Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.

abstract：:Microdialysis was combined with a highly sensitive sequential multiple antigen radioimmunoassay to simultaneously measure extracellular cholecystokinin and neurotensin fragments from discrete regions of the rat brain in vivo. The assay was conducted in 96-well plates and provided a limit of detection for both peptides...

journal_title：Neuroscience

authors： Maidment NT,Siddall BJ,Rudolph VR,Erdelyi E,Evans CJ

更新日期：1991-01-01 00:00:00

abstract：:The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

journal_title：Neuroscience

authors： Pandita RK,Nylén A,Andersson KE

更新日期：1998-08-01 00:00:00

abstract：:Perinatal asphyxia and hypoxia are common causes of morbidity in neonates. Prenatal birth associated with hypoxemia often results in several disorders because of the lack of oxygen in the brain. Survival rates from perinatal hypoxia have improved, but appropriate treatments for recovery are still limited, with great i...

journal_title：Neuroscience

authors： Coveñas R,González-Fuentes J,Rivas-Infante E,Lagartos-Donate MJ,Cebada-Sánchez S,Arroyo-Jiménez MM,Insausti R,Marcos P

更新日期：2014-06-20 00:00:00

abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

journal_title：Neuroscience

authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:Angiogenesis after intracerebral hemorrhage (ICH) injury can effectively alleviate brain damage and improve neurological function. Hypoxia-inducible factor 2α (HIF-2α) is an important angiogenic regulator and exhibits protective effects in several neurological diseases; however, its role in ICH has not yet been report...

journal_title：Neuroscience

authors： Chen H,Xiao H,Gan H,Zhang L,Wang L,Li S,Wang D,Li T,Zhai X,Zhao J

更新日期：2020-11-10 00:00:00

abstract：:The neurotensin/neuromedin N precursor molecule possesses four lysine-arginine dibasic residues which represent potential sites of cleavage by proteolytic maturation enzymes. As shown in the preceding paper, all of these dibasic residues are cleaved to a variable extent in rat brain. The aim of the present study was t...

journal_title：Neuroscience

authors： Woulfe J,Lafortune L,de Nadai F,Kitabgi P,Beaudet A

更新日期：1994-05-01 00:00:00

abstract：:The amygdaloid complex plays an essential role in auditory fear conditioning of the Pavlovian type. The available evidence suggests that the lateral nucleus is the input station of the amygdala for auditory conditioned stimuli, whereas the central medial nucleus is the output for conditioned fear responses. However, t...

journal_title：Neuroscience

authors： Paré D,Smith Y,Paré JF

更新日期：1995-11-01 00:00:00

abstract：:Two major systems of cholinergic projection neurons are found within the centrum of the mammalian brain: the basal nuclear complex, projecting predominantly to the cerebral cortex, amygdala, and hippocampus, and the pontomesencephalotegmental network, innervating primarily the thalamus. Neurons comprising the latter n...

journal_title：Neuroscience

authors： Consolo S,Bertorelli R,Forloni GL,Butcher LL

更新日期：1990-01-01 00:00:00

abstract：:Multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), are crucially dependent on the invasion of activated autoreactive lymphocytes and blood macrophages into the central nervous system (CNS). Proinflammatory mononuclear cells and activated local microglia mediate inflammation, demy...

journal_title：Neuroscience

authors： Bibolini MJ,Scerbo MJ,Roth GA,Monferran CG

更新日期：2014-09-26 00:00:00

abstract：:The origin of the corticothalamic projections to the contralateral mediodorsal nucleus, the collateralization of cortical fibers and their synaptic organization in the ipsi- and contralateral mediodorsal nuclei were investigated in adult rats with double retrograde fluorescent and anterograde tracing. After tracer inj...

journal_title：Neuroscience

authors： Négyessy L,Hámori J,Bentivoglio M

更新日期：1998-06-01 00:00:00

abstract：:The somatosensory neocortex processes extrinsic information from the thalamus and intrinsic information from local circuits. We compared the effects of acetylcholine (Ach) on neocortical field potential responses evoked by stimulation of the whiskers and by local electrical stimulation in the upper layers of the neoco...

journal_title：Neuroscience

authors： Oldford E,Castro-Alamancos MA

更新日期：2003-01-01 00:00:00

abstract：:The present study examines the role of central beta-endorphin in the generation of stimulation-induced analgesia from the ventral midbrain periaqueductal gray of freely-moving rats. Electrical stimulation of the ventral midbrain periaqueductal gray led to an antinociception against noxious heat which gradually subside...

journal_title：Neuroscience

authors： Millan MH,Millan MJ,Herz A

更新日期：1986-07-01 00:00:00

abstract：:Nucleotide-activated P2X channels and P2Y metabotropic receptors participate in nociceptive signaling. Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y agonist) and AMP. They provide...

journal_title：Neuroscience

authors： Vongtau HO,Lavoie EG,Sévigny J,Molliver DC

更新日期：2011-10-13 00:00:00

abstract：:Similarities in cellular morphology, afferentation, efferentation, and neurotransmitter content between the internal and external parts of the pallidum and the substantia nigra pars reticulata have long been noted. Here we present evidence that the globus pallidus, entopedunucular nucleus and substantia nigra pars ret...

journal_title：Neuroscience

authors： Sousa R,Hrinya Tannery N,Lafer EM

更新日期：1990-01-01 00:00:00

abstract：:White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly, and cause damage to neurological and psychological functions. Remyelination often fails because of the limited recruitment of oligodendrocyte progenitor cells (OPCs) to the demyelinated site or the inefficient differentiation of...

journal_title：Neuroscience

authors： Du B,Liang M,Zheng H,Fan C,Zhang H,Lu X,Du Z,Lian Y,Zhang Y,Bi X

更新日期：2020-07-01 00:00:00

abstract：:Tetramethylpyrazine (TMP) is an active compound extracted from the traditional Chinese medicinal herb Chuanxiong. Recently, it has been reported that TMP enhances neurogenesis, and promotes neural stem cell differentiation toward neurons. However, its molecular basis remains unknown. Topoisomerase IIβ (TopoIIβ) is a n...

journal_title：Neuroscience

authors： Yan Y,Zhao J,Cao C,Jia Z,Zhou N,Han S,Wang Y,Xu Y,Zhao J,Yan Y,Cui H

更新日期：2014-10-10 00:00:00

abstract：:An in vitro slice preparation of combined hippocampus and entorhinal cortex from adult rats was used to study the modalities of generation and propagation, as well as the pharmacological properties of the epileptiform activity induced by the muscarinic agonist pilocarpine (10 microM). Simultaneous field potentials rec...

journal_title：Neuroscience

authors： Nagao T,Alonso A,Avoli M

更新日期：1996-05-01 00:00:00

abstract：:Calpain-mediated tau cleavage into the neurotoxic tau45-230 fragment plays an important role in Alzheimer's disease (AD). This tau fragment accumulates mainly in the cytoplasm of degenerating neurons. However, subcellular localization studies indicated that a pool of tau45-230 associates with the cytoskeleton in hippo...

journal_title：Neuroscience

authors： Afreen S,Ferreira A

更新日期：2019-08-01 00:00:00

abstract：:Ponto-geniculo-occipital waves and rapid eye movements (eye saccades) are two prominent phasic events of paradoxical sleep which occur in conjunction. Although they have been studied intensively, the neuronal link between these two events is still poorly understood. On the basis of our previous results, combining brai...

journal_title：Neuroscience

authors： Vanni-Mercier G,Debilly G

更新日期：1998-09-01 00:00:00

abstract：:The contributions of several Ca(2+)-dependent processes to neurotoxicity were examined in primary cultures of rat cortical neurons. The Ca2+ ionophore ionomycin induced a rapid loss of axonal morphology and concomitant release of inositol phosphates that preceded morphological alterations of neuronal cell bodies, chol...

journal_title：Neuroscience

authors： Castillo MR,Babson JR

更新日期：1998-10-01 00:00:00

abstract：:The role of GABA(A) receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABA(A) receptor agonist muscimol (50 ng) nor the antagonist bicuculline (200 ng) unilaterally injected into the mdT elicited any behavioural change. Unilateral injection of the acetylcholine receptor ...

journal_title：Neuroscience

authors： Ikeda H,Kotani A,Lee J,Koshikawa N,Cools AR

更新日期：2009-04-10 00:00:00

abstract：:To evaluate the potential for lipofectin-mediated central nervous system gene transfer, the plasmid coding for cholecystokinin was administered intracerebroventricularly to rats, which have congenital audiogenic seizures and high responses to peripheral electric stimulation-induced analgesia. Previous studies had show...

journal_title：Neuroscience

authors： Zhang LX,Li XL,Smith MA,Post RM,Han JS

更新日期：1997-03-01 00:00:00

abstract：:Lampreys are jawless vertebrates, the most basal group of extant vertebrates. This phylogenetic position makes them invaluable models in comparative studies of the vertebrate central nervous system. Lampreys have been used as vertebrate models to study the neuronal circuits underlying locomotion control and axonal reg...

journal_title：Neuroscience

authors： Valle-Maroto SM,Fernández-López B,Villar-Cerviño V,Barreiro-Iglesias A,Anadón R,Rodicio MC

更新日期：2011-10-27 00:00:00

abstract：:The role of brain corticotropin-releasing hormone receptors in modulating hypothalamic-pituitary-adrenal and sympathoadrenal responses to acute immobilization stress was studied in conscious rats under central corticotropin-releasing hormone receptor blockade by intracerebroventricular injection of a peptide corticotr...

journal_title：Neuroscience

authors： Jezova D,Ochedalski T,Glickman M,Kiss A,Aguilera G

更新日期：1999-01-01 00:00:00

abstract：:'Significant' objects contribute greatly to scene recognition. The lateral occipital complex (LOC), parahippocampal place area (PPA), and retrosplenial cortex (RSC) play a crucial role in the cognitive processing of objects and scenes. However, the associated mechanism between objects and scenes remains unclear. In th...

journal_title：Neuroscience

authors： Wang S,Cao L,Xu J,Zhang G,Lou Y,Liu B

更新日期：2018-02-21 00:00:00

abstract：:Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of the channels containing the NR2B subunit and voltage-independent inhibition of those containing NR2A. Thus, it may represent a f...

journal_title：Neuroscience

authors： Gavazzo P,Tedesco M,Chiappalone M,Zanardi I,Marchetti C

更新日期：2011-03-17 00:00:00

abstract：:The effect of re-exposure of rats to an aversive environment on the induction of long-term potentiation was investigated in the CA3 region 3 and 12 h after contextual conditioning. Electro-physiological recordings showed that re-exposure of rats to the conditioning chamber produced a significant and long-lasting decre...

journal_title：Neuroscience

authors： Garcia R,Tocco G,Baudry M,Thompson RF

更新日期：1998-01-01 00:00:00

abstract：:The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expressio...

journal_title：Neuroscience

authors： Sarret C,Combes P,Micheau P,Gelot A,Boespflug-Tanguy O,Vaurs-Barriere C

更新日期：2010-03-17 00:00:00

abstract：:The motor output of hypoglossal motoneurons to tongue muscles takes place in concert with the respiratory rhythm and is determined by the balance between excitatory glutamatergic transmission and inhibitory transmission mediated by glycine or GABA. The relative contribution by these transmitters is a phasic phenomenon...

journal_title：Neuroscience

authors： Pagnotta SE,Lape R,Quitadamo C,Nistri A

更新日期：2005-01-01 00:00:00

abstract：:The auditory system continuously monitors the environment for irregularities in an automatic, preattentive fashion. This is presumably accomplished by two mechanisms: a sensory mechanism detects a deviant sound on the basis of differential refractoriness of neural populations sensitive to the standard and deviant soun...

journal_title：Neuroscience

authors： Szycik GR,Stadler J,Brechmann A,Münte TF

更新日期：2013-12-03 00:00:00