当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain.

Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain.

Abstract：

:Epigenetic modulation participates in the mechanism of multiple types of pathological pain, so targeting the involved regulators may be a promising strategy for pain treatment. Our previous research identified the analgesic effect of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) on mechanical hyperalgesia in a rat model of bone cancer pain (BCP) via restoration of μ-opioid receptor (MOR) expression. However, the specific types of HDACs contributing to BCP have not been explored. The present study investigated the expression pattern of some common HDACs and found that HDAC2 was up-regulated in a time-dependent manner in the lumbar spinal cord of BCP rats. TSA application suppressed HDAC2 expression in cultured PC12 cells and reversed the augmented HDAC2 in BCP rats. An RNA-interfering strategy confirmed the essential role of HDAC2 in the modulation of mechanical hyperalgesia following tumor cell inoculation, and we further examined its possible downstream targets. Notably, HDAC2 knock-down did not restore MOR expression, but it robustly reversed the down-regulation of potassium-chloride cotransporter 2 (KCC2). The impaired KCC2 expression is a vital mechanism of many types of pathological pain. Therefore, our results demonstrated that HDAC2 in spinal cord contributed to the mechanical hyperalgesia in BCP rats, and this effect may be associated with KCC2 modulation.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Hou X,Weng Y,Wang T,Ouyang B,Li Y,Song Z,Pan Y,Zhang Z,Zou W,Huang C,Guo Q

doi

10.1016/j.neuroscience.2018.02.026

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

138-149

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(18)30144-1

journal_volume

377

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Rapid turnover of spinules at synaptic terminals.

    abstract：:Spinules found in brain consist of small invaginations of plasma membranes which enclose membrane evaginations from adjacent cells. Here, we focus on the dynamic properties of the most common type, synaptic spinules, which reside in synaptic terminals. In order to test whether depolarization triggers synaptic spinule ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.031

    authors： Tao-Cheng JH,Dosemeci A,Gallant PE,Miller S,Galbraith JA,Winters CA,Azzam R,Reese TS

    更新日期：2009-04-21 00:00:00

  • Antidromic burst activity of locus coeruleus neurons during cortical spreading depression.

    abstract：:The electrical activity of locus coeruleus neurons was investigated during cortical spreading depression in urethane-anaesthetized rats. Cortical spreading depression was induced by a direct application of 1-3 M KCl solution to the surface of the cerebral cortex. The occurrence of cortical spreading depression was ass...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00679-3

    authors： Arakawa S,Nakamura S,Kawashima N,Nishiike S,Fujii Y

    更新日期：1997-06-01 00:00:00

  • Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.

    abstract：:Induction of heat shock/stress proteins is a key feature of a universal mechanism of cellular defence to injury known as the "stress response". The present study investigated whether heat shock protein expression correlates with the extent of neuronal injury inflicted by increasingly intense seizure activity. Limbic e...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)92049-p

    authors： Gass P,Prior P,Kiessling M

    更新日期：1995-03-01 00:00:00

  • Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor.

    abstract：:This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, and immunohistochemistry. Fluorogold (FG) retrogra...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.06.048

    authors： Takeda M,Kadoi J,Takahashi M,Nasu M,Matsumoto S

    更新日期：2007-09-07 00:00:00

  • Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors.

    abstract：:Our recent data suggest that noradrenaline (NA) regulates expression of Per1 mRNA in rat C6 cells, as a model of brain astrocytes, by two distinct NA-mediating pathways. Although C6 cells possess potential astrocyte-type characteristics, we hypothesize that astrocytes located in a distinct tissue or organ play specifi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.024

    authors： Sugimoto T,Morioka N,Sato K,Hisaoka K,Nakata Y

    更新日期：2011-06-30 00:00:00

  • Gene expression patterns during enhanced periods of visual cortex plasticity.

    abstract：:During a critical period in its postnatal development the mammalian visual cortex displays susceptibility to experience-dependent alterations of neuronal response properties. Plasticity represents an integrated set of developmental processes controlled by a transcriptional hierarchy that coordinates the action of many...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00570-x

    authors： Prasad SS,Kojic LZ,Li P,Mitchell DE,Hachisuka A,Sawada J,Gu Q,Cynader MS

    更新日期：2002-01-01 00:00:00

  • Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions.

    abstract：:Field and intracellular potentials were recorded from CA1 pyramidal stratum in submerged slices (at 33 degrees). During "normal" oxygenation (95% O2 + 5% CO2), tonic depression of population spikes and field excitatory postsynaptic potentials by endogenous adenosine was demonstrated by (i) the marked enhancement by th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90545-2

    authors： Zhu PJ,Krnjević K

    更新日期：1994-11-01 00:00:00

  • Detection of putative dopamine receptors in neurites outgrowing from locust central nervous system explants using anti-idiotypic dopamine antibodies.

    abstract：:Organotypic cultures established from the third thoracic ganglion of locust embryo have been used to investigate dopamine receptors. In this in vitro system, neurites emerge directly from the explants and form a dense network around the explants, presenting cell surface freely exposed for experimental labelling. Polyc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90088-4

    authors： Vanhems E,Delbos M,Geffard M,Viellemaringe J

    更新日期：1994-02-01 00:00:00

  • A neurophysiological study of prepositus hypoglossi neurons projecting to oculomotor and preoculomotor nuclei in the alert cat.

    abstract：:The activity of 62 antidromically identified prepositus hypoglossi neurons was recorded in 10 alert cats during spontaneous, vestibular or visually induced eye movements. Neurons were antidromically activated from stimulating electrodes implanted in the ipsilateral medial longitudinal fasciculus (n = 24), the ipsilate...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90058-4

    authors： Delgado-García JM,Vidal PP,Gómez C,Berthoz A

    更新日期：1989-01-01 00:00:00

  • Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.

    abstract：:Stimulation of the mu-opioid receptor (MOR) on nociceptors with fentanyl can produce hyperalgesia (opioid-induced hyperalgesia, OIH) and hyperalgesic priming, a model of transition to chronic pain. We investigated if local and systemic administration of biased MOR agonists (PZM21 and TRV130 [oliceridine]), which prefe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.10.015

    authors： Araldi D,Ferrari LF,Levine JD

    更新日期：2018-12-01 00:00:00

  • Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains.

    abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00568-0

    authors： Torp R,Head E,Milgram NW,Hahn F,Ottersen OP,Cotman CW

    更新日期：2000-01-01 00:00:00

  • Neural correlates of the semantic interference effect: new evidence from transcranial direct current stimulation.

    abstract：:In two experiments, we combined a semantic blocked naming paradigm with anodal transcranial direct current stimulation (tDCS) to shed light on the neural correlates of the semantic interference (SI) effect. In particular, prior to the naming task, anodal tDCS was applied over the left superior temporal gyrus (STG, Exp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.046

    authors： Pisoni A,Papagno C,Cattaneo Z

    更新日期：2012-10-25 00:00:00

  • Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors.

    abstract：:The effects of the dopamine D(3) receptor, a putative autoreceptor, have been investigated by comparing behavioral and neurochemical properties of wild-type mice and mice with a genetic deletion of the D(3) receptor. The D(3) knock-out mice were modestly hyper-responsive to a novel environment relative to wild-type mi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00067-2

    authors： Joseph JD,Wang YM,Miles PR,Budygin EA,Picetti R,Gainetdinov RR,Caron MG,Wightman RM

    更新日期：2002-01-01 00:00:00

  • A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.

    abstract：:Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00401-3

    authors： Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

    更新日期：2002-01-01 00:00:00

  • The inferior colliculus of the rat: quantitative immunocytochemical study of GABA and glycine.

    abstract：:Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic. To date, however, a quantitative description of the topographic distribution of GABAergic neurons in the rat's IC and their GABAergic or glyciner...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.12.030

    authors： Merchán M,Aguilar LA,Lopez-Poveda EA,Malmierca MS

    更新日期：2005-01-01 00:00:00

  • Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats.

    abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.037

    authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

    更新日期：2011-06-02 00:00:00

  • Analysis of excitatory synapses in the guinea pig inferior colliculus: a study using electron microscopy and GABA immunocytochemistry.

    abstract：:The inferior colliculus (IC) integrates ascending auditory input from the lower brainstem and descending input from the auditory cortex. Understanding how IC cells integrate these inputs requires identification of their synaptic arrangements. We describe excitatory synapses in the dorsal cortex, central nucleus, and l...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.01.061

    authors： Nakamoto KT,Mellott JG,Killius J,Storey-Workley ME,Sowick CS,Schofield BR

    更新日期：2013-05-01 00:00:00

  • Expression of a developmentally regulated, phosphorylated isoform of microtubule-associated protein 1B in regenerating axons of the sciatic nerve.

    abstract：:Monoclonal antibodies SMI-31 and 150 recognize phosphorylation epitopes on microtubule-associated protein 1B that have been shown to be developmentally down-regulated in the nervous system. We have used these antibodies to establish changes in the pattern of expression of their epitopes on microtubule-associated prote...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00078-4

    authors： Bush MS,Tonge DA,Woolf C,Gordon-Weeks PR

    更新日期：1996-07-01 00:00:00

  • Electrical activity of neurons in the ventrolateral septum and bed nuclei of the stria terminalis in suckled rats: statistical analysis gives evidence for sensitivity to oxytocin and for relation to the milk-ejection reflex.

    abstract：:Our previous results obtained by lesioning or stimulating the ventrolateral part of the lateral septum and the bed nuclei of the stria terminalis suggested that this area is involved in the control of milk ejection pattern in rats. The present study was undertaken with the aim of testing ventrolateral part of the late...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90258-h

    authors： Lambert RC,Moos FC,Ingram CD,Wakerley JB,Kremarik P,Guerné Y,Richard P

    更新日期：1993-05-01 00:00:00

  • Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion.

    abstract：:Prestin (SLC26a5) is an integral membrane motor protein in outer hair cells (OHC) that underlies cochlear amplification. As a voltage-dependent protein, it relies on intrinsic sensor charge to respond to transmembrane voltage (receptor potentials), thereby effecting conformational changes. The protein's electromechani...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.003

    authors： Zhai F,Song L,Bai JP,Dai C,Navaratnam D,Santos-Sacchi J

    更新日期：2020-04-01 00:00:00

  • Immunohistochemical localization of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor subunits in the substantia nigra pars compacta of the rat.

    abstract：:Ionotropic glutamate receptors in the substantia nigra pars compacta regulate the activity of dopamine neurons. We have used dual-label immunofluoresence and confocal laser microscopy to study the localization of subunits of two types of ionotropic receptors within the substantia nigra pars compacta of the rat. Immuno...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00328-5

    authors： Albers DS,Weiss SW,Iadarola MJ,Standaert DG

    更新日期：1999-03-01 00:00:00

  • Time required for transmitter accumulation inside monoaminergic storage vesicles differs in peripheral and in central systems.

    abstract：:Monoamine storage vesicles accumulate transmitters via an active transport process which presents similar pharmacological and bioenergetic properties in all monoaminergic systems. Using [3H]reserpine, a specific ligand of the vesicular monoamine transporter on isolated storage vesicles, we have determined the molecula...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90207-2

    authors： Scherman D,Boschi G

    更新日期：1988-12-01 00:00:00

  • Nucleus accumbens opioids regulate flavor-based preferences in food consumption.

    abstract：:Opioid signaling in the nucleus accumbens (NAcc) regulates feeding behavior, having particularly strong effects on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient con...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.067

    authors： Woolley JD,Lee BS,Fields HL

    更新日期：2006-11-17 00:00:00

  • Nerve growth factor affects uninjured, adult rat septohippocampal cholinergic neurons.

    abstract：:The effect of nerve growth factor on the intact versus injured septohippocampal cholinergic system of adult rats was studied. Nerve growth factor was continuously infused into the lateral ventricle of adult uninjured rats or rats that had received unilateral partial transection of the fimbria. Controls (operated and u...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90309-6

    authors： Fusco M,Oderfeld-Nowak B,Vantini G,Schiavo N,Gradkowska M,Zaremba M,Leon A

    更新日期：1989-01-01 00:00:00

  • Histamine and corticosterone modulate Acid sensing ion channels (ASICs) dependent long-term potentiation at the mouse anterior cingulate cortex.

    abstract：:Increase in proton concentration [H+] or decrease in local and global extracellular pH occurs in both physiological and pathological conditions. Acid-sensing ion channels (ASICs), belonging to the ENaC/Deg superfamily, play an important role in signal transduction as proton sensor. ASICs and in particular ASIC-1a (one...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2021.01.022

    authors： Natalia Gobetto M,González-Inchauspe Osvaldo D Uchitel C

    更新日期：2021-01-22 00:00:00

  • Differences in the multiple step process of inhibition of neurotransmitter release induced by tetanus toxin and botulinum neurotoxins type A and B at Aplysia synapses.

    abstract：:In order to gain insights into the steps (binding, uptake, intracellular effect) which differ in the inhibitory actions of tetanus toxin and botulinum neurotoxins types A or B, their temperature dependencies were investigated at identified cholinergic and non-cholinergic synapses in Aplysia. Upon lowering the temperat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00336-3

    authors： Poulain B,De Paiva A,Deloye F,Doussau F,Tauc L,Weller U,Dolly JO

    更新日期：1996-01-01 00:00:00

  • Analysing functional connectivity in brain slices by a combination of infrared video microscopy, flash photolysis of caged compounds and scanning methods.

    abstract：:We evaluate a novel set-up for scanning functional connectivity in brain slices from the somatosensory cortex of the rat. Upright infrared video microscopy for targeted placement of electrodes is combined with rapid photolysis of bath-applied caged neurotransmitter induced by a xenon flash lamp. Flash photolysis of ca...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00010-4

    authors： Kötter R,Staiger JF,Zilles K,Luhmann HJ

    更新日期：1998-09-01 00:00:00

  • The N170 is Sensitive to Long-term (Personal) Familiarity of a Face Identity.

    abstract：:The N170 is a large deflection of the human electroencephalogram (EEG), peaking at about 170 milliseconds over the occipito-temporal cortex after the sudden onset of a face stimulus. The N170 reflects perceptual awareness of a face and its onset corresponds to the emergence of reliable face-selectivity in the human br...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2020.12.036

    authors： Caharel S,Rossion B

    更新日期：2021-01-16 00:00:00

  • Deregulation of the hypoxia inducible factor-1α pathway in monocytes from sporadic amyotrophic lateral sclerosis patients.

    abstract：:The clinical course of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) is closely related to hypoxia. The normal response to hypoxia involves two pathways in particular: the hypoxia inducible factor 1α (HIF-1α) pathway (which notably controls the synthesis of vascular endothelial growth fact...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.10.040

    authors： Moreau C,Gosset P,Kluza J,Brunaud-Danel V,Lassalle P,Marchetti P,Defebvre L,Destée A,Devos D

    更新日期：2011-01-13 00:00:00

  • Exocytotic release from neuronal cell bodies, dendrites and nerve terminals in sympathetic ganglia of the rat, and its differential regulation.

    abstract：:Stimulant-induced exocytosis has been demonstrated in sympathetic ganglia of the rat by in vitro incubation of excised ganglia in the presence of tannic acid, which stabilizes vesicle cores after their exocytotic release. Sites of exocytosis were observed along non-synaptic regions of the surfaces of neuron somata and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00664-1

    authors： Zaidi ZF,Matthews MR

    更新日期：1997-10-01 00:00:00