Altered Cytoskeletal Composition and Delayed Neurite Elongation in tau45-230-Expressing Hippocampal Neurons.

abstract：:The purpose of the present study was to investigate, by use of in vivo microdialysis technique, the regulatory role of galanin on acetylcholine (ACh) release in the CA1, CA3, and dentate gyrus (DG) subregions of rat dorsal and ventral hippocampus. In the ventral hippocampus, local infusions of galanin (1.5 nmol) into ...

journal_title：Neuroscience

authors： Yoshitake T,Yoshitake S,Savage S,Elvander-Tottie E,Ogren SO,Kehr J

更新日期：2011-12-01 00:00:00

abstract：:Individuals respond faster to presentations of bisensory stimuli (e.g. audio-visual targets) than to presentations of either unisensory constituent in isolation (i.e. to the auditory-alone or visual-alone components of an audio-visual stimulus). This well-established multisensory speeding effect, termed the redundant ...

journal_title：Neuroscience

authors： Shaw LH,Freedman EG,Crosse MJ,Nicholas E,Chen AM,Braiman MS,Molholm S,Foxe JJ

更新日期：2020-06-01 00:00:00

abstract：:In vivo microdialysis was used to measure the effects of partial deafferentation of cortical cholinergic inputs on acetylcholine efflux in young (four to seven months) and aged (24-28 months) male F344/BNNIA rats. Partial deafferentation was produced by bilateral infusions of the immunotoxin 192 immunoglobulin G-sapor...

journal_title：Neuroscience

authors： Fadel J,Sarter M,Bruno JP

更新日期：1999-03-01 00:00:00

abstract：:The p38 member of the mitogen-activated protein kinase superfamily is engaged by phosphorylation in response to environmental stress signals, and may have either permissive or inhibitor roles upon cell proliferation. The cell cycle in the proliferative zone of the retina is tightly controlled and proceeds in synchrony...

journal_title：Neuroscience

authors： Campos CB,Bédard PA,Linden R

更新日期：2002-01-01 00:00:00

abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...

journal_title：Neuroscience

authors： Haj-Dahmane S,Hamon M,Lanfumey L

更新日期：1991-01-01 00:00:00

abstract：:The identification of leptin and a range of novel anorectic and orexigenic peptides has focussed attention on the neural circuitry involved in the genesis of food intake and the reflex control of thermogenesis. Here, the neurotropic virus pseudorabies has been utilised in conjunction with the immunocytochemical locali...

journal_title：Neuroscience

authors： Oldfield BJ,Giles ME,Watson A,Anderson C,Colvill LM,McKinley MJ

更新日期：2002-01-01 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:In vitro autoradiography was used to examine the N-methyl-D-aspartate receptor in the brain of a baboon species, Papio anubis, and compared to that of Papio papio which exhibits a photosensitive epilepsy. The epilepsy originates in the frontal cortex and is accompanied by an enhanced sensitivity to N-methyl-D-aspartat...

journal_title：Neuroscience

authors： Geddes JW,Cooper SM,Cotman CW,Patel S,Meldrum BS

更新日期：1989-01-01 00:00:00

abstract：:While B2 receptors mediate pain and hyperalgesia induced by bradykinin, in normal rats, recent reports indicate that, in the setting of inflammation, B1 receptors also mediate pain and hyperalgesia. Since bradykinin-induced hyperalgesia in normal rats is mediated by prostaglandins released from the postganglionic symp...

journal_title：Neuroscience

authors： Khasar SG,Miao FJ,Levine JD

更新日期：1995-11-01 00:00:00

abstract：:Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López e...

journal_title：Neuroscience

authors： Hernández-López S,Góngora-Alfaro JL,Martínez-Fong D,Rosales MG,Aceves J

更新日期：1994-09-01 00:00:00

abstract：:Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical ...

journal_title：Neuroscience

authors： Lam YW,Sherman SM

更新日期：2013-07-09 00:00:00

abstract：:Calcium is an important mediator of programmed cell death induced by transient cerebral ischemia, and calcium-binding proteins have been implicated in calcium-regulated signal transduction. Apoptosis-linked gene 2 is a calcium-binding protein required for cell death induced by different apoptotic stimuli. By Western b...

journal_title：Neuroscience

authors： Li W,Jin K,Nagayama T,He X,Chang J,Minami M,Graham SH,Simon RP,Greenberg DA

更新日期：2000-01-01 00:00:00

abstract：:In a previous study it has been demonstrated that fear conditioning is associated with a long-lasting potentiation of parallel fiber to Purkinje cell synaptic transmission in vermal lobules V and VI. Since modifications of intrinsic membrane properties have been suggested to mediate some forms of memory processes, we ...

journal_title：Neuroscience

authors： Zhu L,Scelfo B,Tempia F,Sacchetti B,Strata P

更新日期：2006-07-07 00:00:00

abstract：:The importance and diversity of calcium signaling in the brain is mirrored by the expression of a multitude of voltage-activated calcium channel (Ca(V)) isoforms. Whereas the overall distributions of alpha(1) subunits are well established, the expression patterns of distinct channel isoforms in specific brain regions ...

journal_title：Neuroscience

authors： Schlick B,Flucher BE,Obermair GJ

更新日期：2010-05-19 00:00:00

abstract：:This study was designed to examine the effect of voluntary exercise on hippocampal long-term potentiation (LTP) in morphine-dependent rats. The rats were randomly distributed into the saline-sedentary (Sal/Sed), the dependent-sedentary, the saline-exercise (Sal/Exc), and the dependent-exercise (D/Exc) groups. The Sal/...

journal_title：Neuroscience

authors： Miladi-Gorji H,Rashidy-Pour A,Fathollahi Y,Semnanian S,Jadidi M

更新日期：2014-01-03 00:00:00

abstract：:Increase in proton concentration [H+] or decrease in local and global extracellular pH occurs in both physiological and pathological conditions. Acid-sensing ion channels (ASICs), belonging to the ENaC/Deg superfamily, play an important role in signal transduction as proton sensor. ASICs and in particular ASIC-1a (one...

journal_title：Neuroscience

authors： Natalia Gobetto M,González-Inchauspe Osvaldo D Uchitel C

更新日期：2021-01-22 00:00:00

abstract：:The beta-amyloid precursor protein is the precursor of the main component of senile plaques (the beta-amyloid peptide or beta/A4) found in the brain of aged humans and, in higher amounts, in the brain of Alzheimer's disease and Down's syndrome subjects. Four different forms of beta-amyloid precursor protein messenger ...

journal_title：Neuroscience

authors： Solà C,Mengod G,Probst A,Palacios JM

更新日期：1993-03-01 00:00:00

abstract：:Procedures that restrict or fragment sleep can inhibit neurogenesis in the hippocampus of adult rodents, although the underlying mechanism is unknown. We showed that rapid-eye-movement (REM) sleep deprivation (RSD) by the platform-over-water method inhibits hippocampal cell proliferation in adrenalectomized rats with ...

journal_title：Neuroscience

authors： Mueller AD,Mear RJ,Mistlberger RE

更新日期：2011-10-13 00:00:00

abstract：OBJECTIVE:High-mobility group box 1 (HMGB1), an active receptor for advanced glycation endproducts (RAGE), functions as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of vasculature. Diabetes mellitus (DM) is associated with accelerated development of both microvascular and macrovasc...

journal_title：Neuroscience

authors： Ye X,Chopp M,Liu X,Zacharek A,Cui X,Yan T,Roberts C,Chen J

更新日期：2011-09-08 00:00:00

abstract：:Converging evidence in schizophrenia suggests prefrontal cortical neuronal deficits that correlate with exaggerated subcortical dopamine (DA) functions: Excitotoxic lesion of the ventral hippocampus (VH) in neonatal rats is widely considered a putative animal model of schizophrenia as they lead to characteristic post-...

journal_title：Neuroscience

authors： Bhardwaj SK,Beaudry G,Quirion R,Levesque D,Srivastava LK

更新日期：2003-01-01 00:00:00

abstract：:About 7.5million adults in Germany cannot read and write properly despite attending school for several years. They are considered to be functional illiterates. Since the ability to read and write is crucial for being employed and socially accepted, we developed a literacy training to overcome these deficits. In this s...

journal_title：Neuroscience

authors： Boltzmann M,Mohammadi B,Samii A,Münte TF,Rüsseler J

更新日期：2017-03-06 00:00:00

abstract：:N-methyl-D-aspartate-receptors are implicated in several neuropathological conditions including epilepsy. As a model of complex partial seizures, rapid hippocampal kindling was chosen to investigate changes in the expression of messenger RNAs encoding the N-methyl-D-aspartate-receptor subunits NR1, NR2A and NR2B both ...

journal_title：Neuroscience

authors： Pratt GD,Kokaia M,Bengzon J,Kokaia Z,Fritschy JM,Möhler H,Lindvall O

更新日期：1993-11-01 00:00:00

abstract：:Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and gamma-aminobutiric acid (GABA) neurons that are distributed in several VTA sub-nuclei. Here, we investig...

journal_title：Neuroscience

authors： Cornejo MP,Barrile F,De Francesco PN,Portiansky EL,Reynaldo M,Perello M

更新日期：2018-11-10 00:00:00

abstract：:Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

journal_title：Neuroscience

authors： Dipietrantonio HJ,Dymecki SM

更新日期：2009-09-01 00:00:00

abstract：:Stress and withdrawal of female reproductive hormones are known risk factors of postpartum depression. Although both of these factors are capable of powerfully modulating neuronal plasticity, there is no direct electron microscopic evidence of hippocampal spine synapse remodeling in postpartum depression. To address t...

journal_title：Neuroscience

authors： Baka J,Csakvari E,Huzian O,Dobos N,Siklos L,Leranth C,MacLusky NJ,Duman RS,Hajszan T

更新日期：2017-02-20 00:00:00

abstract：:Neurofibrillary tangles in Alzheimer's disease are composed of hyperphosphorylated forms of the microtubule-associated protein tau. Based on biochemical criteria, several enzymes have emerged as potential tau protein kinases, including the extracellularly regulated kinases 1, 2 and 3. In situ hybridization was used to...

journal_title：Neuroscience

authors： Hollister RD,Page KJ,Hyman BT

更新日期：1997-08-01 00:00:00

abstract：:A few hours after peripheral axons of cutaneous afferent neurons have been transected, some of their novel endings become excitable by physical or chemical stimuli. It has been assumed that these axon endings preferentially respond to those stimuli which have excited their previous receptive endings. We studied the pr...

journal_title：Neuroscience

authors： Michaelis M,Blenk KH,Vogel C,Jänig W

更新日期：1999-01-01 00:00:00

abstract：:In spite of the existence of pedunculopontine tegmental nucleus (PPTg) projections to cerebellar nuclei, their nature and functional role is unknown. These fibers may play a crucial role in postural control and may be involved in the beneficial effects induced by deep-brain stimulation (DBS) of brainstem structures in...

journal_title：Neuroscience

authors： Vitale F,Mattei C,Capozzo A,Pietrantoni I,Mazzone P,Scarnati E

更新日期：2016-03-11 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) plays a central role in brain development, regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in 5-HT signaling early in life have critical implications for behavior and mental health across the life span. Drawing on preclinical and emerg...

journal_title：Neuroscience

authors： Brummelte S,Mc Glanaghy E,Bonnin A,Oberlander TF

更新日期：2017-02-07 00:00:00

abstract：:Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes on a genome-wide scale. New methods for high-throughput genotyping have changed the priority for biomedical research to phenotyping, but the human phenome is vast and its dimensionality remains unknown. Phenomics research strategi...

journal_title：Neuroscience

authors： Bilder RM,Sabb FW,Cannon TD,London ED,Jentsch JD,Parker DS,Poldrack RA,Evans C,Freimer NB

更新日期：2009-11-24 00:00:00