Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei.

abstract：:Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...

journal_title：Neuroscience

authors： Zhou Z,Chen S,Zhao H,Wang C,Gao K,Guo Y,Shen Z,Wang Y,Wang H,Mei X

更新日期：2016-08-04 00:00:00

abstract：:Synucleinopathies including Parkinson's disease (PD) are characterized by the accumulation of alpha-synuclein (α-syn) within neural cell bodies and their processes. Transgenic mice overexpressing human wild-type or mutant forms of α-syn under the control of different promoters were developed to analyse the underlying ...

journal_title：Neuroscience

authors： May VE,Nuber S,Marxreiter F,Riess O,Winner B,Winkler J

更新日期：2012-10-11 00:00:00

abstract：:Cytoplasmic pH (pH1) of crayfish lateral giant axons was monitored using antimony microelectrodes placed near septate junctions and variations of internal pH was induced by short applications of ammonium sulfate in the perfusing bath of the preparation. This treatment produced a rapid cell alkalinization followed, aft...

journal_title：Neuroscience

authors： Giaume C,Korn H

更新日期：1982-07-01 00:00:00

abstract：:Previous studies have raised the possibility that a decrease in voltage-gated K+ currents may contribute to hyperexcitability of injured dorsal root ganglion (DRG) neurons and the emergence of neuropathic pain. We examined the effects of axotomy on mRNA levels for various Kv1 family subunits and voltage-gated K+ curre...

journal_title：Neuroscience

authors： Yang EK,Takimoto K,Hayashi Y,de Groat WC,Yoshimura N

更新日期：2004-01-01 00:00:00

abstract：:The solitary nucleus (nucleus tractus solitarii), the first central relay for taste in mammals, was studied anatomically and physiologically in the golden hamster (Mesocricetus auratus). Activity of neurons to anterior tongue stimulation with sucrose, NaCl and KCl were extracellularly recorded. Electrolytic lesions or...

journal_title：Neuroscience

authors： McPheeters M,Hettinger TP,Nuding SC,Savoy LD,Whitehead MC,Frank ME

更新日期：1990-01-01 00:00:00

abstract：:An electropharmacological analysis of the type(s) of calcium channel controlling neurotransmitter release in preganglionic sympathetic nerve terminals in the guinea-pig anterior pelvic ganglion has been carried out. Conventional intracellular recording techniques were used to record excitatory postsynaptic potentials ...

journal_title：Neuroscience

authors： Smith AB,Cunnane TC

更新日期：1999-01-01 00:00:00

abstract：:Monoamine oxidase, monoamine oxidase-A, and monoamine oxidase-B activities were compared in free moving, rapid eye movement sleep-deprived, recovered, and control rat brains. The activities were estimated in the whole brain, cerebrum, cerebellum, whole brainstem, medulla, pons, and midbrain. The flowerpot method was u...

journal_title：Neuroscience

authors： Thakkar M,Mallick BN

更新日期：1993-08-01 00:00:00

abstract：:In the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the Na+-dependent glutamate transporter, which was activated by extracellular K+. Glutamate transport current was measured by a conventional whole-cell patch recording mode under voltage-clamp co...

journal_title：Neuroscience

authors： Noda M,Nakanishi H,Akaike N

更新日期：1999-01-01 00:00:00

abstract：:In a natural acoustic environment, sound stimuli often occur in a contextual acoustic stream. The aim of the present study was to determine how the frequency tuning of auditory cortical neurons is affected by an acoustic context. A forward masking paradigm was used to determine the frequency receptive fields of rat au...

journal_title：Neuroscience

authors： Peng Y,Sun X,Zhang J

更新日期：2010-09-01 00:00:00

abstract：:The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...

journal_title：Neuroscience

authors： Li J,Wu C,Zheng Y,Li R,Li X,She S,Wu H,Peng H,Ning Y,Li L

更新日期：2017-09-17 00:00:00

abstract：:Mutations in γ-aminobutyric acid A receptor (GABAA) subunits and sodium channel genes, especially GABRG2 and SCN1A, have been reported to be associated with febrile seizures (FS) and genetic epilepsy with febrile seizures plus (GEFS+). GEFS+ is a well-known family of epileptic syndrome with autosomal dominant inherita...

journal_title：Neuroscience

authors： Li X,Guo S,Liu K,Zhang C,Chang H,Yang W,Rong S,Hu Q,Cui J,Wang F,Sun T

更新日期：2020-07-01 00:00:00

abstract：:Nucleus raphe magnus contains a large population of raphe-spinal serotonergic neurons that are thought to be involved in descending control of pain transmission and the modulation of opioid analgesia. Intracellular recordings were made from nucleus raphe magnus neurons in the slice preparation. Cells were divided into...

journal_title：Neuroscience

authors： Pan ZZ,Wessendorf MW,Williams JT

更新日期：1993-05-01 00:00:00

abstract：:The cognitive impairment characterizing the phenotype of older adults has been related to the efficiency of the antioxidant system. This study aimed at investigating the effect of memory training (MT) on memory, global cognitive functioning, and the oxidant and antioxidant capacity of plasma. We recruited 52 healthy s...

journal_title：Neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Patruno A,Ballerini P,De Lutiis MA,Felaco M,Grilli A

更新日期：2018-02-01 00:00:00

abstract：:Types and projections of neurons that received cholinergic, purinergic and other fast excitatory synaptic inputs in myenteric ganglia of the guinea-pig distal colon were identified using combined electrophysiological recording, application of selective antagonists, marker dye filling via the recording microelectrode, ...

journal_title：Neuroscience

authors： Nurgali K,Furness JB,Stebbing MJ

更新日期：2003-01-01 00:00:00

abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

journal_title：Neuroscience

authors： Yamamoto Y,Carter CS,Cushing BS

更新日期：2006-01-01 00:00:00

abstract：:Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...

journal_title：Neuroscience

authors： Klarica M,Miše B,Vladić A,Radoš M,Orešković D

更新日期：2013-09-17 00:00:00

abstract：:High densities of mRNAs for three rhythm-related genes, rPeriod1 (rPer1), rPer2, and rClock, which share high homology in Drosophila and mice, were found in the hypothalamic suprachiasmatic nucleus (SCN). The SCN, however, is not the only brain region that expresses these genes. To understand the distributions and pos...

journal_title：Neuroscience

authors： Shieh KR

更新日期：2003-01-01 00:00:00

abstract：:Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during t...

journal_title：Neuroscience

authors： Hueston CM,Cryan JF,Nolan YM

更新日期：2017-12-04 00:00:00

abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

journal_title：Neuroscience

authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

更新日期：2016-03-01 00:00:00

abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

journal_title：Neuroscience

authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

更新日期：2020-04-30 00:00:00

abstract：:Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

journal_title：Neuroscience

authors： Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

更新日期：2019-05-15 00:00:00

abstract：:DNA repair is one of the most essential systems for maintaining the inherited nucleotide sequence of genomic DNA over time. Repair of DNA damage would be particularly important in neurons, because these cells are among the longest-living cells in the body. MSH2 is one of the proteins which are involved in the recognit...

journal_title：Neuroscience

authors： Belloni M,Uberti D,Rizzini C,Ferrari-Toninelli G,Rizzonelli P,Jiricny J,Spano P,Memo M

更新日期：1999-01-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:The study of architectonic differentiation in the cortex is advanced by the articulation of objective definitions based on clear features of the cortical architecture. We adopted areal density profiles as a means of sampling the cortex. On the profiles, we isolated and quantified the density of individual cortical lay...

journal_title：Neuroscience

authors： Mackey S,Petrides M

更新日期：2009-03-31 00:00:00

abstract：:The neuropeptide PACAP modulates synaptic transmission in the hippocampus exerting multiple effects through different receptor subtypes: the underlying mechanisms have not yet been completely elucidated. The neurotransmitter acetylcholine (ACh) also exerts a well-documented modulation of hippocampal synaptic transmiss...

journal_title：Neuroscience

authors： Pecoraro V,Sardone LM,Chisari M,Licata F,Li Volsi G,Perciavalle V,Ciranna L,Costa L

更新日期：2017-01-06 00:00:00

abstract：:To evaluate the potential for lipofectin-mediated central nervous system gene transfer, the plasmid coding for cholecystokinin was administered intracerebroventricularly to rats, which have congenital audiogenic seizures and high responses to peripheral electric stimulation-induced analgesia. Previous studies had show...

journal_title：Neuroscience

authors： Zhang LX,Li XL,Smith MA,Post RM,Han JS

更新日期：1997-03-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) was investigated in the present study to examine whether it could affect the activation status of microglia under microenvironment of spinal cord injury and provide a potential therapeutic treatment for spinal cord injury. We established mouse spinal cord hemisection model...

journal_title：Neuroscience

authors： Guo Y,Zhang H,Yang J,Liu S,Bing L,Gao J,Hao A

更新日期：2013-05-15 00:00:00

abstract：:Brain microvascular endothelial cell (BMEC) injury induced by ischemia-reperfusion (I/R) is the initial stage of blood-brain barrier (BBB) disruption, which results in a poor prognosis in ischemic stroke patients. Autophagy has been shown to have protective effects on BMECs against cerebral ischemic insults. However, ...

journal_title：Neuroscience

authors： Li Z,Li J,Tang N

更新日期：2017-06-23 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) can provide noninvasive detection of brain metabolite changes in vivo in Alzheimer's disease (AD). AD is a prevalent neurodegenerative disorder characterized by deposition of β-amyloid peptides (Aβ) in multiple brain regions. Brain-derived neurotrophic factor (BDNF) is a...

journal_title：Neuroscience

authors： Zhang W,Wang PJ,Li MH,Gao XL,Gu GJ,Shao ZH

更新日期：2013-08-15 00:00:00

abstract：:For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...

journal_title：Neuroscience

authors： Jones OD

更新日期：2015-11-19 00:00:00