Abstract:
:Both systemic and intrathecal capsaicin release and deplete substance P from primary sensory afferents and induce prolonged chemical and thermal analgesia. Given the existence of efferents containing substance P together with a pain-inhibitory serotoninergic pathway, the present study investigated the effects of intraventricular capsaicin upon basal nociception, analgesic responsivity to opiates and substance P immunoreactivity. Following treatment with capsaicin at doses of 25, 50 and 100 micrograms or with vehicle, alterations in basal rodent flinch-jump thresholds as well as analgesic responses to 5 and 2.5 mg/kg of morphine were measured over a post-injection time course. Tissues were then processed for immunocytochemistry for substance P according to the unlabelled antibody peroxidase antiperoxidase procedure. Decreases were noted in jump thresholds only at 72 h following capsaicin. Moreover, morphine analgesia at both doses was attenuated in dose-dependent fashion following capsaicin with the highest dose (100 micrograms) producing a significant decrease in analgesic efficacy. Substance P-like immunoreactivity in capsaicin-treated rats was not appreciably depleted compared with vehicle controls in the substantia gelatinosa of the spinal cord and V cranial nerve, the raphe magnus and periaqueductal gray, the medullary, pontine and mesencephalic reticular formation, the substantia nigra, the corpus striatum and the central nucleus of the amygdala. By contrast, substance P-like immunoreactivity appeared to increase in the medial nucleus of the amygdala. In the absence of depletion of substance P immunoreactivity by the intraventricular capsaicin, the observed alterations in opiate analgesic responses may possibly be due to alterations in other transmitters or peptide systems.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Bodnar RJ,Kirchgessner A,Nilaver G,Mulhern J,Zimmerman EAdoi
10.1016/0306-4522(82)90068-9subject
Has Abstractpub_date
1982-03-01 00:00:00pages
631-8issue
3eissn
0306-4522issn
1873-7544pii
0306-4522(82)90068-9journal_volume
7pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Intracellular recordings were made from neurones in the thalamic reticular nucleus (TRN) and ventro-basal (VB) thalamus in slices of rat midbrain in vitro. Electrical stimulation of the medial lemniscus or TRN resulted in the generation of complex synaptic potentials containing disynaptic inhibitory post-synaptic pote...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2003.08.014
更新日期:2003-01-01 00:00:00
abstract::The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00469-3
更新日期:2001-01-01 00:00:00
abstract::Amyloid-β (Aβ) production and clearance in the brain is a crucial focus of investigations into the pathogenesis of Alzheimer disease. Imbalance between production and clearance leads to accumulation of Aβ. The important Aβ-degrading enzymes in the brain are neprilysin (NEP) and insulin-degrading enzyme (IDE), and defe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.08.030
更新日期:2017-10-24 00:00:00
abstract::Rapid eye movement (REM) sleep deprivation elevates noradrenaline level, which upon acting on alpha1-adrenoceptors increases Na-K-ATPase activity; however, the detailed intracellular mechanism of action was unknown. Since membrane integrity is crucial for maintaining Na-K-ATPase activity as well as ionic exchange and ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.04.069
更新日期:2008-07-31 00:00:00
abstract::Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.09.007
更新日期:2009-12-15 00:00:00
abstract::The effect of pairing two vibrissa stimulations on unit responses of the barrel field of the somatosensory cortex were studied in partially restrained but awake and undrugged rats. Before pairing, one of the stimulations (S2) evoked a stable, short-latency and excitatory response from the recorded unit. Depending on t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(87)90271-5
更新日期:1987-10-01 00:00:00
abstract::Brain-derived neurotrophic factor, basic fibroblast growth factor and des(1-3)-insulin-like growth factor-1, a brain specific form of insulin-like growth factor-1, were analysed, in the rat, for their influence on survival, morphological growth, and transmitter-specific differentiation of dopaminergic neurons in vitro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90534-m
更新日期:1993-02-01 00:00:00
abstract::We have investigated the effect of intracranial injections of the amnestic anti-metabolite, 2-deoxygalactose, and antibodies to the neural cell adhesion molecule on retention of a one-trial passive avoidance task in chicks. Groups of chicks received bilateral intracranial injections of 10 mumol/hemisphere 2-deoxygalac...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90519-l
更新日期:1993-07-01 00:00:00
abstract::Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule. The SNr receives one of the highest densit...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.10.005
更新日期:2010-01-13 00:00:00
abstract::Levels of the pro-inflammatory cytokine interleukin-1beta are known to be elevated in patients with chronic disorders such as Alzheimer's disease. We have investigated the effects of interleukin-1beta on long-term potentiation and N-methyl-D-aspartate receptor-mediated field potentials in the rat dentate gyrus in vitr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00100-1
更新日期:1999-01-01 00:00:00
abstract::The cerebral peptidergic caudodorsal cells of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying behaviour by releasing peptides into (1) the haemolymph, from neurohaemal axon terminals in the periphery of the cerebral commissure and (2) the intercellular space of the central nervous system, from...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(88)90149-2
更新日期:1988-07-01 00:00:00
abstract::Inflammation is crucially involved in many diseases of the CNS. Immune cells may attack the CNS, as in multiple sclerosis, and therefore be responsible for primary damage. Immune cells may also be activated by injury to the CNS, as for example in stroke or brain trauma, secondarily enhancing lesion growth. In general,...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2008.10.005
更新日期:2009-02-06 00:00:00
abstract::Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.01.024
更新日期:2020-03-15 00:00:00
abstract::Up-regulation of proBDNF in ischemic brain and the detrimental role of proBDNF on cellular survival has already been established. We propose that the up-regulated proBDNF may trigger the harmful events and evoke a secondary ischemic damage after ischemia. This study aimed to establish the neuroprotective effects of an...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2020.08.008
更新日期:2020-10-15 00:00:00
abstract::Studies in experimental animals have revealed important roles of neuroactive steroids in the control of central nervous system functions during physiological and pathological conditions, suggesting that they may represent good candidates for the development of neuroprotective strategies for neurodegenerative and psych...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2011.06.024
更新日期:2011-09-15 00:00:00
abstract::Epigenetic modulation participates in the mechanism of multiple types of pathological pain, so targeting the involved regulators may be a promising strategy for pain treatment. Our previous research identified the analgesic effect of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) on mechanical hyperalge...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.02.026
更新日期:2018-05-01 00:00:00
abstract::Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and gamma-aminobutiric acid (GABA) neurons that are distributed in several VTA sub-nuclei. Here, we investig...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.09.027
更新日期:2018-11-10 00:00:00
abstract::In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00308-9
更新日期:1997-02-01 00:00:00
abstract::Although multiple effects of GABA(B) receptor activation on synaptic transmission in the striatum have been described, the precise locations of the receptors mediating these effects have not been determined. To address this issue, we carried out pre-embedding immunogold electron microscopy in the rat using antibodies ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.07.013
更新日期:2005-01-01 00:00:00
abstract::The amygdala is a temporal lobe region that is implicated in emotional information processing. The amygdala also is associated with the processing and modulation of pain sensation. Recently, we demonstrated that in nonhuman primates, the amygdala is necessary for the full expression of cannabinoid-induced antinocicept...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00356-7
更新日期:2003-01-01 00:00:00
abstract::Sulfoglucuronyl carbohydrate is the terminal moiety of neolacto-oligosaccharides, expressed on several glycoproteins of the immunoglobulin superfamily involved in cell-cell recognition and on two glycolipids. Sulfoglucuronyl carbohydrate is temporally and spatially regulated in the developing nervous system. It appear...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00666-0
更新日期:1998-08-01 00:00:00
abstract::Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90442-i
更新日期:1993-08-01 00:00:00
abstract::Clinical observations have shown a link for the high comorbid rate between smoking and psychiatric disorders, including anxiety disorders. However, little is known about the neural mechanism underlying the progression from nicotine dependence to an anxiety disorder. A deficit in fear extinction in general is considere...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.03.005
更新日期:2008-06-02 00:00:00
abstract::Secretogranin II (chromogranin C), originally described as tyrosine sulfated protein of the anterior pituitary, is present in large dense core vesicles of several endocrine cells and neurons. We raised antisera in rabbits to conjugates of two synthetic peptides (bovine secretogranin 133-151 and rat secretogranin 154-1...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90200-y
更新日期:1993-03-01 00:00:00
abstract::This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal lev...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.12.048
更新日期:2008-03-27 00:00:00
abstract::The binding of the GABAA/benzodiazepine receptor agonist [3H]flunitrazepam was studied in the hippocampus of rats kindled by daily stimulation of the Schaffer collaterals, using semi-quantitative autoradiography. Two kindled stages were investigated: (i) 24 h after the last generalized tonic-clonic seizure (fully kind...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00158-f
更新日期:1995-09-01 00:00:00
abstract::Multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), are crucially dependent on the invasion of activated autoreactive lymphocytes and blood macrophages into the central nervous system (CNS). Proinflammatory mononuclear cells and activated local microglia mediate inflammation, demy...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.06.070
更新日期:2014-09-26 00:00:00
abstract::A plethora of studies have indicated that enriched environment (EE) paradigm provokes plastic and morphological changes in astrocytes with accompanying increments of their density and positively affects the behavior of rodents. We also previously documented that EE could be employed to preclude several behavioral abno...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.03.065
更新日期:2016-06-21 00:00:00
abstract::Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2019.07.046
更新日期:2019-10-01 00:00:00
abstract::Decreased levels of soluble ubiquitin carboxy-terminal hydrolase L1 (UCHL1) have been reported in the brains of sporadic Alzheimer's disease (AD) patients, and the introduction of UCHL1 rescued the synaptic and cognitive function of AD model mice. Obviously, a reduction in the levels of UCHL1 may play a role in the pa...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.06.013
更新日期:2014-09-05 00:00:00