OPHN1, GDI1, PAK3, IL1RAPL, TM4SF2, FMR2 and RSK2. To investigate the mechanisms through which alterations of these gene products could result in cognitive impairme...

journal_title：Neuroscience

authors： Boda B,Mas C,Muller D

更新日期：2002-01-01 00:00:00

abstract：:The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...

journal_title：Neuroscience

authors： Wyneken U,Smalla KH,Marengo JJ,Soto D,de la Cerda A,Tischmeyer W,Grimm R,Boeckers TM,Wolf G,Orrego F,Gundelfinger ED

更新日期：2001-01-01 00:00:00

abstract：:Sestrin2 (Sesn2) is a stress response protein which expresses neuroprotective characteristics in some neurodegenerative disorders. However, the impact of Sesn2 on the clinical outcome of stroke is unclear. The nuclear factor-erythroid 2 related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway is a key factor in angiogene...

journal_title：Neuroscience

authors： Wang P,Zhao Y,Li Y,Wu J,Yu S,Zhu J,Li L,Zhao Y

更新日期：2019-07-01 00:00:00

abstract：:Drinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of ...

journal_title：Neuroscience

authors： Ieraci A,Herrera DG

更新日期：2020-02-10 00:00:00

abstract：:The sigma1 (sigma 1) receptor agonists exert potent anti-amnesic effects, as they apparently block the learning impairments either induced by the muscarinic receptor antagonist scopolamine, the N-methyl-D-aspartate receptor antagonist dizocilpine or inherently due to the age-related deficits in senescence-accelerated ...

journal_title：Neuroscience

authors： Maurice T,Su TP,Privat A

更新日期：1998-03-01 00:00:00

abstract：:Neurons in the hypothalamic arcuate nucleus (arcuate neurons) were traced on Golgi-impregnated sections. Dendrites of arcuate neurons showed characteristic orientation patterns. Dendrites along the lateral side follow the convex border of the nucleus by running parallel to the tanycyte processes. Neurons located in th...

journal_title：Neuroscience

authors： Réthelyi M

更新日期：1985-10-01 00:00:00

abstract：:A variety of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, and the antiepileptic drug lamotrigine, were examined for their ability to restore locomotion and other behaviours when injected stereotaxically via indwelling cannulae into the striatum or substantia n...

journal_title：Neuroscience

authors： Kaur S,Starr MS

更新日期：1997-01-01 00:00:00

abstract：:I.c.v. injection of L-ornithine has been shown to have sedative and hypnotic effects on neonatal chicks exposed to acute stressful conditions. To clarify the mechanism, we conducted three experiments under strengthened stressful conditions with corticotropin-releasing factor (CRF). In Experiment 1, the effect of i.c.v...

journal_title：Neuroscience

authors： Kurata K,Shigemi K,Tomonaga S,Aoki M,Morishita K,Denbow DM,Furuse M

更新日期：2011-01-13 00:00:00

abstract：:Endomorphin 2 (EM2) plays essential roles in regulating nociceptive transmission within the spinal dorsal horn, where EM2-immunopositive (EM2-IP) fibers and terminals are densely encountered. However, the origins of these EM2-IP structures are still obscure. Unilateral primary sensory afferents disruption (lumbar 3-6 ...

journal_title：Neuroscience

authors： Hui R,Wang W,Chen T,Lü BC,Li H,Zhang T,Wu SX,Li YQ

更新日期：2010-08-11 00:00:00

abstract：:Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor ...

journal_title：Neuroscience

authors： Inoue M,Xie W,Matsushita Y,Chun J,Aoki J,Ueda H

更新日期：2008-03-18 00:00:00

abstract：:The encoding of reward-predictive stimuli by neurons in the nucleus accumbens (NAcc) depends on integrated synaptic activity from the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) afferent inputs. In a previous study, we found that single electrical stimulation pulses applied to the BLA facilitate mPF...

journal_title：Neuroscience

authors： McGinty VB,Grace AA

更新日期：2009-09-15 00:00:00

abstract：:Developmental or degenerative damage of the neuronal architecture in the entorhinal cortex may disintegrate a functional part of hippocampal input since the entorhinal cortex provides a major source of neocortical and subcortical input to the hippocampus. These alterations, such as seen in Alzheimer's disease, schizop...

journal_title：Neuroscience

authors： Falkenberg T,Metsis M,Timmusk T,Lindefors N

更新日期：1993-12-01 00:00:00

abstract：:Aquaporin-4 (AQP4), a water-selective membrane transport protein, is up-regulated in astrocytes in various inflammatory lesions, including Parkinson disease (PD). However, the exact functional roles of AQP4 in neuroinflammation remain unknown. In the present study, we investigated how AQP4 participates in the neuroinf...

journal_title：Neuroscience

authors： Sun H,Liang R,Yang B,Zhou Y,Liu M,Fang F,Ding J,Fan Y,Hu G

更新日期：2016-03-11 00:00:00

abstract：:The distribution of N-methyl-D-aspartate- (NMDA) and kainic acid- (KA) sensitive ionotropic glutamate receptors (iGluR) in the zebrafish olfactory bulb was assessed using an activity-dependent labeling method. Olfactory bulbs were incubated with an ion channel permeant probe, agmatine (AGB), and iGluR agonists in vitr...

journal_title：Neuroscience

authors： Edwards JG,Michel WC

更新日期：2003-01-01 00:00:00

abstract：:Interactions between neurotransmitters and the immune system represent new prospects for understanding neuroinflammation and associated neurological disease. GABA is the chief inhibitory neurotransmitter but its actions on immune pathways in the brain are unclear. In the present study, we investigated GABAergic transp...

journal_title：Neuroscience

authors： Paul AM,Branton WG,Walsh JG,Polyak MJ,Lu JQ,Baker GB,Power C

更新日期：2014-07-25 00:00:00

abstract：:Early life experiences, particularly the experience with parents, are crucial to phenotypic outcomes in both humans and animals. Although the effects of maternal deprivation on offspring well-being have been studied, paternal deprivation (PD) has received little attention despite documented associations between father...

journal_title：Neuroscience

authors： Tabbaa M,Lei K,Liu Y,Wang Z

更新日期：2017-02-20 00:00:00

abstract：:To investigate whether cholinergic hypofunctions in the brain influence hypothalamic-pituitary-adrenal activity, we examined the effects of cholinergic neurotoxin ethylcholine mustard aziridinium ion on basal and stress-induced levels of corticosterone in rats. Blood sampling from rats following intracerebroventricula...

journal_title：Neuroscience

authors： Endo Y,Yamauchi K,Fueta Y

更新日期：2001-01-01 00:00:00

abstract：:There is increasing evidence that alterations in the focus of attention result in changes in neural responding at the most peripheral levels of the auditory system. To date, however, those studies have not ruled out differences in task demands or overall arousal in explaining differences in responding across intermoda...

journal_title：Neuroscience

authors： Srinivasan S,Keil A,Stratis K,Woodruff Carr KL,Smith DW

更新日期：2012-10-25 00:00:00

abstract：:In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...

journal_title：Neuroscience

authors： Kosaka K,Toida K,Margolis FL,Kosaka T

更新日期：1997-02-01 00:00:00

abstract：:The neuronal distributions of somatostatin and neuropeptide Y and their respective mRNAs in hippocampal slice cultures were examined by immunohistochemical staining and in situ hybridization. For the in situ hybridization we used an alkaline phosphatase-labelled oligodeoxynucleotide probe for somatostatin mRNA and an ...

journal_title：Neuroscience

authors： Finsen BR,Tønder N,Augood S,Zimmer J

更新日期：1992-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder for which there is currently no effective treatment. Studies indicate that enhancing autophagy in mouse models of neurodegenerative disease can ameliorate the behavioral symptoms and pathological damage associated with the accumulation of pathol...

journal_title：Neuroscience

authors： Li Y,Guo Y,Wang X,Yu X,Duan W,Hong K,Wang J,Han H,Li C

更新日期：2015-07-09 00:00:00