Age-related attenuation of stimulated cortical acetylcholine release in basal forebrain-lesioned rats.

abstract：:Sensory-evoked propagating waves are frequently observed in sensory cortex. However, it is largely unknown how an evoked propagating wave affects the activity evoked by subsequent sensory inputs, or how two propagating waves interact when evoked by simultaneous sensory inputs. Using voltage-sensitive dye imaging, we i...

journal_title：Neuroscience

authors： Gao X,Xu W,Wang Z,Takagaki K,Li B,Wu JY

更新日期：2012-08-02 00:00:00

abstract：:Age-related functional alterations in a variety of neurotransmitter systems result in modulation of interneuronal communications which has some relevance in neurological deficits observed in the aging process. The synergistic interactions between protein kinase and inositol 1,4,5-trisphosphate (insP3)/Ca2+ pathways un...

journal_title：Neuroscience

authors： Igwe OJ,Filla MB

更新日期：1995-12-01 00:00:00

abstract：:In the olfactory system, the endocannabinoid system (ECS) regulates sensory perception and memory. A major structure involved in these processes is the anterior piriform cortex (aPC), but the impact of ECS signaling in aPC circuitry is still scantly characterized. Using ex vivo patch clamp experiments in mice and neur...

journal_title：Neuroscience

authors： Terral G,Varilh M,Cannich A,Massa F,Ferreira G,Marsicano G

更新日期：2020-05-01 00:00:00

abstract：:Visually evoked behaviors mediated by the frog optic tectum require cholinergic activity, but the receptor subtypes through which acetylcholine acts are not yet identified. Using quantitative autoradiography and scintillation spectrometry, we examined the binding of [3H]pirenzepine and [3H]AF-DX 384 in the laminated o...

journal_title：Neuroscience

authors： Butt CM,Pauly JR,Wilkins LH,Dwoskin LP,Debski EA

更新日期：2001-01-01 00:00:00

abstract：:Professional Pingju actors have been shown to exhibit practice-induced plastic changes in spontaneous regional brain activity; however, whether these changes are present in resting-state regional cerebral blood flow (CBF) remains largely unclear. Here, twenty professional Pingju opera actors and 20 age-, sex-, and han...

journal_title：Neuroscience

authors： Zhao F,Zhang W,Zhu D,Wang X,Qin W,Liu F

更新日期：2020-06-01 00:00:00

abstract：:Our recent data suggest that noradrenaline (NA) regulates expression of Per1 mRNA in rat C6 cells, as a model of brain astrocytes, by two distinct NA-mediating pathways. Although C6 cells possess potential astrocyte-type characteristics, we hypothesize that astrocytes located in a distinct tissue or organ play specifi...

journal_title：Neuroscience

authors： Sugimoto T,Morioka N,Sato K,Hisaoka K,Nakata Y

更新日期：2011-06-30 00:00:00

abstract：:Parvalbumin is a calcium-binding protein which is thought to play a role in neuronal excitability. In the cerebral cortex parvalbumin is largely found in two subsets of GABAergic neurons, the chandelier and basket cells. A distinguishing characteristic of the chandelier cell is that the terminal portions of its axon f...

journal_title：Neuroscience

authors： Fonseca M,Soriano E,Ferrer I,Martinez A,Tuñon T

更新日期：1993-08-01 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...

journal_title：Neuroscience

authors： Listwak SJ,Rathore P,Herkenham M

更新日期：2013-10-10 00:00:00

abstract：:Ovarian hormones regulate pyramidal cell synapse formation and excitability and interneuronal GABAergic tone in the CA1 region of the adult female rat hippocampus. The role of 17beta-estradiol in these effects is complex and appears to involve a subset of hippocampal interneurons, which express different calcium-bindi...

journal_title：Neuroscience

authors： Nakamura NH,McEwen BS

更新日期：2005-01-01 00:00:00

abstract：:Both systemic and intrathecal capsaicin release and deplete substance P from primary sensory afferents and induce prolonged chemical and thermal analgesia. Given the existence of efferents containing substance P together with a pain-inhibitory serotoninergic pathway, the present study investigated the effects of intra...

journal_title：Neuroscience

authors： Bodnar RJ,Kirchgessner A,Nilaver G,Mulhern J,Zimmerman EA

更新日期：1982-03-01 00:00:00

abstract：:Emerging evidence suggests that brain aquaporins (AQP) play important roles for the dynamic regulation of brain water homeostasis and for the regulation of cerebrospinal fluid production. This review deals with the short- and long-term regulation of AQP4 and AQP9, both expressed in astrocytes, and of AQP1, expressed i...

journal_title：Neuroscience

authors： Gunnarson E,Zelenina M,Aperia A

更新日期：2004-01-01 00:00:00

abstract：:The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

journal_title：Neuroscience

authors： Pandita RK,Nylén A,Andersson KE

更新日期：1998-08-01 00:00:00

abstract：:Neurotransmitter release regulation is highly heterogeneous across the brain. The fundamental units of release, individual boutons, are difficult to access and poorly understood. Here we directly activated single boutons on mechanically isolated nucleus tractus solitarius (NTS) neurons to record unitary synaptic event...

journal_title：Neuroscience

authors： Jin YH,Andresen MC

更新日期：2011-10-13 00:00:00

abstract：:We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....

journal_title：Neuroscience

authors： Lockerbie RO,Autillo-Touati A,Araud D,Seite R,Chneiweiss H,Glowinski J,Prochiantz A

更新日期：1989-01-01 00:00:00

abstract：:The posterior parahippocampal gyrus (PPHG) of the non-human primate brain has a distinct dual role in cortical neural systems. On the one hand, it is a critical link in providing the entorhinal cortex and hippocampal formation with cortical input, while on the other hand it receives output from these structures and pr...

journal_title：Neuroscience

authors： Thangavel R,Van Hoesen GW,Zaheer A

更新日期：2008-06-23 00:00:00

abstract：:Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues from 22 non-familial s...

journal_title：Neuroscience

authors： Lonskaya I,Hebron ML,Algarzae NK,Desforges N,Moussa CE

更新日期：2013-03-01 00:00:00

abstract：:Arising from studies on the amnesia that follows site-specific physical or chemical lesions, the acquisition and consolidation of certain behavioral tasks has been demonstrated to be associated with different hippocampal subregions. Although not absolute, spatial learning is reliant on the dorsal region of the hippoca...

journal_title：Neuroscience

authors： Scully D,Fedriani R,Desouza IE,Murphy KJ,Regan CM

更新日期：2012-05-03 00:00:00

abstract：:Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating synaptic transmission in the central nervous system (CNS). However, there is lack of information about the mechanisms underlying the regulation of amino-acid transport by fast-acting neuromodulators, like ATP. Here, we investigate...

journal_title：Neuroscience

authors： Barros-Barbosa AR,Lobo MG,Ferreirinha F,Correia-de-Sá P,Cordeiro JM

更新日期：2015-10-15 00:00:00

abstract：:Cognitive impairment is one of the common non-motor symptoms in Parkinson's disease (PD). The hippocampus is a critical structure for learning and memory processes. The abnormal synaptic plasticity in the hippocampus is suggested to be associated with cognitive dysfunction in PD. Voltage gated sodium channels (VGSCs) ...

journal_title：Neuroscience

authors： Wang Z,Lin Y,Liu W,Kuang P,Lao W,Ji Y,Zhu H

更新日期：2019-10-15 00:00:00

abstract：:The modulation of the firing discharge of medial septal neurons and of the hippocampal electroencephalogram (EEG) mediated by actions on alpha2-adrenoreceptors (ARs) was investigated in awake rabbits. Bilateral i.c.v. infusion of a relatively low dose (0.5 microg) of the alpha2-AR agonist clonidine produced a reductio...

journal_title：Neuroscience

authors： Kitchigina VF,Kutyreva EV,Brazhnik ES

更新日期：2003-01-01 00:00:00

abstract：:Brain activities in response to acupuncture have been investigated in multiple studies; however, the neuromechanisms of low- and high-frequency transcutaneous electric acupoint stimulation (TEAS) analgesia are unclear. This work aimed to investigate how brain activity and the analgesic effect changed across 30-min low...

journal_title：Neuroscience

authors： Jiang Y,Liu J,Liu J,Han J,Wang X,Cui C

更新日期：2014-05-30 00:00:00

abstract：:Training of a musical skill is known to produce a distributed neural representation of the ability to perceive music and perform musical tasks. In the present study we tested the hypothesis that the audiovisual perception of music involves a wider activation of multimodal sensory and sensorimotor structures in the bra...

journal_title：Neuroscience

authors： Srinivasan N,Bishop J,Yekovich R,Rosenfield DB,Helekar SA

更新日期：2020-10-15 00:00:00

abstract：:It has previously been found that, in the presence of naloxone, the ganglionic blocking drug hexamethonium fails to completely block peristaltic motility in the isolated ileum of the guinea-pig. This hexamethonium-resistant peristaltic activity is coordinated by enteric nerves since it is abolished by tetrodotoxin. In...

journal_title：Neuroscience

authors： Barthó L,Holzer P,Leander S,Lembeck F

更新日期：1989-01-01 00:00:00

abstract：:The mechanism underlying phencyclidine (PCP)-induced apoptosis in perinatal rats and the development of schizophrenia-like behaviors is incompletely understood. We used antagonists for N-methyl-D-aspartate (NMDA) receptor subunit NR2A- and NR2B-containing NMDA receptor to test the hypothesis that the behavioral and ap...

journal_title：Neuroscience

authors： Anastasio NC,Xia Y,O'Connor ZR,Johnson KM

更新日期：2009-11-10 00:00:00

abstract：:The results of a previous experiment suggest that the cell bodies of many jaw closing muscle spindle afferents in the trigeminal mesencephalic nucleus of the rabbit are phasically inhibited during fictive mastication. The aim of this study was to investigate one possible neurotransmitter system that could be involved ...

journal_title：Neuroscience

authors： Kolta A,Dubuc R,Lund JP

更新日期：1993-04-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

journal_title：Neuroscience

authors： van Vliet EA,Aronica E,Gorter JA

更新日期：2014-09-26 00:00:00

abstract：:Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These Gi/o-coupled inhibitory receptors play a major part in shaping dopamine transmission. Found at both somatodendritic and axonal sites, autoreceptors regulate the firi...

journal_title：Neuroscience

authors： Ford CP

更新日期：2014-12-12 00:00:00

abstract：:In these experiments a large portion of the pelvic ganglion of adult female rats was transplanted into the wall of the urinary bladder of the same animals. The morphology and fine structure of the transplants were studied in whole-mounts and in sections for light and electron microscopy, from two days up to four month...

journal_title：Neuroscience

authors： Gabella G,Uvelius B

更新日期：1998-03-01 00:00:00

abstract：:Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes in...

journal_title：Neuroscience

authors： Barnett JH,Smoller JW

更新日期：2009-11-24 00:00:00

abstract：:Animals change their biological activities depending on their nutritional state. Reproductive functions, including sexual behavior, are suppressed under low-energy conditions; however, the underlying neuronal mechanism is poorly understood. Neuropeptide Y (NPY) is an orexigenic molecule released in response to low-ene...

journal_title：Neuroscience

authors： Inaba A,Komori Y,Muroi Y,Kinoshita K,Ishii T

更新日期：2016-04-21 00:00:00